This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008] See more...

Aliases for LIPH Gene

Aliases for LIPH Gene

  • Lipase H 2 3 5
  • Membrane-Associated Phosphatidic Acid-Selective Phospholipase A1-Alpha 3 4
  • LPD Lipase-Related Protein 3 4
  • Phospholipase A1 Member B 3 4
  • Phospholipase A(1) 2 3
  • Lipase, Member H 2 3
  • Lipase Member H 3 4
  • MPA-PLA1 Alpha 3 4
  • LPDLR 3 4
  • PLA1B 3 4
  • Membrane-Bound Phosphatidic Acid-Selective Phospholipase A1 3
  • EC 3.1.1.3 52
  • EC 3.1.1.- 4
  • MPA-PLA1 3
  • EC 3.1.1 52
  • MPAPLA1 4
  • ARWH2 3
  • HYPT7 3
  • LAH2 3
  • AH 3

External Ids for LIPH Gene

Previous GeneCards Identifiers for LIPH Gene

  • GC03M182017
  • GC03M186408
  • GC03M186627
  • GC03M186546
  • GC03M186708
  • GC03M185224
  • GC03M182635

Summaries for LIPH Gene

Entrez Gene Summary for LIPH Gene

  • This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIPH Gene

LIPH (Lipase H) is a Protein Coding gene. Diseases associated with LIPH include Hypotrichosis 7 and Hypotrichosis Simplex. Among its related pathways are Metabolism and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and carboxylic ester hydrolase activity. An important paralog of this gene is LIPI.

UniProtKB/Swiss-Prot Summary for LIPH Gene

  • Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

Gene Wiki entry for LIPH Gene

Additional gene information for LIPH Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LIPH Gene

Genomics for LIPH Gene

GeneHancer (GH) Regulatory Elements for LIPH Gene

Promoters and enhancers for LIPH Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J185548 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 506.6 -1.5 -1467 11.1 ZBTB40 ZNF217 CTCF TCF12 SIN3A GTF2E2 JUND FOS PHB2 ZNF10 LIPH SENP2 TMEM41A VPS8 piR-40154-127
GH03J185511 Enhancer 0.6 ENCODE dbSUPER 12.2 +40.8 40790 1.2 RXRA HNF4A SP1 NONHSAG036884.2 LIPH ENSG00000286086 LOC105374254
GH03J185543 Enhancer 1 ENCODE dbSUPER 6.4 +6.8 6756 4.7 ZNF217 CTCF TCF12 SP1 RELA MEF2C RCOR1 ZBTB7A CTBP1 FOXA2 SENP2 LIPH piR-45035-136
GH03J185517 Enhancer 0.3 ENCODE dbSUPER 12.2 +34.7 34696 0.8 RF00017-4196 LIPH piR-45035-136 NONHSAG036884.2
GH03J184800 Enhancer 0.3 Ensembl ENCODE 6.2 +752.0 752028 1 EPHB3 LINC01840 LIPH THPO VPS8 LOC105374253
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LIPH on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LIPH

Genomic Locations for LIPH Gene

Genomic Locations for LIPH Gene
chr3:185,506,262-185,552,655
(GRCh38/hg38)
Size:
46,394 bases
Orientation:
Minus strand
chr3:185,224,050-185,270,401
(GRCh37/hg19)
Size:
46,352 bases
Orientation:
Minus strand

Genomic View for LIPH Gene

Genes around LIPH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPH Gene

Proteins for LIPH Gene

  • Protein details for LIPH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWY8-LIPH_HUMAN
    Recommended name:
    Lipase member H
    Protein Accession:
    Q8WWY8
    Secondary Accessions:
    • A2IBA7
    • Q8TEC7

    Protein attributes for LIPH Gene

    Size:
    451 amino acids
    Molecular mass:
    50859 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85023.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for LIPH Gene

Selected DME Specific Peptides for LIPH Gene

Q8WWY8:
  • RLDPSDA
  • RPTGSPPVW
  • YFKCDHQ
  • GRITGLD
  • DFYPNGG
  • GLDPAGP
  • GVSLGAH

Post-translational modifications for LIPH Gene

  • Glycosylation at Asn50, Asn66, and Asn357
  • Modification sites at PhosphoSitePlus

Domains & Families for LIPH Gene

Gene Families for LIPH Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for LIPH Gene

Suggested Antigen Peptide Sequences for LIPH Gene

GenScript: Design optimal peptide antigens:
  • Lipase H (A2IBA8_HUMAN)
  • Phospholipase A1 member B (LIPH_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WWY8

UniProtKB/Swiss-Prot:

LIPH_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPH: view

Function for LIPH Gene

Molecular function for LIPH Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sodium vanadate.

