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Aliases for LILRA5 Gene

Aliases for LILRA5 Gene

  • Leukocyte Immunoglobulin Like Receptor A5 2 3 5
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5 2 3
  • Leukocyte Immunoglobulin-Like Receptor 9 3 4
  • CD85 Antigen-Like Family Member F 3 4
  • Leucocyte Ig-Like Receptor A5 2 3
  • LILRB7 3 4
  • ILT-11 3 4
  • ILT11 3 4
  • LIR-9 3 4
  • LIR9 3 4
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 7 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 5 Soluble 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 5 3
  • Immunoglobulin-Like Transcript 11 Protein 3
  • Immunoglobulin-Like Transcript 11 4
  • Leukocyte Ig-Like Receptor 9 3
  • CD85f Antigen 4
  • CD85F 3
  • CD85 3

External Ids for LILRA5 Gene

Previous HGNC Symbols for LILRA5 Gene

  • LILRB7

Previous GeneCards Identifiers for LILRA5 Gene

  • GC19M059511
  • GC19M054818
  • GC19M051140

Summaries for LILRA5 Gene

Entrez Gene Summary for LILRA5 Gene

  • The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for LILRA5 Gene

LILRA5 (Leukocyte Immunoglobulin Like Receptor A5) is a Protein Coding gene. Among its related pathways are Innate Immune System and Osteoclast differentiation. An important paralog of this gene is LILRA6.

UniProtKB/Swiss-Prot for LILRA5 Gene

  • May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.

Additional gene information for LILRA5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA5 Gene

Genomics for LILRA5 Gene

GeneHancer (GH) Regulatory Elements for LILRA5 Gene

Promoters and enhancers for LILRA5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I054311 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 550.8 +0.5 538 2 SPI1 LILRA5 TTYH1 ENSG00000227407 LILRB2 LILRB5 LILRA6 ENSG00000249189 LILRB3 ENSG00000234436 ENSG00000275210
GH19I054199 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.7 +107.4 107429 12.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS9 PRPF31 LENG8 LENG8-AS1 CNOT3 ZNF525 ZNF845 ENSG00000235681 LILRB5 ZNF765
GH19I054368 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -59.7 -59697 8.9 PKNOX1 ZBTB40 YY1 ZNF766 ZNF143 ETV6 ATF7 IKZF2 RUNX3 SMARCA5 LAIR1 FCAR LILRB2 OSCAR LILRA5 VSTM1 LILRB3 LILRB4 LILRB1 LILRA2
GH19I054018 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.7 +292.0 292022 6.8 PKNOX1 ATF1 FOXA2 ARID4B SIN3A GTF3C2 TCF12 ZNF302 ZNF143 ATF7 LILRB3 ENSG00000269288 ZNF415 VSTM1 LILRA5 OSCAR VN1R103P MYADM LILRB2 NLRP12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LILRA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LILRA5 gene promoter:

Genomic Locations for LILRA5 Gene

Genomic Locations for LILRA5 Gene
6,070 bases
Minus strand

Genomic View for LILRA5 Gene

Genes around LILRA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA5 Gene

Proteins for LILRA5 Gene

  • Protein details for LILRA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 5
    Protein Accession:
    Secondary Accessions:
    • A6NHI3

    Protein attributes for LILRA5 Gene

    299 amino acids
    Molecular mass:
    32755 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LILRA5 Gene

    Alternative splice isoforms for LILRA5 Gene


neXtProt entry for LILRA5 Gene

Post-translational modifications for LILRA5 Gene

  • Glycosylation at posLast=4343, posLast=157157, isoforms=2242, and posLast=248248

Other Protein References for LILRA5 Gene

Antibody Products

  • R&D Systems Antibodies for LILRA5 (LILRA5/CD85f)
  • Santa Cruz Biotechnology (SCBT) Antibodies for LILRA5

No data available for DME Specific Peptides for LILRA5 Gene

Domains & Families for LILRA5 Gene

Gene Families for LILRA5 Gene

Protein Domains for LILRA5 Gene

Suggested Antigen Peptide Sequences for LILRA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LILRA5: view

No data available for UniProtKB/Swiss-Prot for LILRA5 Gene

Function for LILRA5 Gene

Molecular function for LILRA5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.

