Subcategory (RNA class) for LINC00673 Gene
Number of RNA Genes sources:
Aliases for LINC00673 Gene
External Ids for LINC00673 Gene
Previous GeneCards Identifiers for LINC00673 Gene
This gene produces a long non-protein coding RNA that is involved in the regulation of gene expression during tumor progression. This transcript can promote cell proliferation in gastric cancer through interaction with enhancer of zeste 2 and other epigenetic suppressors of gene expression, thereby downregulating target genes including Kruppel like factors 2 and 4. This transcript may also act as a tumor suppressor by promoting interaction between protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) and ubiquitin ligase, resulting in degradation of Ptpn11 and lowered oncogenic signalling. Naturally-occurring variation at this locus results in the formation of a binding site for miR-1231, which negatively regulates activity of this transcript. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2017]
GeneCards Summary for LINC00673 Gene
LINC00673 (Long Intergenic Non-Protein Coding RNA 673) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with LINC00673 include Tongue Squamous Cell Carcinoma and Pancreatic Ductal Adenocarcinoma.