This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs ... See more...

Aliases for LILRB5 Gene

Aliases for LILRB5 Gene

  • Leukocyte Immunoglobulin Like Receptor B5 2 3 5
  • LIR-8 2 3 4
  • LIR8 2 3 4
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 5 2 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 5 3 4
  • Leukocyte Immunoglobulin-Like Receptor 8 3 4
  • CD85 Antigen-Like Family Member C 3 4
  • Leucocyte Ig-Like Receptor B5 2 3
  • CD85c Antigen 4
  • LILRB5 5
  • CD85C 3
  • CD85c 2

External Ids for LILRB5 Gene

Previous GeneCards Identifiers for LILRB5 Gene

  • GC19M055617
  • GC19M055178
  • GC19M059430
  • GC19M059446
  • GC19M054754
  • GC19M051081
  • GC19M054261
  • GC19M054278
  • GC19M054283
  • GC19M054360
  • GC19M054388

Summaries for LILRB5 Gene

Entrez Gene Summary for LILRB5 Gene

  • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LILRB5 Gene

LILRB5 (Leukocyte Immunoglobulin Like Receptor B5) is a Protein Coding gene. Diseases associated with LILRB5 include Trichohepatoenteric Syndrome 2. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is LILRB2.

UniProtKB/Swiss-Prot Summary for LILRB5 Gene

Gene Wiki entry for LILRB5 Gene

Additional gene information for LILRB5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LILRB5 Gene

Genomics for LILRB5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LILRB5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054257 Promoter/Enhancer 0.5 EPDnew dbSUPER 600.7 +0.0 8 0.1 LILRB5 NONHSAG026507.2 LILRA6
GH19J054258 Promoter/Enhancer 0.5 Ensembl dbSUPER 600.7 +0.6 600 1 LILRB5 NONHSAG026507.2 LILRA6
GH19J054199 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 41.6 +51.7 51712 12.4 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 RPS9 PRPF31 LENG8-AS1 LENG8 CNOT3 ZNF525 ENSG00000235681 ZNF845 ZNF761 ZNF765
GH19J054260 Enhancer 0.2 Ensembl 600.7 -1.2 -1200 0.2 LILRB5 RNU6-1307P RF00026-515 LILRB2
GH19J054186 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 +67.7 67679 6.8 SP1 HNRNPL CREB1 PRDM10 ZNF629 TFE3 LEF1 IKZF1 NFKBIZ ZNF692 TSEN34 MBOAT7 lnc-TMC4-2 PRPF31 ZNF665 LENG8 LENG8-AS1 CNOT3 ZNF845 ZNF525
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LILRB5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LILRB5

Top Transcription factor binding sites by QIAGEN in the LILRB5 gene promoter:
  • AML1a
  • E47
  • ER-alpha
  • GCNF
  • GCNF-1
  • GCNF-2
  • Hlf
  • POU2F1
  • POU2F1a

Genomic Locations for LILRB5 Gene

Genomic Locations for LILRB5 Gene
chr19:54,249,421-54,257,301
(GRCh38/hg38)
Size:
7,881 bases
Orientation:
Minus strand
chr19:54,754,263-54,761,167
(GRCh37/hg19)
Size:
6,905 bases
Orientation:
Minus strand

Genomic View for LILRB5 Gene

Genes around LILRB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRB5 Gene

Proteins for LILRB5 Gene

  • Protein details for LILRB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75023-LIRB5_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily B member 5
    Protein Accession:
    O75023
    Secondary Accessions:
    • Q8N760

    Protein attributes for LILRB5 Gene

    Size:
    590 amino acids
    Molecular mass:
    64126 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LILRB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRB5 Gene

Post-translational modifications for LILRB5 Gene

  • Glycosylation at Asn139, Asn279, and Asn339
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LILRB5 Gene

Domains & Families for LILRB5 Gene

Gene Families for LILRB5 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for LILRB5 Gene

Suggested Antigen Peptide Sequences for LILRB5 Gene

GenScript: Design optimal peptide antigens:
  • Leukocyte immunoglobulin-like receptor 8 (LIRB5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75023

UniProtKB/Swiss-Prot:

LIRB5_HUMAN :
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain:
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
genes like me logo Genes that share domains with LILRB5: view

Function for LILRB5 Gene

Molecular function for LILRB5 Gene

UniProtKB/Swiss-Prot Function:
May act as receptor for class I MHC antigens.
GENATLAS Biochemistry:
leukocyte immunoglobulin-like receptor,subfamily B,member 5,expressed restrictively on natural killer cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily

Phenotypes From GWAS Catalog for LILRB5 Gene

Gene Ontology (GO) - Molecular Function for LILRB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9548455
genes like me logo Genes that share ontologies with LILRB5: view

Phenotypes for LILRB5 Gene

GenomeRNAi human phenotypes for LILRB5:
genes like me logo Genes that share phenotypes with LILRB5: view

Animal Model Products

CRISPR Products

miRNA for LILRB5 Gene

miRTarBase miRNAs that target LILRB5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LILRB5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRB5 Gene

Localization for LILRB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRB5 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRB5 gene
Compartment Confidence
plasma membrane 3
nucleus 2
extracellular 1
endoplasmic reticulum 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for LILRB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LILRB5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LILRB5 Gene

Pathways & Interactions for LILRB5 Gene

genes like me logo Genes that share pathways with LILRB5: view

Gene Ontology (GO) - Biological Process for LILRB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006952 defense response TAS 9548455
GO:0007166 cell surface receptor signaling pathway TAS 9548455
genes like me logo Genes that share ontologies with LILRB5: view

No data available for SIGNOR curated interactions for LILRB5 Gene

Drugs & Compounds for LILRB5 Gene

(6) Drugs for LILRB5 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atorvastatin Approved Pharma Inhibitor, Competitive 893
Anticholesteremic Agents Pharma 2192
Antimetabolites Pharma 12215
Hydroxymethylglutaryl-CoA Reductase Inhibitors Pharma 2271
Hypolipidemic Agents Pharma 2916
genes like me logo Genes that share compounds with LILRB5: view

Transcripts for LILRB5 Gene

mRNA/cDNA for LILRB5 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LILRB5

Alternative Splicing Database (ASD) splice patterns (SP) for LILRB5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4: - - -
SP5: -
SP6: - -
SP7:
SP8: -

Relevant External Links for LILRB5 Gene

GeneLoc Exon Structure for
LILRB5

Expression for LILRB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LILRB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Spleen (Hematopoietic System)

mRNA differential expression in normal tissues according to GTEx for LILRB5 Gene

This gene is overexpressed in Spleen (x12.4), Adipose - Visceral (Omentum) (x4.9), and Adipose - Subcutaneous (x4.1).

Protein differential expression in normal tissues from HIPED for LILRB5 Gene

This gene is overexpressed in Serum (50.4) and Gallbladder (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRB5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LILRB5

SOURCE GeneReport for Unigene cluster for LILRB5 Gene:

Hs.655338

mRNA Expression by UniProt/SwissProt for LILRB5 Gene:

O75023-LIRB5_HUMAN
Tissue specificity: Detected in a natural killer (NK) cells.

Evidence on tissue expression from TISSUES for LILRB5 Gene

  • Spleen(4.6)
  • Liver(4.5)
  • Intestine(4.4)
  • Blood(4.4)
  • Bone marrow(4.3)
  • Pancreas(4.1)
  • Muscle(2.7)
  • Stomach(2.4)
  • Kidney(2.3)
  • Heart(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with LILRB5: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LILRB5 Gene

Orthologs for LILRB5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRB5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LILRB5 30 31
  • 95.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC510520 30
  • 74.35 (n)
-- 31
  • 63 (a)
ManyToMany
-- 31
  • 56 (a)
ManyToMany
LILRA4 31
  • 55 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 52 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Lilra5 31
  • 44 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 18 (a)
OneToMany
Species where no ortholog for LILRB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LILRB5 Gene

ENSEMBL:
Gene Tree for LILRB5 (if available)
TreeFam:
Gene Tree for LILRB5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LILRB5: view image

Paralogs for LILRB5 Gene

Variants for LILRB5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LILRB5 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs12975366 - p.Asp247Gly

Additional dbSNP identifiers (rs#s) for LILRB5 Gene

Structural Variations from Database of Genomic Variants (DGV) for LILRB5 Gene

Variant ID Type Subtype PubMed ID
dgv1074e212 CNV gain 25503493
dgv3654n100 CNV gain 25217958
dgv3655n100 CNV gain 25217958
dgv3656n100 CNV gain 25217958
dgv3657n100 CNV gain 25217958
dgv3658n100 CNV gain+loss 25217958
dgv3659n100 CNV gain+loss 25217958
dgv3660n100 CNV gain 25217958
dgv3661n100 CNV gain+loss 25217958
dgv3662n100 CNV gain 25217958
dgv434n27 CNV gain 19166990
dgv6549n54 CNV gain 21841781
esv1003658 CNV gain 20482838
esv2718812 CNV deletion 23290073
esv2718860 CNV deletion 23290073
esv2718863 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv2760520 CNV gain+loss 21179565
esv2763032 CNV gain+loss 21179565
esv3574853 CNV gain 25503493
nsv1057076 CNV loss 25217958
nsv183 CNV deletion 15895083
nsv2546 CNV deletion 18451855
nsv2548 CNV insertion 18451855
nsv428371 CNV gain+loss 18775914
nsv435704 CNV deletion 17901297
nsv510774 CNV deletion 20534489
nsv528370 CNV loss 19592680
nsv580191 CNV gain 21841781
nsv580192 CNV gain+loss 21841781
nsv580193 CNV gain 21841781
nsv580227 CNV loss 21841781
nsv817870 CNV gain 17921354
nsv953615 CNV deletion 24416366

Variation tolerance for LILRB5 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.19; 90.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LILRB5 Gene

Human Gene Mutation Database (HGMD)
LILRB5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LILRB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRB5 Gene

Disorders for LILRB5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LILRB5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
trichohepatoenteric syndrome 2
  • thes2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LILRB5

genes like me logo Genes that share disorders with LILRB5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LILRB5 Gene

Publications for LILRB5 Gene

  1. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PMID: 9548455) Borges L … Cosman D (Journal of immunology (Baltimore, Md. : 1950) 1997) 2 3 4
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Expression of the innate immune receptor LILRB5 on monocytes is associated with mycobacteria exposure. (PMID: 26908331) Hogan LE … Allen RL (Scientific reports 2016) 3

Products for LILRB5 Gene

  • Signalway ELISA kits for LILRB5

Sources for LILRB5 Gene