Aliases for LIN7A Gene
External Ids for LIN7A Gene
Previous GeneCards Identifiers for LIN7A Gene
The protein encoded by this gene is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain. [provided by RefSeq, May 2016]
GeneCards Summary for LIN7A Gene
LIN7A (Lin-7 Homolog A, Crumbs Cell Polarity Complex Component) is a Protein Coding gene. Diseases associated with LIN7A include Pulmonary Aspergilloma. Among its related pathways are Transmission across Chemical Synapses and Neurotransmitter Release Cycle. Gene Ontology (GO) annotations related to this gene include PDZ domain binding and L27 domain binding. An important paralog of this gene is LIN7C.
UniProtKB/Swiss-Prot Summary for LIN7A Gene
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.