Aliases for LILRA6 Gene

Aliases for LILRA6 Gene

  • Leukocyte Immunoglobulin Like Receptor A6 2 3 5
  • ILT8 2 3 4
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 6 2 3
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 6 2 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 6 3 4
  • Immunoglobulin-Like Transcript 8 3 4
  • Leucocyte Ig-Like Receptor A6 2 3
  • Leukocyte Ig-Like Receptor 3 4
  • CD85b 2 3
  • ILT-8 3 4
  • Leukocyte Immunoglobulin Like Receptor B3 3
  • Immunoglobulin-Like Transcript 5 3
  • LILRB3 3
  • LILRB6 3
  • LILRA6 5
  • ILT5 3

External Ids for LILRA6 Gene

Previous HGNC Symbols for LILRA6 Gene

  • LILRB6

Previous GeneCards Identifiers for LILRA6 Gene

  • GC19M059413
  • GC19M054740
  • GC19M054721
  • GC19M054260
  • GC19M054277
  • GC19M054345
  • GC19M054354
  • GC19M054363
  • GC19M054391
  • GC19M054284
  • GC19M054287
  • GC19M054290
  • GC19M054306
  • GC19M054318
  • GC19M054326
  • GC19M054335
  • GC19M054341
  • GC19M054419
  • GC19M054453

Summaries for LILRA6 Gene

GeneCards Summary for LILRA6 Gene

LILRA6 (Leukocyte Immunoglobulin Like Receptor A6) is a Protein Coding gene. Diseases associated with LILRA6 include Shwartzman Phenomenon. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. An important paralog of this gene is LILRB3.

UniProtKB/Swiss-Prot Summary for LILRA6 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LILRA6 Gene

Genomics for LILRA6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LILRA6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054240 Promoter 0.8 EPDnew Ensembl 256.4 +0.6 590 2 ZIC2 GLIS1 LILRA6 LILRP1 RPS9 LILRB5 MK280272-001 LILRB3
GH19J054243 Promoter 0.3 Ensembl 250.7 -1.1 -1110 0.2 LILRA6 ENSG00000249189 lnc-LILRB5-1 LILRB5 RPS9
GH19J054199 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 22.4 +37.2 37202 12.4 BCLAF1 SP1 ZNF207 ZNF600 NCOR1 MYC IKZF1 SSRP1 ZNF580 ZNF592 RPS9 HSALNG0127488 PRPF31 LENG8-AS1 LENG8 CNOT3 ZNF525 ENSG00000235681 ZNF845 ZNF761
GH19J054186 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 +53.2 53169 6.8 SP1 ZNF207 MYC NCOR1 ZNF600 IKZF1 SSRP1 JUND ZNF580 ATF2 TSEN34 MBOAT7 lnc-TMC4-2 PRPF31 ZNF665 LENG8 LENG8-AS1 CNOT3 ZNF845 ZNF525
GH19J054282 Enhancer 0.7 FANTOM5 ENCODE dbSUPER 14.3 -40.2 -40158 1.1 KLF1 IKZF1 LILRB2 MIR4752 LILRB3 LAIR1 LILRA6 LILRB5 ENSG00000249189 OSCAR MYADM VSTM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LILRA6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LILRA6

Top Transcription factor binding sites by QIAGEN in the LILRA6 gene promoter:
  • AML1a
  • GCNF
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • NF-kappaB1

Genomic Locations for LILRA6 Gene

Latest Assembly
6,202 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Ensembl)
25,913 bases
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr19(ALT_REF_LOCI_1):212,163-217,575 (-)
  • chr19(ALT_REF_LOCI_7):211,579-217,752 (-)
  • chr19(ALT_REF_LOCI_8):213,633-217,778 (-)
  • chr19(ALT_REF_LOCI_9):213,919-217,758 (-)

Genomic View for LILRA6 Gene

Genes around LILRA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA6 Gene

Proteins for LILRA6 Gene

  • Protein details for LILRA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 6
    Protein Accession:

