Aliases for LIN7B Gene
External Ids for LIN7B Gene
Previous GeneCards Identifiers for LIN7B Gene
GeneCards Summary for LIN7B Gene
LIN7B (Lin-7 Homolog B, Crumbs Cell Polarity Complex Component) is a Protein Coding gene. Diseases associated with LIN7B include Attention Deficit-Hyperactivity Disorder. Among its related pathways are Neurotransmitter Release Cycle and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and L27 domain binding. An important paralog of this gene is LIN7C.
UniProtKB/Swiss-Prot Summary for LIN7B Gene
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).