The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in to... See more...

Aliases for LHX8 Gene

Aliases for LHX8 Gene

  • LIM Homeobox 8 2 3 5
  • LIM/Homeobox Protein Lhx8 3 4
  • LIM-Homeodomain Protein Lhx8 3
  • LIM Homeobox Protein 8 4
  • LHX7 3

External Ids for LHX8 Gene

Previous GeneCards Identifiers for LHX8 Gene

  • GC01P075306
  • GC01P075594
  • GC01P073728

Summaries for LHX8 Gene

Entrez Gene Summary for LHX8 Gene

  • The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for LHX8 Gene

LHX8 (LIM Homeobox 8) is a Protein Coding gene. Diseases associated with LHX8 include Odontoma and Cerebral Hemisphere Lipoma. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is LHX6.

UniProtKB/Swiss-Prot Summary for LHX8 Gene

  • Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

Additional gene information for LHX8 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LHX8 Gene

Genomics for LHX8 Gene

GeneHancer (GH) Regulatory Elements for LHX8 Gene

Promoters and enhancers for LHX8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J075100 Promoter/Enhancer 0.8 EPDnew CraniofacialAtlas 500.3 -27.9 -27917 0.4 TCF12 SIN3A JUND GLIS1 YY1 FOXA1 SP1 LHX8 piR-59769-028 piR-33432-018
GH01J075162 Enhancer 0.2 Ensembl 11 +34.3 34267 1 LHX8 ENSG00000224127 ENSG00000224149 RF00026-051 RNU6-622P
GH01J075136 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 0.4 +10.6 10566 9.6 ZSCAN5C ZBTB26 EZH2 SMC3 ZBTB17 ZNF263 NANOG SIN3A ZNF335 SUZ12 SLC44A5 CRYZ ENSG00000272864 ENSG00000224127 LHX8 RF00026-051 RNU6-622P
GH01J075125 Enhancer 0.5 FANTOM5 0.7 -3.1 -3149 0.4 E2F6 AFF1 L3MBTL2 RBFOX2 MGA ENSG00000261213 SLC44A5 LHX8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LHX8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LHX8

Top Transcription factor binding sites by QIAGEN in the LHX8 gene promoter:
  • AREB6
  • CUTL1
  • Egr-4
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx2-5
  • Pax-4a
  • PPAR-gamma1
  • PPAR-gamma2
  • YY1

Genomic Locations for LHX8 Gene

Genomic Locations for LHX8 Gene
chr1:75,128,434-75,161,533
(GRCh38/hg38)
Size:
33,100 bases
Orientation:
Plus strand
chr1:75,594,119-75,627,218
(GRCh37/hg19)
Size:
33,100 bases
Orientation:
Plus strand

Genomic View for LHX8 Gene

Genes around LHX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LHX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHX8 Gene

Proteins for LHX8 Gene

  • Protein details for LHX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68G74-LHX8_HUMAN
    Recommended name:
    LIM/homeobox protein Lhx8
    Protein Accession:
    Q68G74
    Secondary Accessions:
    • E9PGE3

    Protein attributes for LHX8 Gene

    Size:
    356 amino acids
    Molecular mass:
    39301 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LHX8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LHX8 Gene

Post-translational modifications for LHX8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LHX8 Gene

No data available for DME Specific Peptides for LHX8 Gene

Domains & Families for LHX8 Gene

Gene Families for LHX8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for LHX8 Gene

Blocks:
  • Zn-binding protein, LIM
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LHX8 Gene

GenScript: Design optimal peptide antigens:
  • LIM/homeobox protein Lhx8 (LHX8_HUMAN)
  • LIM homeobox 8 (Q6SV70_HUMAN)
  • LIM homeobox 8 (Q6SV71_HUMAN)
  • LIM-homeodomain protein Lhx8 (Q9BYB7_HUMAN)
genes like me logo Genes that share domains with LHX8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LHX8 Gene

Function for LHX8 Gene

Molecular function for LHX8 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

Phenotypes From GWAS Catalog for LHX8 Gene

Gene Ontology (GO) - Molecular Function for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with LHX8: view
genes like me logo Genes that share phenotypes with LHX8: view

Animal Models for LHX8 Gene

MGI Knock Outs for LHX8:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LHX8 Gene

Localization for LHX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHX8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LHX8 gene
Compartment Confidence
nucleus 4
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0001674 female germ cell nucleus IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with LHX8: view

