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The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is invol... See more...
Aliases for LIMS1 Gene
Aliases for LIMS1 Gene
External Ids for LIMS1 Gene
- HGNC: 6616
- Entrez Gene: 3987
- Ensembl: ENSG00000169756
- OMIM: 602567
- UniProtKB: P48059
Previous GeneCards Identifiers for LIMS1 Gene
- GC02P107110
- GC02P107684
- GC02P108755
- GC02P108772
- GC02P108826
- GC02P109150
Summaries for LIMS1 Gene
-
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for LIMS1 Gene
LIMS1 (LIM Zinc Finger Domain Containing 1) is a Protein Coding gene. Diseases associated with LIMS1 include Dilated Cardiomyopathy. Among its related pathways are ERK Signaling and Cell junction organization. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is LIMS2.
UniProtKB/Swiss-Prot Summary for LIMS1 Gene
-
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
Additional gene information for LIMS1 Gene
- HGNC(6616)
- Entrez Gene(3987)
- Ensembl(ENSG00000169756)
- OMIM(602567)
- UniProtKB(P48059)
- Open Targets Platform(ENSG00000169756)
- Search for LIMS1 at DataMed
- Search for LIMS1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LIMS1 Gene
Genomics for LIMS1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LIMS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LIMS1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LIMS1
- Top Transcription factor binding sites by QIAGEN in the LIMS1 gene promoter:
-
- Bach1
- Brachyury
- FOXJ2
- FOXJ2 (long isoform)
- Nkx2-2
- POU2F1
- POU2F1a
- POU2F1b
- POU2F1c
- RSRFC4
Genomic Locations for LIMS1 Gene
Genomic Locations for LIMS1 Gene
- chr2:108,533,671-108,687,246
- (GRCh38/hg38)
- Size:
- 153,576 bases
- Orientation:
- Plus strand
- chr2:109,150,811-109,303,702
- (GRCh37/hg19)
- Size:
- 152,892 bases
- Orientation:
- Plus strand
Genomic View for LIMS1 Gene
Genes around LIMS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q12.3 by HGNC
- 2q12.3 by Entrez Gene
- 2q12.3 by Ensembl
LIMS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LIMS1 Gene
Proteins for LIMS1 Gene
-
Protein details for LIMS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P48059-LIMS1_HUMAN
- Recommended name:
- LIM and senescent cell antigen-like-containing domain protein 1
- Protein Accession:
- P48059
- B2RAJ4
- B7Z483
- B7Z7R3
- B7Z907
- Q53TE0
- Q9BS44
Protein attributes for LIMS1 Gene
- Size:
- 325 amino acids
- Molecular mass:
- 37251 Da
- Quaternary structure:
-
- Interacts (via LIM zinc-binding 5) with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS2. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA. Interacts with SH3/SH2 adapter NCK2, thereby linking the complex to cell surface receptors.
Three dimensional structures from OCA and Proteopedia for LIMS1 Gene
Protein Expression for LIMS1 Gene
Post-translational modifications for LIMS1 Gene
Other Protein References for LIMS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- HUABIO Anti-PINCH Antibody
-
Custom Antibody ServicesOriGene Antibodies for LIMS1
- Novus Biologicals Antibodies for LIMS1
- Invitrogen Antibodies for LIMS1 (AFLGC-LIMS1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for LIMS1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for LIMS1
- Origene Custom Protein Services for LIMS1
- antibodies-online: Show 5 available LIMS1 Proteins ranked by validation data
- Compare Top LIMS1 Proteins
-
Quality Products:
-
Abcam proteins for LIMS1
Assay Products
- antibodies-online: Show 1 available LIMS1 Elisa Kits ranked by validation data
- Compare Top LIMS1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for LIMS1 Gene
Domains & Families for LIMS1 Gene
Gene Families for LIMS1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for LIMS1 Gene
Suggested Antigen Peptide Sequences for LIMS1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ55516, highly similar to Particularly interesting new Cys-His protein (B7Z483_HUMAN)
- cDNA FLJ55165, highly similar to Particularly interesting new Cys-His protein (B7Z7R3_HUMAN)
- LIM and senescent cell antigen-like domains 1, isoform CRA_a (D3DX71_HUMAN)
- Renal carcinoma antigen NY-REN-48 (LIMS1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LIMS1 Gene
Function for LIMS1 Gene
Molecular function for LIMS1 Gene
- UniProtKB/Swiss-Prot Function:
- Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
Phenotypes From GWAS Catalog for LIMS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 10574708 |
| GO:0008270 | zinc ion binding | IDA | 19074270 |
| GO:0019901 | protein kinase binding | IPI | 20926685 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for LIMS1 Gene
- MGI mutant phenotypes for LIMS1:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for LIMS1:
Animal Models for LIMS1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LIMS1 - Select products 50% OFF >
- * LIMS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LIMS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LIMS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for LIMS1
miRNA for LIMS1 Gene
- miRTarBase miRNAs that target LIMS1
-
- mmu-miR-362-5p (MIRT008901)
- mmu-miR-7b-5p (MIRT009221)
- mmu-miR-297a-5p (MIRT013055)
- mmu-miR-24-3p (MIRT013866)
- hsa-miR-421 (MIRT016105)
- hsa-miR-590-3p (MIRT016188)
- hsa-miR-340-5p (MIRT019634)
- hsa-miR-1-3p (MIRT023868)
- hsa-miR-221-3p (MIRT024188)
- hsa-miR-215-5p (MIRT024835)
- hsa-miR-192-5p (MIRT026671)
- hsa-miR-1226-3p (MIRT036467)
- hsa-miR-744-5p (MIRT037466)
- hsa-miR-18a-3p (MIRT040780)
- hsa-miR-505-3p (MIRT041021)
- hsa-miR-513a-3p (MIRT202717)
- hsa-miR-619-3p (MIRT202718)
- hsa-miR-513c-3p (MIRT202719)
- hsa-miR-3606-3p (MIRT202720)
- hsa-miR-4774-5p (MIRT202722)
- hsa-miR-7851-3p (MIRT202723)
- hsa-miR-6507-5p (MIRT297199)
- hsa-miR-129-5p (MIRT399635)
- hsa-miR-507 (MIRT399636)
- hsa-miR-557 (MIRT399637)
- hsa-miR-4279 (MIRT539981)
- hsa-miR-4777-3p (MIRT539982)
- hsa-miR-4503 (MIRT556553)
- hsa-miR-4477a (MIRT556554)
- hsa-miR-4693-5p (MIRT556555)
- hsa-miR-4729 (MIRT556556)
- hsa-miR-6792-5p (MIRT556557)
- hsa-miR-4318 (MIRT556558)
- hsa-miR-892a (MIRT556559)
- hsa-miR-29c-3p (MIRT556560)
- hsa-miR-29a-3p (MIRT556561)
- hsa-miR-29b-3p (MIRT556562)
- hsa-miR-3680-3p (MIRT566936)
- hsa-miR-450b-5p (MIRT566937)
- hsa-miR-5698 (MIRT607706)
- hsa-miR-8057 (MIRT607707)
- hsa-miR-6836-3p (MIRT607708)
- hsa-miR-5001-3p (MIRT607709)
- hsa-miR-143-5p (MIRT607710)
- hsa-miR-23b-5p (MIRT607711)
- hsa-miR-23a-5p (MIRT607712)
- hsa-miR-24-3p (MIRT607713)
- hsa-miR-4284 (MIRT607714)
- hsa-miR-504-3p (MIRT607715)
- hsa-miR-3194-3p (MIRT607716)
- hsa-miR-6829-3p (MIRT607717)
- hsa-miR-6791-3p (MIRT607718)
- hsa-miR-6778-3p (MIRT607719)
- hsa-miR-6499-3p (MIRT607720)
- hsa-miR-2276-3p (MIRT607721)
- hsa-miR-1304-3p (MIRT607722)
- hsa-miR-4532 (MIRT607723)
- hsa-miR-1247-3p (MIRT607724)
- hsa-miR-5693 (MIRT607725)
- hsa-miR-6890-3p (MIRT607726)
- hsa-miR-6796-3p (MIRT607727)
- hsa-miR-4430 (MIRT671552)
- hsa-miR-3652 (MIRT671553)
- hsa-miR-122-5p (MIRT671554)
- hsa-miR-3135b (MIRT671555)
- hsa-miR-4638-5p (MIRT671556)
- hsa-miR-1307-3p (MIRT671557)
- hsa-miR-6741-3p (MIRT671558)
- hsa-miR-30d-5p (MIRT734207)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LIMS1
- Browse OriGene Inhibitory RNA Products For LIMS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIMS1
Clone Products
- Applied Biological Materials (abm): Clones for LIMS1 - Select products 50% OFF >
- * LIMS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MR205021L4V
- MR227467L3V
- MR227467L4V
- MR227470L3V
- MR227470L4V
- RC202765L1V
- RC202765L2V
- RC202765L3V
- RC202765L4V
- RC231164L3V
- RC231164L4V
- RC231171L3V
- RC231171L4V
- RC231185L3V
- RC231185L4V
- RC231200L1V
- RC231200L2V
- RC231200L3V
- RC231200L4V
- RR210510L3V
- RR210510L4V
- MG205021
- MG227467
- MG227470
- MR205021
- MR205021L3
- MR205021L4
- MR227467
- MR227467L3
- MR227467L4
