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This gene produces a long non-coding RNA that regulates the reprogramming of pluripotent stem cells. This RNA suppresses induction of tumor protein p53 after DNA damage. It is thought to act as a sponge for microRNAs that regulate stem cell factors POU class 5 homeobox 1, Nanog, and SRY-box 2. This RNA may also have a extracellular role in modulating response to hypoxia in hepa... See more...
Aliases for LINC-ROR Gene
Subcategory (RNA class) for LINC-ROR Gene
lncRNA
Number of RNA Genes sources:
4 / 17
Aliases for LINC-ROR Gene
External Ids for LINC-ROR Gene
- HGNC: 43773
- Entrez Gene: 100885779
- Ensembl: ENSG00000258609
- OMIM: 615173
Previous GeneCards Identifiers for LINC-ROR Gene
- GC18M054722
Summaries for LINC-ROR Gene
-
This gene produces a long non-coding RNA that regulates the reprogramming of pluripotent stem cells. This RNA suppresses induction of tumor protein p53 after DNA damage. It is thought to act as a sponge for microRNAs that regulate stem cell factors POU class 5 homeobox 1, Nanog, and SRY-box 2. This RNA may also have a extracellular role in modulating response to hypoxia in hepatocellular cancer cells. Expression of this transcript is associated with tumor progression and epithelial to mesenchymal transition and metastasis. [provided by RefSeq, Dec 2017]
GeneCards Summary for LINC-ROR Gene
LINC-ROR (Long Intergenic Non-Protein Coding RNA, Regulator Of Reprogramming) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with LINC-ROR include Triple-Receptor Negative Breast Cancer and Gallbladder Cancer. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.
Additional gene information for LINC-ROR Gene
- HGNC(43773)
- Entrez Gene(100885779)
- Ensembl(ENSG00000258609)
- OMIM(615173)
- Open Targets Platform(ENSG00000258609)
- Search for LINC-ROR at DataMed
- Search for LINC-ROR at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LINC-ROR Gene
Genomics for LINC-ROR Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LINC-ROR Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH18J057069 | Promoter | 0.8 | EPDnew Ensembl | 600.7 | +1.4 | 1418 | 3.4 | ZBTB10 | LINC-ROR piR-32559-195 piR-37656-105 LC027889 BOD1L2 TXNL1 | |
| GH18J057062 | Enhancer | 0.5 | Ensembl | 0.4 | +7.9 | 7918 | 2.8 | ESR1 POLR2A PRDM4 SMARCA4 NR3C1 | piR-32559-194 LC027889 LINC-ROR BOD1L2 TXNL1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LINC-ROR on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for LINC-ROR Gene
Genomic Locations for LINC-ROR Gene
- chr18:57,054,558-57,072,119
- (GRCh38/hg38)
- Size:
- 17,562 bases
- Orientation:
- Minus strand
- chr18:54,721,813-54,739,350
- (GRCh37/hg19)
- Size:
- 17,538 bases
- Orientation:
- Minus strand
Genomic View for LINC-ROR Gene
Genes around LINC-ROR on UCSC Golden Path with GeneCards custom track
LINC-ROR in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 18q21.31 by HGNC
- 18q21.31 by Entrez Gene
- 18q21.31 by Ensembl
LINC-ROR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LINC-ROR Gene
Proteins for LINC-ROR Gene
Post-translational modifications for LINC-ROR Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for LINC-ROR
- Origene Custom Protein Services for LINC-ROR
No data available for DME Specific Peptides for LINC-ROR Gene
Domains & Families for LINC-ROR Gene
No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LINC-ROR Gene
Function for LINC-ROR Gene
Phenotypes From GWAS Catalog for LINC-ROR Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Browse CRISPR knockouts for LINC-ROR
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LINC-ROR Gene
Localization for LINC-ROR Gene
| Compartment | Confidence |
|---|---|
| extracellular | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LINC-ROR Gene
Pathways & Interactions for LINC-ROR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | LncRNA-mediated mechanisms of therapeutic resistance | ||
Pathways by source for LINC-ROR Gene
1 BioSystems pathway for LINC-ROR Gene
No data available for Interacting Proteins and SIGNOR curated interactions for LINC-ROR Gene