Pathways & Interactions for LHX8 Gene

PathCards logo

SuperPathways for LHX8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007611 learning or memory IEA --
GO:0008585 female gonad development IEA --
GO:0021879 forebrain neuron differentiation IEA --
GO:0021884 forebrain neuron development IBA 21873635
genes like me logo Genes that share ontologies with LHX8: view

No data available for Pathways by source and SIGNOR curated interactions for LHX8 Gene

Drugs & Compounds for LHX8 Gene

No Compound Related Data Available

Transcripts for LHX8 Gene

mRNA/cDNA for LHX8 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LHX8 Gene

No ASD Table

Relevant External Links for LHX8 Gene

GeneLoc Exon Structure for
LHX8

Expression for LHX8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LHX8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LHX8 Gene

This gene is overexpressed in Minor Salivary Gland (x14.3), Brain - Caudate (basal ganglia) (x9.1), Brain - Putamen (basal ganglia) (x7.3), Brain - Nucleus accumbens (basal ganglia) (x6.4), and Brain - Hypothalamus (x5.3).

Protein differential expression in normal tissues from HIPED for LHX8 Gene

This gene is overexpressed in Pancreatic juice (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LHX8 Gene



Protein tissue co-expression partners for LHX8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LHX8

SOURCE GeneReport for Unigene cluster for LHX8 Gene:

Hs.403934
genes like me logo Genes that share expression patterns with LHX8: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LHX8 Gene

Orthologs for LHX8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LHX8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LHX8 31 30
  • 99.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LHX8 31 30
  • 95.38 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LHX8 31 30
  • 95.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lhx8 30
  • 88.13 (n)
mouse
(Mus musculus)
Mammalia Lhx8 17 31 30
  • 87.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LHX8 31
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LHX8 31
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves LHX8 31 30
  • 87.07 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LHX8 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lhx8 30
  • 75.46 (n)
zebrafish
(Danio rerio)
Actinopterygii lhx8a 31 30
  • 71.48 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006540 30
  • 53.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta Awh 31 30
  • 50.59 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lim-4 31
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PXL1 33
Species where no ortholog for LHX8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LHX8 Gene

ENSEMBL:
Gene Tree for LHX8 (if available)
TreeFam:
Gene Tree for LHX8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LHX8: view image

Paralogs for LHX8 Gene

(28) SIMAP similar genes for LHX8 Gene using alignment to 3 proteins:

  • LHX8_HUMAN
  • Q6SV70_HUMAN
  • Q6SV71_HUMAN
genes like me logo Genes that share paralogs with LHX8: view

Variants for LHX8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LHX8 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
782378 Benign: not provided 75,156,895(+) G/T SYNONYMOUS_VARIANT
787748 Benign: not provided 75,137,116(+) C/T MISSENSE_VARIANT
787749 Benign: not provided 75,143,169(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for LHX8 Gene

Structural Variations from Database of Genomic Variants (DGV) for LHX8 Gene

Variant ID Type Subtype PubMed ID
esv2632878 CNV deletion 19546169
nsv1078876 OTHER inversion 25765185
nsv1444 CNV insertion 18451855

Variation tolerance for LHX8 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LHX8 Gene

Human Gene Mutation Database (HGMD)
LHX8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LHX8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHX8 Gene

Disorders for LHX8 Gene

MalaCards: The human disease database

(10) MalaCards diseases for LHX8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
odontoma
cerebral hemisphere lipoma
  • lipoma of the cerebral hemisphere
corpus callosum lipoma
  • lipoma of the corpus callosum
neuropathy, hereditary sensory and autonomic, type iia
  • hsan2a
cleft palate, isolated
  • cpi
- elite association - COSMIC cancer census association via MalaCards
Search LHX8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LHX8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LHX8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LHX8 Gene

Publications for LHX8 Gene

  1. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41 54
  2. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PMID: 20672350) Nikopensius T … Metspalu A (Birth defects research. Part A, Clinical and molecular teratology 2010) 3 41 54
  3. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PMID: 20572854) Jagomägi T … Metspalu A (European journal of oral sciences 2010) 3 41 54
  4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 41 54
  5. Analysis of LHX8 mutation in premature ovarian failure. (PMID: 17624344) Qin Y … Rajkovic A (Fertility and sterility 2008) 3 41 54

Products for LHX8 Gene

Sources for LHX8 Gene