Aliases for LIN52 Gene

Aliases for LIN52 Gene

  • Lin-52 DREAM MuvB Core Complex Component 2 3 5
  • Protein Lin-52 Homolog 3 4
  • C14orf46 3 4
  • Chromosome 14 Open Reading Frame 46 2
  • Lin-52 Homolog (C. Elegans) 2
  • Lin-52 Homolog 3
  • C14_5549 3
  • LIN52 5

External Ids for LIN52 Gene

Previous HGNC Symbols for LIN52 Gene

  • C14orf46

Previous GeneCards Identifiers for LIN52 Gene

  • GC14P073622
  • GC14P074551
  • GC14P054718

Summaries for LIN52 Gene

GeneCards Summary for LIN52 Gene

LIN52 (Lin-52 DREAM MuvB Core Complex Component) is a Protein Coding gene. Among its related pathways are Cell cycle Cell cycle (generic schema) and Regulation of PLK1 Activity at G2/M Transition.

Additional gene information for LIN52 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LIN52 Gene

Genomics for LIN52 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LIN52 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LIN52 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LIN52

Top Transcription factor binding sites by QIAGEN in the LIN52 gene promoter:
  • AML1a
  • c-Myb
  • c-Rel
  • N-Myc
  • Pbx1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • Tal-1beta
  • Zic1

Genomic Locations for LIN52 Gene

Genomic Locations for LIN52 Gene
116,698 bases
Plus strand
116,438 bases
Plus strand

Genomic View for LIN52 Gene

Genes around LIN52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIN52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIN52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIN52 Gene

Proteins for LIN52 Gene

  • Protein details for LIN52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein lin-52 homolog
    Protein Accession:

    Protein attributes for LIN52 Gene

    116 amino acids
    Molecular mass:
    13001 Da
    Quaternary structure:
    • Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.

    Three dimensional structures from OCA and Proteopedia for LIN52 Gene

neXtProt entry for LIN52 Gene

Post-translational modifications for LIN52 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LIN52 Gene

Domains & Families for LIN52 Gene

Gene Families for LIN52 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LIN52 Gene


Suggested Antigen Peptide Sequences for LIN52 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ13917 fis, clone Y79AA1000355, highly similar to 12.5 kDa retinal tissue protein (B3KN83_HUMAN)
  • Protein lin-52 homolog (LIN52_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the lin-52 family.
  • Belongs to the lin-52 family.
genes like me logo Genes that share domains with LIN52: view

Function for LIN52 Gene

Phenotypes From GWAS Catalog for LIN52 Gene

genes like me logo Genes that share phenotypes with LIN52: view

Animal Model Products

CRISPR Products

miRNA for LIN52 Gene

miRTarBase miRNAs that target LIN52

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIN52

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LIN52 Gene

Localization for LIN52 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIN52 gene
Compartment Confidence
nucleus 4
cytoskeleton 1
cytosol 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LIN52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0070176 DRM complex IEA --
genes like me logo Genes that share ontologies with LIN52: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LIN52 Gene

Pathways & Interactions for LIN52 Gene

genes like me logo Genes that share pathways with LIN52: view

Pathways by source for LIN52 Gene

1 KEGG pathway for LIN52 Gene

Gene Ontology (GO) - Biological Process for LIN52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0051726 regulation of cell cycle TAS --
genes like me logo Genes that share ontologies with LIN52: view

No data available for SIGNOR curated interactions for LIN52 Gene

Drugs & Compounds for LIN52 Gene

No Compound Related Data Available

Transcripts for LIN52 Gene

mRNA/cDNA for LIN52 Gene

6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIN52

Alternative Splicing Database (ASD) splice patterns (SP) for LIN52 Gene

No ASD Table

Relevant External Links for LIN52 Gene

GeneLoc Exon Structure for

Expression for LIN52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIN52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LIN52 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LIN52 Gene

Protein tissue co-expression partners for LIN52 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LIN52

SOURCE GeneReport for Unigene cluster for LIN52 Gene:


Evidence on tissue expression from TISSUES for LIN52 Gene

  • Nervous system(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with LIN52: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIN52 Gene

Orthologs for LIN52 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIN52 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LIN52 30 31
  • 100 (n)
(Monodelphis domestica)
Mammalia LIN52 31
  • 97 (a)
(Bos Taurus)
Mammalia LIN52 30 31
  • 95.11 (n)
(Canis familiaris)
Mammalia LIN52 30 31
  • 94.54 (n)
(Rattus norvegicus)
Mammalia Lin52 30
  • 91.67 (n)
(Mus musculus)
Mammalia Lin52 30 17 31
  • 91.38 (n)
(Gallus gallus)
Aves LIN52 30 31
  • 78.57 (n)
(Anolis carolinensis)
Reptilia LIN52 31
  • 78 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lin52 30
  • 74.4 (n)
Str.15097 30
(Danio rerio)
Actinopterygii lin52 30 31
  • 75.89 (n)
Dr.16539 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10244 30
Fruit Fly
(Drosophila melanogaster)
Insecta lin-52 31
  • 24 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 66 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1939 30
Species where no ortholog for LIN52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LIN52 Gene

Gene Tree for LIN52 (if available)
Gene Tree for LIN52 (if available)
Evolutionary constrained regions (ECRs) for LIN52: view image

Paralogs for LIN52 Gene

(1) SIMAP similar genes for LIN52 Gene using alignment to 2 proteins:

  • G3V5T8_HUMAN
genes like me logo Genes that share paralogs with LIN52: view

No data available for Paralogs for LIN52 Gene

Variants for LIN52 Gene

Additional dbSNP identifiers (rs#s) for LIN52 Gene

Structural Variations from Database of Genomic Variants (DGV) for LIN52 Gene

Variant ID Type Subtype PubMed ID
dgv1937n100 CNV gain 25217958
dgv1939n100 CNV gain 25217958
dgv1940n100 CNV gain 25217958
esv1167280 CNV insertion 17803354
esv21637 CNV gain 19812545
esv22046 CNV loss 19812545
esv2614022 CNV deletion 19546169
esv2616082 CNV insertion 19546169
esv2748869 CNV deletion 23290073
esv2759997 CNV gain 17122850
esv2760331 CNV gain 21179565
esv3634934 CNV gain 21293372
esv3634935 CNV loss 21293372
nsv1108911 CNV deletion 24896259
nsv520879 CNV loss 19592680
nsv9154 CNV gain 18304495

Variation tolerance for LIN52 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIN52 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LIN52 Gene

Disorders for LIN52 Gene

Additional Disease Information for LIN52

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for LIN52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIN52 Gene

Publications for LIN52 Gene

  1. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. (PMID: 21498570) Litovchick L … DeCaprio JA (Genes & development 2011) 2 3
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Web-based, participant-driven studies yield novel genetic associations for common traits. (PMID: 20585627) Eriksson N … Mountain J (PLoS genetics 2010) 3 41
  4. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. (PMID: 17671431) Schmit F … Gaubatz S (Cell cycle (Georgetown, Tex.) 2007) 3 4
  5. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PMID: 17531812) Litovchick L … DeCaprio JA (Molecular cell 2007) 3 4

Products for LIN52 Gene

Sources for LIN52 Gene