Aliases for LINC01139 Gene

Subcategory (RNA class) for LINC01139 Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for LINC01139 Gene

  • Long Intergenic Non-Protein Coding RNA 1139 2 3 5
  • Long Intergenic Non-Coding RNA For Kinase Activation 2 3
  • LINC01139 2 168
  • TCONS_00000027 3
  • HSALNG0011845 167
  • NONHSAG004770 92
  • LINK-A 3
  • LINKA 3

External Ids for LINC01139 Gene

Previous GeneCards Identifiers for LINC01139 Gene

  • GC01M238645

Summaries for LINC01139 Gene

GeneCards Summary for LINC01139 Gene

LINC01139 (Long Intergenic Non-Protein Coding RNA 1139) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with LINC01139 include Hereditary Hemorrhagic Telangiectasia and Glioma.

Additional gene information for LINC01139 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LINC01139 Gene

Genomics for LINC01139 Gene

GeneHancer (GH) Regulatory Elements for LINC01139 Gene

Promoters and enhancers for LINC01139 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J238484 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 534.9 +1.0 952 3 REST POLR2A FOS CEBPB MAFK TAF1 YY1 CEBPA LINC01139 ENSG00000231877 lnc-RYR2-2
GH01J238408 Enhancer 0.7 Ensembl ENCODE 5.5 +76.4 76408 2.1 JUND FOS REST EZH2 POLR2A TAF1 ATF2 ZBTB21 CEBPB LINC01139 piR-35031-004 lnc-RYR2-2 LOC105373220
GH01J237833 Enhancer 0.2 Ensembl 5.1 +652.5 652459 0.4 LINC01139 LOC100130331 HSALNG0011812 RYR2
GH01J238440 Enhancer 0.2 Ensembl 4.7 +47.6 47559 0.2 LINC01139 lnc-RYR2-2 ENSG00000231877 LOC105373220
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LINC01139 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LINC01139 Gene

Genomic Locations for LINC01139 Gene
chr1:238,476,542-238,486,060
(GRCh38/hg38)
Size:
9,519 bases
Orientation:
Minus strand
chr1:238,643,684-238,649,323
(GRCh37/hg19)
Size:
5,640 bases
Orientation:
Minus strand

Genomic View for LINC01139 Gene

Genes around LINC01139 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LINC01139 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LINC01139 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LINC01139 Gene

Proteins for LINC01139 Gene

Post-translational modifications for LINC01139 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LINC01139 Gene

Domains & Families for LINC01139 Gene

Gene Families for LINC01139 Gene

genes like me logo Genes that share domains with LINC01139: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LINC01139 Gene

Function for LINC01139 Gene

Phenotypes for LINC01139 Gene

genes like me logo Genes that share phenotypes with LINC01139: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LINC01139 Gene

Localization for LINC01139 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LINC01139 Gene

Pathways & Interactions for LINC01139 Gene

PathCards logo

SuperPathways for LINC01139 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for LINC01139 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for LINC01139 Gene

Drugs & Compounds for LINC01139 Gene

No Compound Related Data Available

Transcripts for LINC01139 Gene

mRNA/cDNA for LINC01139 Gene

19 RNACentral transcripts :
1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 NONCODE transcripts :
8 LncBook transcripts :
9 LNCipedia transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for LINC01139 Gene

No ASD Table

Relevant External Links for LINC01139 Gene

GeneLoc Exon Structure for
LINC01139

Expression for LINC01139 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LINC01139 Gene

mRNA differential expression in normal tissues according to GTEx for LINC01139 Gene

This gene is overexpressed in Artery - Tibial (x8.8), Uterus (x7.4), Kidney - Cortex (x7.1), and Cervix - Endocervix (x5.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LINC01139

genes like me logo Genes that share expression patterns with LINC01139: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LINC01139 Gene

Orthologs for LINC01139 Gene

Evolution for LINC01139 Gene

ENSEMBL:
Gene Tree for LINC01139 (if available)
TreeFam:
Gene Tree for LINC01139 (if available)

No data available for Orthologs for LINC01139 Gene

Paralogs for LINC01139 Gene

No data available for Paralogs for LINC01139 Gene

Variants for LINC01139 Gene

Additional dbSNP identifiers (rs#s) for LINC01139 Gene

Structural Variations from Database of Genomic Variants (DGV) for LINC01139 Gene

Variant ID Type Subtype PubMed ID
esv2422256 CNV duplication 17116639
esv2759008 CNV gain 17122850
esv34468 CNV gain 17911159
nsv1000950 CNV gain 25217958
nsv468528 CNV loss 19166990
nsv521612 CNV loss 19592680
nsv549418 CNV loss 21841781
nsv549419 CNV loss 21841781
nsv833004 CNV loss 17160897
nsv833015 CNV loss 17160897

Additional Variant Information for LINC01139 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LINC01139

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for LINC01139 Gene

Disorders for LINC01139 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LINC01139 Gene - From: LncRNADisease

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LINC01139

genes like me logo Genes that share disorders with LINC01139: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LINC01139 Gene

Publications for LINC01139 Gene

  1. The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors. (PMID: 28218907) Lin A … Yang L (Nature cell biology 2017) 2 3 54
  2. Comprehensive transcriptome analysis identifies novel molecular subtypes and subtype-specific RNAs of triple-negative breast cancer. (PMID: 26975198) Liu YR … Shao ZM (Breast cancer research : BCR 2016) 2 3 54
  3. LINK-A lncRNA promotes migration and invasion of ovarian carcinoma cells by activating TGF-β pathway. (PMID: 30061183) Ma J … Xue M (Bioscience reports 2018) 3 54
  4. Long non-coding RNA LINK-A promotes glioma cell growth and invasion via lactate dehydrogenase A. (PMID: 28714007) Wu D … Wan J (Oncology reports 2017) 3 54
  5. The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. (PMID: 26751287) Lin A … Yang L (Nature cell biology 2016) 3 54

Products for LINC01139 Gene

Sources for LINC01139 Gene