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Aliases for LILRA3 Gene

Aliases for LILRA3 Gene

  • Leukocyte Immunoglobulin Like Receptor A3 2 3
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (Without TM Domain), Member 3 2 3
  • Leukocyte Immunoglobulin-Like Receptor 4 3 4
  • Monocyte Inhibitory Receptor HM43/HM31 3 4
  • CD85 Antigen-Like Family Member E 3 4
  • Immunoglobulin-Like Transcript 6 3 4
  • Leucocyte Ig-Like Receptor A3 2 3
  • ILT-6 3 4
  • LIR-4 3 4
  • ILT6 3 4
  • LIR4 3 4
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3 3
  • CD85e Antigen 4
  • CD85E 3
  • HM31 3
  • HM43 3

External Ids for LILRA3 Gene

Previous GeneCards Identifiers for LILRA3 Gene

  • GC19M055680
  • GC19M055224
  • GC19M059475
  • GC19M059491
  • GC19M054798
  • GC19Mj00270

Summaries for LILRA3 Gene

Entrez Gene Summary for LILRA3 Gene

  • This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]

GeneCards Summary for LILRA3 Gene

LILRA3 (Leukocyte Immunoglobulin Like Receptor A3) is a Protein Coding gene. Diseases associated with LILRA3 include Lethal Midline Granuloma. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. Gene Ontology (GO) annotations related to this gene include antigen binding.

UniProtKB/Swiss-Prot for LILRA3 Gene

  • Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.

Gene Wiki entry for LILRA3 Gene

Additional gene information for LILRA3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA3 Gene

Genomics for LILRA3 Gene

GeneHancer (GH) Regulatory Elements for LILRA3 Gene


Top Transcription factor binding sites by QIAGEN in the LILRA3 gene promoter:
  • AML1a

Genomic Locations for LILRA3 Gene

Genomic Locations for LILRA3 Gene
chr19:270,735-280,849
(GRCh38/hg38)
Size:
10,115 bases
Orientation:
Minus strand
chr19:54,799,854-54,809,952
(GRCh37/hg19)
Size:
10,099 bases
Orientation:
Minus strand

Genomic View for LILRA3 Gene

Genes around LILRA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for LILRA3 Gene

Proteins for LILRA3 Gene

  • Protein details for LILRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6C8-LIRA3_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 3
    Protein Accession:
    Q8N6C8
    Secondary Accessions:
    • J3KPM2
    • O15469
    • O15470
    • O75016
    • Q8N151
    • Q8N154
    • Q8NHJ1
    • Q8NHJ2
    • Q8NHJ3
    • Q8NHJ4

    Protein attributes for LILRA3 Gene

    Size:
    439 amino acids
    Molecular mass:
    47472 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LILRA3 Gene

    Alternative splice isoforms for LILRA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRA3 Gene

Post-translational modifications for LILRA3 Gene

  • N-glycosylation is required for ligand binding.
  • Glycosylation at isoforms=2, 3431, isoforms=2, 3341, posLast=302302, posLast=281281, and posLast=140140
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA3 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for LILRA3 Gene

Domains & Families for LILRA3 Gene

Suggested Antigen Peptide Sequences for LILRA3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LILRA3: view

No data available for UniProtKB/Swiss-Prot for LILRA3 Gene

Function for LILRA3 Gene

Molecular function for LILRA3 Gene

UniProtKB/Swiss-Prot Function:
Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
GENATLAS Biochemistry:
leukocyte immunoglobulin-like receptor,subfamily A,member 3,expressed on monocytes and B cells,secreted,acting potentially as a dominant negative soluble receptor that would suppress the function of other LIR molecules,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily

Phenotypes From GWAS Catalog for LILRA3 Gene

Gene Ontology (GO) - Molecular Function for LILRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 9151699
GO:0038023 signaling receptor activity TAS 9151699
genes like me logo Genes that share ontologies with LILRA3: view
genes like me logo Genes that share phenotypes with LILRA3: view

