Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LIN28A Gene

Aliases for LIN28A Gene

  • Lin-28 Homolog A 2 3 5
  • Zinc Finger CCHC Domain-Containing Protein 1 3 4
  • Lin-28A 3 4
  • ZCCHC1 3 4
  • LIN28 3 4
  • CSDD1 3 4
  • Zinc Finger, CCHC Domain Containing 1 3
  • Lin-28 Homolog (C. Elegans) 2
  • RNA-Binding Protein LIN-28 3
  • Protein Lin-28 Homolog A 3
  • LIN-28 3

External Ids for LIN28A Gene

Previous HGNC Symbols for LIN28A Gene

  • LIN28

Previous GeneCards Identifiers for LIN28A Gene

  • GC01P026737
  • GC01P024991

Summaries for LIN28A Gene

Entrez Gene Summary for LIN28A Gene

  • This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]

GeneCards Summary for LIN28A Gene

LIN28A (Lin-28 Homolog A) is a Protein Coding gene. Diseases associated with LIN28A include Embryonal Tumor With Multilayered Rosettes and Central Nervous System Primitive Neuroectodermal Neoplasm. Among its related pathways are Cardiac Progenitor Differentiation and Wnt / Hedgehog / Notch. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and mRNA binding. An important paralog of this gene is LIN28B.

UniProtKB/Swiss-Prot for LIN28A Gene

  • RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:21247876). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). Translational enhancer that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5-GGAG-3 motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity).

Gene Wiki entry for LIN28A Gene

Additional gene information for LIN28A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIN28A Gene

Genomics for LIN28A Gene

GeneHancer (GH) Regulatory Elements for LIN28A Gene

Promoters and enhancers for LIN28A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I026408 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 550.8 +4.0 3973 12.4 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 CBX5 LIN28A HMGN2 ARID1A ACTG1P20 ZNF683 RPL17P9 CD52 UBXN11 GPN2 NPM1P39
GH01I026274 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.4 -126.9 -126884 19.1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 NBN SH3BGRL3 HMGN2 ARID1A CD52 LOC101928324 NPM1P39 UBXN11 CEP85 GPN2 LIN28A
GH01I026313 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11 -92.6 -92608 8.4 HDGF PKNOX1 ATF1 SMAD1 ARNT ARID4B ZNF2 IRF4 BRCA1 ZNF48 CD52 UBXN11 SH3BGRL3 ZNF683 CRYBG2 LIN28A CEP85 ENSG00000236782 ZNF593 FAM110D
GH01I026348 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 -55.8 -55845 12.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 CRYBG2 CD52 UBXN11 CEP85 CNKSR1 LIN28A DHDDS SLC30A2 TRIM63 EXTL1
GH01I027339 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.9 +931.2 931196 4.5 HDGF ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF213 ZNF143 FOS SP3 SYTL1 FAM76A PPP1R8 LOC101928324 LOC101928728 ENSG00000243659 ENSG00000231207 GPR3 ARID1A LIN28A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LIN28A on UCSC Golden Path with GeneCards custom track

Genomic Locations for LIN28A Gene

Genomic Locations for LIN28A Gene
chr1:26,410,778-26,429,728
(GRCh38/hg38)
Size:
18,951 bases
Orientation:
Plus strand
chr1:26,737,269-26,756,219
(GRCh37/hg19)

Genomic View for LIN28A Gene

Genes around LIN28A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIN28A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIN28A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIN28A Gene

Proteins for LIN28A Gene

  • Protein details for LIN28A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9Z2-LN28A_HUMAN
    Recommended name:
    Protein lin-28 homolog A
    Protein Accession:
    Q9H9Z2

    Protein attributes for LIN28A Gene

    Size:
    209 amino acids
    Molecular mass:
    22743 Da
    Quaternary structure:
    • Monomer (By similarity). During skeletal muscle differentiation, associated with translation initiation complexes in the polysomal compartment (PubMed:21247876). Directly interacts with EIF3S2 (By similarity). Interacts with NCL in an RNA-dependent manner (By similarity). Interacts (via C-terminus) with DHX9 (via N- and C-terminus); this interaction occurs in a RNA-independent manner (PubMed:21247876). Interacts with ZCCHC11/TUT4 in the presence of pre-let-7 RNA (PubMed:19703396, PubMed:22118463).
    Miscellaneous:
    • Overexpressed in primary tumors (overall frequency approximately 15%), overexpression being linked to repression of let-7 family miRNAs and derepression of let-7 targets. Facilitates cellular transformation in vitro, and overexpression is associated with advanced disease across multiple tumor types.
    • Reactivation of LIN28A expression enhances tissue repair in some adult tissues by reprogramming cellular bioenergetics. Improves hair regrowth by promoting anagen in hair follicle and accelerates regrowth of cartilage, bone and mesenchyme after ear and digit injuries.

