This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a con... See more...

Aliases for LIPF Gene

Aliases for LIPF Gene

  • Lipase F, Gastric Type 2 3 5
  • Gastric Triacylglycerol Lipase 2 3 4
  • Lipase, Gastric 2 3
  • Gastric Lipase 3 4
  • EC 3.1.1.3 4 50

External Ids for LIPF Gene

Previous GeneCards Identifiers for LIPF Gene

  • GC10P089305
  • GC10P089569
  • GC10P090555
  • GC10P090088
  • GC10P090415
  • GC10P084058

Summaries for LIPF Gene

Entrez Gene Summary for LIPF Gene

  • This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for LIPF Gene

LIPF (Lipase F, Gastric Type) is a Protein Coding gene. Diseases associated with LIPF include Lysosomal Acid Lipase Deficiency and Cholesterol Ester Storage Disease. Among its related pathways are triacylglycerol biosynthesis and Allograft rejection. Gene Ontology (GO) annotations related to this gene include lipid binding and malate dehydrogenase activity. An important paralog of this gene is LIPK.

UniProtKB/Swiss-Prot Summary for LIPF Gene

  • Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:2243091, PubMed:10358049). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (PubMed:2243091).

Tocris Summary for LIPF Gene

  • Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LIPF Gene

Genomics for LIPF Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LIPF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J088664 Promoter 0.3 EPDnew 250.7 0.0 -14 0.1 HSALNG0079531 LIPF RF00017-654 RNLS
GH10J088793 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 10.4 +128.8 128814 3.7 JUND CEBPA YY1 CEBPB TRIM22 CTCF NR2C1 EP300 RXRA RAD21 RNLS LIPN LIPF ENSG00000201548 LIPJ ANKRD22 FAS piR-48369-021 RCBTB2P1 LIPM
GH10J088832 Enhancer 1.3 FANTOM5 Ensembl ENCODE 9.6 +172.1 172060 12.6 BCLAF1 ZNF654 ATF2 BRCA1 ZIC2 YY1 CTCF REST CEBPB DEK ANKRD22 STAMBPL1 FAS ACTA2-AS1 LIPM ENSG00000201548 LIPJ RNLS LIPF LIPN
GH10J088824 Enhancer 0.9 Ensembl ENCODE 10.1 +161.4 161441 3.4 SP1 TRIM22 NR2C1 SMARCA5 ASH2L BHLHE40 ELF1 IKZF1 BMI1 ZNF664 ANKRD22 LIPM ACTA2-AS1 STAMBPL1 ENSG00000201548 LIPJ RNLS LIPF FAS LIPN
GH10J088820 Enhancer 0.7 Ensembl ENCODE 10.9 +156.9 156859 1.8 CEBPB MAX EP300 RFX5 STAT3 RFX1 ZBTB44 CEBPG HSALNG0079541 LIPN ACTA2-AS1 STAMBPL1 LIPF ENSG00000201548 LIPJ RNLS FAS lnc-ACTA2-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LIPF on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LIPF

Top Transcription factor binding sites by QIAGEN in the LIPF gene promoter:
  • FOXF2
  • FOXJ2 (long isoform)
  • FOXO4
  • GATA-2
  • HNF-1
  • HNF-1A
  • SEF-1 (1)
  • SRF
  • SRF (504 AA)
  • STAT5A

Genomic Locations for LIPF Gene

Latest Assembly
chr10:88,664,441-88,678,815
(GRCh38/hg38)
Size:
14,375 bases
Orientation:
Plus strand

Previous Assembly
chr10:90,424,199-90,438,571
(GRCh37/hg19 by Entrez Gene)
Size:
14,373 bases
Orientation:
Plus strand

chr10:90,424,198-90,438,571
(GRCh37/hg19 by Ensembl)
Size:
14,374 bases
Orientation:
Plus strand

Genomic View for LIPF Gene

Genes around LIPF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPF Gene

Proteins for LIPF Gene

  • Protein details for LIPF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07098-LIPG_HUMAN
    Recommended name:
    Gastric triacylglycerol lipase
    Protein Accession:
    P07098
    Secondary Accessions:
    • B7Z723
    • F5H1P4
    • Q2M1P6
    • Q5VXI7
    • Q5VXI8
    • Q658L8

    Protein attributes for LIPF Gene

    Size:
    398 amino acids
    Molecular mass:
    45238 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA29414.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LIPF Gene

    Alternative splice isoforms for LIPF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIPF Gene

Selected DME Specific Peptides for LIPF Gene

P07098:
  • EMAKYDLP
  • GNSRGNTW
  • SQMITYWGYP
  • ALAPVATVKYT
  • TEDGYIL
  • TIGFIAFS
  • FILADAG
  • LADAGYDVW
  • NLPNNSL
  • HNPAGTS
  • YVGHSQGTTIGFI
  • YNHLDFIWAMDAPQ

Post-translational modifications for LIPF Gene

  • Glycosylation at Asn34, Asn99, Asn271, and Asn327
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for LIPF
  • Boster Bio Antibodies for LIPF

Domains & Families for LIPF Gene

Gene Families for LIPF Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted secreted proteins

Protein Domains for LIPF Gene

InterPro:
Blocks:
  • Alpha/beta hydrolase fold
  • Ab-hydrolase associated lipase region
  • Lipase, active site

Suggested Antigen Peptide Sequences for LIPF Gene

GenScript: Design optimal peptide antigens:
  • Gastric triacylglycerol lipase (LIPG_HUMAN)
  • cDNA, FLJ93392, Homo sapiens lipase, gastric (LIPF), mRNA (Q5VXI7_HUMAN)
  • cDNA FLJ50254, highly similar to Gastric triacylglycerol lipase (EC 3.1.1.3) (Q5VXI8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P07098

UniProtKB/Swiss-Prot:

LIPG_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPF: view

Function for LIPF Gene

Molecular function for LIPF Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:2243091, PubMed:10358049). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (PubMed:2243091).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence={ECO:0000269|PubMed:10358049, ECO:0000269|PubMed:2243091};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+); Xref=Rhea:RHEA:39931, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52333, ChEBI:CHEBI:53753; Evidence={ECO:0000269|PubMed:2243091};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2,3-trioctanoylglycerol + H2O = 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate; Xref=Rhea:RHEA:40047, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:76978, ChEBI:CHEBI:76979; Evidence={ECO:0000269|PubMed:2243091};.

Enzyme Numbers (IUBMB) for LIPF Gene

Phenotypes From GWAS Catalog for LIPF Gene

Gene Ontology (GO) - Molecular Function for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity TAS 3304425
GO:0005515 protein binding IPI --
GO:0008289 lipid binding NAS 2753032
GO:0016615 malate dehydrogenase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with LIPF: view

Phenotypes for LIPF Gene

genes like me logo Genes that share phenotypes with LIPF: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIPF

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LIPF Gene

Localization for LIPF Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPF gene
Compartment Confidence
extracellular 4
mitochondrion 3
lysosome 3
plasma membrane 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005739 mitochondrion IEA --
GO:0043231 intracellular membrane-bounded organelle IBA 21873635
genes like me logo Genes that share ontologies with LIPF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LIPF Gene

Pathways & Interactions for LIPF Gene

genes like me logo Genes that share pathways with LIPF: view

Pathways by source for LIPF Gene

1 Qiagen pathway for LIPF Gene
  • CTL Mediated Apoptosis

Gene Ontology (GO) - Biological Process for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006108 malate metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006641 triglyceride metabolic process NAS 3304425
GO:0016042 lipid catabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with LIPF: view

No data available for SIGNOR curated interactions for LIPF Gene

Drugs & Compounds for LIPF Gene

(18) Drugs for LIPF Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma Target, Enzyme, inhibitor Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 63
Palmitic Acid Approved Pharma 27
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
Undecyl-Phosphinic Acid Butyl Ester Experimental Pharma Target 0

(23) Additional Compounds for LIPF Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
506-30-9
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2

(3) Tocris Compounds for LIPF Gene

Compound Action Cas Number
GSK 264220A Endothelial lipase and lipoprotein lipase inhibitor 685506-42-7
Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 96829-58-2
XEN 445 Selective endothelial lipase inhibitor; orally bioavailable 1515856-92-4
genes like me logo Genes that share compounds with LIPF: view

Transcripts for LIPF Gene

mRNA/cDNA for LIPF Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIPF

Alternative Splicing Database (ASD) splice patterns (SP) for LIPF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP2:
SP3: - -
SP4: -

Relevant External Links for LIPF Gene

GeneLoc Exon Structure for
LIPF

Expression for LIPF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIPF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPF Gene

This gene is overexpressed in Stomach (x52.7).

Protein differential expression in normal tissues from HIPED for LIPF Gene

This gene is overexpressed in Stomach (39.3) and Cardia (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LIPF Gene



Protein tissue co-expression partners for LIPF Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LIPF

SOURCE GeneReport for Unigene cluster for LIPF Gene:

Hs.523130

Evidence on tissue expression from TISSUES for LIPF Gene

  • Stomach(5)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with LIPF: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIPF Gene

Orthologs for LIPF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LIPF Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LIPF 29 30
  • 98.94 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LIPF 29 30
  • 85.26 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LIPF 29 30
  • 81.28 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lipf 29 16 30
  • 80.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lipf 29
  • 80.08 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 51 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 42 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 47 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 52 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002353 29
  • 45.85 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG6113 31
  • 38 (a)
CG5932 31
  • 37 (a)
Lip3 30 31
  • 36 (a)
ManyToMany
CG8093 30 31
  • 33 (a)
ManyToMany
CG6753 30 31
  • 32 (a)
ManyToMany
CG11598 30 31
  • 31 (a)
ManyToMany
CG18302 30 31
  • 31 (a)
ManyToMany
Lip4 30
  • 31 (a)
ManyToMany
CG2772 30 31
  • 31 (a)
ManyToMany
CG3635 30 31
  • 31 (a)
ManyToMany
CG18530 31
  • 31 (a)
CG11406 30
  • 30 (a)
ManyToMany
Lip1 30 31
  • 30 (a)
ManyToMany
CG31091 30
  • 29 (a)
ManyToMany
CG11600 30 31
  • 28 (a)
ManyToMany
CG11608 30 31
  • 28 (a)
ManyToMany
CG7329 30 31
  • 27 (a)
ManyToMany
CG31871 30
  • 27 (a)
ManyToMany
CG18284 30
  • 26 (a)
ManyToMany
CG17097 30 31
  • 12 (a)
ManyToMany
CG31872 30
  • 11 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea ZK6.7b 31
  • 45 (a)
ZK6.7a 31
  • 43 (a)
F46B6.8 31
  • 42 (a)
F54F3.3 31
  • 42 (a)
R11G11.14 31
  • 42 (a)
lipl-1 30
  • 41 (a)
ManyToMany
Y57E12B.3 31
  • 41 (a)
F01G10.7 31
  • 37 (a)
K04A8.5 31
  • 36 (a)
lipl-7 30
  • 34 (a)
ManyToMany
Y50E8A.7 31
  • 32 (a)
lipl-8 30
  • 30 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TGL1 30
  • 21 (a)
OneToMany
YEH1 32
Thale Cress
(Arabidopsis thaliana)
eudicotyledons MPL1 29
  • 47.58 (n)
Rice
(Oryza sativa)
Liliopsida Os08g0529800 29
  • 45.05 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 40 (a)
OneToMany
Species where no ortholog for LIPF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for LIPF Gene

ENSEMBL:
Gene Tree for LIPF (if available)
TreeFam:
Gene Tree for LIPF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LIPF: view image
Alliance of Genome Resources:
Additional Orthologs for LIPF

Paralogs for LIPF Gene

Paralogs for LIPF Gene

(6) SIMAP similar genes for LIPF Gene using alignment to 1 proteins:

  • LIPG_HUMAN
genes like me logo Genes that share paralogs with LIPF: view

Variants for LIPF Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LIPF Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs79058739 Likely Benign: not provided 88,675,590(+) G/A
NM_004190.4(LIPF):c.821G>A (p.Arg274His)
MISSENSE
rs17333991 -- p.Pro348Thr
rs6586145 -- p.Phe224Ile
rs814628 -- p.Thr161Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LIPF Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LIPF Gene

Variant ID Type Subtype PubMed ID
esv3624131 CNV loss 21293372
esv3624132 CNV gain 21293372
esv3624134 CNV gain 21293372
nsv831941 CNV gain 17160897

Variation tolerance for LIPF Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.91; 83.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIPF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIPF
Leiden Open Variation Database (LOVD)
LIPF

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPF Gene

Disorders for LIPF Gene

MalaCards: The human disease database

(5) MalaCards diseases for LIPF Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search LIPF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LIPF

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LIPF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIPF Gene

Publications for LIPF Gene

  1. Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest. (PMID: 10358049) Roussel A … Cambillau C (The Journal of biological chemistry 1999) 3 4 22
  2. The acid lipase gene family: three enzymes, one highly conserved gene structure. (PMID: 9186906) Lohse P … Seidel D (Journal of lipid research 1997) 2 3 22
  3. Stereoselectivity of lipases. II. Stereoselective hydrolysis of triglycerides by gastric and pancreatic lipases. (PMID: 2243091) Rogalska E … Verger R (The Journal of biological chemistry 1990) 3 4 22
  4. Molecular cloning of a human gastric lipase and expression of the enzyme in yeast. (PMID: 3304425) Bodmer MW … Lowe PA (Biochimica et biophysica acta 1987) 2 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40

Products for LIPF Gene

Sources for LIPF Gene