This gene encodes a protein expressed in the eye. [provided by RefSeq, Jul 2008] See more...

Aliases for LIN37 Gene

Aliases for LIN37 Gene

  • Lin-37 DREAM MuvB Core Complex Component 2 3 5
  • Protein Lin-37 Homolog 3 4
  • Antolefinin 3 4
  • ZK418.4 2 3
  • F25965 2 3
  • Lin-37 2 3
  • Lin-37 Homolog (C. Elegans) 2
  • Lin-37 Homolog 3
  • Protein F25965 3
  • LIN37 5

External Ids for LIN37 Gene

Previous GeneCards Identifiers for LIN37 Gene

  • GC19P040944
  • GC19P040946
  • GC19P040949
  • GC19P040951
  • GC19P040953
  • GC19P040955
  • GC19P036239
  • GC19P032744
  • GC19P035803
  • GC19P035832
  • GC19P037029
  • GC19P037196
  • GC19P037294
  • GC19P037727
  • GC19P035989
  • GC19P036012
  • GC19P036175
  • GC19P036253
  • GC19P036419
  • GC19P036580
  • GC19P036747
  • GC19P036893

Summaries for LIN37 Gene

Entrez Gene Summary for LIN37 Gene

  • This gene encodes a protein expressed in the eye. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIN37 Gene

LIN37 (Lin-37 DREAM MuvB Core Complex Component) is a Protein Coding gene. Among its related pathways are Cell cycle Cell cycle (generic schema) and Regulation of PLK1 Activity at G2/M Transition.

Additional gene information for LIN37 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LIN37 Gene

Genomics for LIN37 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LIN37 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LIN37 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LIN37

Top Transcription factor binding sites by QIAGEN in the LIN37 gene promoter:
  • CREB
  • deltaCREB
  • NF-1
  • NF-1/L
  • p53
  • PPAR-gamma1
  • PPAR-gamma2
  • ZIC2

Genomic Locations for LIN37 Gene

Genomic Locations for LIN37 Gene
chr19:35,748,361-35,754,519
(GRCh38/hg38)
Size:
6,159 bases
Orientation:
Plus strand
chr19:36,239,262-36,245,420
(GRCh37/hg19)
Size:
6,159 bases
Orientation:
Plus strand

Genomic View for LIN37 Gene

Genes around LIN37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIN37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIN37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIN37 Gene

Proteins for LIN37 Gene

  • Protein details for LIN37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GY3-LIN37_HUMAN
    Recommended name:
    Protein lin-37 homolog
    Protein Accession:
    Q96GY3
    Secondary Accessions:
    • A8KAQ1
    • O14557
    • Q7Z2T9

    Protein attributes for LIN37 Gene

    Size:
    246 amino acids
    Molecular mass:
    28383 Da
    Quaternary structure:
    • Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.
    SequenceCaution:
    • Sequence=AAB81199.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for LIN37 Gene

Post-translational modifications for LIN37 Gene

  • Ubiquitination at Lys98
  • Modification sites at PhosphoSitePlus

Other Protein References for LIN37 Gene

No data available for DME Specific Peptides for LIN37 Gene

Domains & Families for LIN37 Gene

Gene Families for LIN37 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LIN37 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LIN37 Gene

GenScript: Design optimal peptide antigens:
  • Antolefinin (LIN37_HUMAN)
genes like me logo Genes that share domains with LIN37: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LIN37 Gene

Function for LIN37 Gene

Phenotypes From GWAS Catalog for LIN37 Gene

Gene Ontology (GO) - Molecular Function for LIN37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with LIN37: view
genes like me logo Genes that share phenotypes with LIN37: view

Animal Model Products

CRISPR Products

miRNA for LIN37 Gene

miRTarBase miRNAs that target LIN37

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIN37

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LIN37 Gene

Localization for LIN37 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIN37 gene
Compartment Confidence
nucleus 4
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LIN37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0017053 transcriptional repressor complex IEA --
GO:0031523 Myb complex IBA 21873635
genes like me logo Genes that share ontologies with LIN37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LIN37 Gene

Pathways & Interactions for LIN37 Gene

genes like me logo Genes that share pathways with LIN37: view

Pathways by source for LIN37 Gene

1 KEGG pathway for LIN37 Gene

Gene Ontology (GO) - Biological Process for LIN37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0051726 regulation of cell cycle TAS --
genes like me logo Genes that share ontologies with LIN37: view

No data available for SIGNOR curated interactions for LIN37 Gene

Drugs & Compounds for LIN37 Gene

No Compound Related Data Available

Transcripts for LIN37 Gene

mRNA/cDNA for LIN37 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIN37

Alternative Splicing Database (ASD) splice patterns (SP) for LIN37 Gene

No ASD Table

Relevant External Links for LIN37 Gene

GeneLoc Exon Structure for
LIN37

Expression for LIN37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIN37 Gene

Protein differential expression in normal tissues from HIPED for LIN37 Gene

This gene is overexpressed in CD8 Tcells (27.1), Testis (26.4), and Blymphocyte (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LIN37 Gene



Protein tissue co-expression partners for LIN37 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LIN37

SOURCE GeneReport for Unigene cluster for LIN37 Gene:

Hs.529100

Evidence on tissue expression from TISSUES for LIN37 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with LIN37: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIN37 Gene

Orthologs for LIN37 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIN37 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LIN37 30 31
  • 99.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LIN37 30 31
  • 92.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LIN37 30 31
  • 90.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lin37 30 17 31
  • 87.4 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lin37 30
  • 86.99 (n)
Oppossum
(Monodelphis domestica)
Mammalia LIN37 31
  • 81 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LIN37 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lin37 30
  • 62.57 (n)
Zebrafish
(Danio rerio)
Actinopterygii lin37 30 31
  • 59.26 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta mip40 31
  • 21 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
OneToOne
Species where no ortholog for LIN37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LIN37 Gene

ENSEMBL:
Gene Tree for LIN37 (if available)
TreeFam:
Gene Tree for LIN37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LIN37: view image

Paralogs for LIN37 Gene

No data available for Paralogs for LIN37 Gene

Variants for LIN37 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LIN37 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs170758 - p.Ala16Val
rs35617825 - p.Pro172Ser

Additional dbSNP identifiers (rs#s) for LIN37 Gene

Structural Variations from Database of Genomic Variants (DGV) for LIN37 Gene

Variant ID Type Subtype PubMed ID
nsv515536 CNV loss 19592680
nsv579422 CNV loss 21841781
nsv579423 CNV loss 21841781
nsv953286 CNV deletion 24416366

Variation tolerance for LIN37 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIN37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIN37

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIN37 Gene

Disorders for LIN37 Gene

No disorders were found for LIN37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIN37 Gene

Publications for LIN37 Gene

  1. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. (PMID: 21498570) Litovchick L … DeCaprio JA (Genes & development 2011) 2 3
  2. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. (PMID: 17671431) Schmit F … Gaubatz S (Cell cycle (Georgetown, Tex.) 2007) 3 4
  3. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PMID: 17531812) Litovchick L … DeCaprio JA (Molecular cell 2007) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4

Products for LIN37 Gene

Sources for LIN37 Gene