Aliases for LIPF Gene
External Ids for LIPF Gene
Previous GeneCards Identifiers for LIPF Gene
This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for LIPF Gene
LIPF (Lipase F, Gastric Type) is a Protein Coding gene. Diseases associated with LIPF include Lysosomal Acid Lipase Deficiency and Cholesterol Ester Storage Disease. Among its related pathways are triacylglycerol biosynthesis and Allograft rejection. Gene Ontology (GO) annotations related to this gene include lipid binding and malate dehydrogenase activity. An important paralog of this gene is LIPK.
UniProtKB/Swiss-Prot Summary for LIPF Gene
Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:2243091, PubMed:10358049). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (PubMed:2243091).
Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).