    Three dimensional structures from OCA and Proteopedia for LIN28A Gene

neXtProt entry for LIN28A Gene

Post-translational modifications for LIN28A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LIN28A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LIN28A Gene

Domains & Families for LIN28A Gene

Gene Families for LIN28A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for LIN28A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9Z2

UniProtKB/Swiss-Prot:

LN28A_HUMAN :
  • The CSD domain is required for function in muscle differentiation.
  • Belongs to the lin-28 family.
Domain:
  • The CSD domain is required for function in muscle differentiation.
  • The CCHC zinc fingers interact with the GGAG motif at the 3 end of let-7 miRNAs precursors, more generally they bind the 5-NGNNG-3 consensus motif with micromolar affinity. The CSD domain recognizes the loop at the 5 end. The flexible linker allows accommodating variable sequences and lengths among let-7 family members.
Family:
  • Belongs to the lin-28 family.
genes like me logo Genes that share domains with LIN28A: view

Function for LIN28A Gene

Molecular function for LIN28A Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:21247876). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). Translational enhancer that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5-GGAG-3 motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity).
UniProtKB/Swiss-Prot Induction:
Can be negatively regulated by the interaction of microRNAs miR-125a and miR-125b with at least two miRNA responsive elements (miREs) in the 3-UTR of this gene. These interactions may reduce both translation efficiency and mRNA abundance. Negatively regulated by retinoic acid.

Phenotypes From GWAS Catalog for LIN28A Gene

Gene Ontology (GO) - Molecular Function for LIN28A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002151 G-quadruplex RNA binding ISS --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA,IDA 18951094
GO:0003729 mRNA binding IEA --
genes like me logo Genes that share ontologies with LIN28A: view
genes like me logo Genes that share phenotypes with LIN28A: view

Animal Models for LIN28A Gene

MGI Knock Outs for LIN28A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIN28A Gene

Localization for LIN28A Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIN28A Gene

Cytoplasm. Rough endoplasmic reticulum. Cytoplasm, P-body. Cytoplasm, Stress granule. Nucleus, nucleolus. Note=Predominantly cytoplasmic (PubMed:22118463). In the cytoplasm, localizes to peri-endoplasmic reticulum regions and detected in the microsomal fraction derived from rough endoplasmic reticulum (RER) following subcellular fractionation. May be bound to the cytosolic surface of RER on which ER-associated mRNAs are translated (By similarity). Shuttle from the nucleus to the cytoplasm requires RNA-binding (PubMed:17617744). Nucleolar localization is observed in 10-15% of the nuclei in differentiated myotubes (By similarity). {ECO:0000250 UniProtKB:Q8K3Y3, ECO:0000269 PubMed:17617744, ECO:0000269 PubMed:22118463}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIN28A gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 4
extracellular 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LIN28A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA 17617744
GO:0005634 nucleus IEA,IDA 17617744
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA 18604195
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with LIN28A: view

Pathways & Interactions for LIN28A Gene

genes like me logo Genes that share pathways with LIN28A: view

Pathways by source for LIN28A Gene

1 BioSystems pathway for LIN28A Gene
2 Cell Signaling Technology pathways for LIN28A Gene

Gene Ontology (GO) - Biological Process for LIN28A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007281 germ cell development IEA --
GO:0010586 miRNA metabolic process IEA --
GO:0010587 miRNA catabolic process IMP 18951094
GO:0017148 negative regulation of translation ISS --
genes like me logo Genes that share ontologies with LIN28A: view

No data available for SIGNOR curated interactions for LIN28A Gene

Drugs & Compounds for LIN28A Gene

(1) Drugs for LIN28A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2430
genes like me logo Genes that share compounds with LIN28A: view

Transcripts for LIN28A Gene

mRNA/cDNA for LIN28A Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(65) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LIN28A Gene

Lin-28 homolog A (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIN28A Gene

No ASD Table

Relevant External Links for LIN28A Gene

GeneLoc Exon Structure for
LIN28A
ECgene alternative splicing isoforms for
LIN28A

Expression for LIN28A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LIN28A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIN28A Gene

This gene is overexpressed in Testis (x49.8).

