Aliases for LMAN2L Gene
External Ids for LMAN2L Gene
Previous GeneCards Identifiers for LMAN2L Gene
This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016]
GeneCards Summary for LMAN2L Gene
LMAN2L (Lectin, Mannose Binding 2 Like) is a Protein Coding gene. Diseases associated with LMAN2L include Mental Retardation, Autosomal Recessive 52 and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include mannose binding. An important paralog of this gene is LMAN2.
UniProtKB/Swiss-Prot for LMAN2L Gene
May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53.