Phenotypes From GWAS Catalog for LILRA5 Gene

genes like me logo Genes that share phenotypes with LILRA5: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRA5 Gene

Localization for LILRA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA5 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRA5 gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for LILRA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with LILRA5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LILRA5 Gene

Pathways & Interactions for LILRA5 Gene

genes like me logo Genes that share pathways with LILRA5: view

Pathways by source for LILRA5 Gene

Interacting Proteins for LILRA5 Gene

Selected Interacting proteins: A6NI73-LIRA5_HUMAN for LILRA5 Gene via IID

Gene Ontology (GO) - Biological Process for LILRA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with LILRA5: view

No data available for SIGNOR curated interactions for LILRA5 Gene

Drugs & Compounds for LILRA5 Gene

No Compound Related Data Available

Transcripts for LILRA5 Gene

mRNA/cDNA for LILRA5 Gene

(4) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRA5 Gene

Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - -
SP2: - - -
SP4: -

Relevant External Links for LILRA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LILRA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LILRA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRA5 Gene

This gene is overexpressed in Whole Blood (x48.5).

Protein differential expression in normal tissues from HIPED for LILRA5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.2) and Monocytes (28.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRA5 Gene

Protein tissue co-expression partners for LILRA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LILRA5 Gene:


SOURCE GeneReport for Unigene cluster for LILRA5 Gene:


mRNA Expression by UniProt/SwissProt for LILRA5 Gene:

Tissue specificity: Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level).

Evidence on tissue expression from TISSUES for LILRA5 Gene

  • Spleen(2.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with LILRA5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LILRA5 Gene

Orthologs for LILRA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LILRA5 33 34
  • 98.33 (n)
(Canis familiaris)
Mammalia LILRA5 33
  • 73.65 (n)
-- 34
  • 21 (a)
-- 34
  • 21 (a)
(Rattus norvegicus)
Mammalia Lilra5 33
  • 71.6 (n)
(Mus musculus)
Mammalia Lilra5 33 16
  • 69.18 (n)
Gp49a 34
  • 38 (a)
(Bos Taurus)
Mammalia -- 34
  • 51 (a)
-- 34
  • 47 (a)
-- 34
  • 43 (a)
-- 34
  • 43 (a)
-- 34
  • 36 (a)
-- 34
  • 29 (a)
  • 28 (a)
-- 34
  • 25 (a)
-- 34
  • 24 (a)
-- 34
  • 21 (a)
-- 34
  • 18 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 11 (a)
Species where no ortholog for LILRA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA5 Gene

Gene Tree for LILRA5 (if available)
Gene Tree for LILRA5 (if available)

Paralogs for LILRA5 Gene Pseudogenes for LILRA5 Gene

genes like me logo Genes that share paralogs with LILRA5: view

Variants for LILRA5 Gene

Sequence variations from dbSNP and Humsavar for LILRA5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000476591 -- 54,312,747(-) CCCC/CCC intron_variant
rs1000502200 -- 54,313,469(-) G/C upstream_transcript_variant
rs1001247425 -- 54,309,059(-) G/C genic_downstream_transcript_variant, intron_variant
rs1001330477 -- 54,314,152(-) C/T upstream_transcript_variant
rs1001572447 -- 54,313,858(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LILRA5 Gene

Variant ID Type Subtype PubMed ID
nsv960872 CNV duplication 23825009
nsv833878 CNV loss 17160897
nsv527908 CNV gain 19592680
nsv428371 CNV gain+loss 18775914
nsv1148744 OTHER inversion 26484159
esv3644797 CNV gain 21293372
esv3644796 CNV loss 21293372
esv3574853 CNV gain 25503493
esv2763032 CNV gain+loss 21179565
esv2758771 CNV gain+loss 17122850
esv2718860 CNV deletion 23290073
esv2718812 CNV deletion 23290073
dgv6549n54 CNV gain 21841781
dgv3663n100 CNV gain 25217958
dgv3662n100 CNV gain 25217958
dgv3661n100 CNV gain+loss 25217958
dgv3660n100 CNV gain 25217958

Variation tolerance for LILRA5 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LILRA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRA5 Gene

Disorders for LILRA5 Gene

Additional Disease Information for LILRA5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LILRA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRA5 Gene

Publications for LILRA5 Gene

  1. LIR9, an immunoglobulin-superfamily-activating receptor, is expressed as a transmembrane and as a secreted molecule. (PMID: 12393390) Borges L … Kuhlman T (Blood 2003) 3 4 22 58
  2. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H … Ziegler A (Immunogenetics 2000) 2 3 4 58
  3. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
  4. Crystal structure of the human monocyte-activating receptor, "Group 2" leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11). (PMID: 16675463) Shiroishi M … Maenaka K (The Journal of biological chemistry 2006) 3 4 58
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 58

Products for LILRA5 Gene

Sources for LILRA5 Gene

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