The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. Localized in the mitochondrion, this iron-sulfur enzyme catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a potent antioxidant. The deficient expression of this enzyme has been linked to conditions such as diabetes, atherosclerosis and neonatal-onset epi... See more...

Aliases for LIAS Gene

Aliases for LIAS Gene

  • Lipoic Acid Synthetase 2 3 5
  • Lipoyl Synthase, Mitochondrial 2 3 4
  • LAS 2 3 4
  • Lipoate Synthase 3 4
  • EC 2.8.1.8 4 51
  • Lip-Syn 3 4
  • LS 3 4
  • Lipoic Acid Synthase 4
  • HUSSY-01 3
  • HGCLAS 3
  • PDHLD 3
  • LIP1 3
  • LIAS 5

External Ids for LIAS Gene

Previous GeneCards Identifiers for LIAS Gene

  • GC04P039463
  • GC04P039635
  • GC04P039295
  • GC04P039357
  • GC04P039283
  • GC04P039137
  • GC04P038785
  • GC04P039461

Summaries for LIAS Gene

Entrez Gene Summary for LIAS Gene

  • The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. Localized in the mitochondrion, this iron-sulfur enzyme catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a potent antioxidant. The deficient expression of this enzyme has been linked to conditions such as diabetes, atherosclerosis and neonatal-onset epilepsy. Alternative splicing occurs at this locus, and several transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Aug 2020]

GeneCards Summary for LIAS Gene

LIAS (Lipoic Acid Synthetase) is a Protein Coding gene. Diseases associated with LIAS include Hyperglycinemia, Lactic Acidosis, And Seizures and Lipoic Acid Synthetase Deficiency. Among its related pathways are Viral mRNA Translation and Lipoic acid metabolism. Gene Ontology (GO) annotations related to this gene include 4 iron, 4 sulfur cluster binding and lipoate synthase activity.

UniProtKB/Swiss-Prot Summary for LIAS Gene

  • Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LIAS Gene

Genomics for LIAS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LIAS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LIAS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LIAS

Top Transcription factor binding sites by QIAGEN in the LIAS gene promoter:
  • AML1a
  • ER-alpha
  • Gfi-1
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for LIAS Gene

Latest Assembly
chr4:39,459,004-39,485,109
(GRCh38/hg38)
Size:
26,106 bases
Orientation:
Plus strand

Previous Assembly
chr4:39,460,676-39,481,126
(GRCh37/hg19 by Entrez Gene)
Size:
20,451 bases
Orientation:
Plus strand

chr4:39,460,620-39,479,273
(GRCh37/hg19 by Ensembl)
Size:
18,654 bases
Orientation:
Plus strand

Genomic View for LIAS Gene

Genes around LIAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIAS Gene

Proteins for LIAS Gene

  • Protein details for LIAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43766-LIAS_HUMAN
    Recommended name:
    Lipoyl synthase, mitochondrial
    Protein Accession:
    O43766
    Secondary Accessions:
    • A8K873
    • C9JCF6
    • Q8IV62

    Protein attributes for LIAS Gene

    Size:
    372 amino acids
    Molecular mass:
    41911 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LIAS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIAS Gene

Selected DME Specific Peptides for LIAS Gene

O43766:
  • CPNIGEC
  • PLVRSSY
  • YVVLTSV
  • KTSIMLG
  • LTPDFRG
  • TLGQYMQPT
  • TATIMLMG
  • HTVCEEA
  • TSVDRDD

Post-translational modifications for LIAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for LIAS Gene

Gene Families for LIAS Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for LIAS Gene

InterPro:
Blocks:
  • Elongator protein 3/MiaB/NifB
ProtoNet:

Suggested Antigen Peptide Sequences for LIAS Gene

GenScript: Design optimal peptide antigens:
  • Lipoic acid synthase (LIAS_HUMAN)
  • cDNA FLJ76626 (Q6P5Q6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43766

UniProtKB/Swiss-Prot:

LIAS_HUMAN :
  • Belongs to the radical SAM superfamily. Lipoyl synthase family.
Family:
  • Belongs to the radical SAM superfamily. Lipoyl synthase family.
genes like me logo Genes that share domains with LIAS: view

Function for LIAS Gene

Molecular function for LIAS Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:16585, Rhea:RHEA-COMP:9928, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001, Rhea:RHEA-COMP:10475, Rhea:RHEA-COMP:14568, Rhea:RHEA-COMP:14569, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319, ChEBI:CHEBI:29034, ChEBI:CHEBI:29919, ChEBI:CHEBI:33722, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:78809, ChEBI:CHEBI:83100; EC=2.8.1.8; Evidence={ECO:0000255|HAMAP-Rule:MF_03123};.