Enzyme Numbers (IUBMB) for LIPH Gene

Phenotypes From GWAS Catalog for LIPH Gene

Gene Ontology (GO) - Molecular Function for LIPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IDA 12963729
GO:0008201 heparin binding IDA,IEA 12963729
GO:0016298 lipase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with LIPH: view
genes like me logo Genes that share phenotypes with LIPH: view

Human Phenotype Ontology for LIPH Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LIPH Gene

MGI Knock Outs for LIPH:
  • Liph Liph<tm1Aoki>

Animal Model Products

  • Taconic Biosciences Mouse Models for LIPH

CRISPR Products

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for LIPH Gene

Localization for LIPH Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPH Gene

Secreted. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPH gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LIPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,IBA 12963729
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LIPH: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LIPH Gene

Pathways & Interactions for LIPH Gene

genes like me logo Genes that share pathways with LIPH: view

SIGNOR curated interactions for LIPH Gene

Activates:

Gene Ontology (GO) - Biological Process for LIPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0016042 lipid catabolic process IBA,IDA 12963729
genes like me logo Genes that share ontologies with LIPH: view

Drugs & Compounds for LIPH Gene

(24) Additional Compounds for LIPH Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LysoPA(0:0/16:0)
  • 2-palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • Lysophosphatidic Acid(0:0/16:0)
  • LPA(16:0)
  • 2-hexadecanoyl-phosphatidic acid
LysoPA(0:0/18:0)
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic Acid(0:0/18:0)
  • Lysophosphatidic Acid(18:0)
  • 2-stearoyl-glycero-3-phosphate
LysoPA(0:0/18:1(9Z))
  • Lysophosphatidic Acid(18:1)
  • LPA(0:0/18:1(9Z))
  • LPA(0:0/18:1)
  • Lysophosphatidic Acid(0:0/18:1)
  • 2-oleoyl-glycero-3-phosphate
LysoPA(0:0/18:2(9Z,12Z))
  • {3-hydroxy-2-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propoxy}phosphonate
  • LPA(18:2)
  • LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-octadecadienoyl)-phosphatidic acid
  • Lysophosphatidic Acid(18:2)
LysoPA(16:0/0:0)
  • 1-Hexadecanoyl-sn-glycero-3-phosphate
  • 1-Hexadecanoyl-sn-glycero-3-phosphoric acid
  • 1-Palmitoylglycerol 3-phosphoric acid
  • 1-Palmitoyl-sn-glycerol 3-phosphate
  • PLPA
genes like me logo Genes that share compounds with LIPH: view

Transcripts for LIPH Gene

mRNA/cDNA for LIPH Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIPH Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
SP1: -
SP2: - - - -
SP3:
SP4: -

Relevant External Links for LIPH Gene

GeneLoc Exon Structure for
LIPH

Expression for LIPH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIPH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPH Gene

This gene is overexpressed in Colon - Transverse (x9.3), Stomach (x7.3), Esophagus - Mucosa (x5.3), and Minor Salivary Gland (x5.2).

Protein differential expression in normal tissues from HIPED for LIPH Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LIPH Gene



Protein tissue co-expression partners for LIPH Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LIPH

SOURCE GeneReport for Unigene cluster for LIPH Gene:

Hs.68864

mRNA Expression by UniProt/SwissProt for LIPH Gene:

Q8WWY8-LIPH_HUMAN
Tissue specificity: Present in intestine (at protein level). Expressed in colon, prostate, kidney, pancreas, ovary, testis, intestine, lung and pancreas. Expressed at lower level in brain, spleen and heart. In hair, it is prominently expressed in hair follicles, including the stem cell-rich bulge region.

Evidence on tissue expression from TISSUES for LIPH Gene

  • Intestine(4.4)
  • Lung(4.2)
  • Pancreas(4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LIPH Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
Regions:
Head and neck:
  • eye
  • eyelid
  • face
  • forehead
  • head
Limb:
  • arm
  • upper limb
General:
  • hair
  • skin
genes like me logo Genes that share expression patterns with LIPH: view

Orthologs for LIPH Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIPH 31 30
  • 99.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LIPH 31 30
  • 88.32 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LIPH 31 30
  • 87.66 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Liph 30
  • 81.23 (n)
mouse
(Mus musculus)
Mammalia Liph 17 31 30
  • 80.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 75 (a)
OneToMany
-- 31
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LIPH 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves LIPI 30
  • 66.37 (n)
LIPH 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia liph 30
  • 63.64 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68721 30
zebrafish
(Danio rerio)
Actinopterygii zgc:91985 31 30
  • 55.94 (n)
ManyToMany
lipi 31
  • 48 (a)
ManyToMany
wufb08f08 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12174 30
fruit fly
(Drosophila melanogaster)
Insecta CG10357 31
  • 29 (a)
ManyToMany
CG6472 31
  • 27 (a)
ManyToMany
CG34448 31
  • 26 (a)
ManyToMany
CG6271 31
  • 26 (a)
ManyToMany
CG6283 31
  • 25 (a)
ManyToMany
CG10116 31
  • 25 (a)
ManyToMany
CG6277 31
  • 25 (a)
ManyToMany
CG1986 31
  • 25 (a)
ManyToMany
CG6295 31
  • 25 (a)
ManyToMany
CG17192 31
  • 25 (a)
ManyToMany
CG34447 31
  • 25 (a)
ManyToMany
CG14034 31
  • 24 (a)
ManyToMany
CG17191 31
  • 23 (a)
ManyToMany
CG7367 31
  • 22 (a)
ManyToMany
CG18641 31
  • 22 (a)
ManyToMany
sxe2 31
  • 22 (a)
ManyToMany
CG13282 31
  • 22 (a)
ManyToMany
CG17292 31
  • 22 (a)
ManyToMany
CG4267 31
  • 21 (a)
ManyToMany
CG6431 31
  • 21 (a)
ManyToMany
CG5665 31
  • 20 (a)
ManyToMany
CG5162 31
  • 20 (a)
ManyToMany
CG6675 31
  • 20 (a)
ManyToMany
CG4582 31
  • 19 (a)
ManyToMany
Yp3 31
  • 16 (a)
ManyToMany
CG18258 31
  • 16 (a)
ManyToMany
Yp1 31
  • 15 (a)
ManyToMany
Yp2 31
  • 14 (a)
ManyToMany
CG6296 31
  • 14 (a)
ManyToMany
CG6847 31
  • 14 (a)
ManyToMany
Species where no ortholog for LIPH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIPH Gene

