Aliases for LIMS2 Gene
External Ids for LIMS2 Gene
Previous GeneCards Identifiers for LIMS2 Gene
This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for LIMS2 Gene
LIMS2 (LIM Zinc Finger Domain Containing 2) is a Protein Coding gene. Diseases associated with LIMS2 include Muscular Dystrophy, Autosomal Recessive, With Cardiomyopathy And Triangular Tongue and Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2W. Among its related pathways are Cell junction organization and EphB-EphrinB Signaling. An important paralog of this gene is LIMS1.
UniProtKB/Swiss-Prot Summary for LIMS2 Gene
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.