Enzyme Numbers (IUBMB) for LIAS Gene

Phenotypes From GWAS Catalog for LIAS Gene

Gene Ontology (GO) - Molecular Function for LIAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0016740 transferase activity IEA --
GO:0016783 sulfurtransferase activity IEA --
GO:0016992 lipoate synthase activity IEA,ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LIAS: view
genes like me logo Genes that share phenotypes with LIAS: view

Human Phenotype Ontology for LIAS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LIAS Gene

MGI Knock Outs for LIAS:

Animal Models for research

  • Taconic Biosciences Mouse Models for LIAS

miRNA for LIAS Gene

miRTarBase miRNAs that target LIAS

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIAS

No data available for Transcription Factor Targets and HOMER Transcription for LIAS Gene

Localization for LIAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIAS Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIAS gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LIAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA,ISS --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with LIAS: view

Pathways & Interactions for LIAS Gene

genes like me logo Genes that share pathways with LIAS: view

Pathways by source for LIAS Gene

UniProtKB/Swiss-Prot O43766-LIAS_HUMAN

  • Pathway: Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.

Gene Ontology (GO) - Biological Process for LIAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0006954 inflammatory response ISS --
GO:0006979 response to oxidative stress ISS --
GO:0009107 lipoate biosynthetic process IEA,ISS --
GO:0009249 protein lipoylation IEA --
genes like me logo Genes that share ontologies with LIAS: view

No data available for SIGNOR curated interactions for LIAS Gene

Drugs & Compounds for LIAS Gene

(4) Drugs for LIAS Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lipoic acid Approved, Investigational Nutra Target 0
Methionine Approved Nutra 123
Hydrogen sulfide Pharma 16

(8) Additional Compounds for LIAS Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(S)-Lipoic acid
  • (S)-(-)-Lipoic acid
  • (S)-1,2-Dithiolane-3-pentanoic acid
  • (S)-alpha-Lipoic acid
  • L-1,2-Dithiolane 3-valeric acid
  • L-6,8-Thioctic acid
1077-27-6
5'-Deoxyadenosine
  • 5'-Deoxy-adenosine
  • 5'-DAdo nucleoside
4754-39-6
N(6)-(Octanoyl)lysine
  • 2-Amino-6-[(1-hydroxyoctylidene)amino]hexanoate
s-adenosylmethionine
  • (3S)-5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
Sulfide
  • S(2-)
  • Sulphide
  • Sulfanediide
  • Sulfur
  • Sulphide(2-)
18496-25-8
genes like me logo Genes that share compounds with LIAS: view

Transcripts for LIAS Gene

mRNA/cDNA for LIAS Gene

6 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LIAS

Alternative Splicing Database (ASD) splice patterns (SP) for LIAS Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for LIAS Gene

GeneLoc Exon Structure for
LIAS

Expression for LIAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LIAS Gene

This gene is overexpressed in Heart (44.7) and Testis (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LIAS Gene



Protein tissue co-expression partners for LIAS Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LIAS

SOURCE GeneReport for Unigene cluster for LIAS Gene:

Hs.550502

Evidence on tissue expression from TISSUES for LIAS Gene

  • Skin(4.4)
  • Nervous system(2.1)
  • Pancreas(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LIAS Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • ear
  • head
  • mouth
  • pharynx
  • skull
Thorax:
  • heart
  • heart valve
  • lung
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood vessel
  • spinal cord
genes like me logo Genes that share expression patterns with LIAS: view

Primer products for research

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LIAS Gene

Orthologs for LIAS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LIAS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LIAS 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LIAS 30 31
  • 92.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LIAS 30 31
  • 92.29 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LIAS 31
  • 88 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Lias 30 17 31
  • 87.35 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lias 30
  • 86.63 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia LIAS 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LIAS 30 31
  • 77.34 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LIAS 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101735113 30
  • 75.65 (n)
Str.6920 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.8349 30
Zebrafish
(Danio rerio)
Actinopterygii lias 30 31
  • 69.63 (n)
OneToOne
zgc66080 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14170 30
Fruit Fly
(Drosophila melanogaster)
Insecta Las 30 31 32
  • 62.19 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010568 30
  • 59.78 (n)
Worm
(Caenorhabditis elegans)
Secernentea M01F1.3 30 31 32
  • 59.28 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F00836g 30
  • 61.45 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LIP5 30 31 33
  • 59.66 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR231C 30
  • 57.49 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G08415 30
  • 60.76 (n)
Soybean
(Glycine max)
eudicotyledons Gma.3319 30
Rice
(Oryza sativa)
Liliopsida Os05g0511500 30
  • 61.37 (n)
Corn
(Zea mays)
Liliopsida Zm.16017 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9415 31
  • 65 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU00565 30
  • 60.3 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes lip5 30
  • 60 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4454 30
Species where no ortholog for LIAS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LIAS Gene

ENSEMBL:
Gene Tree for LIAS (if available)
TreeFam:
Gene Tree for LIAS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LIAS: view image

Paralogs for LIAS Gene

No data available for Paralogs for LIAS Gene

Variants for LIAS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LIAS Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
835575 Uncertain Significance: Pyruvate dehydrogenase lipoic acid synthetase deficiency 39,465,040(+) T/C
NM_006859.4(LIAS):c.394-6T>C
INTRON
836400 Uncertain Significance: Pyruvate dehydrogenase lipoic acid synthetase deficiency 39,463,541(+) G/A
NM_006859.4(LIAS):c.329G>A (p.Arg110Gln)
MISSENSE
838834 Uncertain Significance: Pyruvate dehydrogenase lipoic acid synthetase deficiency 39,462,275(+) T/A
NM_006859.4(LIAS):c.298T>A (p.Leu100Ile)
MISSENSE_VARIANT,INTRON
839857 Uncertain Significance: Pyruvate dehydrogenase lipoic acid synthetase deficiency 39,460,810(+) C/G
NM_006859.4(LIAS):c.66C>G (p.Cys22Trp)
MISSENSE
844220 Uncertain Significance: Pyruvate dehydrogenase lipoic acid synthetase deficiency 39,473,194(+) G/A
NM_006859.4(LIAS):c.1049G>A (p.Arg350His)
MISSENSE_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LIAS Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LIAS Gene

Variant ID Type Subtype PubMed ID
nsv1010189 CNV gain 25217958
nsv1010784 CNV gain 25217958
nsv1123777 CNV deletion 24896259

Variation tolerance for LIAS Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LIAS Gene

Human Gene Mutation Database (HGMD)
LIAS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIAS

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIAS Gene

Disorders for LIAS Gene

MalaCards: The human disease database

(12) MalaCards diseases for LIAS Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search LIAS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LIAS_HUMAN
  • Hyperglycinemia, lactic acidosis, and seizures (HGCLAS) [MIM:614462]: An enzymatic defect resulting in an autosomal recessive disorder of mitochondrial metabolism. It is characterized by early-onset lactic acidosis, severe encephalomyopathy, and a pyruvate oxidation defect. Affected individuals have neonatal-onset epilepsy, poor growth, psychomotor retardation, muscular hypotonia, lactic acidosis, and elevated glycine concentration in plasma and urine. {ECO:0000269 PubMed:22152680}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for LIAS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LIAS: view

No data available for Genatlas for LIAS Gene

Publications for LIAS Gene

  1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F … Valle G (Yeast (Chichester, England) 2001) 2 3 4
  2. Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5. (PMID: 24334290) Baker PR … Van Hove JL (Brain : a journal of neurology 2014) 3 74
  3. Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation. (PMID: 22152680) Mayr JA … Sperl W (American journal of human genetics 2011) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for LIAS Gene

Sources for LIAS Gene