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This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]
LMAN2 (Lectin, Mannose Binding 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and heat shock protein binding. An important paralog of this gene is LMAN2L.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 20477988 |
GO:0005537 | mannose binding | IBA,IMP | 20477988 |
GO:0030246 | carbohydrate binding | IEA,IDA | 23701871 |
GO:0031072 | heat shock protein binding | IPI | 20477988 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IBA | 21873635 |
GO:0005615 | extracellular space | IDA | 22016386 |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | IBA | 21873635 |
GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | IDA | 15308636 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport to the Golgi and subsequent modification | ||
2 | Vesicle-mediated transport | ||
3 | Metabolism of proteins | ||
4 | Protein processing in endoplasmic reticulum | ||
5 | Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF) |
Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006888 | ER to Golgi vesicle-mediated transport | IBA | 21873635 |
GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | IMP | 20477988 |
GO:0007029 | endoplasmic reticulum organization | IBA | 21873635 |
GO:0007030 | Golgi organization | IBA | 21873635 |
GO:0015031 | protein transport | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Calcium | Nutra | 6556 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LMAN2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LMAN2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LMAN2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lman2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Lman2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | LMAN2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LMAN2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LMAN2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LMAN2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lman2 30 |
|
||
Str.5932 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.22835 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | lman2 30 31 |
|
OneToOne | |
wufb16f04 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5510 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | ile-2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8400 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759396 | CNV | gain | 17122850 |
nsv1161311 | CNV | duplication | 26073780 |
nsv1161312 | CNV | deletion | 26073780 |
nsv428132 | CNV | gain | 18775914 |
nsv471057 | CNV | loss | 18288195 |
nsv509103 | CNV | insertion | 20534489 |
nsv600364 | CNV | loss | 21841781 |
nsv819674 | CNV | loss | 19587683 |
nsv964979 | CNV | duplication | 23825009 |
No disorders were found for LMAN2 Gene.