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Aliases for LILRA2 Gene

Aliases for LILRA2 Gene

  • Leukocyte Immunoglobulin Like Receptor A2 2 3 5
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 2 3
  • Leukocyte Immunoglobulin-Like Receptor 7 3 4
  • CD85 Antigen-Like Family Member H 3 4
  • Immunoglobulin-Like Transcript 1 3 4
  • Leucocyte Ig-Like Receptor A2 2 3
  • LIR-7 3 4
  • ILT1 3 4
  • LIR7 3 4
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 Soluble 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 3
  • CD85h Antigen 4
  • CD85H 3
  • ILT-1 4

External Ids for LILRA2 Gene

Previous GeneCards Identifiers for LILRA2 Gene

  • GC19P055948
  • GC19P055509
  • GC19P059760
  • GC19P059777
  • GC19P055084
  • GC19P051410

Summaries for LILRA2 Gene

Entrez Gene Summary for LILRA2 Gene

  • This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]

GeneCards Summary for LILRA2 Gene

LILRA2 (Leukocyte Immunoglobulin Like Receptor A2) is a Protein Coding gene. Diseases associated with LILRA2 include Leprosy 3. Among its related pathways are Innate Immune System and Osteoclast differentiation. Gene Ontology (GO) annotations related to this gene include receptor activity and antigen binding. An important paralog of this gene is LILRA1.

UniProtKB/Swiss-Prot for LILRA2 Gene

  • Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061).

Gene Wiki entry for LILRA2 Gene

Additional gene information for LILRA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA2 Gene

Genomics for LILRA2 Gene

GeneHancer (GH) Regulatory Elements for LILRA2 Gene

Promoters and enhancers for LILRA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I054571 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 570.7 +0.7 681 3.6 HDAC1 GTF2E2 TEAD4 CEBPG ZNF766 POLR2A EGR1 VEZF1 TRIM24 NFE2 LILRA2 KIR3DX1 LILRA1 ENSG00000269271
GH19I054199 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20 -367.2 -367210 12.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS9 PRPF31 LENG8 LENG8-AS1 CNOT3 ZNF525 ZNF845 ENSG00000235681 LILRB5 ZNF765
GH19I054873 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 30.2 +303.3 303264 5.2 GATA3 ZNF157 POLR2A SPI1 FCAR LILRA2 KIR2DS4 LILRA1 NLRP2 NLRP7 ENSG00000243494 KIR2DL3 EPS8L1 RDH13
GH19I054615 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 11.1 +44.3 44318 2.8 HDGF PKNOX1 SMAD1 BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 LILRB1 LILRA2 LILRP2 LILRB2 LILRB1-AS1
GH19I054592 Promoter/Enhancer 0.7 EPDnew Ensembl 21.5 +21.0 20981 2.2 LILRA1 LILRA2 ENSG00000269271 ENSG00000238094
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LILRA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LILRA2 gene promoter:

Genomic Locations for LILRA2 Gene

Genomic Locations for LILRA2 Gene
chr19:54,572,920-54,590,287
(GRCh38/hg38)
Size:
17,368 bases
Orientation:
Plus strand
chr19:55,084,387-55,099,027
(GRCh37/hg19)

Genomic View for LILRA2 Gene

Genes around LILRA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA2 Gene

Proteins for LILRA2 Gene

  • Protein details for LILRA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N149-LIRA2_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 2
    Protein Accession:
    Q8N149
    Secondary Accessions:
    • O75020

    Protein attributes for LILRA2 Gene

    Size:
    483 amino acids
    Molecular mass:
    52992 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for LILRA2 Gene

    Alternative splice isoforms for LILRA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRA2 Gene

Post-translational modifications for LILRA2 Gene

  • Glycosylation at posLast=6464, posLast=103103, isoforms=2, 3, 4138, posLast=279279, isoforms=2, 3, 4300, posLast=339339, and posLast=429429

Antibody Products

  • R&D Systems Antibodies for LILRA2 (LILRA2/CD85h/ILT1)
  • Abcam antibodies for LILRA2
  • Cloud-Clone Corp. Antibodies for LILRA2

No data available for DME Specific Peptides for LILRA2 Gene

Domains & Families for LILRA2 Gene

Gene Families for LILRA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LILRA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LILRA2: view

No data available for UniProtKB/Swiss-Prot for LILRA2 Gene

Function for LILRA2 Gene

Molecular function for LILRA2 Gene

GENATLAS Biochemistry:
leukocyte immunoglobulin-like receptor,subfamily A,with TM domain,member 3,activating receptor expressed on myeloid cell and subsets of lymphoid cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily
UniProtKB/Swiss-Prot Function:
Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061).