- MR227470
- MR227470L3
- MR227470L4
- RC202765
- RC202765L1
- RC202765L2
- RC202765L3
- RC202765L4
- RC231164
- RC231164L3
- RC231164L4
- RC231171
- RC231171L3
- RC231171L4
- RC231185
- RC231185L3
- RC231185L4
- RC231200
- RC231200L1
- RC231200L2
- RC231200L3
- RC231200L4
- RC232481
- RG202765
- RG231164
- RG231171
- RG231185
- RG231200
- RG232481
- RR210510
- RR210510L3
- RR210510L4
- MR205021L3V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LIMS1
- Addgene plasmids for LIMS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LIMS1
Cell Line Products
-
Horizon Cell Lines for LIMS1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIMS1 Gene
Localization for LIMS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LIMS1 Gene
- Cell junction, focal adhesion. Cell membrane. Peripheral membrane protein. Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| nucleus | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Focal adhesion sites (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005911 | cell-cell junction | IMP | 20926685 |
| GO:0005925 | colocalizes_with focal adhesion | IBA,IDA | 19117955 |
Pathways & Interactions for LIMS1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell junction organization | ||
| 2 | Adhesion |
-
|
|
| 3 | Cytoskeletal Signaling | ||
| 4 | ERK Signaling |
ILK Signaling
.49
|
|
| 5 | Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases |
Cytoskeleton remodeling Integrin outside-in signaling
.37
|
|
Pathways by source for LIMS1 Gene
1 BioSystems pathway for LIMS1 Gene
4 Reactome pathways for LIMS1 Gene
2 GeneGo (Thomson Reuters) pathways for LIMS1 Gene
- Cytoskeleton remodeling Integrin outside-in signaling
- Cytoskeleton remodeling Reverse signaling by ephrin B
1 Qiagen pathway for LIMS1 Gene
- ILK Signaling
2 Cell Signaling Technology pathways for LIMS1 Gene
Interacting Proteins for LIMS1 Gene
Selected Interacting proteins:
P48059-LIMS1_HUMAN
ENSP00000446121
for LIMS1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for LIMS1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001837 | NOT epithelial to mesenchymal transition | IMP | 20926685 |
| GO:0007569 | cell aging | TAS | 7517666 |
| GO:0010628 | positive regulation of gene expression | IMP | 20926685 |
| GO:0010811 | positive regulation of cell-substrate adhesion | IMP | 20926685 |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | IMP | 21343177 |
No data available for SIGNOR curated interactions for LIMS1 Gene
Transcripts for LIMS1 Gene
mRNA/cDNA for LIMS1 Gene
- 13 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000332345 1235 nts (view in UCSC)
- ENST00000338045 1876 nts (view in UCSC)
- ENST00000393310 4392 nts (view in UCSC)
- ENST00000409441 1627 nts (view in UCSC)
- ENST00000410093 1526 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LIMS1 - Select products 50% OFF >
- * LIMS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LIMS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LIMS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for LIMS1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LIMS1
- Browse OriGene Inhibitory RNA Products For LIMS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIMS1
Clone Products
- Applied Biological Materials (abm): Clones for LIMS1 - Select products 50% OFF >
- * LIMS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MR205021L4V
- MR227467L3V
- MR227467L4V
- MR227470L3V
- MR227470L4V
- RC202765L1V
- RC202765L2V
- RC202765L3V
- RC202765L4V
- RC231164L3V
- RC231164L4V
- RC231171L3V
- RC231171L4V
- RC231185L3V
- RC231185L4V
- RC231200L1V
- RC231200L2V
- RC231200L3V
- RC231200L4V
- RR210510L3V
- RR210510L4V
- MG205021
- MG227467
- MG227470
- MR205021
- MR205021L3
- MR205021L4
- MR227467
- MR227467L3
- MR227467L4
- MR227470
- MR227470L3
- MR227470L4
- RC202765
- RC202765L1
- RC202765L2
- RC202765L3
- RC202765L4
- RC231164
- RC231164L3
- RC231164L4
- RC231171
- RC231171L3
- RC231171L4
