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Aliases for LMF2 Gene

Aliases for LMF2 Gene

  • Lipase Maturation Factor 2 2 3 5
  • Transmembrane Protein 112B 2 3 4
  • Transmembrane Protein 153 2 3 4
  • TMEM112B 3 4
  • TMEM153 3 4

External Ids for LMF2 Gene

Previous HGNC Symbols for LMF2 Gene

  • TMEM153
  • TMEM112B

Previous GeneCards Identifiers for LMF2 Gene

  • GC22M049290
  • GC22M050941
  • GC22M033832

Summaries for LMF2 Gene

GeneCards Summary for LMF2 Gene

LMF2 (Lipase Maturation Factor 2) is a Protein Coding gene. Among its related pathways are Metabolism and Lipoprotein metabolism. An important paralog of this gene is LMF1.

UniProtKB/Swiss-Prot for LMF2 Gene

  • Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).

Additional gene information for LMF2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMF2 Gene

Genomics for LMF2 Gene

GeneHancer (GH) Regulatory Elements for LMF2 Gene

Promoters and enhancers for LMF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I050505 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 577.1 0.0 -13 4.2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B E2F8 LMF2 NCAPH2 SYCE3 CHKB ALG12 ENSG00000273192 TRABD PLXNB2 TYMP MIOX
GH22I050626 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 19.7 -120.2 -120183 2.4 HDGF ZNF493 ARID4B SIN3A YBX1 GLI4 ZNF2 ZNF280A GLIS2 KLF7 ARSA BRD1 ZBED4 RABL2B ENSG00000272836 TUBGCP6 PLXNB2 ALG12 CHKB LOC105373095
GH22I050339 Enhancer 0.9 ENCODE 35 +167.6 167616 2.1 HDGF ZNF493 ZNF2 KLF7 ZNF488 ZNF585B GLIS1 MYNN NBN ZNF300 BRD1 RABL2B ALG12 PLXNB2 ENSG00000272836 CHKB TUBGCP6 ZBED4 LMF2 ENSG00000273192
GH22I050670 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.1 -165.2 -165164 4.8 ZNF529 ZFP64 ZSCAN4 KLF17 FEZF1 ZNF2 ZNF335 GLIS2 EGR1 KLF7 SHANK3 BRD1 CPT1B ZBED4 ENSG00000272836 LOC105373095 RABL2B LMF2 NCAPH2 TUBGCP6
GH22I049942 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.1 +558.6 558599 13.5 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A ALG12 ENSG00000272836 RABL2B PLXNB2 TUBGCP6 ZBED4 LMF2 NCAPH2 CHKB BRD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LMF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LMF2 gene promoter:

Genomic Locations for LMF2 Gene

Genomic Locations for LMF2 Gene
chr22:50,502,947-50,507,840
(GRCh38/hg38)
Size:
4,894 bases
Orientation:
Minus strand
chr22:50,941,376-50,946,135
(GRCh37/hg19)

Genomic View for LMF2 Gene

Genes around LMF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMF2 Gene

Proteins for LMF2 Gene

  • Protein details for LMF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU23-LMF2_HUMAN
    Recommended name:
    Lipase maturation factor 2
    Protein Accession:
    Q9BU23
    Secondary Accessions:
    • A6NEZ0
    • Q13392
    • Q6ZNR2
    • Q8WU74
    • Q96C62

    Protein attributes for LMF2 Gene

    Size:
    707 amino acids
    Molecular mass:
    79698 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB03346.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC85437.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

    Alternative splice isoforms for LMF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMF2 Gene

Post-translational modifications for LMF2 Gene

  • Ubiquitination at isoforms=2, 3551, posLast=563563, and isoforms=2, 3607
  • Modification sites at PhosphoSitePlus

Other Protein References for LMF2 Gene

No data available for DME Specific Peptides for LMF2 Gene

Domains & Families for LMF2 Gene

Gene Families for LMF2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for LMF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LMF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BU23

UniProtKB/Swiss-Prot:

LMF2_HUMAN :
  • Belongs to the lipase maturation factor family.
Family:
  • Belongs to the lipase maturation factor family.
genes like me logo Genes that share domains with LMF2: view

Function for LMF2 Gene

Molecular function for LMF2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).

Phenotypes From GWAS Catalog for LMF2 Gene

Gene Ontology (GO) - Molecular Function for LMF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LMF2: view

Phenotypes for LMF2 Gene

genes like me logo Genes that share phenotypes with LMF2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LMF2 Gene

Localization for LMF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMF2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMF2 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LMF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LMF2: view

Pathways & Interactions for LMF2 Gene

genes like me logo Genes that share pathways with LMF2: view

Gene Ontology (GO) - Biological Process for LMF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051604 protein maturation IBA --
genes like me logo Genes that share ontologies with LMF2: view

No data available for SIGNOR curated interactions for LMF2 Gene

Drugs & Compounds for LMF2 Gene

No Compound Related Data Available

Transcripts for LMF2 Gene

Unigene Clusters for LMF2 Gene

Lipase maturation factor 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6: - -
SP7: - -
SP8:

Relevant External Links for LMF2 Gene

GeneLoc Exon Structure for
LMF2
ECgene alternative splicing isoforms for
LMF2

Expression for LMF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LMF2 Gene

Protein differential expression in normal tissues from HIPED for LMF2 Gene

This gene is overexpressed in Nasal epithelium (30.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LMF2 Gene



Protein tissue co-expression partners for LMF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LMF2 Gene:

LMF2

SOURCE GeneReport for Unigene cluster for LMF2 Gene:

Hs.150540

Evidence on tissue expression from TISSUES for LMF2 Gene

  • Skin(4.6)
  • Kidney(4.2)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with LMF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMF2 Gene

Orthologs for LMF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LMF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LMF2 33 34
  • 85.43 (n)
dog
(Canis familiaris)
Mammalia LMF2 33 34
  • 82.08 (n)
mouse
(Mus musculus)
Mammalia Lmf2 33 16 34
  • 80.2 (n)
rat
(Rattus norvegicus)
Mammalia Lmf2 33
  • 79.65 (n)
oppossum
(Monodelphis domestica)
Mammalia LMF2 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LMF2 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves LMF2 33 34
  • 69.42 (n)
lizard
(Anolis carolinensis)
Reptilia LMF2 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lmf2 33
  • 58.66 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53562 33
zebrafish
(Danio rerio)
Actinopterygii lmf2a 33 34
  • 61.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011922 33
  • 48.38 (n)
worm
(Caenorhabditis elegans)
Secernentea K11G12.6 33 34
  • 42.66 (n)
Species where no ortholog for LMF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LMF2 Gene

ENSEMBL:
Gene Tree for LMF2 (if available)
TreeFam:
Gene Tree for LMF2 (if available)

Paralogs for LMF2 Gene

Paralogs for LMF2 Gene

genes like me logo Genes that share paralogs with LMF2: view

Variants for LMF2 Gene

Sequence variations from dbSNP and Humsavar for LMF2 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs376748648 A breast cancer sample 50,506,927(-) G/A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs1000482004 -- 50,508,099(-) /T upstream_transcript_variant
rs1000906384 -- 50,507,287(-) G/A 5_prime_UTR_variant, intron_variant
rs1001088754 -- 50,508,334(-) G/A upstream_transcript_variant
rs1001294311 -- 50,508,204(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LMF2 Gene

Variant ID Type Subtype PubMed ID
esv2758852 CNV loss 17122850
nsv1057656 CNV gain 25217958
nsv1160782 CNV deletion 26073780
nsv3669 CNV insertion 18451855
nsv471224 CNV loss 18288195
nsv482079 CNV gain 20164927
nsv589222 CNV gain 21841781
nsv829340 CNV gain 20364138
nsv834238 CNV loss 17160897
nsv834239 CNV loss 17160897
nsv955201 CNV deletion 24416366

Variation tolerance for LMF2 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.42; 85.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LMF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LMF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMF2 Gene

Disorders for LMF2 Gene

Additional Disease Information for LMF2

No disorders were found for LMF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMF2 Gene

Publications for LMF2 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment. (PMID: 26742120) Kobayashi N … Kondo K (PloS one 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for LMF2 Gene

Sources for LMF2 Gene

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