Aliases for LIPH Gene
External Ids for LIPH Gene
Previous GeneCards Identifiers for LIPH Gene
This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]
GeneCards Summary for LIPH Gene
LIPH (Lipase H) is a Protein Coding gene. Diseases associated with LIPH include Hypotrichosis 7 and Hypotrichosis Simplex. Among its related pathways are Metabolism and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and carboxylic ester hydrolase activity. An important paralog of this gene is LIPI.
UniProtKB/Swiss-Prot Summary for LIPH Gene
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).