ENSEMBL:
Gene Tree for LIPH (if available)
TreeFam:
Gene Tree for LIPH (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LIPH: view image

Paralogs for LIPH Gene

Paralogs for LIPH Gene

(9) SIMAP similar genes for LIPH Gene using alignment to 6 proteins:

  • LIPH_HUMAN
  • A2IBA6_HUMAN
  • A2IBA8_HUMAN
  • F8WE09_HUMAN
  • H7BZL3_HUMAN
  • H7C2X1_HUMAN
genes like me logo Genes that share paralogs with LIPH: view

Variants for LIPH Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LIPH Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs201249971 Pathogenic/Likely Pathogenic: Hypotrichosis 7; Woolly hair, autosomal recessive 2, with or without hypotrichosis; Hereditary hypotrichosis simplex 185,519,292(-) A/T MISSENSE_VARIANT
rs201868115 Pathogenic: Woolly hair, autosomal recessive 2, with or without hypotrichosis 185,519,286(-) G/T MISSENSE_VARIANT
rs267607219 Pathogenic: Woolly hair, autosomal recessive 2, with or without hypotrichosis. Hypotrichosis 7 (HYPT7) [MIM:604379]. Woolly hair autosomal recessive 2 (ARWH2) [MIM:604379] 185,534,860(-) A/Gp.Trp108Arg MISSENSE_VARIANT
rs533334084 Likely Benign: not specified 185,511,657(-) G/A MISSENSE_VARIANT
rs559648418 Pathogenic: Hypotrichosis 7; Woolly hair, autosomal recessive 2, with or without hypotrichosis 185,524,128(-) CTA/C FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for LIPH Gene

Structural Variations from Database of Genomic Variants (DGV) for LIPH Gene

Variant ID Type Subtype PubMed ID
esv1283224 CNV insertion 17803354
esv275409 CNV loss 21479260
nsv1117358 CNV tandem duplication 24896259
nsv1129706 CNV tandem duplication 24896259
nsv237078 CNV deletion 16902084
nsv472241 CNV novel sequence insertion 20440878
nsv829818 CNV loss 17160897

Variation tolerance for LIPH Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIPH Gene

Human Gene Mutation Database (HGMD)
LIPH
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIPH

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPH Gene

Disorders for LIPH Gene

MalaCards: The human disease database

(17) MalaCards diseases for LIPH Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypotrichosis 7
  • hypt7
hypotrichosis simplex
  • hhs
woolly hair syndrome
  • familial woolly hair
hypotrichosis
hypotrichosis 13
  • hypt13
- elite association - COSMIC cancer census association via MalaCards
Search LIPH in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LIPH_HUMAN
  • Hypotrichosis 7 (HYPT7) [MIM:604379]: A condition characterized by the presence of less than the normal amount of hair. Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes. {ECO:0000269 PubMed:17095700, ECO:0000269 PubMed:19167195}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Woolly hair autosomal recessive 2 (ARWH2) [MIM:604379]: A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with hypotrichosis. {ECO:0000269 PubMed:18830268}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for LIPH

genes like me logo Genes that share disorders with LIPH: view

No data available for Genatlas for LIPH Gene

Publications for LIPH Gene

  1. Lipase H, a new member of the triglyceride lipase family synthesized by the intestine. (PMID: 12213196) Jin W … Rader DJ (Genomics 2002) 2 3 4 23 54
  2. A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid. (PMID: 12063250) Sonoda H … Arai H (The Journal of biological chemistry 2002) 2 3 4 23 54
  3. Novel missense mutations in lipase H (LIPH) gene causing autosomal recessive hypotrichosis (LAH2). (PMID: 19167195) Naz G … Ahmad W (Journal of dermatological science 2009) 3 4 23 54
  4. Mutations in the lipase H gene underlie autosomal recessive woolly hair/hypotrichosis. (PMID: 18830268) Shimomura Y … Christiano AM (The Journal of investigative dermatology 2009) 3 4 23 54
  5. Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH. (PMID: 17095700) Kazantseva A … Rogaev EI (Science (New York, N.Y.) 2006) 3 4 23 54

Products for LIPH Gene

Sources for LIPH Gene