The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this pr... See more...

Aliases for LILRA5 Gene

Aliases for LILRA5 Gene

  • Leukocyte Immunoglobulin Like Receptor A5 2 3 5
  • ILT11 2 3 4
  • LIR9 2 3 4
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5 2 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 5 3 4
  • Leukocyte Immunoglobulin-Like Receptor 9 3 4
  • CD85 Antigen-Like Family Member F 3 4
  • Leucocyte Ig-Like Receptor A5 2 3
  • ILT-11 3 4
  • LILRB7 3 4
  • LIR-9 3 4
  • CD85 2 3
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 7 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 5 Soluble 3
  • Immunoglobulin-Like Transcript 11 Protein 3
  • Immunoglobulin-Like Transcript 11 4
  • Leukocyte Ig-Like Receptor 9 3
  • CD85f Antigen 4
  • LILRA5 5
  • CD85F 3
  • CD85f 2

External Ids for LILRA5 Gene

Previous HGNC Symbols for LILRA5 Gene

  • LILRB7

Previous GeneCards Identifiers for LILRA5 Gene

  • GC19M059511
  • GC19M054818
  • GC19M051140

Summaries for LILRA5 Gene

Entrez Gene Summary for LILRA5 Gene

  • The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for LILRA5 Gene

LILRA5 (Leukocyte Immunoglobulin Like Receptor A5) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is LILRA6.

UniProtKB/Swiss-Prot Summary for LILRA5 Gene

  • May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.

Additional gene information for LILRA5 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LILRA5 Gene

Genomics for LILRA5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LILRA5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054311 Promoter/Enhancer 0.7 Ensembl ENCODE 600.7 +0.8 811 1.5 EED SPI1 LILRA5 TTYH1 ENSG00000227407 LILRB2 LILRB5 ENSG00000249189 LILRA6 LILRB3 ENSG00000234436 lnc-LILRA5-2
GH19J054313 Promoter 0.3 EPDnew 600.7 0.0 -1 0.1 LILRA5 TTYH1 ENSG00000227407 LILRB2 LILRB5 ENSG00000249189 LILRA6 LILRB3 VN1R104P ENSG00000275210
GH19J054314 Promoter 0.3 Ensembl 600.7 -0.2 -235 0.4 LILRA5 LILRB2 TTYH1 ENSG00000227407 LILRB5 ENSG00000249189 LILRA6 LILRB3 VN1R104P ENSG00000275210
GH19J054199 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.7 +107.6 107577 12.4 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 RPS9 PRPF31 LENG8-AS1 LENG8 CNOT3 ZNF525 ENSG00000235681 ZNF845 ZNF761 ZNF765
GH19J054018 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 11.7 +292.0 292049 6.8 CREB1 CTCF REST ZNF512 LEF1 IKZF1 JUND ETV6 RFX1 PKNOX1 LILRB3 VSTM1 LILRA5 OSCAR MYADM LILRB2 NLRP12 LAIR1 CACNG8 LILRA6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LILRA5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LILRA5

Top Transcription factor binding sites by QIAGEN in the LILRA5 gene promoter:
  • HEN1
  • POU2F1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for LILRA5 Gene

Genomic Locations for LILRA5 Gene
chr19:54,307,070-54,313,166
(GRCh38/hg38)
Size:
6,097 bases
Orientation:
Minus strand
chr19:54,818,353-54,824,409
(GRCh37/hg19)
Size:
6,057 bases
Orientation:
Minus strand

Genomic View for LILRA5 Gene

Genes around LILRA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA5 Gene

Proteins for LILRA5 Gene

  • Protein details for LILRA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI73-LIRA5_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 5
    Protein Accession:
    A6NI73
    Secondary Accessions:
    • A6NHI3

    Protein attributes for LILRA5 Gene

    Size:
    299 amino acids
    Molecular mass:
    32755 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LILRA5 Gene

    Alternative splice isoforms for LILRA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRA5 Gene

Post-translational modifications for LILRA5 Gene

  • Glycosylation at Asn43, Asn157, Asn242, and Asn248
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA5 Gene

No data available for DME Specific Peptides for LILRA5 Gene

Domains & Families for LILRA5 Gene

Gene Families for LILRA5 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for LILRA5 Gene

Suggested Antigen Peptide Sequences for LILRA5 Gene

GenScript: Design optimal peptide antigens:
  • Leukocyte immunoglobulin-like receptor 9 (LIRA5_HUMAN)
genes like me logo Genes that share domains with LILRA5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LILRA5 Gene

Function for LILRA5 Gene

Molecular function for LILRA5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.

