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Aliases for LIPC Gene

Aliases for LIPC Gene

  • Lipase C, Hepatic Type 2 3 5
  • Triacylglycerol Lipase 2 3
  • Lipase Member C 3 4
  • Lipase, Hepatic 2 3
  • Hepatic Lipase 3 4
  • HTGL 3 4
  • HL 3 4
  • Hepatic Triacylglycerol Lipase 3
  • EC 4
  • HDLCQ12 3
  • LIPH 3

External Ids for LIPC Gene

Previous GeneCards Identifiers for LIPC Gene

  • GC15P054281
  • GC15P051771
  • GC15P056303
  • GC15P056440
  • GC15P056511
  • GC15P058702
  • GC15P035548

Summaries for LIPC Gene

Entrez Gene Summary for LIPC Gene

  • LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIPC Gene

LIPC (Lipase C, Hepatic Type) is a Protein Coding gene. Diseases associated with LIPC include Hepatic Lipase Deficiency and High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 12. Among its related pathways are Glycerolipid metabolism and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include heparin binding and phospholipase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot for LIPC Gene

  • Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Gene Wiki entry for LIPC Gene

Additional gene information for LIPC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPC Gene

Genomics for LIPC Gene

GeneHancer (GH) Regulatory Elements for LIPC Gene

Promoters and enhancers for LIPC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J058410 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 664.7 0.0 -17 1 HDAC1 MEIS2 NFATC3 BACH1 CEBPG E4F1 NUFIP1 VEZF1 IKZF2 ZNF687 LIPC LOC101928635 ALDH1A2
GH15J058431 Promoter/Enhancer 1.1 EPDnew dbSUPER 650.3 +21.4 21403 0.1 HNF1A ATF3 ARID4B HNF4A CREM ZNF205 MIXL1 NR2F2 LIPC ADAM10 ENSG00000277229 ALDH1A2
GH15J058457 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.7 +48.5 48510 4 HDGF IRF4 YY1 ATF7 FOS RUNX3 RXRA JUNB REST PPARG LIPC ADAM10 AQP9 MINDY2 LOC101928725 SNORD3P1 SLTM ENSG00000277790 LIPC-AS1 ALDH1A2
GH15J058465 Enhancer 1.4 Ensembl ENCODE dbSUPER 22.4 +59.6 59573 9.2 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 FOS DEK JUNB ADAM10 LIPC MINDY2 SNORD3P1 LOC101928725 ENSG00000277790 ALDH1A2 LIPC-AS1
GH15J058438 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 17.6 +30.4 30432 5.1 FOXA2 BRCA1 THRB RAD21 RARA YY1 EGR1 FOS SMARCC1 RXRA LIPC SNORD3P1 LOC101928725 MINDY2 ENSG00000277229 LIPC-AS1 ALDH1A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LIPC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LIPC gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • FOXJ2 (long isoform)
  • FOXJ2
  • RORalpha2
  • LCR-F1

Genomic Locations for LIPC Gene

Genomic Locations for LIPC Gene
159,275 bases
Plus strand
158,384 bases
Plus strand

Genomic View for LIPC Gene

Genes around LIPC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPC Gene

Proteins for LIPC Gene

  • Protein details for LIPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatic triacylglycerol lipase
    Protein Accession:
    Secondary Accessions:
    • A2RUB4
    • A8K9B6
    • O43571
    • P78529
    • Q99465

    Protein attributes for LIPC Gene

    499 amino acids
    Molecular mass:
    55914 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LIPC Gene

Post-translational modifications for LIPC Gene

  • Glycosylation at posLast=397397, posLast=362362, isoforms=78, and isoforms=42
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LIPC Gene

Domains & Families for LIPC Gene

Gene Families for LIPC Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LIPC Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Lipase family.
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPC: view

Function for LIPC Gene

Molecular function for LIPC Gene

UniProtKB/Swiss-Prot Function:
Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.
UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
GENATLAS Biochemistry:
lipase,hepatic,53kDa,plasma lipid transport