Transcripts for LINC-ROR Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for LINC-ROR Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00007681C7_9606 | lncRNA | 2603 | 3 |
HGNC: 43773, RefSeq: NR_048536, LNCipedia: LINC-ROR:4, |
| URS000083C204_9606 | lncRNA | 2186 | 3 |
Ensembl: ENST00000645956 (view in UCSC) , LNCipedia: LINC-ROR:9, ENA: LC027886.1:1..2186:ncRNA, |
| URS00008145B3_9606 | lncRNA | 766 | 3 |
Ensembl: ENST00000643706 (view in UCSC) , LNCipedia: LINC-ROR:7, ENA: AB908956.1:1..766:ncRNA, |
| URS000081DD87_9606 | lncRNA | 568 | 3 |
Ensembl: ENST00000644575 (view in UCSC) , LNCipedia: LINC-ROR:10, ENA: AB932951.1:1..568:ncRNA, |
| URS0000D62423_9606 | lncRNA | 2604 | 2 |
Ensembl: ENST00000553704 (view in UCSC) , LNCipedia: LINC-ROR:6, |
LINC-ROR in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for LINC-ROR Gene
- 8 NCBI additional mRNA sequence :
CRISPR Products
- Browse CRISPR knockouts for LINC-ROR
miRNA Products
Inhibitory RNA Products
Relevant External Links for LINC-ROR Gene
- GeneLoc Exon Structure for
- LINC-ROR
Expression for LINC-ROR Gene
mRNA differential expression in normal tissues according to GTEx for LINC-ROR Gene
This gene is overexpressed in Testis (x10.5).
SOURCE GeneReport for Unigene cluster for LINC-ROR Gene:
Hs.742426Evidence on tissue expression from TISSUES for LINC-ROR Gene
- Blood(2.6)
- Nervous system(2.3)
- Liver(2.3)
- Lymph node(2.3)
- Spleen(2.2)
- Intestine(2.2)
- Skin(2.1)
- Muscle(2.1)
- Heart(2)
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LINC-ROR Gene
Orthologs for LINC-ROR Gene
No data available for Orthologs for LINC-ROR Gene
Paralogs for LINC-ROR Gene
No data available for Paralogs for LINC-ROR Gene
Variants for LINC-ROR Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5954n54 | CNV | loss | 21841781 |
| esv2437519 | CNV | insertion | 19546169 |
| esv3431467 | CNV | duplication | 20981092 |
| esv3448993 | CNV | duplication | 20981092 |
| nsv1056480 | CNV | gain | 25217958 |
| nsv458083 | CNV | loss | 19166990 |
Additional Variant Information for LINC-ROR Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LINC-ROR
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for LINC-ROR Gene
Disorders for LINC-ROR Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| triple-receptor negative breast cancer |
|
|
| gallbladder cancer |
|
|
| endometrial cancer |
|
|
| nasopharyngeal carcinoma |
|
|
| thyroid cancer, nonmedullary, 1 |
|
Search LINC-ROR in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LINC-ROR
No data available for UniProtKB/Swiss-Prot and Genatlas for LINC-ROR Gene
Publications for LINC-ROR Gene
- Modulation of hypoxia-signaling pathways by extracellular linc-RoR. (PMID: 24463816) Takahashi K … Patel T (Journal of cell science 2014) 2 3
- Repressing the repressor: a lincRNA as a MicroRNA sponge in embryonic stem cell self-renewal. (PMID: 23597480) Cheng EC … Lin H (Developmental cell 2013) 2 3
- Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal. (PMID: 23541921) Wang Y … Liu H (Developmental cell 2013) 2 3
- The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage. (PMID: 23208419) Zhang A … Mo YY (Cell research 2013) 2 3
- Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. (PMID: 21057500) Loewer S … Rinn JL (Nature genetics 2010) 2 3
ExternalLinks
Products for LINC-ROR Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for LINC-ROR
- Origene Custom Protein Services for LINC-ROR
- Browse OriGene Inhibitory RNA Products For LINC-ROR
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for LINC-ROR
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LINC-ROR
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Addgene plasmids for LINC-ROR
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for LINC-ROR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for LINC-ROR
- Search GeneCopoeia for miRNA 3'UTR Target clone products for LINC-ROR
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for LINC-ROR
Sources for LINC-ROR Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB