The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008] See more...

Aliases for LIPG Gene

Aliases for LIPG Gene

  • Lipase G, Endothelial Type 2 3 5
  • EDL 2 3 4
  • Endothelial Cell-Derived Lipase 3 4
  • Lipase, Endothelial 2 3
  • Endothelial Lipase 3 4
  • Phospholipase A1 3 4
  • EC 3.1.1.3 4 50
  • EL 3 4
  • Lipoprotein Lipase H 3
  • EC 3.1.1.32 4
  • EC 3.1.1 50
  • PRO719 3
  • LIPG 5

External Ids for LIPG Gene

Previous GeneCards Identifiers for LIPG Gene

  • GC18P047247
  • GC18P046887
  • GC18P045340
  • GC18P045342
  • GC18P047088
  • GC18P043942

Summaries for LIPG Gene

Entrez Gene Summary for LIPG Gene

  • The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIPG Gene

LIPG (Lipase G, Endothelial Type) is a Protein Coding gene. Diseases associated with LIPG include Lipase Deficiency, Combined and Hypobetalipoproteinemia, Familial, 2. Among its related pathways are Statin Pathway and Metabolism. Gene Ontology (GO) annotations related to this gene include heparin binding and phospholipase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot Summary for LIPG Gene

  • Exerts both phospholipase and triglyceride lipase activities (PubMed:12032167, PubMed:10318835, PubMed:10192396). More active as a phospholipase than a triglyceride lipase (PubMed:12032167). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (PubMed:12032167). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (PubMed:12032167, PubMed:10192396).

Tocris Summary for LIPG Gene

  • Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LIPG Gene

Genomics for LIPG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LIPG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LIPG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LIPG

Top Transcription factor binding sites by QIAGEN in the LIPG gene promoter:
  • CUTL1
  • MyoD
  • Nkx2-5
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for LIPG Gene

Latest Assembly
chr18:49,560,699-49,599,185
(GRCh38/hg38)
Size:
38,487 bases
Orientation:
Plus strand

Previous Assembly
chr18:47,088,427-47,125,555
(GRCh37/hg19 by Entrez Gene)
Size:
37,129 bases
Orientation:
Plus strand

chr18:47,087,069-47,119,272
(GRCh37/hg19 by Ensembl)
Size:
32,204 bases
Orientation:
Plus strand

Genomic View for LIPG Gene

Genes around LIPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPG Gene

Proteins for LIPG Gene

  • Protein details for LIPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5X9-LIPE_HUMAN
    Recommended name:
    Endothelial lipase
    Protein Accession:
    Q9Y5X9
    Secondary Accessions:
    • B0LPG6
    • Q6P9C8
    • Q6UW82

    Protein attributes for LIPG Gene

    Size:
    500 amino acids
    Molecular mass:
    56795 Da
    Quaternary structure:
    • Head to tail homodimer.
    Miscellaneous:
    • It is termed endothelial lipase due to the fact that it is synthesized in endothelial cells, a characteristic that distinguishes it from other members of the family. However, this protein is also expressed in other cell types.

    Alternative splice isoforms for LIPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIPG Gene

Selected DME Specific Peptides for LIPG Gene

Q9Y5X9:
  • RLSPDDA
  • PVGHIDIYPNGG
  • CLSCRKNRCN
  • GRITGLD
  • VHLIGYSLGAHV
  • RVKSGETQ
  • KMYLKTR
  • GLDPAGP

Post-translational modifications for LIPG Gene

  • Glycosylation at Asn80, Asn136, Asn393, Asn469, and Asn491
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for LIPG

Domains & Families for LIPG Gene

Gene Families for LIPG Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for LIPG Gene

InterPro:
Blocks:
  • Lipase, active site
  • Lipoxygenase, LH2 domain
  • Lipase
  • Lipoprotein lipase signature

Suggested Antigen Peptide Sequences for LIPG Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57818, highly similar to Endothelial lipase (EC 3.1.1.3) (B4DTR8_HUMAN)
  • Endothelial cell-derived lipase (LIPE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y5X9

UniProtKB/Swiss-Prot:

