Aliases for LLGL2 Gene
Previous GeneCards Identifiers for LLGL2 Gene
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for LLGL2 Gene
LLGL2 (LLGL2, Scribble Cell Polarity Complex Component) is a Protein Coding gene. Diseases associated with LLGL2 include Retinitis Pigmentosa 24. Among its related pathways are Actin Nucleation by ARP-WASP Complex and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include PDZ domain binding. An important paralog of this gene is LLGL1.
UniProtKB/Swiss-Prot for LLGL2 Gene
Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.