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Aliases for LMBR1L Gene

Aliases for LMBR1L Gene

  • Limb Development Membrane Protein 1 Like 2 3 5
  • Lipocalin-Interacting Membrane Receptor 3 4
  • Limb Region 1 Protein Homolog-Like 3 4
  • LIMR 3 4
  • Lipocalin-1 Interacting Membrane Receptor 3
  • Lipocalin-1-Interacting Membrane Receptor 4
  • Limb Development Membrane Protein 1-Like 2
  • Limb Region 1 Homolog (Mouse)-Like 2
  • Limb Region 1-Like Protein -Like 3
  • Limb Region 1 Homolog-Like 3
  • Protein LMBR1L 3
  • KIAA1174 4

External Ids for LMBR1L Gene

Previous GeneCards Identifiers for LMBR1L Gene

  • GC12M047778
  • GC12M049490
  • GC12M046523

Summaries for LMBR1L Gene

GeneCards Summary for LMBR1L Gene

LMBR1L (Limb Development Membrane Protein 1 Like) is a Protein Coding gene. An important paralog of this gene is LMBR1.

UniProtKB/Swiss-Prot for LMBR1L Gene

  • Probable LCN1 receptor. May mediate LCN1 endocytosis.

Gene Wiki entry for LMBR1L Gene

Additional gene information for LMBR1L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMBR1L Gene

Genomics for LMBR1L Gene

GeneHancer (GH) Regulatory Elements for LMBR1L Gene

Promoters and enhancers for LMBR1L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I049108 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 565.2 +0.8 800 3.2 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF207 FOS DEK SP3 LMBR1L CCNT1 KANSL2 DDX23 KMT2D FAM186B LOC105369760 PIR56837 GC12M049098
GH12I048865 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 113.3 +244.7 244670 2.2 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 RND1 DDX23 KMT2D KANSL2 LOC390314 CCNT1 LMBR1L SENP1 BCDIN3D PRPF40B
GH12I049129 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 94.6 -20.5 -20467 4.6 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ENSG00000200309 GC12M049133 TUBA1B DDX23 LMBR1L KMT2D SMARCD1 LOC390314 BCDIN3D CCNT1
GH12I049263 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 74.6 -155.6 -155629 6.6 CLOCK DMAP1 YY1 ZNF213 ZNF143 ZNF263 SP3 NFYC ZFP41 MEF2D TUBA1C ENSG00000258101 DDX23 KMT2D CCNT1 LMBR1L LOC390314 KANSL2 SMARCD1 BCDIN3D
GH12I049055 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 60.7 +52.4 52397 6.7 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 GC12P049057 DDX23 LOC390314 LMBR1L CCNT1 KANSL2 KMT2D LOC100422296 SENP1 PRPF40B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LMBR1L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LMBR1L gene promoter:

Genomic Locations for LMBR1L Gene

Genomic Locations for LMBR1L Gene
chr12:49,096,551-49,110,900
(GRCh38/hg38)
Size:
14,350 bases
Orientation:
Minus strand
chr12:49,490,919-49,504,683
(GRCh37/hg19)

Genomic View for LMBR1L Gene

Genes around LMBR1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMBR1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMBR1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMBR1L Gene

Proteins for LMBR1L Gene

  • Protein details for LMBR1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX01-LMBRL_HUMAN
    Recommended name:
    Protein LMBR1L
    Protein Accession:
    Q6UX01
    Secondary Accessions:
    • Q969J4
    • Q96BY8
    • Q96HN8
    • Q9NT09
    • Q9NVE1
    • Q9NVU9
    • Q9ULP6

    Protein attributes for LMBR1L Gene

    Size:
    489 amino acids
    Molecular mass:
    55209 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86488.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LMBR1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMBR1L Gene

Post-translational modifications for LMBR1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LMBR1L Gene

Domains & Families for LMBR1L Gene

Gene Families for LMBR1L Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for LMBR1L Gene

Suggested Antigen Peptide Sequences for LMBR1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UX01

UniProtKB/Swiss-Prot:

LMBRL_HUMAN :
  • Belongs to the LIMR family.
Family:
  • Belongs to the LIMR family.
genes like me logo Genes that share domains with LMBR1L: view

Function for LMBR1L Gene

Molecular function for LMBR1L Gene

UniProtKB/Swiss-Prot Function:
Probable LCN1 receptor. May mediate LCN1 endocytosis.

