LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008] See more...

Aliases for LIPC Gene

Aliases for LIPC Gene

  • Lipase C, Hepatic Type 2 3 5
  • HTGL 2 3 4
  • HL 2 3 4
  • Hepatic Triacylglycerol Lipase 3 4
  • Triacylglycerol Lipase 2 3
  • Lysophospholipase 3 4
  • Phospholipase A1 3 4
  • Lipase, Hepatic 2 3
  • Lipase Member C 3 4
  • Hepatic Lipase 3 4
  • EC 3.1.1.3 4 50
  • EC 3.1.1.32 4
  • EC 3.1.1.5 4
  • EC 3.1.1 50
  • HDLCQ12 3
  • LIPH 3
  • LIPC 5

External Ids for LIPC Gene

Previous GeneCards Identifiers for LIPC Gene

  • GC15P054281
  • GC15P051771
  • GC15P056303
  • GC15P056440
  • GC15P056511
  • GC15P058702
  • GC15P035548

Summaries for LIPC Gene

Entrez Gene Summary for LIPC Gene

  • LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIPC Gene

LIPC (Lipase C, Hepatic Type) is a Protein Coding gene. Diseases associated with LIPC include Hepatic Lipase Deficiency and High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 12. Among its related pathways are Statin Pathway and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include heparin binding and phospholipase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot Summary for LIPC Gene

  • Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:7592706, PubMed:8798474, PubMed:12032167, PubMed:26193433). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (PubMed:26193433).

Gene Wiki entry for LIPC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LIPC Gene

Genomics for LIPC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LIPC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LIPC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LIPC

Top Transcription factor binding sites by QIAGEN in the LIPC gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • LCR-F1
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha2

Genomic Locations for LIPC Gene

Latest Assembly
chr15:58,410,457-58,569,844
(GRCh38/hg38)
Size:
159,388 bases
Orientation:
Plus strand

Previous Assembly
chr15:58,724,190-58,862,043
(GRCh37/hg19 by Entrez Gene)
Size:
137,854 bases
Orientation:
Plus strand

chr15:58,702,768-58,861,151
(GRCh37/hg19 by Ensembl)
Size:
158,384 bases
Orientation:
Plus strand

Genomic View for LIPC Gene

Genes around LIPC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPC Gene

Proteins for LIPC Gene

  • Protein details for LIPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11150-LIPC_HUMAN
    Recommended name:
    Hepatic triacylglycerol lipase
    Protein Accession:
    P11150
    Secondary Accessions:
    • A2RUB4
    • A8K9B6
    • O43571
    • P78529
    • Q99465

    Protein attributes for LIPC Gene

    Size:
    499 amino acids
    Molecular mass:
    55914 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for LIPC Gene

Selected DME Specific Peptides for LIPC Gene

P11150:
  • RLSPDDA
  • KCSHERS
  • KIQFINQ
  • GRITGLD
  • NKTYSFL
  • DFYPNGG
  • EHMGLSVG
  • VHLIGYSLGAHV
  • PFKVYHYQ
  • HLFIDSL
  • VKAGETQ

Post-translational modifications for LIPC Gene

  • Glycosylation at Asn42, Asn78, Asn362, and Asn397
  • Modification sites at PhosphoSitePlus

Domains & Families for LIPC Gene

Gene Families for LIPC Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted secreted proteins

Protein Domains for LIPC Gene

InterPro:
Blocks:
  • Lipase, active site
  • Lipoxygenase, LH2 domain
  • Lipase
  • Hepatic lipase signature

Suggested Antigen Peptide Sequences for LIPC Gene

GenScript: Design optimal peptide antigens:
  • LIPC protein (A6H8L5_HUMAN)
  • Hepatic lipase (B9TXP1_HUMAN)
  • Lipase member C (LIPC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P11150

UniProtKB/Swiss-Prot:

LIPC_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPC: view

Function for LIPC Gene

Molecular function for LIPC Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:7592706, PubMed:8798474, PubMed:12032167, PubMed:26193433). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (PubMed:26193433).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence={ECO:0000269|PubMed:12032167, ECO:0000269|PubMed:26193433, ECO:0000269|PubMed:7592706, ECO:0000269|PubMed:8798474};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence={ECO:0000250|UniProtKB:P07867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence={ECO:0000269|PubMed:12032167, ECO:0000269|PubMed:26193433, ECO:0000269|PubMed:7592706};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+); Xref=Rhea:RHEA:38575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945; Evidence={ECO:0000269|PubMed:12032167, ECO:0000269|PubMed:7592706, ECO:0000269|PubMed:8798474};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38699, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669, ChEBI:CHEBI:76083; Evidence={ECO:0000269|PubMed:7592706};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+); Xref=Rhea:RHEA:40475, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:35020, ChEBI:CHEBI:76478; Evidence={ECO:0000269|PubMed:7592706};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:41384, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999; Evidence={ECO:0000269|PubMed:12032167};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38511, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52333, ChEBI:CHEBI:73990; Evidence={ECO:0000250|UniProtKB:P07867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38391, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75824; Evidence={ECO:0000250|UniProtKB:P07867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine; Xref=Rhea:RHEA:40499, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:64765, ChEBI:CHEBI:74617; Evidence={ECO:0000250|UniProtKB:P07867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence={ECO:0000250|UniProtKB:P07867};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+); Xref=Rhea:RHEA:38651, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75735, ChEBI:CHEBI:75938; Evidence={ECO:0000250|UniProtKB:P07867};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=16 mM for 1,2,3-tri-(9Z-octadecenoyl)-glycerol {ECO:0000269|PubMed:8798474}; Vmax=1.4 umol/min/ug enzyme with 1,2,3-tri-(9Z-octadecenoyl)-glycerol as substrate {ECO:0000269|PubMed:8798474};
UniProtKB/Swiss-Prot EnzymeRegulation:
Phospholipase A1 and triacylglycerol lipase are inhibited by sphingomyelin.
GENATLAS Biochemistry:
lipase,hepatic,53kDa,plasma lipid transport

Enzyme Numbers (IUBMB) for LIPC Gene

Phenotypes From GWAS Catalog for LIPC Gene

Gene Ontology (GO) - Molecular Function for LIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004465 lipoprotein lipase activity IBA 21873635
GO:0004620 phospholipase activity IBA,TAS 3244012
GO:0004622 lysophospholipase activity IEA --
GO:0004806 triglyceride lipase activity IEA,IDA 182536
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LIPC: view
genes like me logo Genes that share phenotypes with LIPC: view

Human Phenotype Ontology for LIPC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LIPC Gene

MGI Knock Outs for LIPC:

miRNA for LIPC Gene

miRTarBase miRNAs that target LIPC

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIPC

No data available for Transcription Factor Targets and HOMER Transcription for LIPC Gene

Localization for LIPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPC gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 2
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2
cytoskeleton 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA,IDA 2839510
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0034364 high-density lipoprotein particle IEA --
genes like me logo Genes that share ontologies with LIPC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LIPC Gene

Pathways & Interactions for LIPC Gene

genes like me logo Genes that share pathways with LIPC: view

Gene Ontology (GO) - Biological Process for LIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IBA,IDA 182536
GO:0008203 cholesterol metabolic process IEA --
GO:0016042 lipid catabolic process IBA 21873635
GO:0019433 triglyceride catabolic process IBA,IDA 182536
genes like me logo Genes that share ontologies with LIPC: view

No data available for SIGNOR curated interactions for LIPC Gene

Drugs & Compounds for LIPC Gene

(53) Drugs for LIPC Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluvastatin Approved Pharma HMGCR inhibitor 0
Pravastatin Approved Pharma 170
Simvastatin Approved Pharma HMG-CoA reductase inhibitor 592
Palmitic Acid Approved Pharma 27
Stearic acid Approved, Experimental Pharma 0

(70) Additional Compounds for LIPC Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • Dodecenoyl-CoA
  • Dodecenoyl+2-dodecenoyl, (e)-isomer
  • Dodecenoyl-coenzyme A
  • Dodecenoyl+2-dodecenoyl
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with LIPC: view

Transcripts for LIPC Gene

mRNA/cDNA for LIPC Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIPC

Alternative Splicing Database (ASD) splice patterns (SP) for LIPC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1:
SP2:
SP3: - - - -
SP4: - - -
SP5:

Relevant External Links for LIPC Gene

GeneLoc Exon Structure for
LIPC

Expression for LIPC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIPC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPC Gene

This gene is overexpressed in Liver (x39.0).

Protein differential expression in normal tissues from HIPED for LIPC Gene

This gene is overexpressed in Colon muscle (39.7), Platelet (11.3), Liver (9.4), and Fetal Liver (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LIPC Gene



Protein tissue co-expression partners for LIPC Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LIPC

SOURCE GeneReport for Unigene cluster for LIPC Gene:

Hs.654472

Evidence on tissue expression from TISSUES for LIPC Gene

  • Liver(4.7)
  • Kidney(4.4)
  • Blood(2.3)
  • Heart(2.1)
  • Muscle(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LIPC Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • integumentary
Regions:
Head and neck:
  • ear
Thorax:
  • heart
General:
  • blood
  • blood vessel
  • skin
genes like me logo Genes that share expression patterns with LIPC: view

No data available for mRNA Expression by UniProt/SwissProt for LIPC Gene

Orthologs for LIPC Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LIPC 29 30
  • 99.13 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LIPC 29
  • 85.82 (n)
HTGL 30
  • 77 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LIPC 29 30
  • 84.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lipc 29
  • 80.56 (n)
Mouse
(Mus musculus)
Mammalia Lipc 29 16 30
  • 80.5 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LIPC 30
  • 61 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LIPC 30
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LIPC 29 30
  • 67.76 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LIPC 30
  • 54 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lipc 29
  • 62.04 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17530 29
Zebrafish
(Danio rerio)
Actinopterygii lipca 29 30
  • 60.64 (n)
OneToOne
zgc64081 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG6847 31
  • 37 (a)
CG6472 31
  • 33 (a)
CG5966 30
  • 24 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 22 (a)
ManyToMany
-- 30
  • 21 (a)
ManyToMany
Species where no ortholog for LIPC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LIPC Gene

ENSEMBL:
Gene Tree for LIPC (if available)
TreeFam:
Gene Tree for LIPC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LIPC: view image
Alliance of Genome Resources:
Additional Orthologs for LIPC

Paralogs for LIPC Gene

Paralogs for LIPC Gene

(7) SIMAP similar genes for LIPC Gene using alignment to 5 proteins:

  • LIPC_HUMAN
  • A6H8L5_HUMAN
  • B9TXP1_HUMAN
  • E7EUJ1_HUMAN
  • E7EUK6_HUMAN
genes like me logo Genes that share paralogs with LIPC: view

Variants for LIPC Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for LIPC Gene

LIPC_HUMAN-P11150
Genetic variations in LIPC define the high density lipoprotein cholesterol level quantitative trait locus 12 (HDLCQ12) [MIM:612797].
LIPC_HUMAN-P11150
Genetic variations in LIPC are associated with non-insulin-dependent diabetes mellitus susceptibility (NIDDM susceptibility) [MIM:125853].

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LIPC Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
1034118 Pathogenic: Hepatic lipase deficiency 58,548,533(+) AG/A
NM_000236.3(LIPC):c.1014del (p.Arg338fs)
FRAMESHIFT
1034119 Pathogenic: Hepatic lipase deficiency 58,541,969(+) T/C
NM_000236.3(LIPC):c.456+2T>C
SPLICE_DONOR
1034120 Pathogenic: Hepatic lipase deficiency 58,548,366(+) C/A
NM_000236.3(LIPC):c.845C>A (p.Ser282Ter)
NONSENSE
885098 Likely Benign: Hepatic lipase deficiency 58,545,727(+) C/T
NM_000236.3(LIPC):c.575-15C>T
INTRON
885172 Uncertain Significance: Hepatic lipase deficiency 58,563,608(+) G/C
NM_000236.3(LIPC):c.1273G>C (p.Val425Leu)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LIPC Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LIPC Gene

Variant ID Type Subtype PubMed ID
dgv2608n100 CNV gain 25217958
esv1002236 CNV gain 20482838
esv25142 CNV gain 19812545
esv2760372 CNV loss 21179565
esv2761874 CNV loss 21179565
esv3302978 CNV tandem duplication 20981092
esv3410982 CNV insertion 20981092
esv3581728 CNV loss 25503493
esv3581729 CNV loss 25503493
esv3581730 CNV loss 25503493
esv3636629 CNV loss 21293372
nsv1043362 CNV loss 25217958
nsv1047048 CNV loss 25217958
nsv1122971 CNV deletion 24896259
nsv1133218 CNV tandem duplication 24896259
nsv474584 CNV novel sequence insertion 20440878
nsv522373 CNV loss 19592680
nsv524065 CNV loss 19592680
nsv524098 CNV loss 19592680
nsv569598 CNV loss 21841781
nsv569600 CNV loss 21841781
nsv569601 CNV loss 21841781
nsv7266 OTHER inversion 18451855
nsv827345 CNV gain 20364138
nsv94680 CNV deletion 16902084

Variation tolerance for LIPC Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIPC Gene

Human Gene Mutation Database (HGMD)
LIPC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIPC
Leiden Open Variation Database (LOVD)
LIPC

SNP Genotyping and Copy Number Assays for research

Disorders for LIPC Gene

MalaCards: The human disease database

(36) MalaCards diseases for LIPC Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
hepatic lipase deficiency
  • lipc deficiency
high density lipoprotein cholesterol level quantitative trait locus 12
  • hdlcq12
3-hydroxy-3-methylglutaryl-coa lyase deficiency
  • hmgcld
type 2 diabetes mellitus
  • t2d
lipase deficiency, combined
  • lipoprotein lipase deficiency with hepatic triglyceride lipase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search LIPC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LIPC_HUMAN
  • Hepatic lipase deficiency (HL deficiency) [MIM:614025]: A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. {ECO:0000269 PubMed:10660332, ECO:0000269 PubMed:1301939}. Note=The disease is caused by variants affecting the gene represented in this entry.

Genatlas disease for LIPC Gene

coronary atherosclerosis,premature,dyslipidemia

Additional Disease Information for LIPC

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LIPC: view

Publications for LIPC Gene

  1. The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects. (PMID: 18364377) Grarup N … Pedersen O (The Journal of clinical endocrinology and metabolism 2008) 3 4 22 40 72
  2. The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study. (PMID: 15126514) Todorova B … Finnish Diabetes Prevention Study (The Journal of clinical endocrinology and metabolism 2004) 3 4 22 40 72
  3. Human hepatic lipase mutations and polymorphisms. (PMID: 1301939) Hegele RA … Connelly PW (Human mutation 1992) 3 4 22 72
  4. A hepatic lipase gene mutation associated with heritable lipolytic deficiency. (PMID: 1671786) Hegele RA … Connelly PW (The Journal of clinical endocrinology and metabolism 1991) 3 22 40 72
  5. Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. (PMID: 20160193) Weissglas-Volkov D … Pajukanta P (Circulation. Cardiovascular genetics 2010) 3 22 40

Products for LIPC Gene

Sources for LIPC Gene