LIMS1 Gene (Protein Coding)

LIM Zinc Finger Domain Containing 1

GC02P108534
GIFtS:
41
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is invol... See more...

Aliases for LIMS1 Gene

Aliases for LIMS1 Gene

  • LIM Zinc Finger Domain Containing 1 2 3 5
  • Particularly Interesting New Cys-His Protein 1 2 3 4
  • PINCH1 2 3 4
  • PINCH 2 3 4
  • LIM And Senescent Cell Antigen-Like-Containing Domain Protein 1 3 4
  • LIM And Senescent Cell Antigen-Like Domains 1 2 3
  • Renal Carcinoma Antigen NY-REN-48 3 4
  • LIM-Type Zinc Finger Domains 1 2 3
  • Senescent Cell Antigen 2 3
  • PINCH-1 3 4
  • LIMS1 5

External Ids for LIMS1 Gene

Previous GeneCards Identifiers for LIMS1 Gene

  • GC02P107110
  • GC02P107684
  • GC02P108755
  • GC02P108772
  • GC02P108826
  • GC02P108609
  • GC02P109150

Summaries for LIMS1 Gene

Entrez Gene Summary for LIMS1 Gene

  • The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for LIMS1 Gene

LIMS1 (LIM Zinc Finger Domain Containing 1) is a Protein Coding gene. Diseases associated with LIMS1 include Colorectal Cancer and Dilated Cardiomyopathy. Among its related pathways are Cell junction organization and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is LIMS3.

UniProtKB/Swiss-Prot Summary for LIMS1 Gene

  • Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.

Gene Wiki entry for LIMS1 Gene

Additional gene information for LIMS1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LIMS1 Gene

Genomics for LIMS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for LIMS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J108583 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 275.9 +56.8 56762 13.7 BCLAF1 SP1 NCOR1 ZNF654 IKZF1 JUND ZNF592 ZSCAN16 NFIC NONO LIMS1 GCC2 RANBP2 HSALNG0017737 LIMS3-LOC440895
GH02J108611 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 258.5 +84.2 84205 13.5 BCLAF1 SP1 ZNF207 IKZF1 ZNF600 ZNF592 POLR2A NFIC ZIC2 BCL11A LIMS1 GCC2 SULT1C4 LIMS1-AS1 RANBP2 LIMS3-LOC440895 HSALNG0017737
GH02J108532 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.9 1926 5.9 ZNF207 IKZF1 MYC ZNF600 ZNF580 POLR2A CEBPA NFIC ZIC2 ZBTB10 GCC2-AS1 HSALNG0017733 LIMS1 GCC2 RANBP2 SULT1C4 RGPD4 lnc-LIMS1-1 HSALNG0017737
GH02J108652 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 250.1 +121.4 121409 5.8 IKZF1 NCOR1 ZNF592 MNT TAF9B SMARCA5 ZNF146 PRDM10 BHLHE40 ZNF318 LIMS3-LOC440895 LIMS1 GCC2 piR-47246-001 RANBP2
GH02J108607 Promoter/Enhancer 0.5 EPDnew dbSUPER 250.2 +73.5 73457 0.1 LIMS1 LIMS3-LOC440895 HSALNG0017737 RANBP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LIMS1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LIMS1

Top Transcription factor binding sites by QIAGEN in the LIMS1 gene promoter:
  • Bach1
  • Brachyury
  • FOXJ2
  • FOXJ2 (long isoform)
  • Nkx2-2
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • RSRFC4

Genomic Locations for LIMS1 Gene

Latest Assembly
chr2:108,533,671-108,687,246
(GRCh38/hg38)
Size:
153,576 bases
Orientation:
Plus strand

Previous Assembly
chr2:109,150,127-109,303,702
(GRCh37/hg19 by Entrez Gene)
Size:
153,576 bases
Orientation:
Plus strand

chr2:109,150,857-109,303,702
(GRCh37/hg19 by Ensembl)
Size:
152,846 bases
Orientation:
Plus strand

Genomic View for LIMS1 Gene

Genes around LIMS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIMS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIMS1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LIMS1 Gene

Proteins for LIMS1 Gene

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  • Protein details for LIMS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48059-LIMS1_HUMAN
    Recommended name:
    LIM and senescent cell antigen-like-containing domain protein 1
    Protein Accession:
    P48059
    Secondary Accessions:
    • B2RAJ4
    • B7Z483
    • B7Z7R3
    • B7Z907
    • Q53TE0
    • Q9BS44

    Protein attributes for LIMS1 Gene

    Size:
    325 amino acids
    Molecular mass:
    37251 Da
    Quaternary structure:
    • Interacts (via LIM zinc-binding 5) with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS2. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA. Interacts with SH3/SH2 adapter NCK2, thereby linking the complex to cell surface receptors.

    Three dimensional structures from OCA and Proteopedia for LIMS1 Gene

    Alternative splice isoforms for LIMS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIMS1 Gene

Protein Expression for LIMS1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LIMS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LIMS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LIMS1 Gene

Domains & Families for LIMS1 Gene

Gene Families for LIMS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LIMS1 Gene

InterPro:
Blocks:
  • Zn-binding protein, LIM

Suggested Antigen Peptide Sequences for LIMS1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55516, highly similar to Particularly interesting new Cys-His protein (B7Z483_HUMAN)
  • cDNA FLJ55165, highly similar to Particularly interesting new Cys-His protein (B7Z7R3_HUMAN)
  • LIM and senescent cell antigen-like domains 1, isoform CRA_a (D3DX71_HUMAN)
  • Renal carcinoma antigen NY-REN-48 (LIMS1_HUMAN)
genes like me logo Genes that share domains with LIMS1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LIMS1 Gene

Function for LIMS1 Gene

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  6. Cell Lines for research

Molecular function for LIMS1 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.

Phenotypes From GWAS Catalog for LIMS1 Gene

Gene Ontology (GO) - Molecular Function for LIMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10574708
GO:0008270 zinc ion binding IDA 19074270
GO:0019901 protein kinase binding IPI 20926685
GO:0044877 protein-containing complex binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LIMS1: view
genes like me logo Genes that share phenotypes with LIMS1: view

Animal Models for LIMS1 Gene

MGI Knock Outs for LIMS1:

Animal Models for research

miRNA for LIMS1 Gene

miRTarBase miRNAs that target LIMS1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIMS1

Clone products for research

  • Addgene plasmids for LIMS1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIMS1 Gene

Localization for LIMS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIMS1 Gene

Cell junction, focal adhesion. Cell membrane. Peripheral membrane protein. Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIMS1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Focal adhesion sites (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LIMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0005911 cell-cell junction IBA,IMP 20926685
GO:0005925 colocalizes_with focal adhesion IBA,IDA 19117955
genes like me logo Genes that share ontologies with LIMS1: view

Pathways & Interactions for LIMS1 Gene

genes like me logo Genes that share pathways with LIMS1: view

Pathways by source for LIMS1 Gene

1 BioSystems pathway for LIMS1 Gene
2 GeneGo (Thomson Reuters) pathways for LIMS1 Gene
  • Cytoskeleton remodeling Integrin outside-in signaling
  • Cytoskeleton remodeling Reverse signaling by ephrin B
1 Qiagen pathway for LIMS1 Gene
  • ILK Signaling
2 Cell Signaling Technology pathways for LIMS1 Gene

Gene Ontology (GO) - Biological Process for LIMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001837 NOT epithelial to mesenchymal transition IMP 20926685
GO:0007569 cell aging TAS 7517666
GO:0010628 positive regulation of gene expression IMP 20926685
GO:0010811 positive regulation of cell-substrate adhesion IMP 20926685
GO:0033209 tumor necrosis factor-mediated signaling pathway IMP 21343177
genes like me logo Genes that share ontologies with LIMS1: view

No data available for SIGNOR curated interactions for LIMS1 Gene

Drugs & Compounds for LIMS1 Gene

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(2) Drugs for LIMS1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with LIMS1: view

Transcripts for LIMS1 Gene

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mRNA/cDNA for LIMS1 Gene

13 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIMS1

Clone products for research

  • Addgene plasmids for LIMS1

Alternative Splicing Database (ASD) splice patterns (SP) for LIMS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - -
SP8: -
SP9: - - - -
SP10: - -
SP11: - - - - - - -
SP12:

Relevant External Links for LIMS1 Gene

GeneLoc Exon Structure for
LIMS1

Expression for LIMS1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIMS1 Gene

mRNA expression in normal human tissues for LIMS1 Gene
mRNA expression by GTEx for LIMS1 GenemRNA expression by BioGPS for LIMS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LIMS1 Gene

This gene is overexpressed in Platelet (21.5) and Peripheral blood mononuclear cells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LIMS1 Gene



Protein tissue co-expression partners for LIMS1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LIMS1

SOURCE GeneReport for Unigene cluster for LIMS1 Gene:

Hs.597715

mRNA Expression by UniProt/SwissProt for LIMS1 Gene:

P48059-LIMS1_HUMAN
Tissue specificity: Expressed in most tissues except in the brain.