Phenotypes From GWAS Catalog for LMBR1L Gene

Gene Ontology (GO) - Molecular Function for LMBR1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 11287427
GO:0005515 protein binding IPI 11287427
genes like me logo Genes that share ontologies with LMBR1L: view
genes like me logo Genes that share phenotypes with LMBR1L: view

Animal Models for LMBR1L Gene

MGI Knock Outs for LMBR1L:

Animal Model Products

CRISPR Products

miRNA for LMBR1L Gene

miRTarBase miRNAs that target LMBR1L

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LMBR1L Gene

Localization for LMBR1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMBR1L Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMBR1L gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for LMBR1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA 11287427
GO:0005887 integral component of plasma membrane IDA 11287427
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LMBR1L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LMBR1L Gene

Pathways & Interactions for LMBR1L Gene

SuperPathways for LMBR1L Gene

No Data Available

Interacting Proteins for LMBR1L Gene

Gene Ontology (GO) - Biological Process for LMBR1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis IMP 12591932
genes like me logo Genes that share ontologies with LMBR1L: view

No data available for Pathways by source and SIGNOR curated interactions for LMBR1L Gene

Drugs & Compounds for LMBR1L Gene

No Compound Related Data Available

Transcripts for LMBR1L Gene

Unigene Clusters for LMBR1L Gene

Limb region 1 homolog (mouse)-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMBR1L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9a · 9b ·
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3:
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - -
SP12:
SP13: - - - - - - - - -
SP14: - - - - -
SP15:
SP16: - - - - - -
SP17: - - -
SP18: - - - - -
SP19: - - - - - - - - - - - - - -
SP20:
SP21: - - - -
SP22:

ExUns: 9c · 9d ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4:
SP5: - - - - - - - - -
SP6:
SP7: - - -
SP8: - - - - - - - -
SP9: -
SP10:
SP11:
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:

Relevant External Links for LMBR1L Gene

GeneLoc Exon Structure for
LMBR1L
ECgene alternative splicing isoforms for
LMBR1L

Expression for LMBR1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LMBR1L Gene

NURSA nuclear receptor signaling pathways regulating expression of LMBR1L Gene:

LMBR1L

SOURCE GeneReport for Unigene cluster for LMBR1L Gene:

Hs.272838

mRNA Expression by UniProt/SwissProt for LMBR1L Gene:

Q6UX01-LMBRL_HUMAN
Tissue specificity: Expressed in testis, pituitary gland, adrenal gland, trachea, placenta, thymus, cerebellum, stomach, mammary gland, spinal cord. A weaker expression is detected in colon, pancreas, and prostate.

Evidence on tissue expression from TISSUES for LMBR1L Gene

  • Nervous system(4.9)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with LMBR1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMBR1L Gene

Orthologs for LMBR1L Gene

This gene was present in the common ancestor of animals.

Orthologs for LMBR1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LMBR1L 33 34
  • 98.5 (n)
cow
(Bos Taurus)
Mammalia LMBR1L 33 34
  • 93.05 (n)
dog
(Canis familiaris)
Mammalia LMBR1L 33 34
  • 91.82 (n)
oppossum
(Monodelphis domestica)
Mammalia LMBR1L 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lmbr1l 33 16 34
  • 89.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LMBR1L 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves LMBR1L 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LMBR1L 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lmbr1l 33
  • 69.94 (n)
Str.6325 33
African clawed frog
(Xenopus laevis)
Amphibia limr-pending-prov 33
zebrafish
(Danio rerio)
Actinopterygii lmbr1l 33 34
  • 68.29 (n)
sbcb582 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006880 33
  • 56.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5807 33 34
  • 55.48 (n)
worm
(Caenorhabditis elegans)
Secernentea R05D3.2 33 34
  • 45.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5928 34
  • 33 (a)
OneToMany
Species where no ortholog for LMBR1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LMBR1L Gene

ENSEMBL:
Gene Tree for LMBR1L (if available)
TreeFam:
Gene Tree for LMBR1L (if available)

Paralogs for LMBR1L Gene

Paralogs for LMBR1L Gene

genes like me logo Genes that share paralogs with LMBR1L: view

Variants for LMBR1L Gene

Sequence variations from dbSNP and Humsavar for LMBR1L Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000146181 -- 49,098,649(-) A/G intron_variant
rs1000322578 -- 49,111,531(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000760827 -- 49,097,402(-) G/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000815726 -- 49,109,990(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000866048 -- 49,099,823(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LMBR1L Gene

Variant ID Type Subtype PubMed ID
esv3629447 CNV loss 21293372

Variation tolerance for LMBR1L Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LMBR1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LMBR1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMBR1L Gene

Disorders for LMBR1L Gene

Additional Disease Information for LMBR1L

No disorders were found for LMBR1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMBR1L Gene

Publications for LMBR1L Gene

  1. Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display. (PMID: 11287427) Wojnar P … Redl B (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells. (PMID: 12591932) Wojnar P … Redl B (The Journal of biological chemistry 2003) 3 4 22 58
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  4. Lipocalin-interacting-membrane-receptor (LIMR) mediates cellular internalization of beta-lactoglobulin. (PMID: 17991420) Fluckinger M … Redl B (Biochimica et biophysica acta 2008) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for LMBR1L Gene

Sources for LMBR1L Gene

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