Aliases for LINC00974 Gene

Subcategory (RNA class) for LINC00974 Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for LINC00974 Gene

  • Long Intergenic Non-Protein Coding RNA 974 2 3 5
  • LINC00974 2 168
  • NONHSAG021780 92
  • HSALNG0141637 167

External Ids for LINC00974 Gene

Previous GeneCards Identifiers for LINC00974 Gene

  • GC17M039708

Summaries for LINC00974 Gene

GeneCards Summary for LINC00974 Gene

LINC00974 (Long Intergenic Non-Protein Coding RNA 974) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with LINC00974 include Hepatocellular Carcinoma and Oral Submucous Fibrosis.

Additional gene information for LINC00974 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LINC00974 Gene

Genomics for LINC00974 Gene

GeneHancer (GH) Regulatory Elements for LINC00974 Gene

Promoters and enhancers for LINC00974 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J041566 Enhancer 0.6 Ensembl 500.7 -0.1 -137 1 ZNF148 SPI1 ZFHX2 EHMT2 ZBTB5 ZNF521 ZBTB40 GABPB1 EGR2 ETV6 LINC00974 KRT16 KRT19 KRT9
GH17J041546 Enhancer 1.4 ENCODE CraniofacialAtlas dbSUPER 5.7 +18.7 18689 3.9 ZNF217 CTCF NRF1 TCF12 JUND FOS ZFX ZIC2 ZBTB10 CLOCK SMARCE1 KLHL10 ENSG00000267758 KRT14 STAT5A ACLY NAGLU KRT15 LINC00974 piR-48749-013
GH17J041662 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.7 -96.1 -96137 2.2 RXRA ZNF217 CTCF ZNF639 ZIC2 ZBTB10 ZBTB26 REST KLF7 ZBTB25 LINC00974 ENSG00000278954 lnc-EIF1-3 KRT42P
GH17J041554 Enhancer 0.7 Ensembl ENCODE 5.7 +12.1 12064 2.2 ZKSCAN8 GATA3 ZFP91 CEBPG ATF4 GATA2 ZNF24 TRIM28 ESRRA ATF3 LINC00974 piR-48749-013
GH17J041551 Enhancer 0.3 Ensembl dbSUPER 4.6 +15.8 15763 1.2 KRT19 KRT15 LINC00974 KRT16 piR-48749-013
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LINC00974 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LINC00974 Gene

Genomic Locations for LINC00974 Gene
chr17:41,549,605-41,567,364
(GRCh38/hg38)
Size:
17,760 bases
Orientation:
Minus strand
chr17:39,705,858-39,710,747
(GRCh37/hg19)
Size:
4,890 bases
Orientation:
Minus strand

Genomic View for LINC00974 Gene

Genes around LINC00974 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LINC00974 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LINC00974 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LINC00974 Gene

Proteins for LINC00974 Gene

Post-translational modifications for LINC00974 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LINC00974 Gene

Domains & Families for LINC00974 Gene

Gene Families for LINC00974 Gene

genes like me logo Genes that share domains with LINC00974: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LINC00974 Gene

Function for LINC00974 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LINC00974 Gene

Localization for LINC00974 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LINC00974 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LINC00974 Gene

Pathways & Interactions for LINC00974 Gene

PathCards logo

SuperPathways for LINC00974 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for LINC00974 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for LINC00974 Gene

Drugs & Compounds for LINC00974 Gene

No Compound Related Data Available

Transcripts for LINC00974 Gene

mRNA/cDNA for LINC00974 Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 NONCODE transcripts :
1 LncBook transcripts :
1 LNCipedia transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for LINC00974 Gene

No ASD Table

Relevant External Links for LINC00974 Gene

GeneLoc Exon Structure for
LINC00974

Expression for LINC00974 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LINC00974 Gene

mRNA differential expression in normal tissues according to GTEx for LINC00974 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x22.4) and Colon - Transverse (x15.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LINC00974

genes like me logo Genes that share expression patterns with LINC00974: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LINC00974 Gene

Orthologs for LINC00974 Gene

Evolution for LINC00974 Gene

ENSEMBL:
Gene Tree for LINC00974 (if available)
TreeFam:
Gene Tree for LINC00974 (if available)

No data available for Orthologs for LINC00974 Gene

Paralogs for LINC00974 Gene

No data available for Paralogs for LINC00974 Gene

Variants for LINC00974 Gene

Additional dbSNP identifiers (rs#s) for LINC00974 Gene

Structural Variations from Database of Genomic Variants (DGV) for LINC00974 Gene

Variant ID Type Subtype PubMed ID
esv2758690 CNV gain+loss 17122850
esv34903 CNV gain 17911159
esv3640588 CNV gain 21293372
esv3640590 CNV gain 21293372
nsv1063389 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv510711 CNV deletion 20534489
nsv827992 CNV gain 20364138
nsv9555 CNV gain 18304495

Additional Variant Information for LINC00974 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LINC00974

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for LINC00974 Gene

Disorders for LINC00974 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LINC00974 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
oral submucous fibrosis
  • oral cavity submucous fibrosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LINC00974

genes like me logo Genes that share disorders with LINC00974: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LINC00974 Gene

Publications for LINC00974 Gene

  1. A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma. (PMID: 25476897) Tang J … Sun B (Cell death & disease 2014) 2 3 54
  2. Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition. (PMID: 30884781) Lin CY … Lu MY (International journal of molecular sciences 2019) 3 54
  3. LncRNA LINC00974 activates TGF-β/Smad signaling to promote oral fibrogenesis. (PMID: 30447113) Fang CY … Tsai LL (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2019) 3 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 54

Products for LINC00974 Gene

Sources for LINC00974 Gene