This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs ... See more...

Aliases for LILRB1 Gene

Aliases for LILRB1 Gene

  • Leukocyte Immunoglobulin Like Receptor B1 2 3 5
  • LIR-1 2 3 4
  • MIR-7 2 3 4
  • ILT2 2 3 4
  • LIR1 2 3 4
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 1 2 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 3 4
  • Monocyte/Macrophage Immunoglobulin-Like Receptor 7 3 4
  • CD85 Antigen-Like Family Member J 3 4
  • Myeloid Inhibitory Receptor 7 2 3
  • Leucocyte Ig-Like Receptor B1 2 3
  • ILT-2 3 4
  • PIR-B 2 3
  • MIR7 3 4
  • PIRB 2 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 Soluble Isoform 3
  • Leukocyte Immunoglobulin-Like Receptor 1 4
  • Immunoglobulin-Like Transcript 2 4
  • Ig-Like Transcript 2 3
  • CD85j Antigen 4
  • LILRB1 5
  • CD85J 3
  • CD85j 2
  • CD85 2

External Ids for LILRB1 Gene

Previous GeneCards Identifiers for LILRB1 Gene

  • GC19P055947
  • GC19P055510
  • GC19P059761
  • GC19P059776
  • GC19P059820
  • GC19P055085
  • GC19P051451
  • GC19P054574
  • GC19P054617

Summaries for LILRB1 Gene

Entrez Gene Summary for LILRB1 Gene

  • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LILRB1 Gene

LILRB1 (Leukocyte Immunoglobulin Like Receptor B1) is a Protein Coding gene. Diseases associated with LILRB1 include Alzheimer Disease 12 and Severe Pre-Eclampsia. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein phosphatase 1 binding. An important paralog of this gene is LILRB2.

UniProtKB/Swiss-Prot Summary for LILRB1 Gene

  • Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:29262349, PubMed:19304799). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251).

Gene Wiki entry for LILRB1 Gene

Additional gene information for LILRB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LILRB1 Gene

Genomics for LILRB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LILRB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054615 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 612.1 +1.2 1191 4.6 SP1 POLR2A BACH1 STAT3 RELA SMAD5 TCF12 IKZF2 RCOR1 TRIM22 LILRB1 LILRA2 KIR3DX1 LILRP2 LILRB2 piR-30791-044 LILRB4
GH19J054629 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 611.6 +13.9 13891 1.6 POLR2A LILRB1 KIR3DX1 LILRB2 piR-30791-044 NONHSAG026538.2 LILRB4
GH19J054661 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE 10 +45.7 45651 3.6 SP1 IKZF2 POLR2A EED ARID3A DPF2 RELB RUNX3 BCL11A IKZF1 LILRB4 FCAR LAIR1 KIR3DX1 LILRB2 KIR2DL3 LILRB1 LILRA5 LILRB3 LILRA1
GH19J054642 Promoter/Enhancer 1.2 EPDnew FANTOM5 Ensembl ENCODE 13.7 +26.6 26571 4.2 NFE2 ZNF316 PRDM10 MAFK LILRB4 MN297616 MIR8061 lnc-LILRB4-1 LILRA1 LILRA2 LAIR1 FCAR LILRB1 LILRB3
GH19J054199 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.2 -411.3 -411341 12.4 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 RPS9 PRPF31 LENG8-AS1 LENG8 CNOT3 ZNF525 ENSG00000235681 ZNF845 ZNF761 ZNF765
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LILRB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LILRB1

Top Transcription factor binding sites by QIAGEN in the LILRB1 gene promoter:
  • AML1a

Genomic Locations for LILRB1 Gene

Genomic Locations for LILRB1 Gene
chr19:54,616,930-54,637,925
(GRCh38/hg38)
Size:
20,996 bases
Orientation:
Plus strand
chr19:55,085,346-55,149,007
(GRCh37/hg19)
Size:
63,662 bases
Orientation:
Plus strand

Genomic View for LILRB1 Gene

Genes around LILRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRB1 Gene

Proteins for LILRB1 Gene

  • Protein details for LILRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHL6-LIRB1_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily B member 1
    Protein Accession:
    Q8NHL6
    Secondary Accessions:
    • A2IXV4
    • A8MXT0
    • O75024
    • O75025
    • Q8NHJ9
    • Q8NHK0

    Protein attributes for LILRB1 Gene

    Size:
    650 amino acids
    Molecular mass:
    70819 Da
    Quaternary structure:
    • Binds PTPN6 when phosphorylated (PubMed:9285411). Binds FCER1A and FCGR1A (PubMed:9842885, PubMed:11907092). Interacts with human cytomegalovirus/HHV-5 protein UL18 (PubMed:10591185). Interacts with peptide-bound HLA-G-B2M complex (PubMed:16455647). Interacts with peptide-bound HLA-F-B2M complex but not with peptide-free HLA-F open conformer. It does not probe the peptide sequence directly (PubMed:28636952).
    Miscellaneous:
    • [Isoform 5]: May act as dominant negative regulator and block the interaction between membrane-associated isoforms and HLA-class I.

    Three dimensional structures from OCA and Proteopedia for LILRB1 Gene

    Alternative splice isoforms for LILRB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRB1 Gene

Post-translational modifications for LILRB1 Gene

  • Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
  • Glycosylation at Asn281, Asn302, and Asn341
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for LILRB1

No data available for DME Specific Peptides for LILRB1 Gene

Domains & Families for LILRB1 Gene

Gene Families for LILRB1 Gene

Protein Domains for LILRB1 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
ProtoNet:

Suggested Antigen Peptide Sequences for LILRB1 Gene

GenScript: Design optimal peptide antigens:
  • LIR-1 (D9IDM4_HUMAN)
  • LIR-1 (D9IDM5_HUMAN)
  • LIR-1 (D9IDM6_HUMAN)
  • LIR-1 (D9IDM7_HUMAN)
  • LIR-1 (D9IDM8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHL6

UniProtKB/Swiss-Prot:

LIRB1_HUMAN :
  • Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain:
  • Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
genes like me logo Genes that share domains with LILRB1: view

Function for LILRB1 Gene

Molecular function for LILRB1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:29262349, PubMed:19304799). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251).
GENATLAS Biochemistry:
leukocyte immunoglobulin-like receptor,subfamily B,member 1,expressed on monocytes,B cells,dentritic cells and natural killer cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily,binding to MHC class I molecules A2,B44

Phenotypes From GWAS Catalog for LILRB1 Gene

Gene Ontology (GO) - Molecular Function for LILRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 NOT amyloid-beta binding IDA 24052308
GO:0005515 protein binding IPI 11169396
GO:0008157 protein phosphatase 1 binding IPI 9285411
GO:0023025 MHC class Ib protein complex binding IDA 17056715
GO:0023029 MHC class Ib protein binding IDA 11169396
genes like me logo Genes that share ontologies with LILRB1: view
genes like me logo Genes that share phenotypes with LILRB1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LILRB1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRB1 Gene

Localization for LILRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRB1 Gene

Cell membrane. Single-pass type I membrane protein.
[Isoform 5]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRB1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LILRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA 15585844
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IDA 9285411
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LILRB1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LILRB1 Gene

Pathways & Interactions for LILRB1 Gene

genes like me logo Genes that share pathways with LILRB1: view

Pathways by source for LILRB1 Gene

1 Cell Signaling Technology pathway for LILRB1 Gene

SIGNOR curated interactions for LILRB1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LILRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001915 negative regulation of T cell mediated cytotoxicity IDA 21213105
GO:0002230 positive regulation of defense response to virus by host IDA 18398485
GO:0002250 adaptive immune response IEA --
GO:0002309 T cell proliferation involved in immune response IDA 18094328
GO:0002719 negative regulation of cytokine production involved in immune response IDA 18094328
genes like me logo Genes that share ontologies with LILRB1: view

Drugs & Compounds for LILRB1 Gene

(3) Drugs for LILRB1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556
genes like me logo Genes that share compounds with LILRB1: view

Transcripts for LILRB1 Gene

mRNA/cDNA for LILRB1 Gene

6 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LILRB1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRB1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
SP1:
SP2:
SP3:
SP4:

Relevant External Links for LILRB1 Gene

GeneLoc Exon Structure for
LILRB1

Expression for LILRB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LILRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRB1 Gene

This gene is overexpressed in Spleen (x11.7) and Whole Blood (x9.5).

Protein differential expression in normal tissues from HIPED for LILRB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (39.2) and Monocytes (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRB1 Gene



Protein tissue co-expression partners for LILRB1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LILRB1

SOURCE GeneReport for Unigene cluster for LILRB1 Gene:

Hs.667388

mRNA Expression by UniProt/SwissProt for LILRB1 Gene:

Q8NHL6-LIRB1_HUMAN
Tissue specificity: Expressed in B cells, monocytes and various dendritic cell (DC) subsets including myeloid, plasmacytoid and tolerogenic DCs (at protein level) (PubMed:20448110, PubMed:9285411, PubMed:9842885, PubMed:24453251). Expressed in decidual macrophages (at protein level) (PubMed:19304799). Expressed in decidual NK cells (at protein level) (PubMed:29262349).

Evidence on tissue expression from TISSUES for LILRB1 Gene

  • Blood(4.6)
  • Spleen(3.1)
  • Nervous system(2.5)
  • Lymph node(2.4)
  • Liver(2.2)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with LILRB1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LILRB1 Gene

Orthologs for LILRB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRB1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LILRB1 30
  • 92.7 (n)
LIRC 31
  • 83 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 60 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 51 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Pira2 31
  • 32 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 19 (a)
OneToMany
Species where no ortholog for LILRB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LILRB1 Gene

ENSEMBL:
Gene Tree for LILRB1 (if available)
TreeFam:
Gene Tree for LILRB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LILRB1: view image

Paralogs for LILRB1 Gene

(52) SIMAP similar genes for LILRB1 Gene using alignment to 11 proteins:

  • LIRB1_HUMAN
  • A8MVE2_HUMAN
  • C9JPH8_HUMAN
  • D9IDM4_HUMAN
  • D9IDM5_HUMAN
  • D9IDM6_HUMAN
  • D9IDM7_HUMAN
  • D9IDM8_HUMAN
  • D9IDM9_HUMAN
  • D9IDN1_HUMAN
  • F6TER3_HUMAN
genes like me logo Genes that share paralogs with LILRB1: view

Variants for LILRB1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LILRB1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1045818 - p.His301Tyr
rs1061679 - p.Leu68Pro
rs1061680 - p.Ile142Thr
rs1061681 - p.Ser155Ile
rs1138737 - p.Leu459Val

Additional dbSNP identifiers (rs#s) for LILRB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for LILRB1 Gene

Variant ID Type Subtype PubMed ID
dgv16e196 CNV duplication 17116639
dgv17e196 CNV deletion 17116639
dgv435n27 CNV loss 19166990
dgv6563n54 CNV loss 21841781
esv2667609 CNV deletion 23128226
esv2718872 CNV deletion 23290073
esv2718879 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv2762051 CNV loss 21179565
esv3644812 CNV loss 21293372
nsv1061739 CNV gain+loss 25217958
nsv1065887 CNV loss 25217958
nsv1148744 OTHER inversion 26484159
nsv1160664 CNV deletion 26073780
nsv428372 CNV gain+loss 18775914
nsv458799 CNV gain 19166990
nsv470158 CNV loss 18288195
nsv470159 CNV gain 18288195
nsv516569 CNV gain+loss 19592680
nsv522872 CNV loss 19592680
nsv523723 CNV loss 19592680
nsv580240 CNV gain 21841781
nsv580241 CNV loss 21841781
nsv580242 CNV gain 21841781
nsv817871 CNV loss 17921354
nsv828639 CNV loss 20364138
nsv963081 CNV duplication 23825009
nsv9760 CNV loss 18304495

Variation tolerance for LILRB1 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.26; 76.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LILRB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LILRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRB1 Gene

Disorders for LILRB1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for LILRB1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease 12
  • ad12
severe pre-eclampsia
  • antepartum severe pre-eclampsia
bare lymphocyte syndrome, type i
  • bls, type i
malaria
  • malaria, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LILRB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with LILRB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LILRB1 Gene

Publications for LILRB1 Gene

  1. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. (PMID: 9285411) Cosman D … Hsu ML (Immunity 1997) 2 3 4 23
  2. Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. (PMID: 16014635) Kuroki K … Tokunaga K (Human molecular genetics 2005) 3 23 41
  3. Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. (PMID: 10941837) Liu WR … Arm JP (Immunogenetics 2000) 3 4 23
  4. Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2). (PMID: 11114384) Chapman TL … Bjorkman PJ (Immunity 2000) 3 4 23
  5. The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. (PMID: 10591185) Chapman TL … Bjorkman PJ (Immunity 1999) 3 4 23

Products for LILRB1 Gene

Sources for LILRB1 Gene