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The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the mate... See more...
Aliases for LIF Gene
Aliases for LIF Gene
External Ids for LIF Gene
- HGNC: 6596
- Entrez Gene: 3976
- Ensembl: ENSG00000128342
- OMIM: 159540
- UniProtKB: P15018
Previous GeneCards Identifiers for LIF Gene
- GC22M027332
- GC22M028960
- GC22M030636
- GC22M013598
Summaries for LIF Gene
-
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
GeneCards Summary for LIF Gene
LIF (LIF Interleukin 6 Family Cytokine) is a Protein Coding gene. Diseases associated with LIF include Leukemia and Myeloid Leukemia. Among its related pathways are PEDF Induced Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity.
UniProtKB/Swiss-Prot Summary for LIF Gene
-
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Additional gene information for LIF Gene
- HGNC(6596)
- Entrez Gene(3976)
- Ensembl(ENSG00000128342)
- OMIM(159540)
- UniProtKB(P15018)
- Open Targets Platform(ENSG00000128342)
- Monarch Initiative
- Search for LIF at DataMed
- Search for LIF at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LIF Gene
Genomics for LIF Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LIF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LIF on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LIF
- Top Transcription factor binding sites by QIAGEN in the LIF gene promoter:
-
- ATF-2
- c-Jun
- c-Myc
- Max
- STAT1
- STAT1beta
- STAT3
- STAT5A
Genomic Locations for LIF Gene
Genomic Locations for LIF Gene
- chr22:30,240,453-30,257,487
- (GRCh38/hg38)
- Size:
- 17,035 bases
- Orientation:
- Minus strand
- chr22:30,636,436-30,642,840
- (GRCh37/hg19)
- Size:
- 6,405 bases
- Orientation:
- Minus strand
Genomic View for LIF Gene
Genes around LIF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.2 by HGNC
- 22q12.2 by Entrez Gene
- 22q12.2 by Ensembl
LIF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LIF Gene
Proteins for LIF Gene
-
Protein details for LIF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15018-LIF_HUMAN
- Recommended name:
- Leukemia inhibitory factor
- Protein Accession:
- P15018
- B2RCW7
- B5MC23
- Q52LZ2
Protein attributes for LIF Gene
- Size:
- 202 amino acids
- Molecular mass:
- 22008 Da
- Quaternary structure:
- No Data Available
Protein Expression for LIF Gene
Post-translational modifications for LIF Gene
-
Glycosylation at Asn31, Asn56, Asn85, Asn95, Asn118, and Asn138
- NX_P15018 (NX_P15018-1)
Other Protein References for LIF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents LIF Antibody
- Creative Diagnostics Anti-LIF monoclonal antibody, clone 0935
- Novus Biologicals Antibodies for LIF
-
Abcam antibodies for LIF
- Invitrogen Antibodies for LIF (AFLGC-Lif)
- antibodies-online: Show 72 available LIF Antibodies ranked by validation data
- Compare Top LIF Antibodies
-
Recommended
- 97 WB Antibodies (anti-human)
- 17 IHC (p) Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 1 Neut Antibody (anti-human)
- 60 WB Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 32 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for LIF
-
Santa Cruz Biotechnology (SCBT) Antibodies for LIF
- Sino Biological Antibodies for LIF
Protein Products
- G Biosciences Human LIF/Leukemia inhibitory factor, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for LIF
- Origene Custom Protein Services for LIF
- Sino Biological Recombinant Proteins for LIF
- Sino Biological Cell Lysates for LIF
- ProSpec Recombinant Proteins for LIF
-
Abcam proteins for LIF
Assay Products
- RayBiotech Human LIF ELISA
- Creative Diagnostics Mouse LIF ELISA Kit
-
Custom Assay ServicesOriGene ELISA Kits for LIF
- Novus Biologicals ELISA Kits for LIF
- antibodies-online: Show 99 available LIF Elisa Kits ranked by validation data
- Compare Top LIF Elisa Kits
-
Quality Products:
- ABIN625036
- ABIN1115753
- ABIN367615
- ABIN414891
- ABIN4993150
- ABIN5521069
- ABIN2684878
- ABIN5668637
- ABIN1029106
- ABIN5592313
- ABIN1115755
- ABIN367712
- ABIN5521070
- ABIN5510575
- ABIN5669843
- ABIN2851326
- ABIN628069
- ABIN5526767
