Aliases for LMAN1 Gene
External Ids for LMAN1 Gene
Previous HGNC Symbols for LMAN1 Gene
Previous GeneCards Identifiers for LMAN1 Gene
The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015]
GeneCards Summary for LMAN1 Gene
LMAN1 (Lectin, Mannose Binding 1) is a Protein Coding gene. Diseases associated with LMAN1 include Factor V And Factor Viii, Combined Deficiency Of, 1 and Factor V And Factor Viii, Combined Deficiency Of, 2. Among its related pathways are Cytoskeletal Signaling and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and mannose binding. An important paralog of this gene is LMAN1L.
UniProtKB/Swiss-Prot for LMAN1 Gene
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.