Animal Model Products

CRISPR Products

miRNA for LILRA3 Gene

miRTarBase miRNAs that target LILRA3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LILRA3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRA3 Gene

Localization for LILRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRA3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LILRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0035579 specific granule membrane TAS --
GO:0070821 tertiary granule membrane TAS --
GO:0101003 ficolin-1-rich granule membrane TAS --
genes like me logo Genes that share ontologies with LILRA3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LILRA3 Gene

Pathways & Interactions for LILRA3 Gene

genes like me logo Genes that share pathways with LILRA3: view

Interacting Proteins for LILRA3 Gene

Gene Ontology (GO) - Biological Process for LILRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0006952 defense response TAS 9151699
GO:0007165 signal transduction TAS 9151699
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with LILRA3: view

No data available for SIGNOR curated interactions for LILRA3 Gene

Drugs & Compounds for LILRA3 Gene

No Compound Related Data Available

Transcripts for LILRA3 Gene

Unigene Clusters for LILRA3 Gene

Leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LILRA3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA3 Gene

No ASD Table

Relevant External Links for LILRA3 Gene

GeneLoc Exon Structure for
LILRA3
ECgene alternative splicing isoforms for
LILRA3

Expression for LILRA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LILRA3 Gene

mRNA differential expression in normal tissues according to GTEx for LILRA3 Gene

This gene is overexpressed in Whole Blood (x43.9) and Spleen (x4.3).

Protein differential expression in normal tissues from HIPED for LILRA3 Gene

This gene is overexpressed in Serum (43.0), Monocytes (7.7), and Plasma (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRA3 Gene



NURSA nuclear receptor signaling pathways regulating expression of LILRA3 Gene:

LILRA3

SOURCE GeneReport for Unigene cluster for LILRA3 Gene:

Hs.113277

mRNA Expression by UniProt/SwissProt for LILRA3 Gene:

Q8N6C8-LIRA3_HUMAN
Tissue specificity: Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.

Evidence on tissue expression from TISSUES for LILRA3 Gene

  • Blood(4.4)
  • Lung(4)
genes like me logo Genes that share expression patterns with LILRA3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LILRA3 Gene

Orthologs for LILRA3 Gene

No data available for Orthologs and Evolution for LILRA3 Gene

Paralogs for LILRA3 Gene

No data available for Paralogs for LILRA3 Gene

Variants for LILRA3 Gene

Sequence variations from dbSNP and Humsavar for LILRA3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs11574606 -- p.Pro3Ser
rs4473306 -- p.Tyr301His
rs6509862 -- p.Leu107Arg

Variation tolerance for LILRA3 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LILRA3 Gene

Human Gene Mutation Database (HGMD)
LILRA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LILRA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LILRA3 Gene

Disorders for LILRA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LILRA3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
lethal midline granuloma
  • malignant granuloma of face
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LILRA3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LILRA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LILRA3 Gene

Publications for LILRA3 Gene

  1. Association of immunoglobulin-like transcript 6 deficiency with Sjögren's syndrome. (PMID: 19790059) Kabalak G … Witte T (Arthritis and rheumatism 2009) 3 22 44 58
  2. Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy controls. (PMID: 12651072) Wiśniewski A … Kuśnierczyk P (Human immunology 2003) 3 22 44 58
  3. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PMID: 9548455) Borges L … Cosman D (Journal of immunology (Baltimore, Md. : 1950) 1997) 2 3 4 58
  4. Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. (PMID: 9278324) Arm JP … Austen KF (Journal of immunology (Baltimore, Md. : 1950) 1997) 2 3 4 58
  5. Glycosylation in a mammalian expression system is critical for the production of functionally active leukocyte immunoglobulin-like receptor A3 protein. (PMID: 24085305) Lee TH … Tedla N (The Journal of biological chemistry 2013) 3 4 58

Products for LILRA3 Gene

Sources for LILRA3 Gene

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