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Aliases for LMBRD2 Gene

Aliases for LMBRD2 Gene

  • LMBR1 Domain Containing 2 2 3 5
  • LMBR1 Domain-Containing Protein 2 3

External Ids for LMBRD2 Gene

Previous GeneCards Identifiers for LMBRD2 Gene

  • GC05M036140
  • GC05M036054

Summaries for LMBRD2 Gene

GeneCards Summary for LMBRD2 Gene

LMBRD2 (LMBR1 Domain Containing 2) is a Protein Coding gene.

Additional gene information for LMBRD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMBRD2 Gene

Genomics for LMBRD2 Gene

GeneHancer (GH) Regulatory Elements for LMBRD2 Gene

Promoters and enhancers for LMBRD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J036150 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 659.3 -3.2 -3228 9.4 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC LMBRD2 SKP2 RNU6-1305P GC05P036156 NIPBL UGT3A2 ENSG00000251591 ENSG00000272103 NADK2 PIR31598
GH05J035851 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6 +295.9 295870 8.6 PKNOX1 BATF IRF4 RAD21 RFX5 ATF7 FOS ETV6 IKZF2 RUNX3 IL7R LOC105374724 LOC100506406 CAPSL RNU7-130P LMBRD2 SPEF2 ENSG00000279737
GH05J036066 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 7.8 +85.3 85260 1.4 CTCF USF1 ZNF223 SIN3A ZIC2 ZNF335 ZFHX2 ZNF366 POLR2A ZBTB48 UGT3A2 LMBRD2 GC05M036000
GH05J035883 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 5.6 +267.9 267913 2.4 JUN EBF1 BATF HIC1 POLR2A EED FOS ETV6 IKZF2 RUNX3 IL7R LOC105374724 LMBRD2 ENSG00000279737
GH05J036722 Enhancer 1.3 FANTOM5 Ensembl ENCODE 4.1 -572.2 -572176 3 HDGF PKNOX1 BATF IRF4 ZNF766 ATF7 FOS BCLAF1 IKZF2 RUNX3 ENSG00000250155 CPLANE1 LMBRD2 NIPBL GC05P036714
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LMBRD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LMBRD2 gene promoter:
  • STAT3
  • PPAR-gamma1
  • PPAR-gamma2
  • CUTL1
  • STAT1

Genomic Locations for LMBRD2 Gene

Genomic Locations for LMBRD2 Gene
chr5:36,098,412-36,151,961
(GRCh38/hg38)
Size:
53,550 bases
Orientation:
Minus strand
chr5:36,098,514-36,152,063
(GRCh37/hg19)
Size:
53,550 bases
Orientation:
Minus strand

Genomic View for LMBRD2 Gene

Genes around LMBRD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMBRD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMBRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMBRD2 Gene

Proteins for LMBRD2 Gene

  • Protein details for LMBRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DH5-LMBD2_HUMAN
    Recommended name:
    LMBR1 domain-containing protein 2
    Protein Accession:
    Q68DH5
    Secondary Accessions:
    • B3KRB6
    • Q9NTC7

    Protein attributes for LMBRD2 Gene

    Size:
    695 amino acids
    Molecular mass:
    81172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LMBRD2 Gene

Post-translational modifications for LMBRD2 Gene

  • Ubiquitination at isoforms=296 and isoforms=282
  • Glycosylation at isoforms=85 and isoforms=78
  • Modification sites at PhosphoSitePlus

Other Protein References for LMBRD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LMBRD2 Gene

Domains & Families for LMBRD2 Gene

Gene Families for LMBRD2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for LMBRD2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LMBRD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q68DH5

UniProtKB/Swiss-Prot:

LMBD2_HUMAN :
  • Belongs to the LIMR family.
Family:
  • Belongs to the LIMR family.
genes like me logo Genes that share domains with LMBRD2: view

Function for LMBRD2 Gene

Phenotypes From GWAS Catalog for LMBRD2 Gene

genes like me logo Genes that share phenotypes with LMBRD2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LMBRD2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMBRD2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LMBRD2 Gene

Localization for LMBRD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMBRD2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMBRD2 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LMBRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LMBRD2: view

Pathways & Interactions for LMBRD2 Gene

SuperPathways for LMBRD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LMBRD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LMBRD2 Gene

Drugs & Compounds for LMBRD2 Gene

No Compound Related Data Available

Transcripts for LMBRD2 Gene

mRNA/cDNA for LMBRD2 Gene

Unigene Clusters for LMBRD2 Gene

LMBR1 domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LMBRD2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMBRD2 Gene

No ASD Table

Relevant External Links for LMBRD2 Gene

GeneLoc Exon Structure for
LMBRD2
ECgene alternative splicing isoforms for
LMBRD2

Expression for LMBRD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LMBRD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LMBRD2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.7), Frontal cortex (16.4), and Adrenal (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LMBRD2 Gene



Protein tissue co-expression partners for LMBRD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LMBRD2 Gene:

LMBRD2

SOURCE GeneReport for Unigene cluster for LMBRD2 Gene:

Hs.294103
genes like me logo Genes that share expression patterns with LMBRD2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMBRD2 Gene

Orthologs for LMBRD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LMBRD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LMBRD2 34 33
  • 99.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LMBRD2 34 33
  • 93.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LMBRD2 34 33
  • 93.19 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LMBRD2 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 91 (a)
OneToMany
-- 34
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Lmbrd2 33
  • 89.91 (n)
mouse
(Mus musculus)
Mammalia Lmbrd2 16 34 33
  • 89.24 (n)
chicken
(Gallus gallus)
Aves LMBRD2 34 33
  • 81.85 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LMBRD2 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lmbrd2 33
  • 74.69 (n)
African clawed frog
(Xenopus laevis)
Amphibia dkfzp434h2226-prov 33
zebrafish
(Danio rerio)
Actinopterygii lmbrd2a 34
  • 74 (a)
OneToMany
lmbrd2b 34 33
  • 69.75 (n)
OneToMany
wufk97a10 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002467 33
  • 52.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8135 34 33
  • 52.45 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_C47G2.4 33
  • 49.94 (n)
C47G2.4 34
  • 37 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G65290 33
  • 44.08 (n)
rice
(Oryza sativa)
Liliopsida Os06g0218900 33
  • 44.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
Cin.8406 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8406 33
Species where no ortholog for LMBRD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LMBRD2 Gene

ENSEMBL:
Gene Tree for LMBRD2 (if available)
TreeFam:
Gene Tree for LMBRD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LMBRD2: view image

Paralogs for LMBRD2 Gene

No data available for Paralogs for LMBRD2 Gene

Variants for LMBRD2 Gene

Sequence variations from dbSNP and Humsavar for LMBRD2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000044719 -- 36,117,879(-) G/A coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000139652 -- 36,152,468(-) T/C/G upstream_transcript_variant
rs1000149901 -- 36,103,738(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000161397 -- 36,109,741(-) A/T intron_variant
rs1000183908 -- 36,131,397(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LMBRD2 Gene

Variant ID Type Subtype PubMed ID
nsv830262 CNV gain 17160897
nsv4795 CNV deletion 18451855
esv3604707 CNV gain 21293372
esv32711 CNV gain 17666407

Variation tolerance for LMBRD2 Gene

Residual Variation Intolerance Score: 9.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LMBRD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LMBRD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMBRD2 Gene

Disorders for LMBRD2 Gene

Additional Disease Information for LMBRD2

No disorders were found for LMBRD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMBRD2 Gene

Publications for LMBRD2 Gene

  1. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. (PMID: 19176441) Yang JJ … Relling MV (JAMA 2009) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for LMBRD2 Gene

Sources for LMBRD2 Gene

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