Phenotypes From GWAS Catalog for LILRA5 Gene

genes like me logo Genes that share phenotypes with LILRA5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LILRA5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRA5 Gene

Localization for LILRA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA5 Gene

Cell membrane. Single-pass type I membrane protein.
[Isoform 3]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRA5 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LILRA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 19009525
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LILRA5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LILRA5 Gene

Pathways & Interactions for LILRA5 Gene

genes like me logo Genes that share pathways with LILRA5: view

Interacting Proteins for LILRA5 Gene

Gene Ontology (GO) - Biological Process for LILRA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0043410 positive regulation of MAPK cascade IMP 19009525
GO:0045087 innate immune response IEA --
GO:0050718 positive regulation of interleukin-1 beta secretion IDA 12393390
GO:0050729 positive regulation of inflammatory response IDA 12393390
genes like me logo Genes that share ontologies with LILRA5: view

No data available for SIGNOR curated interactions for LILRA5 Gene

Drugs & Compounds for LILRA5 Gene

No Compound Related Data Available

Transcripts for LILRA5 Gene

mRNA/cDNA for LILRA5 Gene

4 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LILRA5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for LILRA5 Gene

GeneLoc Exon Structure for
LILRA5

Expression for LILRA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LILRA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRA5 Gene

This gene is overexpressed in Whole Blood (x48.5).

Protein differential expression in normal tissues from HIPED for LILRA5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.2) and Monocytes (28.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRA5 Gene



Protein tissue co-expression partners for LILRA5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LILRA5

SOURCE GeneReport for Unigene cluster for LILRA5 Gene:

Hs.710986

mRNA Expression by UniProt/SwissProt for LILRA5 Gene:

A6NI73-LIRA5_HUMAN
Tissue specificity: Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level).

Evidence on tissue expression from TISSUES for LILRA5 Gene

  • Spleen(2.4)
  • Blood(2.4)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with LILRA5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LILRA5 Gene

Orthologs for LILRA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LILRA5 30 31
  • 98.33 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LILRA5 30
  • 73.65 (n)
-- 31
  • 21 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Lilra5 30
  • 71.6 (n)
Mouse
(Mus musculus)
Mammalia Lilra5 30 17
  • 69.18 (n)
Gp49a 31
  • 38 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 51 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
LILRA4 31
  • 28 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
-- 31
  • 18 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 11 (a)
OneToMany
Species where no ortholog for LILRA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LILRA5 Gene

ENSEMBL:
Gene Tree for LILRA5 (if available)
TreeFam:
Gene Tree for LILRA5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LILRA5: view image

Paralogs for LILRA5 Gene

Pseudogenes.org Pseudogenes for LILRA5 Gene

genes like me logo Genes that share paralogs with LILRA5: view

Variants for LILRA5 Gene

Additional dbSNP identifiers (rs#s) for LILRA5 Gene

Structural Variations from Database of Genomic Variants (DGV) for LILRA5 Gene

Variant ID Type Subtype PubMed ID
dgv3660n100 CNV gain 25217958
dgv3661n100 CNV gain+loss 25217958
dgv3662n100 CNV gain 25217958
dgv3663n100 CNV gain 25217958
dgv6549n54 CNV gain 21841781
esv2718812 CNV deletion 23290073
esv2718860 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv2763032 CNV gain+loss 21179565
esv3574853 CNV gain 25503493
esv3644796 CNV loss 21293372
esv3644797 CNV gain 21293372
nsv1148744 OTHER inversion 26484159
nsv428371 CNV gain+loss 18775914
nsv527908 CNV gain 19592680
nsv833878 CNV loss 17160897
nsv960872 CNV duplication 23825009

Variation tolerance for LILRA5 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LILRA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LILRA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LILRA5 Gene

Disorders for LILRA5 Gene

Additional Disease Information for LILRA5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for LILRA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRA5 Gene

Publications for LILRA5 Gene

  1. LIR9, an immunoglobulin-superfamily-activating receptor, is expressed as a transmembrane and as a secreted molecule. (PMID: 12393390) Borges L … Kuhlman T (Blood 2003) 3 4 23
  2. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H … Ziegler A (Immunogenetics 2000) 2 3 4
  3. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 41
  4. Crystal structure of the human monocyte-activating receptor, "Group 2" leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11). (PMID: 16675463) Shiroishi M … Maenaka K (The Journal of biological chemistry 2006) 3 4
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3

Products for LILRA5 Gene

Sources for LILRA5 Gene