Protein differential expression in normal tissues from HIPED for LIN28A Gene

This gene is overexpressed in Fetal ovary (50.0) and Fetal testis (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LIN28A Gene



Protein tissue co-expression partners for LIN28A Gene

NURSA nuclear receptor signaling pathways regulating expression of LIN28A Gene:

LIN28A

SOURCE GeneReport for Unigene cluster for LIN28A Gene:

Hs.86154

mRNA Expression by UniProt/SwissProt for LIN28A Gene:

Q9H9Z2-LN28A_HUMAN
Tissue specificity: Expressed in embryonic stem cells, placenta and testis. Tends to be up-regulated in HER2-overexpressing breast tumors.

Evidence on tissue expression from TISSUES for LIN28A Gene

  • Nervous system(2.4)
  • Skin(2.3)
  • Heart(2)
  • Liver(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with LIN28A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LIN28A Gene

Orthologs for LIN28A Gene

This gene was present in the common ancestor of animals.

Orthologs for LIN28A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIN28A 33 34
  • 97.29 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 96 (a)
OneToMany
-- 34
  • 92 (a)
OneToMany
LIN28A 33
  • 90.57 (n)
dog
(Canis familiaris)
Mammalia LIN28A 33 34
  • 92.2 (n)
oppossum
(Monodelphis domestica)
Mammalia LIN28A 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lin28a 33 16 34
  • 91.07 (n)
rat
(Rattus norvegicus)
Mammalia Lin28a 33
  • 90.43 (n)
chicken
(Gallus gallus)
Aves LIN28A 33 34
  • 77.45 (n)
lizard
(Anolis carolinensis)
Reptilia LIN28A 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lin28a 33
  • 68.39 (n)
Str.916 33
zebrafish
(Danio rerio)
Actinopterygii CABZ01041200.1 34
  • 71 (a)
OneToMany
lin28a 33 34
  • 70 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta lin-28 34
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-28 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToMany
Species where no ortholog for LIN28A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LIN28A Gene

ENSEMBL:
Gene Tree for LIN28A (if available)
TreeFam:
Gene Tree for LIN28A (if available)

Paralogs for LIN28A Gene

Paralogs for LIN28A Gene

(1) SIMAP similar genes for LIN28A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for LIN28A Gene

genes like me logo Genes that share paralogs with LIN28A: view

Variants for LIN28A Gene

Sequence variations from dbSNP and Humsavar for LIN28A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000171638 -- 26,419,111(+) G/A intron_variant
rs1000406104 -- 26,411,907(+) G/C intron_variant
rs1000423129 -- 26,411,134(+) G/T intron_variant
rs1000448239 -- 26,422,910(+) T/C intron_variant
rs1000461672 -- 26,418,137(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LIN28A Gene

Variant ID Type Subtype PubMed ID
nsv1014791 CNV gain 25217958
nsv1077272 CNV deletion 25765185
nsv945840 CNV duplication 23825009

Variation tolerance for LIN28A Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIN28A Gene

Human Gene Mutation Database (HGMD)
LIN28A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIN28A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIN28A Gene

Disorders for LIN28A Gene

MalaCards: The human disease database

(7) MalaCards diseases for LIN28A Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
embryonal tumor with multilayered rosettes
  • ependymoblastoma
central nervous system primitive neuroectodermal neoplasm
  • cpnet
childhood endodermal sinus tumor
  • childhood endodermal sinus neoplasm
ependymoblastoma
alport syndrome, autosomal recessive
  • autosomal recessive alport syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LIN28A

genes like me logo Genes that share disorders with LIN28A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIN28A Gene

Publications for LIN28A Gene

  1. Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. (PMID: 18951094) Heo I … Kim VN (Molecular cell 2008) 3 4 22 58
  2. Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites. (PMID: 12798299) Moss EG … Tang L (Developmental biology 2003) 2 3 4 58
  3. Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). (PMID: 22898984) Thornton JE … Gregory RI (RNA (New York, N.Y.) 2012) 3 4 58
  4. Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes. (PMID: 21247876) Jin J … Huang Y (Nucleic acids research 2011) 3 4 58
  5. Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. (PMID: 22118463) Piskounova E … Gregory RI (Cell 2011) 3 4 58

Products for LIN28A Gene

Sources for LIN28A Gene

Content
Loading form....