LIMK2 Gene (Protein Coding)

LIM Domain Kinase 2

GC22P031212
GIFtS:
49
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a un... See more...

Aliases for LIMK2 Gene

Aliases for LIMK2 Gene

  • LIM Domain Kinase 2 2 3 4 5
  • EC 2.7.11.1 4 51
  • LIMK-2 4
  • LIMK2 5

External Ids for LIMK2 Gene

Previous GeneCards Identifiers for LIMK2 Gene

  • GC22P028304
  • GC22P029932
  • GC22P031608
  • GC22P014569

Summaries for LIMK2 Gene

Entrez Gene Summary for LIMK2 Gene

  • There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIMK2 Gene

LIMK2 (LIM Domain Kinase 2) is a Protein Coding gene. Diseases associated with LIMK2 include Williams-Beuren Syndrome. Among its related pathways are Androgen receptor signaling pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LIMK1.

UniProtKB/Swiss-Prot Summary for LIMK2 Gene

  • Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865).

Tocris Summary for LIMK2 Gene

  • LIM kinases (LIMKs), EC 2.7.11.1, are dual specificity kinases (serine/threonine and tyrosine), which phosphorylate and inactivate cofilin (a key regulator of actin cytoskeleton dynamics). There are two isoforms of LIMK: LIMK1 and LIMK2.

Gene Wiki entry for LIMK2 Gene

Additional gene information for LIMK2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LIMK2 Gene

Genomics for LIMK2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for LIMK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LIMK2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LIMK2

Top Transcription factor binding sites by QIAGEN in the LIMK2 gene promoter:
  • c-Myc
  • E47
  • HEN1
  • LCR-F1
  • Max1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • Pax-6
  • Tal-1beta

Genomic Locations for LIMK2 Gene

Latest Assembly
chr22:31,212,239-31,280,080
(GRCh38/hg38)
Size:
67,842 bases
Orientation:
Plus strand

Previous Assembly
chr22:31,608,284-31,676,066
(GRCh37/hg19 by Entrez Gene)
Size:
67,783 bases
Orientation:
Plus strand

chr22:31,608,225-31,676,066
(GRCh37/hg19 by Ensembl)
Size:
67,842 bases
Orientation:
Plus strand

Genomic View for LIMK2 Gene

Genes around LIMK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIMK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIMK2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LIMK2 Gene

Proteins for LIMK2 Gene

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  • Protein details for LIMK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53671-LIMK2_HUMAN
    Recommended name:
    LIM domain kinase 2
    Protein Accession:
    P53671
    Secondary Accessions:
    • A8K6H5
    • Q7KZ80
    • Q7L3H5
    • Q96E10
    • Q99464
    • Q9UFU0

    Protein attributes for LIMK2 Gene

    Size:
    638 amino acids
    Molecular mass:
    72232 Da
    Quaternary structure:
    • [Isoform LIMK2a]: Interacts with LIMK2b.
    • [Isoform LIMK2b]: Interacts with LIMK2a.
    • Binds ROCK1 and MARF1 (Ref.9, PubMed:11018042, PubMed:10436159). Interacts with NISCH (By similarity).
    SequenceCaution:
    • Sequence=AAB54055.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LIMK2 Gene

    Alternative splice isoforms for LIMK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIMK2 Gene

Protein Expression for LIMK2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for LIMK2 Gene

P53671:
  • RYTVVGNPYWMAPEM
  • HPNVLKFIGVLYK
  • VLKFIGVLYKDK
  • CHGCSLLMTGP
  • GMAYLHSM
  • DPFPWQQKV
  • FSFGIVLCEIIG
  • IIHRDLN
  • SCFRCSECQ
  • DRILEING
  • KYHPECF
  • TLYCGKCHN
  • SQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVM

Post-translational modifications for LIMK2 Gene

  • Phosphorylated on serine and/or threonine residues by ROCK1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LIMK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for LIMK2 Gene

Gene Families for LIMK2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for LIMK2 Gene

InterPro:
Blocks:
  • PDZ/DHR/GLGF domain
  • Zn-binding protein, LIM
ProtoNet:

Suggested Antigen Peptide Sequences for LIMK2 Gene

GenScript: Design optimal peptide antigens:
  • LIM domain kinase 2 isoform 2a (B5BU33_HUMAN)
  • LIM domain kinase 2 (LIMK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P53671

UniProtKB/Swiss-Prot:

LIMK2_HUMAN :
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with LIMK2: view

Function for LIMK2 Gene

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  6. Cell Lines for research

Molecular function for LIMK2 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:8537403};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:8537403};.
GENATLAS Biochemistry:
LIM motif containing protein kinase 2,cytosolic,alternatively spliced in two isoforms LIMK2A and LIMK2B differentially regulated in a tissue specific manner

Enzyme Numbers (IUBMB) for LIMK2 Gene

Phenotypes From GWAS Catalog for LIMK2 Gene

Gene Ontology (GO) - Molecular Function for LIMK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,TAS 8537403
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0005515 protein binding IPI 22328514
genes like me logo Genes that share ontologies with LIMK2: view
genes like me logo Genes that share phenotypes with LIMK2: view

Animal Models for LIMK2 Gene

MGI Knock Outs for LIMK2:
  • Limk2 Limk2<tm1a(EUCOMM)Wtsi>
  • Limk2 Limk2<tm1.1Tnak>

Animal Models for research

  • Taconic Biosciences Mouse Models for LIMK2

miRNA for LIMK2 Gene

miRTarBase miRNAs that target LIMK2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIMK2

Clone products for research

  • Addgene plasmids for LIMK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIMK2 Gene

Localization for LIMK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIMK2 Gene

Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
[Isoform LIMK2a]: Cytoplasm. Nucleus.
[Isoform LIMK2b]: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Mainly present in the cytoplasm and is scarcely translocated to the nucleus. {ECO:0000269 PubMed:8954941}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIMK2 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3
plasma membrane 2
golgi apparatus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LIMK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,TAS 8954941
GO:0005737 cytoplasm IBA,TAS 8537403
GO:0005801 cis-Golgi network IEA --
GO:0005813 centrosome IDA 25849865
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with LIMK2: view

Pathways & Interactions for LIMK2 Gene

PathCards logo

SuperPathways for LIMK2 Gene

SuperPathway Contained pathways
1 Semaphorin interactions
Sema4D in semaphorin signaling
.89
Sema4D induced cell migration and growth-cone collapse
.89
RHO GTPases Activate ROCKs
.52
Semaphorin interactions
.40
2 Actin Nucleation by ARP-WASP Complex
Actin Nucleation and Branching
.66
CDC42 Pathway
.41
RhoA Pathway
.35
3 EPH-Ephrin signaling
EPH-Ephrin signaling
.51
EPHB-mediated forward signaling
.44
Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
.35
4 Apoptotic Pathways in Synovial Fibroblasts
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
5 fMLP Pathway
CCR3 Pathway in Eosinophils
.44
Internalin Pathway
.31
genes like me logo Genes that share pathways with LIMK2: view

Pathways by source for LIMK2 Gene

2 Sino Biological pathways for LIMK2 Gene
6 GeneGo (Thomson Reuters) pathways for LIMK2 Gene
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cytoskeleton remodeling CDC42 in cellular processes
  • Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
  • Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
  • Immune response CCR3 signaling in eosinophils
14 Qiagen pathways for LIMK2 Gene
  • Actin Nucleation and Branching
  • Actin-Based Motility by Rho Family GTPases
  • Breast Cancer Regulation by Stathmin1
  • CCR3 Pathway in Eosinophils
  • CDC42 Pathway
1 Cell Signaling Technology pathway for LIMK2 Gene

SIGNOR curated interactions for LIMK2 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LIMK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 25849865
GO:0006468 protein phosphorylation IDA 22328514
GO:0007283 spermatogenesis IEA --
GO:0016310 phosphorylation TAS 8537403
GO:0030036 actin cytoskeleton organization IBA 21873635
genes like me logo Genes that share ontologies with LIMK2: view

Drugs & Compounds for LIMK2 Gene

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(6) Drugs for LIMK2 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra 0
LIMKi 3 Pharma LIMK2 inhibitor, Potent LIM kinase inhibitor; antitumor 0

(4) Additional Compounds for LIMK2 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0
SR 7826
1219728-20-7
T 5601640
924473-59-6

(3) Tocris Compounds for LIMK2 Gene

Compound Action Cas Number
LIMKi 3 Potent LIM kinase inhibitor; antitumor 1338247-35-0
SR 7826 Potent and selective LIMK inhibitor; antitumor 1219728-20-7
T 5601640 Selective LIMK2 inhibitor; antitumor 924473-59-6

(1) ApexBio Compounds for LIMK2 Gene

Compound Action Cas Number
LIMKi 3 LIMK2 inhibitor 1338247-35-0
genes like me logo Genes that share compounds with LIMK2: view

Drug products for research

Transcripts for LIMK2 Gene

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mRNA/cDNA for LIMK2 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIMK2

Clone products for research

  • Addgene plasmids for LIMK2

Alternative Splicing Database (ASD) splice patterns (SP) for LIMK2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - - -
SP2: - - - - - - - - - - - - -
SP3: -
SP4:
SP5: - - - - - - -
SP6: - - -
SP7:
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - -
SP12:
SP13:
SP14:
SP15:

ExUns: 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - - -
SP3: -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for LIMK2 Gene

GeneLoc Exon Structure for
LIMK2

Expression for LIMK2 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIMK2 Gene

mRNA expression in normal human tissues for LIMK2 Gene
mRNA expression by GTEx for LIMK2 GenemRNA expression by BioGPS for LIMK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIMK2 Gene

This gene is overexpressed in Whole Blood (x11.5).