Enzyme Numbers (IUBMB) for LIPC Gene

Phenotypes From GWAS Catalog for LIPC Gene

Gene Ontology (GO) - Molecular Function for LIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity TAS 3244012
GO:0004806 triglyceride lipase activity IEA,TAS --
GO:0005515 protein binding IEA --
GO:0008201 heparin binding IEA --
GO:0016298 lipase activity IEA --
genes like me logo Genes that share ontologies with LIPC: view
genes like me logo Genes that share phenotypes with LIPC: view

Human Phenotype Ontology for LIPC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LIPC Gene

MGI Knock Outs for LIPC:

Animal Model Products

CRISPR Products

miRNA for LIPC Gene

miRTarBase miRNAs that target LIPC

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIPC

No data available for Transcription Factor Targets and HOMER Transcription for LIPC Gene

Localization for LIPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPC Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPC gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
plasma membrane 1
cytoskeleton 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for LIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA,IEA 2839510
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0034364 high-density lipoprotein particle IEA --
genes like me logo Genes that share ontologies with LIPC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LIPC Gene

Pathways & Interactions for LIPC Gene

genes like me logo Genes that share pathways with LIPC: view

Gene Ontology (GO) - Biological Process for LIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IDA 182536
GO:0008203 cholesterol metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0019433 triglyceride catabolic process IDA 182536
genes like me logo Genes that share ontologies with LIPC: view

No data available for SIGNOR curated interactions for LIPC Gene

Drugs & Compounds for LIPC Gene

(52) Drugs for LIPC Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluvastatin Approved Pharma Competitive, Inhibitor HMGCR inhibitor 62
Pravastatin Approved Pharma Competitive, Inhibitor 154
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 537
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist 23
Stearic acid Approved, Experimental Pharma 0

(68) Additional Compounds for LIPC Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
genes like me logo Genes that share compounds with LIPC: view

Transcripts for LIPC Gene

mRNA/cDNA for LIPC Gene

Unigene Clusters for LIPC Gene

Lipase, hepatic:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIPC

Alternative Splicing Database (ASD) splice patterns (SP) for LIPC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP3: - - - -
SP4: - - -

Relevant External Links for LIPC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIPC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LIPC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPC Gene

This gene is overexpressed in Liver (x39.0).

Protein differential expression in normal tissues from HIPED for LIPC Gene

This gene is overexpressed in Colon muscle (39.7), Platelet (11.3), Liver (9.4), and Fetal Liver (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LIPC Gene

Protein tissue co-expression partners for LIPC Gene

NURSA nuclear receptor signaling pathways regulating expression of LIPC Gene:


SOURCE GeneReport for Unigene cluster for LIPC Gene:


Evidence on tissue expression from TISSUES for LIPC Gene

  • Liver(4.6)
  • Kidney(4.2)
  • Blood(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LIPC Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • cardiovascular
  • integumentary
Head and neck:
  • ear
  • heart
  • blood
  • blood vessel
  • skin
genes like me logo Genes that share expression patterns with LIPC: view

No data available for mRNA Expression by UniProt/SwissProt for LIPC Gene

Orthologs for LIPC Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LIPC 34 33
  • 99.13 (n)
(Canis familiaris)
Mammalia LIPC 33
  • 85.82 (n)
  • 77 (a)
(Bos Taurus)
Mammalia LIPC 34 33
  • 84.48 (n)
(Rattus norvegicus)
Mammalia Lipc 33
  • 80.56 (n)
(Mus musculus)
Mammalia Lipc 16 34 33
  • 80.5 (n)
(Monodelphis domestica)
Mammalia LIPC 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia LIPC 34
  • 52 (a)
(Gallus gallus)
Aves LIPC 34 33
  • 67.76 (n)
(Anolis carolinensis)
Reptilia LIPC 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lipc 33
  • 62.04 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17530 33
(Danio rerio)
Actinopterygii lipca 34 33
  • 60.64 (n)
zgc64081 33
fruit fly
(Drosophila melanogaster)
Insecta CG6847 35
  • 37 (a)
CG6472 35
  • 33 (a)
CG5966 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
-- 34
  • 21 (a)
Species where no ortholog for LIPC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIPC Gene

Gene Tree for LIPC (if available)
Gene Tree for LIPC (if available)
Evolutionary constrained regions (ECRs) for LIPC: view image

Paralogs for LIPC Gene

Paralogs for LIPC Gene

(7) SIMAP similar genes for LIPC Gene using alignment to 5 proteins:

  • A6H8L5_HUMAN
genes like me logo Genes that share paralogs with LIPC: view

Variants for LIPC Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for LIPC Gene

Genetic variations in LIPC define the high density lipoprotein cholesterol level quantitative trait locus 12 (HDLCQ12) [MIM:612797].
Genetic variations in LIPC are associated with non-insulin-dependent diabetes mellitus susceptibility (NIDDM susceptibility) [MIM:125853].

Sequence variations from dbSNP and Humsavar for LIPC Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs113298164 pathogenic, Hepatic lipase deficiency, Hepatic lipase deficiency (HL deficiency) [MIM:614025] 58,563,549(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs121912502 conflicting-interpretations-of-pathogenicity, Hepatic lipase deficiency, Hepatic lipase deficiency (HL deficiency) [MIM:614025] 58,548,387(+) C/T coding_sequence_variant, missense_variant
rs140272400 likely-benign, Hepatic lipase deficiency 58,560,876(+) A/G coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs141018530 uncertain-significance, Hepatic lipase deficiency 58,541,827(+) G/A coding_sequence_variant, missense_variant
rs143550925 uncertain-significance, Hepatic lipase deficiency 58,538,450(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for LIPC Gene

Variant ID Type Subtype PubMed ID
dgv2608n100 CNV gain 25217958
esv1002236 CNV gain 20482838
esv25142 CNV gain 19812545
esv2760372 CNV loss 21179565
esv2761874 CNV loss 21179565
esv3302978 CNV tandem duplication 20981092
esv3410982 CNV insertion 20981092
esv3581728 CNV loss 25503493
esv3581729 CNV loss 25503493
esv3581730 CNV loss 25503493
esv3636629 CNV loss 21293372
nsv1043362 CNV loss 25217958
nsv1047048 CNV loss 25217958
nsv1122971 CNV deletion 24896259
nsv1133218 CNV tandem duplication 24896259
nsv474584 CNV novel sequence insertion 20440878
nsv522373 CNV loss 19592680
nsv524065 CNV loss 19592680
nsv524098 CNV loss 19592680
nsv569598 CNV loss 21841781
nsv569600 CNV loss 21841781
nsv569601 CNV loss 21841781
nsv7266 OTHER inversion 18451855
nsv827345 CNV gain 20364138
nsv94680 CNV deletion 16902084

Variation tolerance for LIPC Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIPC Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for LIPC Gene

MalaCards: The human disease database

(22) MalaCards diseases for LIPC Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search LIPC in MalaCards View complete list of genes associated with diseases


  • Hepatic lipase deficiency (HL deficiency) [MIM:614025]: A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. {ECO:0000269 PubMed:10660332, ECO:0000269 PubMed:1301939}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for LIPC Gene

coronary atherosclerosis,premature,dyslipidemia

Additional Disease Information for LIPC

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LIPC: view

Publications for LIPC Gene

  1. The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects. (PMID: 18364377) Grarup N … Pedersen O (The Journal of clinical endocrinology and metabolism 2008) 3 4 22 44 58
  2. The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study. (PMID: 15126514) Todorova B … Finnish Diabetes Prevention Study (The Journal of clinical endocrinology and metabolism 2004) 3 4 22 44 58
  3. Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women. (PMID: 19489872) Lamon-Fava S … Herrington DM (Clinical endocrinology 2010) 3 22 44 58
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 22 44 58
  5. Combined hepatic lipase -514C/T and cholesteryl ester transfer protein I405V polymorphisms are associated with the risk of coronary artery disease. (PMID: 19810818) Ghatrehsamani K … Noori M (Genetic testing and molecular biomarkers 2009) 3 22 44 58

Products for LIPC Gene

Sources for LIPC Gene

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