Aliases for LHX4-AS1 Gene

Data sources for LHX4-AS1 Gene:

Subcategory (RNA class) for LHX4-AS1 Gene

lncRNA

Aliases for LHX4-AS1 Gene

External Ids for LHX4-AS1 Gene

Summaries for LHX4-AS1 Gene

GeneCards Summary for LHX4-AS1 Gene

LHX4-AS1 (LHX4 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with LHX4-AS1 include Pituitary Hormone Deficiency, Combined, 4 and Pituitary Hormone Deficiency, Combined, 1. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include lipid binding and fatty-acyl-CoA binding.

Additional gene information for LHX4-AS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LHX4-AS1 Gene

Genomics for LHX4-AS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LHX4-AS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LHX4-AS1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for LHX4-AS1 Gene

Latest Assembly
chr1:180,269,652-180,502,954
(GRCh38/hg38)
Size:
233,303 bases
Orientation:
Minus strand

Previous Assembly
chr1:180,238,798-180,243,816
(GRCh37/hg19 by Entrez Gene)
Size:
5,019 bases
Orientation:
Minus strand

Genomic View for LHX4-AS1 Gene

Genes around LHX4-AS1 on UCSC Golden Path with GeneCards custom track
LHX4-AS1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
LHX4-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHX4-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHX4-AS1 Gene

Proteins for LHX4-AS1 Gene

Post-translational modifications for LHX4-AS1 Gene

No Post-translational modifications

Other Protein References for LHX4-AS1 Gene

No data available for DME Specific Peptides for LHX4-AS1 Gene

Domains & Families for LHX4-AS1 Gene

Gene Families for LHX4-AS1 Gene

genes like me logo Genes that share domains with LHX4-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LHX4-AS1 Gene

Function for LHX4-AS1 Gene

Phenotypes From GWAS Catalog for LHX4-AS1 Gene

Gene Ontology (GO) - Molecular Function for LHX4-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IEA --
GO:0005515 protein binding IPI --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with LHX4-AS1: view

miRNA for LHX4-AS1 Gene

miRTarBase miRNAs that target LHX4-AS1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LHX4-AS1 Gene

Localization for LHX4-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LHX4-AS1 gene
Compartment Confidence
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LHX4-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LHX4-AS1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for LHX4-AS1 Gene

Pathways & Interactions for LHX4-AS1 Gene

genes like me logo Genes that share pathways with LHX4-AS1: view

Interacting Proteins for LHX4-AS1 Gene

Gene Ontology (GO) - Biological Process for LHX4-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006637 acyl-CoA metabolic process TAS --
genes like me logo Genes that share ontologies with LHX4-AS1: view

No data available for SIGNOR curated interactions for LHX4-AS1 Gene

Drugs & Compounds for LHX4-AS1 Gene

No Compound Related Data Available

Transcripts for LHX4-AS1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for LHX4-AS1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C729_9606 lncRNA 2657 1

RefSeq: NR_037642,

URS00009B66ED_9606 lncRNA 3082 2

LncBook: HSALNT0018236,

NONCODE: NONHSAT152606.1,

URS00008C1F41_9606 lncRNA 4805 1

LNCipedia: LHX4-AS1:7,

URS0001BD4245_9606 lncRNA 3084 1

LncBook: HSALNT0018236,

URS00003570A3_9606 lncRNA 2672 1

LNCipedia: LHX4-AS1:8,

LHX4-AS1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for LHX4-AS1 Gene

3 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for LHX4-AS1 Gene

No ASD Table

Relevant External Links for LHX4-AS1 Gene

GeneLoc Exon Structure for
LHX4-AS1

Expression for LHX4-AS1 Gene

Protein differential expression in normal tissues from HIPED for LHX4-AS1 Gene

This gene is overexpressed in Lymph node (11.2), Monocytes (9.8), and Testis (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for LHX4-AS1 Gene



Protein tissue co-expression partners for LHX4-AS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LHX4-AS1

Evidence on tissue expression from TISSUES for LHX4-AS1 Gene

  • Lung(4.3)
  • Nervous system(2.4)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LHX4-AS1 Gene

Orthologs for LHX4-AS1 Gene

Evolution for LHX4-AS1 Gene

ENSEMBL:
Gene Tree for LHX4-AS1 (if available)
TreeFam:
Gene Tree for LHX4-AS1 (if available)

No data available for Orthologs for LHX4-AS1 Gene

Paralogs for LHX4-AS1 Gene

No data available for Paralogs for LHX4-AS1 Gene

Variants for LHX4-AS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LHX4-AS1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
873865 Uncertain Significance: Short stature-pituitary and cerebellar defects-small sella turcica syndrome 180,271,414(-) C/A
NM_033343.4(LHX4):c.486C>A (p.Thr162=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
873866 Likely Benign: Short stature-pituitary and cerebellar defects-small sella turcica syndrome 180,274,255(-) A/C
NM_033343.4(LHX4):c.849A>C (p.Gly283=)
SYNONYMOUS
874814 Uncertain Significance: Short stature-pituitary and cerebellar defects-small sella turcica syndrome 180,274,413(-) G/A
NM_033343.4(LHX4):c.1007G>A (p.Ser336Asn)
MISSENSE
874815 Benign: Short stature-pituitary and cerebellar defects-small sella turcica syndrome 180,274,566(-) A/C
NM_033343.4(LHX4):c.1160A>C (p.His387Pro)
MISSENSE
874816 Benign: Short stature-pituitary and cerebellar defects-small sella turcica syndrome 180,274,571(-) C/A
NM_033343.4(LHX4):c.1165C>A (p.Pro389Thr)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LHX4-AS1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LHX4-AS1 Gene

Variant ID Type Subtype PubMed ID
dgv474n100 CNV gain 25217958
nsv1013076 CNV gain 25217958
nsv466239 CNV gain 19166990
nsv548345 CNV gain 21841781
nsv832004 CNV gain 17160897

Additional Variant Information for LHX4-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LHX4-AS1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for LHX4-AS1 Gene

Disorders for LHX4-AS1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LHX4-AS1 Gene - From: CVR and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LHX4-AS1

genes like me logo Genes that share disorders with LHX4-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LHX4-AS1 Gene

Publications for LHX4-AS1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
  3. Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4. (PMID: 11567216) Machinis K … Amselem S (American journal of human genetics 2001) 74
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3

Products for LHX4-AS1 Gene

Sources for LHX4-AS1 Gene