Subcategory (RNA class) for LINC-ROR Gene
Aliases for LINC-ROR Gene
External Ids for LINC-ROR Gene
Previous GeneCards Identifiers for LINC-ROR Gene
This gene produces a long non-coding RNA that regulates the reprogramming of pluripotent stem cells. This RNA suppresses induction of tumor protein p53 after DNA damage. It is thought to act as a sponge for microRNAs that regulate stem cell factors POU class 5 homeobox 1, Nanog, and SRY-box 2. This RNA may also have a extracellular role in modulating response to hypoxia in hepatocellular cancer cells. Expression of this transcript is associated with tumor progression and epithelial to mesenchymal transition and metastasis. [provided by RefSeq, Dec 2017]
GeneCards Summary for LINC-ROR Gene
LINC-ROR (Long Intergenic Non-Protein Coding RNA, Regulator Of Reprogramming) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with LINC-ROR include Triple-Receptor Negative Breast Cancer and Gallbladder Cancer. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.