Aliases for LMBR1L Gene
External Ids for LMBR1L Gene
Previous GeneCards Identifiers for LMBR1L Gene
GeneCards Summary for LMBR1L Gene
LMBR1L (Limb Development Membrane Protein 1 Like) is a Protein Coding gene. Diseases associated with LMBR1L include Immune System Organ Benign Neoplasm and Thymus Lipoma. An important paralog of this gene is LMBR1.
UniProtKB/Swiss-Prot Summary for LMBR1L Gene
Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685).