LIPE_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPG: view

Function for LIPG Gene

Molecular function for LIPG Gene

UniProtKB/Swiss-Prot Function:
Exerts both phospholipase and triglyceride lipase activities (PubMed:12032167, PubMed:10318835, PubMed:10192396). More active as a phospholipase than a triglyceride lipase (PubMed:12032167). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (PubMed:12032167). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (PubMed:12032167, PubMed:10192396).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence={ECO:0000269|PubMed:10192396, ECO:0000269|PubMed:10318835, ECO:0000269|PubMed:12032167};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence={ECO:0000269|PubMed:12032167};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+); Xref=Rhea:RHEA:38575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945; Evidence={ECO:0000269|PubMed:12032167};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+); Xref=Rhea:RHEA:40475, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:35020, ChEBI:CHEBI:76478; Evidence={ECO:0000269|PubMed:12032167};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:41384, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999; Evidence={ECO:0000269|PubMed:12032167};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by serum and NaCl.

Enzyme Numbers (IUBMB) for LIPG Gene

Phenotypes From GWAS Catalog for LIPG Gene

Gene Ontology (GO) - Molecular Function for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004465 lipoprotein lipase activity IEA,IBA 21873635
GO:0004620 phospholipase activity IBA,IDA 10192396
GO:0004806 triglyceride lipase activity IEA,IDA 12032167
GO:0005515 protein binding IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with LIPG: view
genes like me logo Genes that share phenotypes with LIPG: view

Animal Models for LIPG Gene

MGI Knock Outs for LIPG:

miRNA for LIPG Gene

miRTarBase miRNAs that target LIPG

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIPG

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIPG Gene

Localization for LIPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPG Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPG gene
Compartment Confidence
extracellular 5
endosome 5
golgi apparatus 5
plasma membrane 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA,IDA 10192396
GO:0005769 early endosome IDA 23918928
GO:0005794 Golgi apparatus IDA 23918928
GO:0009986 cell surface IDA 23918928
genes like me logo Genes that share ontologies with LIPG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LIPG Gene

Pathways & Interactions for LIPG Gene

genes like me logo Genes that share pathways with LIPG: view

Pathways by source for LIPG Gene

Gene Ontology (GO) - Biological Process for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA,TAS 10192396
GO:0006633 fatty acid biosynthetic process IBA 21873635
GO:0007584 response to nutrient IEA --
GO:0008283 cell proliferation IEA --
GO:0009395 phospholipid catabolic process NAS 19136670
genes like me logo Genes that share ontologies with LIPG: view

No data available for SIGNOR curated interactions for LIPG Gene

Drugs & Compounds for LIPG Gene

(20) Drugs for LIPG Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved Pharma 27
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
Orlistat Approved, Investigational Pharma Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 63
arachidonic acid Experimental Pharma 41

(21) Additional Compounds for LIPG Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
506-30-9
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2

(3) Tocris Compounds for LIPG Gene

Compound Action Cas Number
GSK 264220A Endothelial lipase and lipoprotein lipase inhibitor 685506-42-7
Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 96829-58-2
XEN 445 Selective endothelial lipase inhibitor; orally bioavailable 1515856-92-4

(1) ApexBio Compounds for LIPG Gene

Compound Action Cas Number
XEN445 Endothelial lipase(EL) inhibitor 1515856-92-4
genes like me logo Genes that share compounds with LIPG: view

Drug products for research

Transcripts for LIPG Gene

mRNA/cDNA for LIPG Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIPG

Alternative Splicing Database (ASD) splice patterns (SP) for LIPG Gene

No ASD Table

Relevant External Links for LIPG Gene

GeneLoc Exon Structure for
LIPG

Expression for LIPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPG Gene

This gene is overexpressed in Thyroid (x25.3) and Liver (x10.6).

Protein differential expression in normal tissues from HIPED for LIPG Gene

This gene is overexpressed in Placenta (39.7) and Prostate (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LIPG Gene



Protein tissue co-expression partners for LIPG Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LIPG

SOURCE GeneReport for Unigene cluster for LIPG Gene:

Hs.465102

mRNA Expression by UniProt/SwissProt for LIPG Gene:

Q9Y5X9-LIPE_HUMAN
Tissue specificity: High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosarcoma cell lines. Not detected in heart, brain and muscle.

