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Aliases for LIPI Gene

Aliases for LIPI Gene

  • Lipase I 2 3 5
  • Cancer/Testis Antigen 17 2 3 4
  • Membrane-Associated Phosphatidic Acid-Selective Phospholipase A1-Beta 3 4
  • Lipase, Member I 2 3
  • MPA-PLA1 Beta 3 4
  • LPD Lipase 3 4
  • CT17 3 4
  • LPDL 3 4
  • Membrane-Associated Phospholipase A1 Beta 2
  • Lipase Member I 3
  • EC 56
  • EC 56
  • EC 3.1.1.- 4
  • EC 3.1.1 56
  • PLA1C 3
  • PRED5 3

External Ids for LIPI Gene

Previous GeneCards Identifiers for LIPI Gene

  • GC21M012145
  • GC21U900126
  • GC21M014407
  • GC21M015481
  • GC21M000851

Summaries for LIPI Gene

Entrez Gene Summary for LIPI Gene

  • The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for LIPI Gene

LIPI (Lipase I) is a Protein Coding gene. Diseases associated with LIPI include Hypertriglyceridemia, Familial and Hyperlipoproteinemia, Type Iv. Among its related pathways are Metabolism and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include heparin binding and phospholipase activity. An important paralog of this gene is LIPH.

UniProtKB/Swiss-Prot for LIPI Gene

  • Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

Additional gene information for LIPI Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPI Gene

Genomics for LIPI Gene

GeneHancer (GH) Regulatory Elements for LIPI Gene

Promoters and enhancers for LIPI Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I014210 Promoter 0.5 EPDnew 550.8 +0.1 90 0.1 LIPI ERLEC1P1
GH21I014026 Promoter/Enhancer 1.4 Ensembl ENCODE 4.6 +183.2 183205 2.2 HDAC1 PKNOX1 ATF1 TAF9B RB1 SIN3A ZBTB40 RFX5 POLR2B ELK1 ENSG00000224905 LOC105377134 ANKRD20A18P RHOT1P2 LIPI
GH21I014225 Enhancer 0.2 FANTOM5 10.6 -14.3 -14313 0.1 RBM11 ABCC13 LIPI
GH21I014479 Enhancer 0.2 FANTOM5 2.3 -268.3 -268253 0.1 SAMSN1 LIPI HSPA13 SAMSN1-AS1
GH21I014115 Enhancer 0.6 ENCODE 0.2 +94.7 94714 1.1 HDGF PKNOX1 ZNF687 SMAD1 EBF1 TARDBP IKZF1 NBN ATF7 PRDM1 ENSG00000224905 ERLEC1P1 LIPI
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LIPI on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LIPI gene promoter:

Genomic Locations for LIPI Gene

Genomic Locations for LIPI Gene
102,578 bases
Minus strand

Genomic View for LIPI Gene

Genes around LIPI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPI Gene

Proteins for LIPI Gene

  • Protein details for LIPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lipase member I
    Protein Accession:
    Secondary Accessions:
    • G1JSG3
    • G1JSG4
    • G1JSG5
    • G1JSG6
    • G1JSG7
    • G1JSG8
    • G1JSG9

    Protein attributes for LIPI Gene

    460 amino acids
    Molecular mass:
    52992 Da
    Quaternary structure:
    • Interacts with heparin with a high affinity.

    Alternative splice isoforms for LIPI Gene

neXtProt entry for LIPI Gene

Selected DME Specific Peptides for LIPI Gene


Post-translational modifications for LIPI Gene

  • Glycosylation at isoforms=2, 3, 4, 5, 6, 763 and posLast=396396
  • Modification sites at PhosphoSitePlus

Domains & Families for LIPI Gene

Gene Families for LIPI Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for LIPI Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Lipase family.
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPI: view

Function for LIPI Gene

Molecular function for LIPI Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sodium vanadate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

Enzyme Numbers (IUBMB) for LIPI Gene

Gene Ontology (GO) - Molecular Function for LIPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity TAS --
GO:0008201 heparin binding IDA,IEA 12963729
GO:0016787 hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with LIPI: view
genes like me logo Genes that share phenotypes with LIPI: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LIPI Gene

Localization for LIPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPI Gene

Isoform 1: Membrane. Secreted. Note=May associate with lipid draft.
Isoform 2: Membrane. Note=May associate with lipid draft.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPI gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for LIPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LIPI: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LIPI Gene

Pathways & Interactions for LIPI Gene

genes like me logo Genes that share pathways with LIPI: view

Interacting Proteins for LIPI Gene

Selected Interacting proteins: Q6XZB0-LIPI_HUMAN for LIPI Gene via IID

Gene Ontology (GO) - Biological Process for LIPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0016042 lipid catabolic process IEA,IDA 12963729
genes like me logo Genes that share ontologies with LIPI: view

No data available for SIGNOR curated interactions for LIPI Gene

Drugs & Compounds for LIPI Gene

(23) Additional Compounds for LIPI Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with LIPI: view

Transcripts for LIPI Gene

mRNA/cDNA for LIPI Gene

(7) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LIPI Gene

Lipase, member I:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIPI Gene

No ASD Table

Relevant External Links for LIPI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIPI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LIPI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPI Gene

This gene is overexpressed in Colon - Sigmoid (x6.9), Thyroid (x6.6), and Uterus (x4.6).

Protein differential expression in normal tissues from HIPED for LIPI Gene

This gene is overexpressed in Prostate (49.8) and Adipocyte (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LIPI Gene

Protein tissue co-expression partners for LIPI Gene

NURSA nuclear receptor signaling pathways regulating expression of LIPI Gene:


SOURCE GeneReport for Unigene cluster for LIPI Gene:


mRNA Expression by UniProt/SwissProt for LIPI Gene:

Tissue specificity: Expressed in testis. Expressed exclusively at the connecting piece of the sperm.