Evidence on tissue expression from TISSUES for LIMS1 Gene

  • Blood(4.5)
  • Bone marrow(4.4)
  • Heart(3.6)
  • Nervous system(3.5)
  • Lung(3.2)
  • Muscle(2.7)
  • Kidney(2.4)
  • Intestine(2.4)
  • Skin(2.3)
  • Lymph node(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with LIMS1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIMS1 Gene

Orthologs for LIMS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIMS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LIMS1 29
  • 99.41 (n)
Cow
(Bos Taurus)
 Mammalia MGC142792 30
  • 96 (a)
 OneToMany
LIMS1 29
  • 89.91 (n)
Dog
(Canis familiaris)
 Mammalia -- 30
  • 91 (a)
 OneToMany
LIMS1 29
  • 90.01 (n)
Mouse
(Mus musculus)
 Mammalia Lims1 29 16 30
  • 90.72 (n)
 OneToMany
Rat
(Rattus norvegicus)
 Mammalia Lims1 29
  • 90.72 (n)
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 88 (a)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 82 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves -- 30
  • 86 (a)
 ManyToMany
-- 30
  • 84 (a)
 ManyToMany
LIMS1 29 30
  • 82.87 (n)
 ManyToMany
-- 30
  • 79 (a)
 ManyToMany
-- 30
  • 69 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 92 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia lims1 29
  • 82.87 (n)
Str.8448 29
African clawed frog
(Xenopus laevis)
 Amphibia Xl.12605 29
Zebrafish
(Danio rerio)
 Actinopterygii lims1 29 30
  • 80.85 (n)
 ManyToMany
lims2 30
  • 73 (a)
 ManyToMany
wufc32c03 29
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.5292 29
Fruit Fly
(Drosophila melanogaster)
 Insecta stck 29 30 31
  • 65.2 (n)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003429 29
  • 64.35 (n)
Worm
(Caenorhabditis elegans)
 Secernentea unc-97 29 30 31
  • 63.03 (n)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.11312 30
  • 67 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.4597 29
Species where no ortholog for LIMS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LIMS1 Gene

ENSEMBL:
Gene Tree for LIMS1 (if available)
TreeFam:
Gene Tree for LIMS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LIMS1: view image
Alliance of Genome Resources:
Additional Orthologs for LIMS1

Paralogs for LIMS1 Gene

Paralogs for LIMS1 Gene

(22) SIMAP similar genes for LIMS1 Gene using alignment to 7 proteins:

  • LIMS1_HUMAN
  • A8MUY2_HUMAN
  • C9JF46_HUMAN
  • D3DX71_HUMAN
  • F8WB59_HUMAN
  • F8WC86_HUMAN
  • F8WE10_HUMAN
genes like me logo Genes that share paralogs with LIMS1: view

Variants for LIMS1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LIMS1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs150889011 Benign: not provided 108,680,724(+) G/A
NM_001193485.3(LIMS1):c.1003G>A (p.Val335Met) 		MISSENSE
rs200615079 Benign: not provided 108,680,689(+) C/G
NM_001193485.3(LIMS1):c.974-6C>G 		INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LIMS1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LIMS1 Gene

Variant ID Type Subtype PubMed ID
dgv153e55 CNV gain 17911159
dgv4036n100 CNV gain 25217958
esv2720498 CNV deletion 23290073
esv2759081 CNV gain 17122850
esv3591929 CNV loss 21293372
nsv1139724 CNV duplication 24896259
nsv1149522 OTHER inversion 26484159
nsv521122 CNV loss 19592680
nsv527491 CNV loss 19592680
nsv834328 CNV gain 17160897
nsv961854 CNV duplication 23825009
nsv961855 CNV duplication 23825009

Variation tolerance for LIMS1 Gene

Gene Damage Index Score: 2.56; 44.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIMS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIMS1
Leiden Open Variation Database (LOVD)
LIMS1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIMS1 Gene

Disorders for LIMS1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LIMS1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
colorectal cancer
  • crc
dilated cardiomyopathy
  • congestive cardiomyopathy
- elite association - COSMIC cancer census association via MalaCards
Search LIMS1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LIMS1

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LIMS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIMS1 Gene

Publications for LIMS1 Gene

  1. Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. (PMID: 19117955) Yang Y … Qin J (The Journal of biological chemistry 2009) 3 4 22
  2. The structural basis of integrin-linked kinase-PINCH interactions. (PMID: 19074270) Chiswell BP … Calderwood DA (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 22
  3. Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling. (PMID: 12794636) Velyvis A … Qin J (Nature structural biology 2003) 3 4 22
  4. Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. (PMID: 11078733) Velyvis A … Qin J (The Journal of biological chemistry 2001) 3 4 22
  5. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. (PMID: 10022929) Tu Y … Wu C (Molecular and cellular biology 1999) 2 3 4

ExternalLinks

View latest publications for LIMS1 gene in Mastermind

Products for LIMS1 Gene

  • Addgene plasmids for LIMS1

Sources for LIMS1 Gene