- RC231185
- RC231185L3
- RC231185L4
- RC231200
- RC231200L1
- RC231200L2
- RC231200L3
- RC231200L4
- RC232481
- RG202765
- RG231164
- RG231171
- RG231185
- RG231200
- RG232481
- RR210510
- RR210510L3
- RR210510L4
- MR205021L3V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LIMS1
- Addgene plasmids for LIMS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LIMS1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP12: |
Relevant External Links for LIMS1 Gene
- GeneLoc Exon Structure for
- LIMS1
Expression for LIMS1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Intermediate Mesoderm (Gastrulation Derivatives)
- Mesonephric cells Mesonephros
- Mesonephros
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Gonad
- Mesonephric cells Mesonephros
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Kidney (Urinary System)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Limb (Muscoskeletal System)
This gene is overexpressed in Platelet (21.5) and Peripheral blood mononuclear cells (11.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LIMS1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LIMS1
SOURCE GeneReport for Unigene cluster for LIMS1 Gene:
Hs.597715mRNA Expression by UniProt/SwissProt for LIMS1 Gene:
P48059-LIMS1_HUMAN
Tissue specificity:
Expressed in most tissues except in the brain.
Evidence on tissue expression from TISSUES for LIMS1 Gene
- Blood(4.5)
- Bone marrow(4.4)
- Heart(3.7)
- Nervous system(3.6)
- Lung(3.3)
- Muscle(2.9)
- Kidney(2.5)
- Intestine(2.5)
- Skin(2.5)
- Lymph node(2.2)
- Liver(2.2)
Primer Products
-
OriGene qPCR primer pairs for LIMS1
-
OriGene qPCR primer pairs and template standards for LIMS1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIMS1 Gene
Orthologs for LIMS1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LIMS1 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | MGC142792 31 |
|
OneToMany | |
| LIMS1 30 |
|
||||
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| LIMS1 30 |
|
||||
| Mouse (Mus musculus) |
Mammalia | Lims1 30 17 31 |
|
OneToMany | |
| Rat (Rattus norvegicus) |
Mammalia | Lims1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| LIMS1 30 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lims1 30 |
|
||
| Str.8448 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12605 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | lims1 30 31 |
|
ManyToMany | |
| lims2 31 |
|
ManyToMany | |||
| wufc32c03 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5292 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | stck 30 31 32 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003429 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | unc-97 30 31 32 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11312 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4597 30 |
|
- Species where no ortholog for LIMS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for LIMS1 Gene
- ENSEMBL:
- Gene Tree for LIMS1 (if available)
- TreeFam:
- Gene Tree for LIMS1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LIMS1: view image
Paralogs for LIMS1 Gene
Paralogs for LIMS1 Gene
(22) SIMAP similar genes for LIMS1 Gene using alignment to 7 proteins:
- LIMS1_HUMAN
- A8MUY2_HUMAN
- C9JF46_HUMAN
- D3DX71_HUMAN
- F8WB59_HUMAN
- F8WC86_HUMAN
- F8WE10_HUMAN
Variants for LIMS1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv153e55 | CNV | gain | 17911159 |
| dgv4036n100 | CNV | gain | 25217958 |
| esv2720498 | CNV | deletion | 23290073 |
| esv2759081 | CNV | gain | 17122850 |
| esv3591929 | CNV | loss | 21293372 |
| nsv1139724 | CNV | duplication | 24896259 |
| nsv1149522 | OTHER | inversion | 26484159 |
| nsv521122 | CNV | loss | 19592680 |
| nsv527491 | CNV | loss | 19592680 |
| nsv834328 | CNV | gain | 17160897 |
| nsv961854 | CNV | duplication | 23825009 |
| nsv961855 | CNV | duplication | 23825009 |
Gene Damage Index Score:
2.56;
