Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LINC00312 Gene

Subcategory (RNA class) for LINC00312 Gene

lncRNA

Quality Score for this RNA gene is

13

Aliases for LINC00312 Gene

  • Long Intergenic Non-Protein Coding RNA 312 2 3
  • Loss Of Heterozygosity, 3, Chromosomal Region 2, Gene A 2 3
  • Nasopharyngeal Carcinoma Candidate 7 2 3
  • Estrogen Receptor Repressor 10 2 3
  • LMCD1 Downstream Neighbor 2 3
  • NCRNA00312 3 4
  • LOH3CR2A 3 4
  • Loss Of Heterozygosity 3 Chromosomal Region 2 Gene A Protein 4
  • Non-Protein Coding RNA 312 2
  • LMCD1DN 3
  • ERR-10 3
  • ERR10 3
  • NAG-7 3
  • NAG7 3

External Ids for LINC00312 Gene

ORGUL Members for LINC00312 Gene

Previous HGNC Symbols for LINC00312 Gene

  • LOH3CR2A
  • NCRNA00312

Summaries for LINC00312 Gene

Entrez Gene Summary for LINC00312 Gene

  • This gene produces an intronless transcript that is thought to function as a tumor suppressor. This transcript is downregulated in nasopharyngeal carcinoma and is a negative regulator of estrogen receptor signaling. A common polymorphism in this transcript allows the production of a 94 aa open reading frame in some individuals, which may interact directly with estrogen receptor 1 (PMID:15474036). This open reading frame does not exist on the reference genome haplotype, which is hypothesized to function through a non-coding RNA product. [provided by RefSeq, Mar 2017]

GeneCards Summary for LINC00312 Gene

LINC00312 (Long Intergenic Non-Protein Coding RNA 312) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with LINC00312 include Nasopharyngeal Carcinoma and Thyroid Cancer.

Additional gene information for LINC00312 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LINC00312 Gene

Genomics for LINC00312 Gene

GeneHancer (GH) Regulatory Elements for LINC00312 Gene

Promoters and enhancers for LINC00312 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J008571 Enhancer 0.4 Ensembl dbSUPER 658.1 -0.3 -281 0.2 LINC00312 LMCD1-AS1 LMCD1 CAV3 PIR52959
GH03J008558 Enhancer 1.1 Ensembl ENCODE dbSUPER 6.6 -11.2 -11158 4.1 HDAC1 ATF1 ARNT TEAD4 TAL1 FOSL1 TCF12 NCOR1 VEZF1 SCRT2 LMCD1-AS1 LMCD1 LINC00312 PIR52959
GH03J008573 Enhancer 0.8 ENCODE dbSUPER 8.5 +4.0 3978 5 MAFG ZBTB40 NR2F2 FOSL1 ZNF316 GATA3 SCRT2 FOS PRDM1 MAFK GC03M008577 LINC00312 ENSG00000224884 LMCD1-AS1 LMCD1
GH03J008538 Enhancer 0.7 ENCODE dbSUPER 5.7 -32.7 -32677 1.2 ZNF316 MAFG FOS EMSY MAFK LINC00312 PIR52959 LMCD1 LMCD1-AS1
GH03J008581 Enhancer 0.4 dbSUPER 7.7 +10.2 10188 1.9 ZNF316 MAFK LINC00312 GC03M008577 ENSG00000224884 LMCD1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LINC00312 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LINC00312 Gene

Genomic Locations for LINC00312 Gene
chr3:8,571,782-8,574,668
(GRCh38/hg38)
Size:
2,887 bases
Orientation:
Plus strand
chr3:8,613,468-8,615,580
(GRCh37/hg19)
Size:
2,113 bases
Orientation:
Plus strand

Genomic View for LINC00312 Gene

Genes around LINC00312 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LINC00312 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LINC00312 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LINC00312 Gene

Proteins for LINC00312 Gene

  • Protein details for LINC00312 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6C7-L3R2A_HUMAN
    Recommended name:
    Putative uncharacterized protein encoded by LINC00312
    Protein Accession:
    Q9Y6C7

