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The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
LIF (LIF Interleukin 6 Family Cytokine) is a Protein Coding gene. Diseases associated with LIF include Leukemia and Myeloid Leukemia. Among its related pathways are ERK Signaling and Interleukin-4 and 13 signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IPI | 8999038 |
GO:0005125 | cytokine activity | IDA | 7957045 |
GO:0005146 | leukemia inhibitory factor receptor binding | IPI | 8999038 |
GO:0005515 | protein binding | IPI | 14527405 |
GO:0008083 | growth factor activity | IDA | 7957045 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA,IC | 12643274 |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
|
IL-6 Pathway
.61
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
|
2 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
3 | Akt Signaling |
Akt Signaling
.60
|
p38 Signaling
.60
|
4 | PAK Pathway |
Antioxidant Action of Vitamin-C
.56
|
PAK Pathway
.56
|
5 | NFAT and Cardiac Hypertrophy |
NFAT and Cardiac Hypertrophy
.42
|
Signaling Involved in Cardiac Hypertrophy
.42
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001974 | blood vessel remodeling | IEA | -- |
GO:0006955 | immune response | IEA | -- |
GO:0007260 | tyrosine phosphorylation of STAT protein | IEA | -- |
GO:0007275 | multicellular organism development | TAS | 3143918 |
GO:0007566 | embryo implantation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LIF 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LIF 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LIF 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lif 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Lif 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LIF 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | LIF 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LIF 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs41281637 | Benign: not specified | 30,244,004(-) |
C/T NM_002309.5(LIF):c.256G>A (p.Val86Met) |
MISSENSE |
Disorder | Aliases | PubMed IDs |
---|---|---|
leukemia |
|
|
myeloid leukemia |
|
|
ectopic pregnancy |
|
|
embryonal carcinoma |
|
|
complement deficiency |
|
|