Aliases for LMNTD1 Gene

Aliases for LMNTD1 Gene

  • Lamin Tail Domain Containing 1 2 3 5
  • Intermediate Filament Tail Domain-Containing Protein 1 3 4
  • Intermediate Filament Tail Domain Containing 1 2 3
  • Lamin Tail Domain-Containing Protein 1 3 4
  • IFLTD1 3 4
  • FLJ36004 2
  • LMNARS1 3
  • PAS1C1 3
  • LMNTD1 5
  • Pas1c1 2

External Ids for LMNTD1 Gene

Previous HGNC Symbols for LMNTD1 Gene

  • IFLTD1

Previous GeneCards Identifiers for LMNTD1 Gene

  • GC12M025410
  • GC12M025412
  • GC12M025430
  • GC12M025432
  • GC12M025438
  • GC12M025443
  • GC12M025414
  • GC12M025416
  • GC12M025418
  • GC12M025420
  • GC12M025422
  • GC12M025424
  • GC12M025426
  • GC12M025428
  • GC12M025447

Summaries for LMNTD1 Gene

GeneCards Summary for LMNTD1 Gene

LMNTD1 (Lamin Tail Domain Containing 1) is a Protein Coding gene. Diseases associated with LMNTD1 include Respiratory System Benign Neoplasm and Lung Adenoma. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT8.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LMNTD1 Gene

Genomics for LMNTD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LMNTD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J025648 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 250.7 -0.3 -260 1.6 ZSCAN16 ZIC2 CEBPB MAX ZNF341 RAD21 RFX5 SMC3 PRDM6 ZNF24 LMNTD1 HSALNG0089930 RASSF8
GH12J025614 Enhancer 1.1 Ensembl ENCODE 10.7 +32.9 32903 3.4 BHLHE40 ZEB1 CEBPB ZNF395 ZNF639 MAX EP300 RAD21 NUFIP1 STAT3 LMNTD1 MN298114-035 ENSG00000257009 KRAS
GH12J025692 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 0.3 -43.7 -43729 4.9 FEZF1 BRCA1 BHLHE40 ZIC2 ZNF610 CEBPB ZNF395 GTF2E2 ZNF639 MAX TDGP1 RASSF8 RASSF8-AS1 HSALNG0089932 LMNTD1 HSALNG0089935
GH12J025653 Enhancer 0.5 Ensembl 0.4 -5.4 -5397 1.6 GABPA SPI1 POLR2A ZNF548 GATA2 CHD2 EP300 TDGP1 RASSF8 RASSF8-AS1 LMNTD1 HSALNG0089930
GH12J025655 Enhancer 0.5 ENCODE 0.4 -7.3 -7319 1.3 ZNF217 CTBP1 SMARCE1 PKNOX1 DPF2 KLF9 LMNTD1 HSALNG0089930 RASSF8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LMNTD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LMNTD1

Genomic Locations for LMNTD1 Gene

Latest Assembly
239,298 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
172,497 bases
Minus strand

(GRCh37/hg19 by Ensembl)
239,273 bases
Minus strand

Genomic View for LMNTD1 Gene

Genes around LMNTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMNTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMNTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMNTD1 Gene

Proteins for LMNTD1 Gene

  • Protein details for LMNTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lamin tail domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DL27
    • B4DY70
    • Q8IY38

    Protein attributes for LMNTD1 Gene

    388 amino acids
    Molecular mass:
    43408 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LMNTD1 Gene


neXtProt entry for LMNTD1 Gene

Post-translational modifications for LMNTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LMNTD1 Gene

Domains & Families for LMNTD1 Gene

Gene Families for LMNTD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LMNTD1 Gene

Suggested Antigen Peptide Sequences for LMNTD1 Gene

GenScript: Design optimal peptide antigens:
  • Intermediate filament tail domain-containing protein 1 (ILFT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with LMNTD1: view

Function for LMNTD1 Gene

Phenotypes From GWAS Catalog for LMNTD1 Gene

genes like me logo Genes that share phenotypes with LMNTD1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMNTD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LMNTD1 Gene

Localization for LMNTD1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMNTD1 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LMNTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with LMNTD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LMNTD1 Gene

Pathways & Interactions for LMNTD1 Gene

PathCards logo

SuperPathways for LMNTD1 Gene

No Data Available

Interacting Proteins for LMNTD1 Gene

Gene Ontology (GO) - Biological Process for LMNTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with LMNTD1: view

No data available for Pathways by source and SIGNOR curated interactions for LMNTD1 Gene

Drugs & Compounds for LMNTD1 Gene

No Compound Related Data Available

Transcripts for LMNTD1 Gene

mRNA/cDNA for LMNTD1 Gene

11 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMNTD1

Alternative Splicing Database (ASD) splice patterns (SP) for LMNTD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: -

Relevant External Links for LMNTD1 Gene

GeneLoc Exon Structure for

Expression for LMNTD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LMNTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LMNTD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LMNTD1

Evidence on tissue expression from TISSUES for LMNTD1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with LMNTD1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMNTD1 Gene

Orthologs for LMNTD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LMNTD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFLTD1 30 31
  • 98.61 (n)
(Canis familiaris)
Mammalia IFLTD1 30 31
  • 77.69 (n)
(Bos Taurus)
Mammalia IFLTD1 30 31
  • 74.86 (n)
(Rattus norvegicus)
Mammalia Ifltd1 30
  • 67.03 (n)
(Mus musculus)
Mammalia Ifltd1 30 31
  • 66.67 (n)
Lmntd1 17
(Monodelphis domestica)
Mammalia IFLTD1 31
  • 35 (a)
(Anolis carolinensis)
Reptilia IFLTD1 31
  • 38 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 15 (a)
Species where no ortholog for LMNTD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LMNTD1 Gene

Gene Tree for LMNTD1 (if available)
Gene Tree for LMNTD1 (if available)
Evolutionary constrained regions (ECRs) for LMNTD1: view image

Paralogs for LMNTD1 Gene

Variants for LMNTD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LMNTD1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs1479500 - p.Thr366Ser
rs34074522 - p.Ala290Thr
rs34326830 - p.Glu267Gly
rs34732786 - p.Thr289Ala
rs35450203 - p.Ala264Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LMNTD1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LMNTD1 Gene

Variant ID Type Subtype PubMed ID
dgv262e214 CNV loss 21293372
esv1242262 CNV deletion 17803354
esv21824 CNV loss 19812545
esv2488733 CNV deletion 19546169
esv2665786 CNV deletion 23128226
esv2759885 CNV loss 17122850
esv3303102 CNV tandem duplication 20981092
esv3304453 CNV mobile element insertion 20981092
esv3306210 CNV mobile element insertion 20981092
esv3309343 CNV mobile element insertion 20981092
esv3339773 CNV insertion 20981092
esv3372528 CNV insertion 20981092
esv3407156 CNV insertion 20981092
esv3441415 CNV insertion 20981092
esv3548905 CNV deletion 23714750
esv3628896 CNV loss 21293372
esv3628897 CNV gain 21293372
esv3628898 CNV loss 21293372
esv3628902 CNV gain 21293372
esv5503 OTHER inversion 19470904
nsv1110892 OTHER inversion 24896259
nsv1143560 CNV deletion 24896259
nsv1159990 CNV deletion 26073780
nsv437731 CNV loss 16327808
nsv509460 CNV insertion 20534489
nsv519712 CNV loss 19592680
nsv520540 CNV loss 19592680
nsv832354 CNV gain 17160897
nsv951342 CNV deletion 24416366

Variation tolerance for LMNTD1 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LMNTD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMNTD1 Gene

Disorders for LMNTD1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LMNTD1 Gene - From: COP

Disorder Aliases PubMed IDs
respiratory system benign neoplasm
lung adenoma
  • adenoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LMNTD1

genes like me logo Genes that share disorders with LMNTD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LMNTD1 Gene

Publications for LMNTD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  4. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill SJ … Livingston DM (Genes & development 2014) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3

Products for LMNTD1 Gene

Sources for LMNTD1 Gene