    Protein attributes for LINC00312 Gene

    Size:
    94 amino acids
    Molecular mass:
    11024 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LINC00312 Gene

Post-translational modifications for LINC00312 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LINC00312 Gene

Domains & Families for LINC00312 Gene

Gene Families for LINC00312 Gene

Protein Domains for LINC00312 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for LINC00312 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LINC00312: view

No data available for UniProtKB/Swiss-Prot for LINC00312 Gene

Function for LINC00312 Gene

Phenotypes for LINC00312 Gene

genes like me logo Genes that share phenotypes with LINC00312: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LINC00312

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LINC00312 Gene

Localization for LINC00312 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LINC00312 Gene

Pathways & Interactions for LINC00312 Gene

SuperPathways for LINC00312 Gene

No Data Available

Interacting Proteins for LINC00312 Gene

Gene Ontology (GO) - Biological Process for LINC00312 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LINC00312 Gene

Drugs & Compounds for LINC00312 Gene

No Compound Related Data Available

Transcripts for LINC00312 Gene

Unigene Clusters for LINC00312 Gene

Long intergenic non-protein coding RNA 312:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LINC00312

Alternative Splicing Database (ASD) splice patterns (SP) for LINC00312 Gene

No ASD Table

Relevant External Links for LINC00312 Gene

GeneLoc Exon Structure for
LINC00312
ECgene alternative splicing isoforms for
LINC00312

Expression for LINC00312 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LINC00312 Gene

NURSA nuclear receptor signaling pathways regulating expression of LINC00312 Gene:

LINC00312

SOURCE GeneReport for Unigene cluster for LINC00312 Gene:

Hs.433151
genes like me logo Genes that share expression patterns with LINC00312: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LINC00312 Gene

Orthologs for LINC00312 Gene

No data available for Orthologs and Evolution for LINC00312 Gene

Paralogs for LINC00312 Gene

No data available for Paralogs for LINC00312 Gene

Variants for LINC00312 Gene

Sequence variations from dbSNP and Humsavar for LINC00312 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1001666445 -- 8,572,379(+) G/A non_coding_transcript_variant
rs1001995561 -- 8,571,990(+) G/A non_coding_transcript_variant
rs1003403018 -- 8,573,680(+) C/T non_coding_transcript_variant
rs1004126775 -- 8,572,114(+) T/C non_coding_transcript_variant
rs1004193132 -- 8,570,667(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LINC00312 Gene

Variant ID Type Subtype PubMed ID
esv3595218 CNV loss 21293372
nsv1011096 CNV loss 25217958

Additional Variant Information for LINC00312 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LINC00312

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for LINC00312 Gene

Disorders for LINC00312 Gene

MalaCards: The human disease database

(5) MalaCards diseases for LINC00312 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nasopharyngeal carcinoma
  • npca
thyroid cancer
  • malignant neoplasm of thyroid gland
bladder cancer
  • bladder cancer, somatic
lung cancer
  • lung cancer, susceptibility to
pharynx cancer
  • pharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LINC00312

genes like me logo Genes that share disorders with LINC00312: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LINC00312 Gene

Publications for LINC00312 Gene

  1. Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer. (PMID: 12918109) Zhang XM … Li J (World journal of gastroenterology 2003) 2 3 22 58
  2. Effects of NPC-associated gene NAG7 on cell cycle and apoptosis in nasopharyngeal carcinoma cells. (PMID: 12452030) Tan C … Li GY (Ai zheng = Aizheng = Chinese journal of cancer 2002) 2 3 22 58
  3. Transcriptome interrogation of human myometrium identifies differentially expressed sense-antisense pairs of protein-coding and long non-coding RNA genes in spontaneous labor at term. (PMID: 24168098) Romero R … Lipovich L (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2014) 2 3 58
  4. Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma. (PMID: 23529758) Zhang W … Li G (Journal of molecular histology 2013) 2 3 58
  5. ERR-10: a new repressor in transcriptional signaling activation of estrogen receptor-alpha. (PMID: 15474036) Meng Q … Fan S (FEBS letters 2004) 3 22 58

Products for LINC00312 Gene

Sources for LINC00312 Gene

Content
Loading form....