Aliases for LIN54 Gene
External Ids for LIN54 Gene
Previous GeneCards Identifiers for LIN54 Gene
LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]
GeneCards Summary for LIN54 Gene
LIN54 (Lin-54 DREAM MuvB Core Complex Component) is a Protein Coding gene. Diseases associated with LIN54 include Spondyloarthropathy 1 and Anemia Of Prematurity. Among its related pathways are Cell cycle Cell cycle (generic schema) and Regulation of PLK1 Activity at G2/M Transition. An important paralog of this gene is TESMIN.
UniProtKB/Swiss-Prot Summary for LIN54 Gene
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17671431, PubMed:17531812). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17671431, PubMed:17531812). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258).