Phenotypes From GWAS Catalog for LILRA2 Gene

Gene Ontology (GO) - Molecular Function for LILRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001791 IgM binding IDA 27572839
GO:0003823 antigen binding TAS 9548455
GO:0004872 receptor activity TAS 9548455
genes like me logo Genes that share ontologies with LILRA2: view
genes like me logo Genes that share phenotypes with LILRA2: view

Animal Model Products

CRISPR Products

miRNA for LILRA2 Gene

miRTarBase miRNAs that target LILRA2

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for LILRA2 (LILRA2/CD85h/ILT1)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRA2 Gene

Localization for LILRA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA2 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform 4: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRA2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LILRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 22479404
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LILRA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LILRA2 Gene

Pathways & Interactions for LILRA2 Gene

genes like me logo Genes that share pathways with LILRA2: view

Pathways by source for LILRA2 Gene

Gene Ontology (GO) - Biological Process for LILRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002220 innate immune response activating cell surface receptor signaling pathway IDA 27572839
GO:0002283 neutrophil activation involved in immune response IDA 27572839
GO:0002376 immune system process IEA --
GO:0006952 defense response TAS 9548455
GO:0007165 signal transduction TAS 9548455
genes like me logo Genes that share ontologies with LILRA2: view

No data available for SIGNOR curated interactions for LILRA2 Gene

Drugs & Compounds for LILRA2 Gene

No Compound Related Data Available

Transcripts for LILRA2 Gene

mRNA/cDNA for LILRA2 Gene

(13) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRA2 Gene

Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for LILRA2 (LILRA2/CD85h/ILT1)

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA2 Gene

No ASD Table

Relevant External Links for LILRA2 Gene

GeneLoc Exon Structure for
LILRA2
ECgene alternative splicing isoforms for
LILRA2

Expression for LILRA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LILRA2 Gene

mRNA differential expression in normal tissues according to GTEx for LILRA2 Gene

This gene is overexpressed in Whole Blood (x42.4).

Protein differential expression in normal tissues from HIPED for LILRA2 Gene

This gene is overexpressed in Serum (48.3) and Monocytes (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LILRA2 Gene



Protein tissue co-expression partners for LILRA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LILRA2 Gene:

LILRA2

SOURCE GeneReport for Unigene cluster for LILRA2 Gene:

Hs.655593

mRNA Expression by UniProt/SwissProt for LILRA2 Gene:

Q8N149-LIRA2_HUMAN
Tissue specificity: Detected on the surface of all peripheral blood monocytes, neutrophils, basophils and eosinophils (at protein level) (PubMed:12529506, PubMed:22479404). Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cells and natural killer (NK) cells (PubMed:9548455).

Evidence on tissue expression from TISSUES for LILRA2 Gene

  • Blood(4.4)
  • Lung(4.1)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with LILRA2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LILRA2 Gene

Orthologs for LILRA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LILRA2 33 34
  • 97.42 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 53 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 37 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 20 (a)
OneToMany
Species where no ortholog for LILRA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA2 Gene

ENSEMBL:
Gene Tree for LILRA2 (if available)
TreeFam:
Gene Tree for LILRA2 (if available)

Paralogs for LILRA2 Gene

genes like me logo Genes that share paralogs with LILRA2: view

Variants for LILRA2 Gene

Sequence variations from dbSNP and Humsavar for LILRA2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000101165 -- 54,577,741(+) G/T genic_downstream_transcript_variant, intron_variant
rs1000107535 -- 54,573,840(+) C/T 5_prime_UTR_variant
rs1000174357 -- 54,585,879(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000283635 -- 54,579,648(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000396759 -- 54,581,957(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LILRA2 Gene

Variant ID Type Subtype PubMed ID
nsv9759 CNV gain 18304495
nsv961248 CNV duplication 23825009
nsv522872 CNV loss 19592680
nsv470158 CNV loss 18288195
nsv1148744 OTHER inversion 26484159
nsv1065887 CNV loss 25217958
esv7755 CNV loss 19470904
esv2758771 CNV gain+loss 17122850
esv2718872 CNV deletion 23290073
esv2667609 CNV deletion 23128226
esv2519988 CNV deletion 19546169
dgv6563n54 CNV loss 21841781
dgv435n27 CNV loss 19166990
dgv3664n100 CNV gain 25217958
dgv3663n100 CNV gain 25217958
dgv17e196 CNV deletion 17116639
dgv16e196 CNV duplication 17116639

Variation tolerance for LILRA2 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.52; 71.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LILRA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LILRA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRA2 Gene

Disorders for LILRA2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LILRA2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
leprosy 3
  • leprosy, susceptibility to, 3
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LILRA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LILRA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LILRA2 Gene

Publications for LILRA2 Gene

  1. Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. (PMID: 19230061) Chen Y … Gao GF (Journal of molecular biology 2009) 3 4 22 58
  2. Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis. (PMID: 18273033) Mamegano K … Tsuchiya N (Genes and immunity 2008) 3 22 44 58
  3. Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. (PMID: 12529506) Tedla N … Arm JP (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 22 58
  4. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PMID: 9548455) Borges L … Cosman D (Journal of immunology (Baltimore, Md. : 1950) 1997) 2 3 4 58
  5. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. (PMID: 9079806) Samaridis J … Colonna M (European journal of immunology 1997) 2 3 22 58

Products for LILRA2 Gene

Sources for LILRA2 Gene

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