- ABIN4970815
- ABIN2949108
- ABIN1115754
- ABIN416358
- ABIN368159
- ABIN5521072
- ABIN5670504
- ABIN1571028
- ABIN627255
- ABIN5592314
- ABIN5656399
- ABIN4970816
- ABIN5521068
- ABIN1563603
- ABIN2949106
- ABIN364783
- ABIN5072743
-
Boster Bio ELISA Kits for LIF
-
Signalway ELISA kits for LIF
No data available for DME Specific Peptides for LIF Gene
Domains & Families for LIF Gene
Gene Families for LIF Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for LIF Gene
- InterPro:
- Blocks:
-
- Leukemia inhibitory factor
- ProtoNet:
Suggested Antigen Peptide Sequences for LIF Gene
- GenScript: Design optimal peptide antigens:
-
- Melanoma-derived LPL inhibitor (LIF_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P15018- Family:
-
- Belongs to the LIF/OSM family.
Function for LIF Gene
Molecular function for LIF Gene
- UniProtKB/Swiss-Prot Function:
- LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
- GENATLAS Biochemistry:
- leukemia inhibitory factor (differentiation-stimulating factor),interleukin-6 cytokine family member stimulating hematopoiesis,platelet production,localized distally to the breakpoint in t(11;22)(q24;q12)
LifeMap Function Summary for LIF Gene
It affects the following cells:
- Eye
- Neural Tube
LIF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Brain
- Ovary
- Gonad
Phenotypes From GWAS Catalog for LIF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IPI | 8999038 |
| GO:0005125 | cytokine activity | IDA | 7957045 |
| GO:0005146 | leukemia inhibitory factor receptor binding | IPI | 8999038 |
| GO:0005515 | protein binding | IPI | 14527405 |
| GO:0008083 | growth factor activity | IDA | 7957045 |
Phenotypes for LIF Gene
- MGI mutant phenotypes for LIF:
-
inferred from 3 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for LIF:
-
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Increased transferrin (TF) endocytosis
- Decreased G3BP1 protein expression and assembly in stress granules after arsenite stimulation
- Decreased ionizing radiation sensitivity
- Decreased POU5F1-GFP protein expression
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Increased HDAC inhibitor resistance
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LIF - Select products 50% OFF >
- * LIF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LIF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LIF
-
Santa Cruz Biotechnology (SCBT) CRISPR for LIF
miRNA for LIF Gene
- miRTarBase miRNAs that target LIF
-
- hsa-miR-125b-5p (MIRT001037)
- hsa-miR-26a-5p (MIRT001039)
- hsa-miR-346 (MIRT001040)
- hsa-miR-199a-5p (MIRT004325)
- hsa-miR-125a-5p (MIRT004326)
- hsa-miR-223-3p (MIRT006248)
- hsa-miR-335-5p (MIRT018057)
- hsa-miR-26b-5p (MIRT029582)
- hsa-miR-330-5p (MIRT038243)
- bta-miR-181a (MIRT053968)
- hsa-miR-3180-5p (MIRT721337)
- hsa-miR-4279 (MIRT721338)
- hsa-miR-6749-3p (MIRT721339)
- hsa-miR-4711-3p (MIRT721340)
- hsa-miR-6744-3p (MIRT721341)
- hsa-miR-4757-5p (MIRT721342)
- hsa-miR-6845-3p (MIRT721343)
- hsa-miR-660-3p (MIRT721344)
- hsa-miR-5193 (MIRT721345)
- hsa-miR-199b-5p (MIRT721346)
- hsa-miR-4673 (MIRT721347)
- hsa-miR-4645-5p (MIRT721348)
- hsa-miR-6733-3p (MIRT721349)
- hsa-miR-4650-5p (MIRT721350)
- mmu-miR-223-3p (MIRT733882)
- hsa-miR-181c-3p (MIRT738037)
- hsa-miR-1972 (MIRT738675)
- hsa-miR-3156-3p (MIRT740450)
- hsa-miR-3655 (MIRT741919)
- hsa-miR-3922-5p (MIRT742980)
- hsa-miR-3928-3p (MIRT743043)
- hsa-miR-4286 (MIRT743738)
- hsa-miR-4301 (MIRT743861)
- hsa-miR-432-5p (MIRT744089)
- hsa-miR-4708-3p (MIRT747359)
- hsa-miR-4768-5p (MIRT748641)
- hsa-miR-510-5p (MIRT749732)
- hsa-miR-532-3p (MIRT750336)
- hsa-miR-6081 (MIRT751762)
- hsa-miR-624-5p (MIRT752574)
- hsa-miR-6778-3p (MIRT755406)
- hsa-miR-6833-3p (MIRT757149)
- hsa-miR-6873-3p (MIRT758050)
- hsa-miR-766-5p (MIRT759643)
- hsa-miR-890 (MIRT760432)
- hsa-miR-1288-5p (MIRT790087)
- hsa-miR-4330 (MIRT790436)
- hsa-miR-4454 (MIRT790457)
- hsa-miR-5100 (MIRT790695)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LIF
- Browse OriGene Inhibitory RNA Products For LIF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIF
Clone Products
- Applied Biological Materials (abm): Clones for LIF - Select products 50% OFF >
- * LIF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223120
- MG223901
- MR223120
- MR223120L3
- MR223120L4
- MR223901
- MR223901L3
- MR223901L4
- RC210818
- RC210818L1
- RC210818L2
- RC210818L3
- RC210818L4
- RC231599
- RG210818
- RG231599
- RR205959
- RR205959L3
- RR205959L4
- MR223120L3V
- MR223120L4V
- MR223901L3V
- MR223901L4V
- RC210818L1V
- RC210818L2V
- RC210818L3V
- RC210818L4V
- RR205959L3V
- RR205959L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LIF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LIF
Cell Line Products
-
Horizon Cell Lines for LIF
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIF Gene
Localization for LIF Gene
Subcellular locations from UniProtKB/Swiss-Prot for LIF Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| nucleus | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA,IC | 12643274 |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for LIF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
|
IL-6 Pathway
.61
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
|
| 2 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
| 3 | Akt Signaling |
Akt Signaling
.60
|
p38 Signaling
.60
|
| 4 | PAK Pathway |
Antioxidant Action of Vitamin-C
.56
|
PAK Pathway
.56
|
| 5 | NFAT and Cardiac Hypertrophy |
NFAT and Cardiac Hypertrophy
.42
|
Signaling Involved in Cardiac Hypertrophy
.42
|
Pathways by source for LIF Gene
5 BioSystems pathways for LIF Gene
7 Reactome pathways for LIF Gene
1 R&D Systems pathway for LIF Gene
18 Qiagen pathways for LIF Gene
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- Endothelin-1 Signaling Pathway
- ERK Signaling
Interacting Proteins for LIF Gene
Selected Interacting proteins:
P15018-LIF_HUMAN
ENSP00000249075
for LIF Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for LIF
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001974 | blood vessel remodeling | IEA | -- |
| GO:0006955 | immune response | IEA | -- |
| GO:0007260 | tyrosine phosphorylation of STAT protein | IEA | -- |
| GO:0007275 | multicellular organism development | TAS | 3143918 |
| GO:0007566 | embryo implantation | IEA | -- |
Drugs & Compounds for LIF Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for LIF Gene
mRNA/cDNA for LIF Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000249075 3871 nts (view in UCSC)
- ENST00000403987 592 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LIF - Select products 50% OFF >
- * LIF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LIF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LIF
-
Santa Cruz Biotechnology (SCBT) CRISPR for LIF
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LIF
- Browse OriGene Inhibitory RNA Products For LIF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIF
Clone Products
- Applied Biological Materials (abm): Clones for LIF - Select products 50% OFF >
- * LIF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223120
- MG223901
- MR223120
- MR223120L3
- MR223120L4
- MR223901
- MR223901L3
- MR223901L4
- RC210818
- RC210818L1
- RC210818L2
- RC210818L3
- RC210818L4
- RC231599
- RG210818
- RG231599
- RR205959
- RR205959L3
- RR205959L4
- MR223120L3V
- MR223120L4V
- MR223901L3V
- MR223901L4V
- RC210818L1V
- RC210818L2V
- RC210818L3V
- RC210818L4V
- RR205959L3V
- RR205959L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LIF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LIF
Relevant External Links for LIF Gene
- GeneLoc Exon Structure for
- LIF
Expression for LIF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Inner Cell Mass (Early Embryo)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- Mesenchymal Stem Cells (Uncategorized)
-
Adipose (Muscoskeletal System)
- Visceral White Preadipocytes Visceral White Adipose
- NULL (Integumentary System)
- Uncategorized
- Umbilical Cord (Extraembryonic Tissues)
- Eye (Sensory Organs)
-
Dermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for LIF Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x4.6) and Prostate (x4.4).