Evidence on tissue expression from TISSUES for LIPG Gene

  • Heart(4.5)
  • Nervous system(4.4)
  • Bone marrow(4.2)
  • Eye(3.2)
  • Liver(3.1)
  • Intestine(3)
  • Lung(3)
  • Thyroid gland(2.9)
  • Kidney(2.6)
  • Blood(2.4)
  • Pancreas(2.3)
  • Skin(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with LIPG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LIPG Gene

Orthologs for LIPG Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LIPG 29 30
  • 99.47 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 90 (a)
OneToMany
-- 30
  • 78 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LIPG 29 30
  • 85.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC509808 29
  • 84.65 (n)
Mouse
(Mus musculus)
Mammalia Lipg 29 16 30
  • 81.9 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lipg 29
  • 81.06 (n)
Oppossum
(Monodelphis domestica)
Mammalia LIPG 30
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LIPG 29 30
  • 70.18 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LIPG 30
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lipg 29
  • 66.53 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69106 29
Zebrafish
(Danio rerio)
Actinopterygii lipg 29 30
  • 62.63 (n)
OneToOne
zgc55345 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG6271 31
  • 37 (a)
CG6277 31
  • 37 (a)
CG6472 31
  • 34 (a)
CG5966 30
  • 24 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 25 (a)
ManyToMany
-- 30
  • 22 (a)
ManyToMany
Species where no ortholog for LIPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LIPG Gene

ENSEMBL:
Gene Tree for LIPG (if available)
TreeFam:
Gene Tree for LIPG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LIPG: view image
Alliance of Genome Resources:
Additional Orthologs for LIPG

Paralogs for LIPG Gene

Paralogs for LIPG Gene

(7) SIMAP similar genes for LIPG Gene using alignment to 4 proteins:

  • LIPE_HUMAN
  • B4DTR8_HUMAN
  • J3KTN7_HUMAN
  • J3QQQ0_HUMAN
genes like me logo Genes that share paralogs with LIPG: view

Variants for LIPG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LIPG Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs1048946414 Likely Benign: not provided 49,586,758(+) T/C
NM_006033.4(LIPG):c.1389T>C (p.Cys463=)
SYNONYMOUS
rs61729805 Benign: not provided 49,581,514(+) C/G
NM_006033.4(LIPG):c.893C>G (p.Thr298Ser)
MISSENSE
rs150879681 -- p.Gly96Ser
rs2000813 -- p.Thr111Ile
rs9963243 -- p.Gly26Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LIPG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LIPG Gene

Variant ID Type Subtype PubMed ID
esv1216550 CNV deletion 17803354
nsv1150682 CNV insertion 26484159
nsv438288 CNV loss 16468122
nsv576863 CNV gain 21841781

Variation tolerance for LIPG Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIPG Gene

Human Gene Mutation Database (HGMD)
LIPG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIPG
Leiden Open Variation Database (LOVD)
LIPG

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPG Gene

Disorders for LIPG Gene

MalaCards: The human disease database

(10) MalaCards diseases for LIPG Gene - From: COP and GCD

Disorder Aliases PubMed IDs
lipase deficiency, combined
  • lipoprotein lipase deficiency with hepatic triglyceride lipase deficiency
hypobetalipoproteinemia, familial, 2
  • fhbl2
lipid metabolism disorder
  • dyslipidemia
hyperlipoproteinemia, type i
  • lipoprotein lipase deficiency
atherosclerosis susceptibility
  • aths
- elite association - COSMIC cancer census association via MalaCards
Search LIPG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LIPG

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LIPG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIPG Gene

Publications for LIPG Gene

  1. Cloning of a unique lipase from endothelial cells extends the lipase gene family. (PMID: 10318835) Hirata K … Quertermous T (The Journal of biological chemistry 1999) 2 3 4 22
  2. Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. (PMID: 19287092) Edmondson AC … Rader DJ (The Journal of clinical investigation 2009) 3 22 40
  3. The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations. (PMID: 19411665) Jensen MK … Overvad K (European heart journal 2009) 3 22 40
  4. Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study. (PMID: 19380136) Smith CE … Ordovás JM (Atherosclerosis 2009) 3 22 40
  5. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (PMID: 18193043) Willer CJ … Abecasis GR (Nature genetics 2008) 3 22 40

Products for LIPG Gene