Aliases for LILRA2 Gene
- Leukocyte Immunoglobulin Like Receptor A2 2 3 5
- Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 2 3
- Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 3 4
- Leukocyte Immunoglobulin-Like Receptor 7 3 4
- CD85 Antigen-Like Family Member H 3 4
- Immunoglobulin-Like Transcript 1 3 4
- Leucocyte Ig-Like Receptor A2 2 3
External Ids for LILRA2 Gene
Previous GeneCards Identifiers for LILRA2 Gene
This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]
GeneCards Summary for LILRA2 Gene
LILRA2 (Leukocyte Immunoglobulin Like Receptor A2) is a Protein Coding gene. Among its related pathways are B cell receptor signaling pathway (KEGG) and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is LILRA1.
UniProtKB/Swiss-Prot Summary for LILRA2 Gene
Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061).