This gene is overexpressed in Cerebrospinal fluid (57.7) and Bone marrow mesenchymal stem cell (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LIF Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LIF
SOURCE GeneReport for Unigene cluster for LIF Gene:
Hs.2250Evidence on tissue expression from TISSUES for LIF Gene
- Intestine(4.5)
- Nervous system(3.1)
- Skin(2.9)
- Muscle(2.8)
- Heart(2.8)
- Blood(2.7)
- Liver(2.6)
- Kidney(2.6)
- Bone marrow(2.5)
- Lung(2.5)
- Pancreas(2.4)
- Bone(2.3)
- Spleen(2.3)
- Adrenal gland(2.3)
- Eye(2.3)
- Lymph node(2.2)
- Thyroid gland(2.1)
- Stomach(2.1)
Primer Products
-
OriGene qPCR primer pairs for LIF
-
OriGene qPCR primer pairs and template standards for LIF
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIF Gene
Orthologs for LIF Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LIF 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LIF 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LIF 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Lif 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Lif 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | LIF 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | LIF 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LIF 30 31 |
|
OneToOne |
- Species where no ortholog for LIF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for LIF Gene
- ENSEMBL:
- Gene Tree for LIF (if available)
- TreeFam:
- Gene Tree for LIF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LIF: view image
Paralogs for LIF Gene
No data available for Paralogs for LIF Gene
Variants for LIF Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LIF Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs41281637 | Benign: not specified | 30,244,004(-) | C/T | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.59;
44.93% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LIF Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIF Gene
Disorders for LIF Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukemia |
|
|
| myeloid leukemia |
|
|
| ectopic pregnancy |
|
|
| embryonal carcinoma |
|
|
| plasmacytoma |
|
Search LIF in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LIF
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for LIF Gene
Publications for LIF Gene
- An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. (PMID: 17652170) Huyton T … Garrett TP (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 23
- Association of the leukemia inhibitory factor gene mutation and the antiphospholipid antibodies in the peripheral blood of infertile women. (PMID: 18298054) Králícková M … Vetvicka V (Folia microbiologica 2007) 3 23 41
- Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. (PMID: 14527405) Boulanger MJ … Garcia KC (Molecular cell 2003) 3 4 23
- Neuropoietic cytokines in the hematopoietic fold. (PMID: 1714745) Bazan JF (Neuron 1991) 2 3 23
- Expression of LIF and LIF receptor beta in Alzheimer's and Parkinson's diseases. (PMID: 20074285) Soilu-Hänninen M … Hukkanen V (Acta neurologica Scandinavica 2010) 3 23
ExternalLinks
Products for LIF Gene
- View all 25 R&D Systems LIF (LIF) Products
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- antibodies-online: Show 72 available LIF Antibodies ranked by validation data
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- 97 WB Antibodies (anti-human)
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- antibodies-online: Show 99 available LIF Elisa Kits ranked by validation data
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- antibodies-online: Show 111 available LIF Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for LIF
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Sources for LIF Gene
- (1) GeneCards
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