    Protein attributes for LILRA6 Gene

    481 amino acids
    Molecular mass:
    52399 Da
    Quaternary structure:
    No Data Available
    • Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for LILRA6 Gene


neXtProt entry for LILRA6 Gene

Post-translational modifications for LILRA6 Gene

  • Glycosylation at Asn139, Asn280, Asn301, and Asn340
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA6 Gene

No data available for DME Specific Peptides for LILRA6 Gene

Domains & Families for LILRA6 Gene

Gene Families for LILRA6 Gene

Suggested Antigen Peptide Sequences for LILRA6 Gene

GenScript: Design optimal peptide antigens:
  • Leukocyte Ig-like receptor (LIRA6_HUMAN)
genes like me logo Genes that share domains with LILRA6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LILRA6 Gene

Function for LILRA6 Gene

Molecular function for LILRA6 Gene

UniProtKB/Swiss-Prot Function:
May act as receptor for class I MHC antigens.

Phenotypes From GWAS Catalog for LILRA6 Gene

genes like me logo Genes that share phenotypes with LILRA6: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LILRA6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LILRA6 Gene

Localization for LILRA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA6 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRA6 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for LILRA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LILRA6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LILRA6 Gene

Pathways & Interactions for LILRA6 Gene

genes like me logo Genes that share pathways with LILRA6: view

Gene Ontology (GO) - Biological Process for LILRA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with LILRA6: view

No data available for SIGNOR curated interactions for LILRA6 Gene

Drugs & Compounds for LILRA6 Gene

No Compound Related Data Available

Transcripts for LILRA6 Gene

mRNA/cDNA for LILRA6 Gene

44 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LILRA6

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA6 Gene

No ASD Table

Relevant External Links for LILRA6 Gene

GeneLoc Exon Structure for

Expression for LILRA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LILRA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Blood (Hematopoietic System)

mRNA differential expression in normal tissues according to GTEx for LILRA6 Gene

This gene is overexpressed in Whole Blood (x38.4) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for LILRA6 Gene

This gene is overexpressed in Monocytes (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRA6 Gene

Protein tissue co-expression partners for LILRA6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LILRA6

Evidence on tissue expression from TISSUES for LILRA6 Gene

  • Spleen(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with LILRA6: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LILRA6 Gene

Orthologs for LILRA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LILRA6 29
  • 93.56 (n)
  • 64 (a)
(Rattus norvegicus)
Mammalia LOC690948 29
  • 68.27 (n)
(Bos Taurus)
Mammalia -- 30
  • 67 (a)
  • 60 (a)
-- 30
  • 59 (a)
-- 30
  • 55 (a)
-- 30
  • 54 (a)
-- 30
  • 51 (a)
-- 30
  • 50 (a)
-- 30
  • 49 (a)
-- 30
  • 42 (a)
-- 30
  • 36 (a)
-- 30
  • 27 (a)
(Canis familiaris)
Mammalia -- 30
  • 46 (a)
-- 30
  • 43 (a)
(Mus musculus)
Mammalia Gm15448 30
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 20 (a)
Species where no ortholog for LILRA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LILRA6 Gene

Gene Tree for LILRA6 (if available)
Gene Tree for LILRA6 (if available)
Evolutionary constrained regions (ECRs) for LILRA6: view image
Alliance of Genome Resources:
Additional Orthologs for LILRA6

Paralogs for LILRA6 Gene

(58) SIMAP similar genes for LILRA6 Gene using alignment to 23 proteins:

  • B5ME96_HUMAN
  • I6L897_HUMAN
  • U5QB67_HUMAN
  • U5XH19_HUMAN
  • U5XH23_HUMAN
  • U5XH26_HUMAN
  • U5XI37_HUMAN
  • U5XKI1_HUMAN Pseudogenes for LILRA6 Gene

genes like me logo Genes that share paralogs with LILRA6: view

Variants for LILRA6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LILRA6 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs61734495 Benign: not specified 54,241,620(-) C/T
NM_024318.4(LILRA6):c.614G>A (p.Arg205Gln)
rs1052966 -- p.Gly149Arg
rs1052975 -- p.Pro288Arg
rs620207 -- p.Leu69Trp
rs8104206 -- p.Tyr400His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LILRA6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LILRA6 Gene

