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Aliases for LILRB5 Gene

Aliases for LILRB5 Gene

  • Leukocyte Immunoglobulin Like Receptor B5 2 3 5
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 5 2 3
  • Leukocyte Immunoglobulin-Like Receptor 8 3 4
  • CD85 Antigen-Like Family Member C 3 4
  • Leucocyte Ig-Like Receptor B5 2 3
  • LIR-8 3 4
  • LIR8 3 4
  • Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 5 3
  • CD85c Antigen 4
  • CD85C 3

External Ids for LILRB5 Gene

Previous GeneCards Identifiers for LILRB5 Gene

  • GC19M055617
  • GC19M055178
  • GC19M059430
  • GC19M059446
  • GC19M054754
  • GC19M051081
  • GC19M054261
  • GC19M054278

Summaries for LILRB5 Gene

Entrez Gene Summary for LILRB5 Gene

  • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LILRB5 Gene

LILRB5 (Leukocyte Immunoglobulin Like Receptor B5) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Osteoclast differentiation. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is LILRB2.

UniProtKB/Swiss-Prot for LILRB5 Gene

  • May act as receptor for class I MHC antigens.

Gene Wiki entry for LILRB5 Gene

Additional gene information for LILRB5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRB5 Gene

Genomics for LILRB5 Gene

GeneHancer (GH) Regulatory Elements for LILRB5 Gene

Promoters and enhancers for LILRB5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054257 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.7 +0.0 15 0.1 LILRB5 GC19M054340
GH19J054258 Enhancer 0.4 Ensembl dbSUPER 650.7 +0.2 207 0.2 LILRB5 GC19M054340
GH19J054199 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 41.5 +51.6 51598 12.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS9 PRPF31 LENG8 CNOT3 LENG8-AS1 ZNF525 ZNF845 ENSG00000235681 LILRB5 ZNF765
GH19J054186 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 +67.7 67686 6.8 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 TSEN34 MBOAT7 PRPF31 ZNF665 ZNF677 LENG8 LENG8-AS1 CNOT3 ZNF845 ZNF525
GH19J054282 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -25.6 -25641 1.1 KLF1 POLR2A IKZF1 LILRB2 MIR4752 LILRB3 LAIR1 LILRA6 LILRB5 ENSG00000249189 OSCAR MYADM VSTM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LILRB5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LILRB5 gene promoter:
  • AML1a
  • Hlf
  • GCNF
  • GCNF-1
  • GCNF-2
  • ER-alpha
  • E47
  • POU2F1a
  • POU2F1

Genomic Locations for LILRB5 Gene

Genomic Locations for LILRB5 Gene
7,878 bases
Minus strand
6,905 bases
Minus strand

Genomic View for LILRB5 Gene

Genes around LILRB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRB5 Gene

Proteins for LILRB5 Gene

  • Protein details for LILRB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily B member 5
    Protein Accession:
    Secondary Accessions:
    • Q8N760

    Protein attributes for LILRB5 Gene

    590 amino acids
    Molecular mass:
    64126 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LILRB5 Gene


neXtProt entry for LILRB5 Gene

Post-translational modifications for LILRB5 Gene

  • Glycosylation at isoforms=2, 3339, posLast=279279, and posLast=139139
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for LILRB5 (LILRB5/CD85c/LIR-8)
  • Boster Bio Antibodies for LILRB5

No data available for DME Specific Peptides for LILRB5 Gene

Domains & Families for LILRB5 Gene

Gene Families for LILRB5 Gene

Protein Domains for LILRB5 Gene

Suggested Antigen Peptide Sequences for LILRB5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
genes like me logo Genes that share domains with LILRB5: view

Function for LILRB5 Gene

Molecular function for LILRB5 Gene

UniProtKB/Swiss-Prot Function:
May act as receptor for class I MHC antigens.
GENATLAS Biochemistry:
leukocyte immunoglobulin-like receptor,subfamily B,member 5,expressed restrictively on natural killer cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily

Phenotypes From GWAS Catalog for LILRB5 Gene

Gene Ontology (GO) - Molecular Function for LILRB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9548455
genes like me logo Genes that share ontologies with LILRB5: view

Phenotypes for LILRB5 Gene

genes like me logo Genes that share phenotypes with LILRB5: view

Animal Model Products

miRNA for LILRB5 Gene

miRTarBase miRNAs that target LILRB5

Clone Products

  • R&D Systems cDNA Clones for LILRB5 (LILRB5/CD85c/LIR-8)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRB5 Gene

Localization for LILRB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRB5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRB5 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for LILRB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LILRB5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LILRB5 Gene

Pathways & Interactions for LILRB5 Gene

genes like me logo Genes that share pathways with LILRB5: view

Pathways by source for LILRB5 Gene

Gene Ontology (GO) - Biological Process for LILRB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006952 defense response TAS 9548455
GO:0007166 cell surface receptor signaling pathway TAS 9548455
genes like me logo Genes that share ontologies with LILRB5: view

No data available for SIGNOR curated interactions for LILRB5 Gene

Drugs & Compounds for LILRB5 Gene

(7) Drugs for LILRB5 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anticholesteremic Agents Pharma 2147
Antimetabolites Pharma 12587
Atorvastatin Calcium Pharma HMG-CoA reductase inhibitor 793
Calcium, Dietary Pharma 6089
Hydroxymethylglutaryl-CoA Reductase Inhibitors Pharma 2090
genes like me logo Genes that share compounds with LILRB5: view

Transcripts for LILRB5 Gene

mRNA/cDNA for LILRB5 Gene

(8) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRB5 Gene

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for LILRB5 (LILRB5/CD85c/LIR-8)

Alternative Splicing Database (ASD) splice patterns (SP) for LILRB5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP4: - - -
SP5: -
SP6: - -
SP8: -

Relevant External Links for LILRB5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LILRB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LILRB5 Gene

mRNA differential expression in normal tissues according to GTEx for LILRB5 Gene

This gene is overexpressed in Spleen (x12.4), Adipose - Visceral (Omentum) (x4.9), and Adipose - Subcutaneous (x4.1).

Protein differential expression in normal tissues from HIPED for LILRB5 Gene

This gene is overexpressed in Serum (50.4) and Gallbladder (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRB5 Gene

NURSA nuclear receptor signaling pathways regulating expression of LILRB5 Gene:


SOURCE GeneReport for Unigene cluster for LILRB5 Gene:


mRNA Expression by UniProt/SwissProt for LILRB5 Gene:

Tissue specificity: Detected in a natural killer (NK) cells.

Evidence on tissue expression from TISSUES for LILRB5 Gene

  • Spleen(4.5)
  • Intestine(4.4)
  • Liver(4.4)
  • Blood(4.3)
  • Bone marrow(4.1)
  • Pancreas(4.1)
  • Muscle(2.6)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with LILRB5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LILRB5 Gene

Orthologs for LILRB5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRB5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LILRB5 34 33
  • 95.76 (n)
(Bos Taurus)
Mammalia LOC510520 33
  • 74.35 (n)
-- 34
  • 63 (a)
-- 34
  • 56 (a)
  • 55 (a)
-- 34
  • 53 (a)
-- 34
  • 50 (a)
-- 34
  • 49 (a)
-- 34
  • 46 (a)
-- 34
  • 45 (a)
-- 34
  • 40 (a)
-- 34
  • 39 (a)
-- 34
  • 38 (a)
(Canis familiaris)
Mammalia -- 34
  • 52 (a)
-- 34
  • 49 (a)
(Mus musculus)
Mammalia Lilra5 34
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 18 (a)
Species where no ortholog for LILRB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRB5 Gene

Gene Tree for LILRB5 (if available)
Gene Tree for LILRB5 (if available)
Evolutionary constrained regions (ECRs) for LILRB5: view image

Paralogs for LILRB5 Gene

Variants for LILRB5 Gene

Sequence variations from dbSNP and Humsavar for LILRB5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000067660 -- 54,253,845(-) C/G intron_variant
rs1000234223 -- 54,257,705(-) G/T upstream_transcript_variant
rs1000678478 -- 54,258,299(-) C/T upstream_transcript_variant
rs1001068589 -- 54,257,578(-) C/T upstream_transcript_variant
rs1001767992 -- 54,258,933(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LILRB5 Gene

Variant ID Type Subtype PubMed ID
dgv1074e212 CNV gain 25503493
dgv3654n100 CNV gain 25217958
dgv3655n100 CNV gain 25217958
dgv3656n100 CNV gain 25217958
dgv3657n100 CNV gain 25217958
dgv3658n100 CNV gain+loss 25217958
dgv3659n100 CNV gain+loss 25217958
dgv3660n100 CNV gain 25217958
dgv3661n100 CNV gain+loss 25217958
dgv3662n100 CNV gain 25217958
dgv434n27 CNV gain 19166990
dgv6549n54 CNV gain 21841781
esv1003658 CNV gain 20482838
esv2718812 CNV deletion 23290073
esv2718860 CNV deletion 23290073
esv2718863 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv2760520 CNV gain+loss 21179565
esv2763032 CNV gain+loss 21179565
esv3574853 CNV gain 25503493
nsv1057076 CNV loss 25217958
nsv183 CNV deletion 15895083
nsv2546 CNV deletion 18451855
nsv2548 CNV insertion 18451855
nsv428371 CNV gain+loss 18775914
nsv435704 CNV deletion 17901297
nsv510774 CNV deletion 20534489
nsv528370 CNV loss 19592680
nsv580191 CNV gain 21841781
nsv580192 CNV gain+loss 21841781
nsv580193 CNV gain 21841781
nsv580227 CNV loss 21841781
nsv817870 CNV gain 17921354
nsv953615 CNV deletion 24416366

Variation tolerance for LILRB5 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.19; 90.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LILRB5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRB5 Gene

Disorders for LILRB5 Gene

Additional Disease Information for LILRB5

No disorders were found for LILRB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRB5 Gene

Publications for LILRB5 Gene

  1. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PMID: 9548455) Borges L … Cosman D (Journal of immunology (Baltimore, Md. : 1950) 1997) 2 3 4 58
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Expression of the innate immune receptor LILRB5 on monocytes is associated with mycobacteria exposure. (PMID: 26908331) Hogan LE … Allen RL (Scientific reports 2016) 3 58

Products for LILRB5 Gene

Sources for LILRB5 Gene

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