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Aliases for LIPM Gene

Aliases for LIPM Gene

  • Lipase Family Member M 2 3 5
  • Lipase-Like Abhydrolase Domain-Containing Protein 3 3 4
  • Lipase-Like, Ab-Hydrolase Domain Containing 3 2 3
  • LIPL3 3 4
  • Lipase Member M 3
  • EC 56
  • EC 56
  • EC 3.1.1.- 4
  • BA304I5.1 3
  • Lipase M 3
  • EC 3.1.1 56

External Ids for LIPM Gene

Previous HGNC Symbols for LIPM Gene

  • LIPL3

Previous GeneCards Identifiers for LIPM Gene

  • GC10P090553
  • GC10P084197

Summaries for LIPM Gene

GeneCards Summary for LIPM Gene

LIPM (Lipase Family Member M) is a Protein Coding gene. Diseases associated with LIPM include Hypotrichosis 1. Among its related pathways are Metabolism and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds. An important paralog of this gene is LIPA.

UniProtKB/Swiss-Prot for LIPM Gene

  • Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

Additional gene information for LIPM Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPM Gene

Genomics for LIPM Gene

GeneHancer (GH) Regulatory Elements for LIPM Gene

Promoters and enhancers for LIPM Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I088802 Promoter 0.5 EPDnew 550.8 0.0 -22 0.1 LIPM RCBTB2P1
GH10I088800 Enhancer 0.3 ENCODE 550.8 -1.8 -1771 0.1 EGR2 LIPM RCBTB2P1
GH10I088878 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9 +81.5 81486 10.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF213 STAMBPL1 RPL11P3 KIF20B FAS ACTA2-AS1 ENSG00000201548 RNLS LIPJ LIPM LIPN
GH10I088835 Enhancer 1.2 FANTOM5 Ensembl ENCODE 9.9 +32.8 32812 1 RB1 ZNF2 IRF4 BRCA1 RAD21 RFX5 YY1 ZEB1 ZNF366 ZNF143 ACTA2-AS1 STAMBPL1 LIPM LIPF ANKRD22 FAS LIPN IFIT3 IFIT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LIPM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LIPM gene promoter:

Genomic Locations for LIPM Gene

Genomic Locations for LIPM Gene
19,293 bases
Plus strand

Genomic View for LIPM Gene

Genes around LIPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPM Gene

Proteins for LIPM Gene

  • Protein details for LIPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lipase member M
    Protein Accession:
    Secondary Accessions:
    • A6PVS3
    • B2RXK7
    • B5MCR3

    Protein attributes for LIPM Gene

    423 amino acids
    Molecular mass:
    48233 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LIPM Gene


neXtProt entry for LIPM Gene

Selected DME Specific Peptides for LIPM Gene


Post-translational modifications for LIPM Gene

Other Protein References for LIPM Gene

Domains & Families for LIPM Gene

Gene Families for LIPM Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for LIPM Gene

Suggested Antigen Peptide Sequences for LIPM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Lipase family.
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPM: view

Function for LIPM Gene

Molecular function for LIPM Gene

UniProtKB/Swiss-Prot Function:
Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

Enzyme Numbers (IUBMB) for LIPM Gene

Phenotypes From GWAS Catalog for LIPM Gene

Gene Ontology (GO) - Molecular Function for LIPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004465 lipoprotein lipase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
genes like me logo Genes that share ontologies with LIPM: view
genes like me logo Genes that share phenotypes with LIPM: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LIPM Gene

Localization for LIPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPM Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPM gene
Compartment Confidence
extracellular 5
mitochondrion 2
lysosome 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for LIPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with LIPM: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LIPM Gene

Pathways & Interactions for LIPM Gene

genes like me logo Genes that share pathways with LIPM: view

Gene Ontology (GO) - Biological Process for LIPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with LIPM: view

No data available for SIGNOR curated interactions for LIPM Gene

Drugs & Compounds for LIPM Gene

No Compound Related Data Available

Transcripts for LIPM Gene

mRNA/cDNA for LIPM Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LIPM Gene

Lipase, family member M:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIPM Gene

No ASD Table

Relevant External Links for LIPM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIPM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LIPM Gene

mRNA differential expression in normal tissues according to GTEx for LIPM Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x22.2) and Skin - Not Sun Exposed (Suprapubic) (x19.0).

NURSA nuclear receptor signaling pathways regulating expression of LIPM Gene:


SOURCE GeneReport for Unigene cluster for LIPM Gene:


mRNA Expression by UniProt/SwissProt for LIPM Gene:

Tissue specificity: Exclusively expressed in the epidermis within the granular keratinocytes.

Evidence on tissue expression from TISSUES for LIPM Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with LIPM: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIPM Gene

Orthologs for LIPM Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LIPM Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LIPM 33 34
  • 99.37 (n)
(Bos Taurus)
Mammalia LIPM 33 34
  • 89.2 (n)
(Rattus norvegicus)
Mammalia Lipm 33
  • 85.78 (n)
(Mus musculus)
Mammalia Lipm 33 16 34
  • 85.47 (n)
(Canis familiaris)
Mammalia LIPM 33 34
  • 85.2 (n)
(Monodelphis domestica)
Mammalia LIPM 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia LIPM 34
  • 73 (a)
(Gallus gallus)
Aves -- 34
  • 49 (a)
(Anolis carolinensis)
Reptilia LIPM 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10481 33
fruit fly
(Drosophila melanogaster)
Insecta CG31871 33
  • 48.9 (n)
CG18530 34
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002872 33
  • 46.59 (n)
(Caenorhabditis elegans)
Secernentea lipl-5 34
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TGL1 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for LIPM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LIPM Gene

Gene Tree for LIPM (if available)
Gene Tree for LIPM (if available)

Paralogs for LIPM Gene

Paralogs for LIPM Gene

(6) SIMAP similar genes for LIPM Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LIPM: view

Variants for LIPM Gene

Sequence variations from dbSNP and Humsavar for LIPM Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000067367 -- 88,812,580(+) T/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000354405 -- 88,818,048(+) T/A genic_downstream_transcript_variant, intron_variant
rs1000423386 -- 88,812,264(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000465223 -- 88,811,399(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000922087 -- 88,806,746(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LIPM Gene

Variant ID Type Subtype PubMed ID
nsv831942 CNV gain 17160897
nsv831941 CNV gain 17160897
nsv7484 CNV insertion 18451855
nsv551840 CNV gain 21841781
nsv1043015 CNV gain 25217958
esv3624142 CNV loss 21293372
esv3624141 CNV gain 21293372
esv3624140 CNV loss 21293372
esv3624139 CNV gain 21293372

Variation tolerance for LIPM Gene

Gene Damage Index Score: 5.13; 69.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIPM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPM Gene

Disorders for LIPM Gene

MalaCards: The human disease database

(1) MalaCards diseases for LIPM Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypotrichosis 1
  • hypt1
- elite association - COSMIC cancer census association via MalaCards
Search LIPM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LIPM

genes like me logo Genes that share disorders with LIPM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIPM Gene

Publications for LIPM Gene

  1. Large-scale identification of human genes implicated in epidermal barrier function. (PMID: 17562024) Toulza E … Guerrin M (Genome biology 2007) 3 4 58
  2. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q … O'Donnell CJ (BMC medical genetics 2007) 44 58
  3. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PMID: 17903307) Wilk JB … O'Connor GT (BMC medical genetics 2007) 44 58
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for LIPM Gene

Sources for LIPM Gene

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