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Aliases for LMNTD2 Gene

Aliases for LMNTD2 Gene

  • Lamin Tail Domain Containing 2 2 3 5
  • C11orf35 3 4
  • Lamin Tail Domain-Containing Protein 2 3
  • Chromosome 11 Open Reading Frame 35 2

External Ids for LMNTD2 Gene

Previous HGNC Symbols for LMNTD2 Gene

  • C11orf35

Summaries for LMNTD2 Gene

GeneCards Summary for LMNTD2 Gene

LMNTD2 (Lamin Tail Domain Containing 2) is a Protein Coding gene.

Additional gene information for LMNTD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMNTD2 Gene

Genomics for LMNTD2 Gene

GeneHancer (GH) Regulatory Elements for LMNTD2 Gene

Promoters and enhancers for LMNTD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J000559 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 657.4 -2.1 -2135 7.5 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B FOS LMNTD2 GC11M000563 RASSF7 PHRF1 HRAS TMEM80 PKP3 RNH1 PTDSS2 ENSG00000254815
GH11J000556 Promoter 0.7 EPDnew 650.7 +4.3 4279 0.1 SUZ12 EZH2 ENSG00000254815 LMNTD2 GC11P000559 LRRC56 HRAS
GH11J000534 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 7 +24.5 24491 4.3 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A ZBTB7B POLR2B LRRC56 HRAS RNH1 TMEM80 PHRF1 ENSG00000255237 LMNTD2 LOC101059906
GH11J000636 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 5.5 -78.3 -78339 5.5 KLF1 ZBTB6 ZIC2 HIC1 ZFP69B GLIS2 POLR2A GLIS1 ZNF341 RBM22 GC11P000643 GC11P000641 GC11P000637 DRD4 TMEM80 PTDSS2 CDHR5 HRAS LMNTD2 OR4F2P
GH11J000514 Enhancer 0.6 ENCODE dbSUPER 12.8 +45.6 45557 1.8 CEBPB CEBPG LOC105376507 RNH1 HRAS ENSG00000254815 RASSF7 LMNTD2 PTDSS2 CEND1 SLC25A22 RPLP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LMNTD2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LMNTD2 Gene

Genomic Locations for LMNTD2 Gene
5,931 bases
Minus strand

Genomic View for LMNTD2 Gene

Genes around LMNTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMNTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMNTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMNTD2 Gene

Proteins for LMNTD2 Gene

  • Protein details for LMNTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lamin tail domain-containing protein 2
    Protein Accession:

    Protein attributes for LMNTD2 Gene

    634 amino acids
    Molecular mass:
    70379 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LMNTD2 Gene

Post-translational modifications for LMNTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LMNTD2 Gene

Domains & Families for LMNTD2 Gene

Gene Families for LMNTD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LMNTD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LMNTD2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for LMNTD2 Gene

Function for LMNTD2 Gene

genes like me logo Genes that share phenotypes with LMNTD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMNTD2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LMNTD2 Gene

Localization for LMNTD2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMNTD2 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LMNTD2 Gene

Pathways & Interactions for LMNTD2 Gene

SuperPathways for LMNTD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LMNTD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for LMNTD2 Gene

Drugs & Compounds for LMNTD2 Gene

No Compound Related Data Available

Transcripts for LMNTD2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMNTD2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMNTD2 Gene

No ASD Table

Relevant External Links for LMNTD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LMNTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LMNTD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LMNTD2 Gene

This gene is overexpressed in Fetal heart (58.2) and Plasma (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LMNTD2 Gene

Protein tissue co-expression partners for LMNTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LMNTD2 Gene:

genes like me logo Genes that share expression patterns with LMNTD2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMNTD2 Gene

Orthologs for LMNTD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LMNTD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11H11orf35 33
  • 98.62 (n)
C11orf35 34
  • 97 (a)
(Canis familiaris)
Mammalia C18H11orf35 33
  • 71.33 (n)
C11orf35 34
  • 52 (a)
(Mus musculus)
Mammalia 1600016N20Rik 34 33
  • 67.53 (n)
Lmntd2 16
(Rattus norvegicus)
Mammalia RGD1307439 33
  • 65.46 (n)
(Bos Taurus)
Mammalia C11orf35 34
  • 54 (a)
(Monodelphis domestica)
Mammalia C11orf35 34
  • 32 (a)
(Anolis carolinensis)
Reptilia C11orf35 34
  • 41 (a)
Species where no ortholog for LMNTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LMNTD2 Gene

Gene Tree for LMNTD2 (if available)
Gene Tree for LMNTD2 (if available)
Evolutionary constrained regions (ECRs) for LMNTD2: view image

Paralogs for LMNTD2 Gene

No data available for Paralogs for LMNTD2 Gene

Variants for LMNTD2 Gene

Sequence variations from dbSNP and Humsavar for LMNTD2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000454829 -- 554,607(-) G/A downstream_transcript_variant
rs1000856296 -- 562,111(-) C/T upstream_transcript_variant
rs1001272694 -- 556,153(-) G/A intron_variant
rs1001576130 -- 559,692(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001759149 -- 561,199(-) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LMNTD2 Gene

Variant ID Type Subtype PubMed ID
dgv1522n54 CNV loss 21841781
dgv1523n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv2759794 CNV loss 17122850
esv3625070 CNV loss 21293372
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1077764 OTHER inversion 25765185
nsv1159791 CNV deletion 26073780
nsv467634 CNV loss 19166990
nsv467635 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv469924 CNV gain 18288195
nsv527327 CNV loss 19592680
nsv528415 CNV loss 19592680
nsv552854 CNV loss 21841781
nsv552856 CNV gain 21841781
nsv951270 CNV deletion 24416366

Variation tolerance for LMNTD2 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.96; 68.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LMNTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMNTD2 Gene

Disorders for LMNTD2 Gene

Additional Disease Information for LMNTD2

No disorders were found for LMNTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMNTD2 Gene

Publications for LMNTD2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58

Products for LMNTD2 Gene

Sources for LMNTD2 Gene

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