Protein differential expression in normal tissues from HIPED for LIMK2 Gene

This gene is overexpressed in Pancreatic juice (42.2), Placenta (12.6), and Heart (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LIMK2 Gene



Protein tissue co-expression partners for LIMK2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LIMK2

SOURCE GeneReport for Unigene cluster for LIMK2 Gene:

Hs.474596

Evidence on tissue expression from TISSUES for LIMK2 Gene

  • Lung(4.5)
  • Nervous system(4.5)
  • Skin(2.5)
  • Blood(2.3)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with LIMK2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIMK2 Gene

Orthologs for LIMK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIMK2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LIMK2 30 31
  • 99.27 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia LIMK2 30 31
  • 91.95 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia LIMK2 30 31
  • 90.13 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Limk2 30
  • 88.51 (n)
Mouse
(Mus musculus)
 Mammalia Limk2 30 17 31
  • 88.35 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia LIMK2 31
  • 86 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia LIMK2 31
  • 81 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves LIMK2 30 31
  • 79.47 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 35 (a)
 ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia limk2 30
  • 65.23 (n)
Zebrafish
(Danio rerio)
 Actinopterygii limk2 30 31
  • 68.13 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta LIMK1 31
  • 21 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea kin-21 31
  • 17 (a)
 ManyToMany
Y52D5A.2 31
  • 17 (a)
 ManyToMany
K09B11.5 31
  • 17 (a)
 ManyToMany
T25B9.5 31
  • 16 (a)
 ManyToMany
Y69E1A.3 31
  • 16 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 41 (a)
 OneToMany
Species where no ortholog for LIMK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LIMK2 Gene

ENSEMBL:
Gene Tree for LIMK2 (if available)
TreeFam:
Gene Tree for LIMK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LIMK2: view image

Paralogs for LIMK2 Gene

Paralogs for LIMK2 Gene

(9) SIMAP similar genes for LIMK2 Gene using alignment to 7 proteins:

  • LIMK2_HUMAN
  • B5BU33_HUMAN
  • B5MC51_HUMAN
  • C9JK61_HUMAN
  • E7EUC1_HUMAN
  • L8E7T4_HUMAN
  • L8E888_HUMAN

Pseudogenes.org Pseudogenes for LIMK2 Gene

genes like me logo Genes that share paralogs with LIMK2: view

Variants for LIMK2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LIMK2 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs114531016 Benign: not provided 31,267,889(+) G/A
NM_005569.4(LIMK2):c.1242G>A (p.Lys414=) 		SYNONYMOUS
rs2229874 - p.Arg381His
rs34875793 - p.Pro296Arg
rs34930775 - p.Arg213Cys
rs35422808 - p.Arg418Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LIMK2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LIMK2 Gene

Variant ID Type Subtype PubMed ID
esv2543296 CNV insertion 19546169
esv3436353 CNV duplication 20981092
nsv1110864 OTHER inversion 24896259
nsv1125754 CNV tandem duplication 24896259
nsv459871 CNV loss 19166990
nsv588893 CNV loss 21841781
nsv962787 CNV duplication 23825009

Variation tolerance for LIMK2 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.49; 71.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIMK2 Gene

Human Gene Mutation Database (HGMD)
LIMK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIMK2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIMK2 Gene

Disorders for LIMK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LIMK2 Gene - From: COP

Disorder Aliases PubMed IDs
williams-beuren syndrome
  • wbs
- elite association - COSMIC cancer census association via MalaCards
Search LIMK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LIMK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LIMK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIMK2 Gene

Publications for LIMK2 Gene

  1. Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs. (PMID: 8537403) Okano I … Mizuno K (The Journal of biological chemistry 1995) 2 3 4 23
  2. Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. (PMID: 11340065) Sumi T … Nakamura T (The Journal of biological chemistry 2001) 3 4 23
  3. Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. (PMID: 11018042) Sumi T … Nakamura T (The Journal of biological chemistry 2001) 3 4 23
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4
  5. Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking. (PMID: 25849865) Kim J … Kim J (Nature communications 2015) 3 4

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