44.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LIMS1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LIMS1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIMS1 Gene
Disorders for LIMS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dilated cardiomyopathy |
|
|
Search LIMS1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LIMS1
No data available for UniProtKB/Swiss-Prot and Genatlas for LIMS1 Gene
Publications for LIMS1 Gene
- Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. (PMID: 19117955) Yang Y … Qin J (The Journal of biological chemistry 2009) 3 4 23
- The structural basis of integrin-linked kinase-PINCH interactions. (PMID: 19074270) Chiswell BP … Calderwood DA (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 23
- Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling. (PMID: 12794636) Velyvis A … Qin J (Nature structural biology 2003) 3 4 23
- Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. (PMID: 11078733) Velyvis A … Qin J (The Journal of biological chemistry 2001) 3 4 23
- The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. (PMID: 10022929) Tu Y … Wu C (Molecular and cellular biology 1999) 2 3 4
ExternalLinks
Products for LIMS1 Gene
- Custom Antibody ServicesOriGene Antibodies for LIMS1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for LIMS1
- Origene Custom Protein Services for LIMS1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LIMS1
- Browse OriGene Inhibitory RNA Products For LIMS1
- OriGene qPCR primer pairs for LIMS1
- OriGene qPCR primer pairs and template standards for LIMS1
- OriGene CRISPR knockouts for LIMS1
- MR205021L4V
- MR227467L3V
- MR227467L4V
- MR227470L3V
- MR227470L4V
- RC202765L1V
- RC202765L2V
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- RC231164L3V
- RC231164L4V
- RC231171L3V
- RC231171L4V
- RC231185L3V
- RC231185L4V
- RC231200L1V
- RC231200L2V
- RC231200L3V
- RC231200L4V
- RR210510L3V
- RR210510L4V
- MG205021
- MG227467
- MG227470
- MR205021
- MR205021L3
- MR205021L4
- MR227467
- MR227467L3
- MR227467L4
- MR227470
- MR227470L3
- MR227470L4
- RC202765
- RC202765L1
- RC202765L2
- RC202765L3
- RC202765L4
- RC231164
- RC231164L3
- RC231164L4
- RC231171
- RC231171L3
- RC231171L4
- RC231185
- RC231185L3
- RC231185L4
- RC231200
- RC231200L1
- RC231200L2
- RC231200L3
- RC231200L4
- RC232481
- RG202765
- RG231164
- RG231171
- RG231185
- RG231200
- RG232481
- RR210510
- RR210510L3
- RR210510L4
- MR205021L3V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LIMS1
- Sino Biological Human cDNA Clone for LIMS1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for LIMS1
- Novus Biologicals proteins and lysates for LIMS1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for LIMS1
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for LIMS1 (AFLGC-LIMS1)
- VectorBuilder Custom and pre-made DNA vectors for LIMS1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for LIMS1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for LIMS1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for LIMS1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for LIMS1
- Addgene plasmids for LIMS1
- antibodies-online: Show 49 available LIMS1 Antibodies ranked by validation data
- Compare Top LIMS1 Antibodies
- antibodies-online: Show 1 available LIMS1 Elisa Kits ranked by validation data
- Compare Top LIMS1 Elisa Kits
- Quality Products:
- antibodies-online: Show 5 available LIMS1 Proteins ranked by validation data
- Compare Top LIMS1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for LIMS1
- Search Santa Cruz Biotechnology (SCBT) for LIMS1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LIMS1
- Horizon Cell Lines for LIMS1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LIMS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LIMS1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for LIMS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIMS1
Sources for LIMS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB