Aliases for LIMK2 Gene
External Ids for LIMK2 Gene
- HGNC: 6614
- Entrez Gene: 3985
- Ensembl: ENSG00000182541
- OMIM: 601988
- UniProtKB: P53671
Previous GeneCards Identifiers for LIMK2 Gene
- GC22P028304
- GC22P029932
- GC22P031608
- GC22P014569
Summaries for LIMK2 Gene
-
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for LIMK2 Gene
LIMK2 (LIM Domain Kinase 2) is a Protein Coding gene. Among its related pathways are EGF/EGFR Signaling Pathway and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LIMK1.
UniProtKB/Swiss-Prot for LIMK2 Gene
-
Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.
-
LIM kinases (LIMKs), EC 2.7.11.1, are dual specificity kinases (serine/threonine and tyrosine), which phosphorylate and inactivate cofilin (a key regulator of actin cytoskeleton dynamics). There are two isoforms of LIMK: LIMK1 and LIMK2.
Additional gene information for LIMK2 Gene
- Monarch Initiative
- Search for LIMK2 at DataMed
- Search for LIMK2 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIMK2 Gene
Genomics for LIMK2 Gene
GeneHancer (GH) Regulatory Elements for LIMK2 Gene
Promoters and enhancers for LIMK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around LIMK2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LIMK2 gene promoter:
-
- LCR-F1
- Pax-6
- Tal-1beta
- E47
- HEN1
- c-Myc
- Max1
- NF-AT
- NF-AT1
- NF-AT2
Regulatory Element Products
Genomic Locations for LIMK2 Gene
Genomic Locations for LIMK2 Gene
- chr22:31,212,239-31,280,080
- (GRCh38/hg38)
- Size:
- 67,842 bases
- Orientation:
- Plus strand
- chr22:31,608,225-31,676,066
- (GRCh37/hg19)
- Size:
- 67,842 bases
- Orientation:
- Plus strand
Genomic View for LIMK2 Gene
Genes around LIMK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.2 by Entrez Gene
- 22q12.2 by HGNC
- 22q12.2 by Ensembl
LIMK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LIMK2 Gene
Proteins for LIMK2 Gene
-
Protein details for LIMK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P53671-LIMK2_HUMAN
- Recommended name:
- LIM domain kinase 2
- Protein Accession:
- P53671
- A8K6H5
- Q7KZ80
- Q7L3H5
- Q96E10
- Q99464
- Q9UFU0
Protein attributes for LIMK2 Gene
- Size:
- 638 amino acids
- Molecular mass:
- 72232 Da
- Quaternary structure:
-
- Binds ROCK1 and MARF1 (Ref.9, PubMed:11018042, PubMed:10436159). Interacts with PARD3. Interacts with NISCH (By similarity).
- SequenceCaution:
-
- Sequence=AAB54055.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for LIMK2 Gene
Post-translational modifications for LIMK2 Gene
- Phosphorylated on serine and/or threonine residues by ROCK1.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for LIMK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for LIMK2
- Novus Biologicals Antibodies for LIMK2
-
Abcam antibodies for LIMK2
- Invitrogen Antibodies for LIMK2
- GeneTex LIMK2 Antibody for LIMK2
-
Santa Cruz Biotechnology (SCBT) Antibodies for LIMK2
Protein Products
-
OriGene Purified Proteins for LIMK2
- Search Origene for MassSpec and Protein Over-expression Lysates for LIMK2
- Origene Custom Protein Services for LIMK2
- Search GeneTex for Proteins for LIMK2
-
Abcam proteins for LIMK2
Assay Products
No data available for DME Specific Peptides for LIMK2 Gene
Domains & Families for LIMK2 Gene
Gene Families for LIMK2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for LIMK2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for LIMK2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P53671UniProtKB/Swiss-Prot:
LIMK2_HUMAN :- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
- Family:
-
- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Function for LIMK2 Gene
Molecular function for LIMK2 Gene
- UniProtKB/Swiss-Prot Function:
- Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- GENATLAS Biochemistry:
- LIM motif containing protein kinase 2,cytosolic,alternatively spliced in two isoforms LIMK2A and LIMK2B differentially regulated in a tissue specific manner
Enzyme Numbers (IUBMB) for LIMK2 Gene
Phenotypes From GWAS Catalog for LIMK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | TAS | 8537403 |
| GO:0004871 | obsolete signal transducer activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 22939624 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for LIMK2 Gene
- MGI mutant phenotypes for LIMK2:
-
inferred from 5 alleles
- cardiovascular system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- endocrine/exocrine gland phenotype
- cellular phenotype
- craniofacial phenotype
- reproductive system phenotype
- skeleton phenotype
- hearing/vestibular/ear phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for LIMK2:
-
- Increased HPV18 LCR reporter activity
- Decreased substrate adherent cell growth
- Decreased shRNA abundance (Z-score < -2)
- Increased epidermal growth factor receptor (EGFR) surface abundance
- Increased shRNA abundance (Z-score > 2)
- Decreased HIV-1 infection
- Decreased ionizing radiation sensitivity
- Decreased cell migration
- Increased cell viability after pRB stimulation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased viability after Maraba virus infection
- Increased cell number in S
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
Animal Models for LIMK2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for LIMK2
- Cyagen custom Knockout/knockin (KOKI) mouse models for LIMK2
-
CRISPR Products
-
OriGene CRISPR knockouts for LIMK2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LIMK2
- genomics-online: gRNA clones - Search results for 152 available LIMK2 gene related products
- Overview of 152 available LIMK2 gene related products
-
Recommended
- Applied Biological Materials CRISPR for LIMK2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LIMK2
- GenScript: Design CRISPR guide RNA sequences for LIMK2
miRNA for LIMK2 Gene
- miRTarBase miRNAs that target LIMK2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for LIMK2
- Browse OriGene Inhibitory RNA Products For LIMK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIMK2
- genomics-online: shRNA clones - Search results for 152 available LIMK2 gene related products
- Overview of 152 available LIMK2 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for LIMK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LIMK2
- VectorBuilder custom plasmid, inducible vectors for LIMK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LIMK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LIMK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LIMK2
- genomics-online: cdna clones - Search results for 152 available LIMK2 gene related products
- Overview of 152 available LIMK2 gene related products
-
Recommended
- orf clones - Search results for 152 available LIMK2 gene related products
- Overview of 152 available LIMK2 gene related products
-
Recommended
- Applied Biological Materials Clones for LIMK2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LIMK2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIMK2 Gene
Localization for LIMK2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LIMK2 Gene
- Isoform LIMK2a: Cytoplasm. Nucleus. Note=Isoform LIMK2a is distributed in the cytoplasm and the nucleus.
- Isoform LIMK2b: Cytoplasm. Nucleus. Note=Isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| cytoskeleton | 2 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 8954941 |
| GO:0005737 | cytoplasm | TAS | 8537403 |
| GO:0005801 | cis-Golgi network | IEA | -- |
Pathways & Interactions for LIMK2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Semaphorin interactions | ||
| 2 | Actin Nucleation by ARP-WASP Complex |
.41
|
.35
|
| 3 | EPH-Ephrin signaling | ||
| 4 | Apoptotic Pathways in Synovial Fibroblasts |
.65
|
|
| 5 | fMLP Pathway | ||
Pathways by source for LIMK2 Gene
1 Sino Biological pathway for LIMK2 Gene
5 BioSystems pathways for LIMK2 Gene
11 Reactome pathways for LIMK2 Gene
3 KEGG pathways for LIMK2 Gene
6 GeneGo (Thomson Reuters) pathways for LIMK2 Gene
- Cell adhesion Integrin-mediated cell adhesion and migration
- Cytoskeleton remodeling CDC42 in cellular processes
- Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
- Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
- Immune response CCR3 signaling in eosinophils
14 Qiagen pathways for LIMK2 Gene
1 Cell Signaling Technology pathway for LIMK2 Gene
Interacting Proteins for LIMK2 Gene
Selected Interacting proteins:
P53671-LIMK2_HUMAN
ENSP00000339916
for LIMK2 Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for LIMK2
SIGNOR curated interactions for LIMK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
| GO:0016310 | phosphorylation | TAS | 8537403 |
| GO:0035556 | intracellular signal transduction | IBA | -- |
| GO:0042325 | regulation of phosphorylation | IEA | -- |
Drugs & Compounds for LIMK2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 | ||
| LIMKi 3 | Pharma | LIMK2 inhibitor, Potent LIM kinase inhibitor; antitumor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
||
| SR 7826 |
|
1219728-20-7 |
|
|
||
| T 5601640 |
|
924473-59-6 |
|
|
(3) Tocris Compounds for LIMK2 Gene
Drug Products
Transcripts for LIMK2 Gene
mRNA/cDNA for LIMK2 Gene
- (3) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (710) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000462625 1042 bps (uc062dif.1)
- ENST00000406516 2657 bps (uc062dig.1)
- ENST00000331728 3670 bps (uc003akh.4)
- ENST00000425203 606 bps (uc062dii.1)
- ENST00000333611 3462 bps (uc003akk.4)
Unigene Clusters for LIMK2 Gene
- LIM domain kinase 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for LIMK2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LIMK2
- genomics-online: gRNA clones - Search results for 152 available LIMK2 gene related products
- Overview of 152 available LIMK2 gene related products
-
Recommended
- Applied Biological Materials CRISPR for LIMK2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LIMK2
- GenScript: Design CRISPR guide RNA sequences for LIMK2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for LIMK2
- Browse OriGene Inhibitory RNA Products For LIMK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIMK2
- genomics-online: shRNA clones - Search results for 152 available LIMK2 gene related products
- Overview of 152 available LIMK2 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for LIMK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LIMK2
- VectorBuilder custom plasmid, inducible vectors for LIMK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LIMK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LIMK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LIMK2
- genomics-online: cdna clones - Search results for 152 available LIMK2 gene related products
- Overview of 152 available LIMK2 gene related products
-
Recommended
- orf clones - Search results for 152 available LIMK2 gene related products
- Overview of 152 available LIMK2 gene related products
-
Recommended
- Applied Biological Materials Clones for LIMK2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: |
| ExUns: | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||
| SP3: | - | ||||||||||||||||||
| SP4: | - | - | |||||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | |||||||||||||||||||
| SP7: | |||||||||||||||||||
| SP8: | |||||||||||||||||||
| SP9: | |||||||||||||||||||
| SP10: | |||||||||||||||||||
| SP11: | |||||||||||||||||||
| SP12: | |||||||||||||||||||
| SP13: | |||||||||||||||||||
| SP14: | |||||||||||||||||||
| SP15: |
Expression for LIMK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- T Helper Cells Peripheral Blood
- T-Cytotoxic Cells Peripheral Blood
- Hematopoietic Bone Marrow
- Brain (Nervous System)
-
Eye (Sensory Organs)
- Cholinergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- Cholinergic Amacrine Cells Inner Nuclear Layer
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Trophoblast (Extraembryonic Tissues)
- Mural Trophectoderm Cells Mural Trophectoderm
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for LIMK2 Gene
This gene is overexpressed in Whole Blood (x11.5).
This gene is overexpressed in Pancreatic juice (42.2), Placenta (12.6), and Heart (11.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LIMK2 Gene
NURSA nuclear receptor signaling pathways regulating expression of LIMK2 Gene:
LIMK2SOURCE GeneReport for Unigene cluster for LIMK2 Gene:
Hs.474596mRNA Expression by UniProt/SwissProt for LIMK2 Gene:
P53671-LIMK2_HUMAN
Tissue specificity:
Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed.
Evidence on tissue expression from TISSUES for LIMK2 Gene
- Lung(4.5)
- Nervous system(4.4)
Primer Products
-
OriGene qPCR primer pairs and template standards for LIMK2
-
OriGene qPCR primer pairs for LIMK2
- genomics-online: primer clones - Search results for 152 available LIMK2 gene related products
- Overview of 152 available LIMK2 gene related products
-
Recommended
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LIMK2 Gene
Orthologs for LIMK2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LIMK2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LIMK2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | LIMK2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Limk2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Limk2 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | LIMK2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | LIMK2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LIMK2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | limk2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | limk2 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | LIMK1 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | kin-21 34 |
|
ManyToMany | |
| Y52D5A.2 34 |
|
ManyToMany | |||
| K09B11.5 34 |
|
ManyToMany | |||
| T25B9.5 34 |
|
ManyToMany | |||
| Y69E1A.3 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for LIMK2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for LIMK2 Gene
- ENSEMBL:
- Gene Tree for LIMK2 (if available)
- TreeFam:
- Gene Tree for LIMK2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LIMK2: view image
Paralogs for LIMK2 Gene
(9) SIMAP similar genes for LIMK2 Gene using alignment to 7 proteins:
- LIMK2_HUMAN
- B5BU33_HUMAN
- B5MC51_HUMAN
- C9JK61_HUMAN
- E7EUC1_HUMAN
- L8E7T4_HUMAN
- L8E888_HUMAN
Pseudogenes.org Pseudogenes for LIMK2 Gene
Variants for LIMK2 Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000015860 | -- | 31,212,744(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000068151 | -- | 31,212,454(+) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000084059 | -- | 31,271,243(+) | C/G | intron_variant | |
| rs1000139953 | -- | 31,264,502(+) | G/A | intron_variant | |
| rs1000151162 | -- | 31,218,941(+) | G/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2543296 | CNV | insertion | 19546169 |
| esv3436353 | CNV | duplication | 20981092 |
| nsv1110864 | OTHER | inversion | 24896259 |
| nsv1125754 | CNV | tandem duplication | 24896259 |
| nsv459871 | CNV | loss | 19166990 |
| nsv588893 | CNV | loss | 21841781 |
| nsv962787 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.49;
71.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LIMK2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIMK2 Gene
Disorders for LIMK2 Gene
Additional Disease Information for LIMK2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for LIMK2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIMK2 Gene
Publications for LIMK2 Gene
- Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs. (PMID: 8537403) Okano I … Mizuno K (The Journal of biological chemistry 1995) 2 3 4 22 58
- Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. (PMID: 11018042) Sumi T … Nakamura T (The Journal of biological chemistry 2001) 3 4 22 58
- Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. (PMID: 11340065) Sumi T … Nakamura T (The Journal of biological chemistry 2001) 3 4 22 58
- The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4 58
- A genome-wide association study for diabetic nephropathy genes in African Americans. (PMID: 21150874) McDonough CW … Bowden DW (Kidney international 2011) 3 44 58
Products for LIMK2 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LIMK2
- antibodies-online: Search results for 138 available LIMK2 Antibodies ranked by validation data
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Sources for LIMK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
- (144) ProteoGenix
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- (146) TISSUES
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- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
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- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
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- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt