Aliases for LMNTD2 Gene

Aliases for LMNTD2 Gene

  • Lamin Tail Domain Containing 2 2 3 5
  • Lamin Tail Domain-Containing Protein 2 3 4
  • C11orf35 3 4
  • Chromosome 11 Open Reading Frame 35 2
  • MGC35138 2
  • LMNTD2 5

External Ids for LMNTD2 Gene

Previous HGNC Symbols for LMNTD2 Gene

  • C11orf35

Summaries for LMNTD2 Gene

GeneCards Summary for LMNTD2 Gene

LMNTD2 (Lamin Tail Domain Containing 2) is a Protein Coding gene.

Additional gene information for LMNTD2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LMNTD2 Gene

Genomics for LMNTD2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LMNTD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LMNTD2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LMNTD2

Genomic Locations for LMNTD2 Gene

Genomic Locations for LMNTD2 Gene
5,931 bases
Minus strand
5,930 bases
Minus strand

Genomic View for LMNTD2 Gene

Genes around LMNTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMNTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMNTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMNTD2 Gene

Proteins for LMNTD2 Gene

  • Protein details for LMNTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lamin tail domain-containing protein 2
    Protein Accession:

    Protein attributes for LMNTD2 Gene

    634 amino acids
    Molecular mass:
    70379 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LMNTD2 Gene

Post-translational modifications for LMNTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LMNTD2 Gene

Domains & Families for LMNTD2 Gene

Gene Families for LMNTD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LMNTD2 Gene

genes like me logo Genes that share domains with LMNTD2: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LMNTD2 Gene

Function for LMNTD2 Gene

Phenotypes From GWAS Catalog for LMNTD2 Gene

genes like me logo Genes that share phenotypes with LMNTD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMNTD2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LMNTD2 Gene

Localization for LMNTD2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMNTD2 gene
Compartment Confidence
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LMNTD2 Gene

Pathways & Interactions for LMNTD2 Gene

PathCards logo

SuperPathways for LMNTD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LMNTD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for LMNTD2 Gene

Drugs & Compounds for LMNTD2 Gene

No Compound Related Data Available

Transcripts for LMNTD2 Gene

mRNA/cDNA for LMNTD2 Gene

5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMNTD2

Alternative Splicing Database (ASD) splice patterns (SP) for LMNTD2 Gene

No ASD Table

Relevant External Links for LMNTD2 Gene

GeneLoc Exon Structure for

Expression for LMNTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LMNTD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LMNTD2 Gene

This gene is overexpressed in Fetal heart (58.2) and Plasma (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LMNTD2 Gene

Protein tissue co-expression partners for LMNTD2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LMNTD2

genes like me logo Genes that share expression patterns with LMNTD2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMNTD2 Gene

Orthologs for LMNTD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LMNTD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11H11orf35 30
  • 98.62 (n)
C11orf35 31
  • 97 (a)
(Canis familiaris)
Mammalia C18H11orf35 30
  • 71.33 (n)
C11orf35 31
  • 52 (a)
(Mus musculus)
Mammalia 1600016N20Rik 30 31
  • 67.53 (n)
Lmntd2 17
(Rattus norvegicus)
Mammalia RGD1307439 30
  • 65.46 (n)
(Bos Taurus)
Mammalia C11orf35 31
  • 54 (a)
(Monodelphis domestica)
Mammalia C11orf35 31
  • 32 (a)
(Anolis carolinensis)
Reptilia C11orf35 31
  • 41 (a)
Species where no ortholog for LMNTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LMNTD2 Gene

Gene Tree for LMNTD2 (if available)
Gene Tree for LMNTD2 (if available)
Evolutionary constrained regions (ECRs) for LMNTD2: view image

Paralogs for LMNTD2 Gene

No data available for Paralogs for LMNTD2 Gene

Variants for LMNTD2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LMNTD2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs2061586 - p.Ala44Thr

Additional dbSNP identifiers (rs#s) for LMNTD2 Gene

Structural Variations from Database of Genomic Variants (DGV) for LMNTD2 Gene

Variant ID Type Subtype PubMed ID
dgv1522n54 CNV loss 21841781
dgv1523n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv2759794 CNV loss 17122850
esv3625070 CNV loss 21293372
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1077764 OTHER inversion 25765185
nsv1159791 CNV deletion 26073780
nsv467634 CNV loss 19166990
nsv467635 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv469924 CNV gain 18288195
nsv527327 CNV loss 19592680
nsv528415 CNV loss 19592680
nsv552854 CNV loss 21841781
nsv552856 CNV gain 21841781
nsv951270 CNV deletion 24416366

Variation tolerance for LMNTD2 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.96; 68.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LMNTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMNTD2 Gene

Disorders for LMNTD2 Gene

No disorders were found for LMNTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMNTD2 Gene

Publications for LMNTD2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4

Products for LMNTD2 Gene

Sources for LMNTD2 Gene