Phenotype-based relationships between genes and organs from Gene ORGANizer for LIPI Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • skeletal muscle
Head and neck:
  • ear
  • heart
  • duodenum
  • intestine
  • liver
  • pancreas
  • small intestine
  • blood vessel
  • skin
genes like me logo Genes that share expression patterns with LIPI: view

No data available for Evidence on tissue expression from TISSUES for LIPI Gene

Orthologs for LIPI Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPI Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LIPI 33 34
  • 99.1 (n)
(Canis familiaris)
Mammalia LIPI 33 34
  • 84.62 (n)
(Mus musculus)
Mammalia Lipi 33 16
  • 75.98 (n)
(Rattus norvegicus)
Mammalia Lipi 33
  • 75.91 (n)
(Bos Taurus)
Mammalia LIPI 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia LIPI 34
  • 48 (a)
(Gallus gallus)
Aves LIPI 34
  • 47 (a)
(Anolis carolinensis)
Reptilia LIPI 34
  • 42 (a)
(Danio rerio)
Actinopterygii zgc:91985 34
  • 40 (a)
lipi 34
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34448 34
  • 29 (a)
CG10116 34
  • 28 (a)
CG10357 34
  • 27 (a)
CG14034 34
  • 27 (a)
CG34447 34
  • 27 (a)
CG6472 34
  • 27 (a)
CG6295 34
  • 26 (a)
CG1986 34
  • 25 (a)
CG6283 34
  • 25 (a)
CG17191 34
  • 24 (a)
CG17292 34
  • 24 (a)
CG6271 34
  • 24 (a)
CG6277 34
  • 24 (a)
CG7367 34
  • 24 (a)
sxe2 34
  • 24 (a)
CG17192 34
  • 23 (a)
CG18641 34
  • 23 (a)
CG5665 34
  • 23 (a)
CG6431 34
  • 23 (a)
CG4267 34
  • 22 (a)
CG5162 34
  • 22 (a)
CG6675 34
  • 22 (a)
CG13282 34
  • 20 (a)
CG4582 34
  • 20 (a)
CG18258 34
  • 18 (a)
CG6847 34
  • 16 (a)
Yp1 34
  • 16 (a)
Yp2 34
  • 16 (a)
Yp3 34
  • 16 (a)
CG6296 34
  • 14 (a)
Species where no ortholog for LIPI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIPI Gene

Gene Tree for LIPI (if available)
Gene Tree for LIPI (if available)

Paralogs for LIPI Gene

Paralogs for LIPI Gene

(5) SIMAP similar genes for LIPI Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LIPI: view

Variants for LIPI Gene

Sequence variations from dbSNP and Humsavar for LIPI Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs11909217 risk-factor, Hypertriglyceridemia, susceptibility to, Hypertriglyceridemia, familial (FHTR) [MIM:145750] 14,189,302(-) C/T coding_sequence_variant, missense_variant
rs1000011911 -- 14,196,807(-) C/A intron_variant
rs1000029523 -- 14,186,777(-) C/T intron_variant
rs1000036434 -- 14,152,211(-) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000053824 -- 14,135,050(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LIPI Gene

Variant ID Type Subtype PubMed ID
dgv4385n100 CNV gain 25217958
esv1678679 CNV deletion 17803354
esv2723174 CNV deletion 23290073
esv3575380 CNV gain 25503493
esv3646422 CNV gain 21293372
esv3893371 CNV gain 25118596
esv3893372 CNV loss 25118596
nsv1056787 CNV loss 25217958
nsv1058072 CNV gain 25217958
nsv1058202 CNV loss 25217958
nsv1143254 CNV deletion 24896259
nsv523395 CNV loss 19592680
nsv527017 CNV loss 19592680
nsv587043 CNV loss 21841781

Variation tolerance for LIPI Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.93; 94.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIPI Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPI Gene

Disorders for LIPI Gene

MalaCards: The human disease database

(4) MalaCards diseases for LIPI Gene - From: HGMD, OMIM, GTR, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypertriglyceridemia, familial
  • hypertriglyceridemia, susceptibility to
hyperlipoproteinemia, type iv
  • carbohydrate-inducible hyperlipemia
  • infection by listeria monocytogenes
cardiac tamponade
  • pericardial tamponade
- elite association - COSMIC cancer census association via MalaCards
Search LIPI in MalaCards View complete list of genes associated with diseases


  • Hypertriglyceridemia, familial (FHTR) [MIM:145750]: A common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis. {ECO:0000269 PubMed:12719377}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for LIPI

genes like me logo Genes that share disorders with LIPI: view

No data available for Genatlas for LIPI Gene

Publications for LIPI Gene

  1. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. (PMID: 12719377) Wen XY … Stewart AK (Human molecular genetics 2003) 2 3 4 22 58
  2. Expression of multiple membrane-associated phospholipase A1 beta transcript variants and lysophosphatidic acid receptors in Ewing tumor cells. (PMID: 21132378) Schmiedel BJ … Staege MS (Molecular biology reports 2011) 3 4 58
  3. Membrane-associated phospholipase A1 beta (LIPI) Is an Ewing tumour-associated cancer/testis antigen. (PMID: 18435455) Foell JL … Staege MS (Pediatric blood & cancer 2008) 3 22 58
  4. Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta. (PMID: 12963729) Hiramatsu T … Arai H (The Journal of biological chemistry 2003) 3 4 58
  5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 58

Products for LIPI Gene

Sources for LIPI Gene

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