Aliases for LIMS1 Gene
External Ids for LIMS1 Gene
Previous GeneCards Identifiers for LIMS1 Gene
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for LIMS1 Gene
LIMS1 (LIM Zinc Finger Domain Containing 1) is a Protein Coding gene. Diseases associated with LIMS1 include Conotruncal Heart Malformations. Among its related pathways are Primary Focal Segmental Glomerulosclerosis FSGS and ERK Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is LIMS2.
UniProtKB/Swiss-Prot for LIMS1 Gene
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.