Free for academic non-profit institutions. Other users need a Commercial license
This gene produces a long non-coding RNA that regulates the reprogramming of pluripotent stem cells. This RNA suppresses induction of tumor protein p53 after DNA damage. It is thought to act as a sponge for microRNAs that regulate stem cell factors POU class 5 homeobox 1, Nanog, and SRY-box 2. This RNA may also have a extracellular role in modulating response to hypoxia in hepatocellular cancer cells. Expression of this transcript is associated with tumor progression and epithelial to mesenchymal transition and metastasis. [provided by RefSeq, Dec 2017]
LINC-ROR (Long Intergenic Non-Protein Coding RNA, Regulator Of Reprogramming) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with LINC-ROR include Triple-Receptor Negative Breast Cancer and Endometrial Cancer. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH18J057069 | Promoter | 0.4 | Ensembl | 750.6 | +1.4 | 1418 | 3.4 | ZBTB10 | AB844430 LINC-ROR piR-37656-105 piR-32559-195 LC027889 | |
GH18J057062 | Enhancer | 0.3 | Ensembl | 0.4 | +7.9 | 7918 | 2.8 | POLR2A PRDM4 | piR-32559-194 AB844430 LC027889 LINC-ROR |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | LncRNA-mediated mechanisms of therapeutic resistance |
SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000033497 | -- | 57,065,711(-) | G/A/C | intron_variant | |
rs1000162953 | -- | 57,064,037(-) | C/G | intron_variant | |
rs1000228685 | -- | 57,070,781(-) | T/A/C | intron_variant | |
rs1000569538 | -- | 57,062,385(-) | C/T | intron_variant | |
rs1000632445 | -- | 57,068,087(-) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5954n54 | CNV | loss | 21841781 |
esv2437519 | CNV | insertion | 19546169 |
esv3431467 | CNV | duplication | 20981092 |
esv3448993 | CNV | duplication | 20981092 |
nsv1056480 | CNV | gain | 25217958 |
nsv458083 | CNV | loss | 19166990 |
Disorder | Aliases | PubMed IDs |
---|---|---|
triple-receptor negative breast cancer |
|
|
endometrial cancer |
|
|
gallbladder cancer |
|
|
nasopharyngeal carcinoma |
|
|
pancreatic cancer |
|