Variant ID Type Subtype PubMed ID
dgv1072e212 CNV gain 25503493
dgv1073e212 CNV loss 25503493
dgv1074e212 CNV gain 25503493
dgv1075e212 CNV gain 25503493
dgv2026e59 CNV duplication 20981092
dgv3654n100 CNV gain 25217958
dgv3655n100 CNV gain 25217958
dgv3656n100 CNV gain 25217958
dgv3657n100 CNV gain 25217958
dgv3658n100 CNV gain+loss 25217958
dgv3659n100 CNV gain+loss 25217958
dgv3660n100 CNV gain 25217958
dgv432n27 CNV loss 19166990
dgv433n27 CNV loss 19166990
dgv434n27 CNV gain 19166990
dgv598n67 CNV gain 20364138
dgv6548n54 CNV gain 21841781
dgv6549n54 CNV gain 21841781
dgv6551n54 CNV loss 21841781
dgv6555n54 CNV gain 21841781
dgv671e214 CNV gain 21293372
dgv77e180 CNV gain 20482838
esv1003658 CNV gain 20482838
esv1006598 CNV insertion 20482838
esv23225 CNV gain+loss 19812545
esv2421809 OTHER complex 20811451
esv2663554 CNV deletion 23128226
esv2718812 CNV deletion 23290073
esv2718859 CNV deletion 23290073
esv2718860 CNV deletion 23290073
esv2756707 CNV loss 18971310
esv2758771 CNV gain+loss 17122850
esv2760520 CNV gain+loss 21179565
esv2763032 CNV gain+loss 21179565
esv32835 CNV gain 17666407
esv3390177 CNV duplication 20981092
esv3574853 CNV gain 25503493
esv3584744 CNV loss 24956385
esv3644786 CNV loss 21293372
esv3893247 CNV loss 25118596
esv6034 CNV loss 19470904
nsv1057076 CNV loss 25217958
nsv1060193 CNV gain 25217958
nsv1061096 CNV gain+loss 25217958
nsv1066425 CNV gain 25217958
nsv1115551 CNV duplication 24896259
nsv1131442 CNV deletion 24896259
nsv1132481 CNV duplication 24896259
nsv1142120 CNV deletion 24896259
nsv1151876 CNV duplication 26484159
nsv1160663 OTHER complex 26073780
nsv183 CNV deletion 15895083
nsv2546 CNV deletion 18451855
nsv2548 CNV insertion 18451855
nsv428371 CNV gain+loss 18775914
nsv433320 CNV loss 18776910
nsv433322 CNV loss 18776910
nsv442773 CNV gain+loss 18776908
nsv458783 CNV loss 19166990
nsv498906 CNV loss 21111241
nsv510774 CNV deletion 20534489
nsv513760 CNV insertion 21212237
nsv517129 CNV gain+loss 19592680
nsv580148 CNV loss 21841781
nsv580149 CNV gain 21841781
nsv580150 CNV loss 21841781
nsv580191 CNV gain 21841781
nsv580192 CNV gain+loss 21841781
nsv580193 CNV gain 21841781
nsv580227 CNV loss 21841781
nsv817868 CNV gain+loss 17921354
nsv817869 CNV loss 17921354
nsv817870 CNV gain 17921354
nsv953615 CNV deletion 24416366
nsv960942 OTHER complex 23825009
nsv9752 CNV gain+loss 18304495
nsv978848 CNV duplication 23825009

Variation tolerance for LILRA6 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.93; 89.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LILRA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRA6 Gene

Disorders for LILRA6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LILRA6 Gene - From: COP

Disorder Aliases PubMed IDs
shwartzman phenomenon
  • shwartzman reaction
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LILRA6

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LILRA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LILRA6 Gene

Publications for LILRA6 Gene

  1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H … Ziegler A (Immunogenetics 2000) 2 3 4
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 40
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  5. Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population. (PMID: 33526815) Hirayasu K … Hanayama R (Journal of human genetics 2021) 3

Products for LILRA6 Gene

Sources for LILRA6 Gene