This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. [provided by RefSeq, Dec 2016] See more...

Aliases for LINC02210-CRHR1 Gene

Aliases for LINC02210-CRHR1 Gene

  • LINC02210-CRHR1 Readthrough 2 3 5
  • Corticotropin Releasing Hormone Receptor 1, Isoform CRA_b 13
  • CRHR1-IT1-CRHR1 Readthrough 3
  • CRHR1-IT1-CRHR1 Protein 3
  • CRHR1-IT1-CRHR1 3
  • LINC02210-CRHR1 5
  • MGC57346-CRHR1 3

External Ids for LINC02210-CRHR1 Gene

Previous GeneCards Identifiers for LINC02210-CRHR1 Gene

  • GC17P045672
  • GC17P045677
  • GC17P045682
  • GC17P045757
  • GC17P045627
  • GC17P045631
  • GC17P045645
  • GC17P045658

Summaries for LINC02210-CRHR1 Gene

Entrez Gene Summary for LINC02210-CRHR1 Gene

  • This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. [provided by RefSeq, Dec 2016]

GeneCards Summary for LINC02210-CRHR1 Gene

LINC02210-CRHR1 (LINC02210-CRHR1 Readthrough) is a Protein Coding gene. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Corticotropin-releasing hormone signaling pathway. An important paralog of this gene is CRHR1.

Additional gene information for LINC02210-CRHR1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LINC02210-CRHR1 Gene

Genomics for LINC02210-CRHR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LINC02210-CRHR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LINC02210-CRHR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LINC02210-CRHR1

Genomic Locations for LINC02210-CRHR1 Gene

Genomic Locations for LINC02210-CRHR1 Gene
chr17:45,620,344-45,835,828
(GRCh38/hg38)
Size:
215,485 bases
Orientation:
Plus strand
chr17:43,699,274-43,893,909
(GRCh37/hg19)
Size:
194,636 bases
Orientation:
Plus strand

Genomic View for LINC02210-CRHR1 Gene

Genes around LINC02210-CRHR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LINC02210-CRHR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LINC02210-CRHR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LINC02210-CRHR1 Gene

Proteins for LINC02210-CRHR1 Gene

  • Protein details for LINC02210-CRHR1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R9X9-A0A024R9X9_HUMAN
    Recommended name:
    Corticotropin releasing hormone receptor 1, isoform CRA_b
    Protein Accession:
    A0A024R9X9

    Protein attributes for LINC02210-CRHR1 Gene

    Size:
    240 amino acids
    Molecular mass:
    28122 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LINC02210-CRHR1 Gene

Post-translational modifications for LINC02210-CRHR1 Gene

No Post-translational modifications

Other Protein References for LINC02210-CRHR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LINC02210-CRHR1 Gene

Domains & Families for LINC02210-CRHR1 Gene

Gene Families for LINC02210-CRHR1 Gene

Unknown:
  • Belongs to the G-protein coupled receptor 2 family.
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for LINC02210-CRHR1 Gene

genes like me logo Genes that share domains with LINC02210-CRHR1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LINC02210-CRHR1 Gene

Function for LINC02210-CRHR1 Gene

Phenotypes From GWAS Catalog for LINC02210-CRHR1 Gene

Gene Ontology (GO) - Molecular Function for LINC02210-CRHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity IEA --
genes like me logo Genes that share ontologies with LINC02210-CRHR1: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LINC02210-CRHR1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LINC02210-CRHR1 Gene

Localization for LINC02210-CRHR1 Gene

Gene Ontology (GO) - Cellular Components for LINC02210-CRHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LINC02210-CRHR1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for LINC02210-CRHR1 Gene

Pathways & Interactions for LINC02210-CRHR1 Gene

genes like me logo Genes that share pathways with LINC02210-CRHR1: view

Pathways by source for LINC02210-CRHR1 Gene

Interacting Proteins for LINC02210-CRHR1 Gene

Gene Ontology (GO) - Biological Process for LINC02210-CRHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with LINC02210-CRHR1: view

No data available for SIGNOR curated interactions for LINC02210-CRHR1 Gene

Drugs & Compounds for LINC02210-CRHR1 Gene

No Compound Related Data Available

Transcripts for LINC02210-CRHR1 Gene

mRNA/cDNA for LINC02210-CRHR1 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LINC02210-CRHR1

Alternative Splicing Database (ASD) splice patterns (SP) for LINC02210-CRHR1 Gene

No ASD Table

Relevant External Links for LINC02210-CRHR1 Gene

GeneLoc Exon Structure for
LINC02210-CRHR1

Expression for LINC02210-CRHR1 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LINC02210-CRHR1 Gene

Orthologs for LINC02210-CRHR1 Gene

Evolution for LINC02210-CRHR1 Gene

ENSEMBL:
Gene Tree for LINC02210-CRHR1 (if available)
TreeFam:
Gene Tree for LINC02210-CRHR1 (if available)

No data available for Orthologs for LINC02210-CRHR1 Gene

Paralogs for LINC02210-CRHR1 Gene

Variants for LINC02210-CRHR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LINC02210-CRHR1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
708229 Benign: not provided 45,830,440(+) C/T SYNONYMOUS_VARIANT
749169 Likely Benign: not provided 45,821,425(+) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
768893 Benign: not provided 45,816,518(+) T/C SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
771768 Benign: not provided 45,816,520(+) C/T MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
780430 Benign: not provided 45,830,084(+) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for LINC02210-CRHR1 Gene

Additional Variant Information for LINC02210-CRHR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LINC02210-CRHR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for LINC02210-CRHR1 Gene

Disorders for LINC02210-CRHR1 Gene

No disorders were found for LINC02210-CRHR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LINC02210-CRHR1 Gene

Publications for LINC02210-CRHR1 Gene

  1. Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling. (PMID: 23576434) Dunn HA … Ferguson SS (The Journal of biological chemistry 2013) 3
  2. Structure of class B GPCR corticotropin-releasing factor receptor 1. (PMID: 23863939) Hollenstein K … Marshall FH (Nature 2013) 3
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
  4. Human protein factory for converting the transcriptome into an in vitro-expressed proteome,. (PMID: 19054851) Goshima N … Nomura N (Nature methods 2008) 3
  5. Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels. (PMID: 18292205) Tao J … Soong TW (Molecular pharmacology 2008) 3

Products for LINC02210-CRHR1 Gene

Sources for LINC02210-CRHR1 Gene