Aliases for LHX4-AS1 Gene

Subcategory (RNA class) for LHX4-AS1 Gene

lncRNA

Number of RNA Genes sources:

3 / 17

Aliases for LHX4-AS1 Gene

  • LHX4 Antisense RNA 1 2 3
  • LHX4-AS1 2 165
  • Acyl-CoA-Binding Domain-Containing Protein 6 4
  • Acyl-CoA Binding Domain Containing 6 5
  • NONHSAG003623.2 91
  • HSALNG0008807 164
  • ACBD6 5

External Ids for LHX4-AS1 Gene

Summaries for LHX4-AS1 Gene

GeneCards Summary for LHX4-AS1 Gene

LHX4-AS1 (LHX4 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with LHX4-AS1 include Pituitary Hormone Deficiency, Combined, 1. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. Gene Ontology (GO) annotations related to this gene include lipid binding and fatty-acyl-CoA binding.

UniProtKB/Swiss-Prot Summary for LHX4-AS1 Gene

  • Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids.

Additional gene information for LHX4-AS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LHX4-AS1 Gene

Genomics for LHX4-AS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LHX4-AS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LHX4-AS1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for LHX4-AS1 Gene

Genomic Locations for LHX4-AS1 Gene
chr1:180,269,653-180,502,954
(GRCh38/hg38)
Size:
233,302 bases
Orientation:
Minus strand
chr1:180,238,788-180,245,359
(GRCh37/hg19)
Size:
6,572 bases
Orientation:
Minus strand

Genomic View for LHX4-AS1 Gene

Genes around LHX4-AS1 on UCSC Golden Path with GeneCards custom track
LHX4-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
LHX4-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHX4-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHX4-AS1 Gene

Proteins for LHX4-AS1 Gene

  • Protein details for LHX4-AS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR61-ACBD6_HUMAN
    Recommended name:
    Acyl-CoA-binding domain-containing protein 6
    Protein Accession:
    Q9BR61

    Protein attributes for LHX4-AS1 Gene

    Size:
    282 amino acids
    Molecular mass:
    31151 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LHX4-AS1 Gene

neXtProt entry for LHX4-AS1 Gene

Post-translational modifications for LHX4-AS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LHX4-AS1 Gene

No data available for DME Specific Peptides for LHX4-AS1 Gene

Domains & Families for LHX4-AS1 Gene

Gene Families for LHX4-AS1 Gene

Protein Domains for LHX4-AS1 Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
  • Acyl-coA-binding protein, ACBP
ProtoNet:
genes like me logo Genes that share domains with LHX4-AS1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LHX4-AS1 Gene

Function for LHX4-AS1 Gene

Molecular function for LHX4-AS1 Gene

UniProtKB/Swiss-Prot Function:
Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids.

Phenotypes From GWAS Catalog for LHX4-AS1 Gene

Gene Ontology (GO) - Molecular Function for LHX4-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IEA --
GO:0005515 protein binding IPI --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with LHX4-AS1: view

miRNA for LHX4-AS1 Gene

miRTarBase miRNAs that target LHX4-AS1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LHX4-AS1 Gene

Localization for LHX4-AS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHX4-AS1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LHX4-AS1 gene
Compartment Confidence
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LHX4-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LHX4-AS1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LHX4-AS1 Gene

Pathways & Interactions for LHX4-AS1 Gene

genes like me logo Genes that share pathways with LHX4-AS1: view

Gene Ontology (GO) - Biological Process for LHX4-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006637 acyl-CoA metabolic process TAS --
genes like me logo Genes that share ontologies with LHX4-AS1: view

No data available for SIGNOR curated interactions for LHX4-AS1 Gene

Drugs & Compounds for LHX4-AS1 Gene

No Compound Related Data Available

Transcripts for LHX4-AS1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for LHX4-AS1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C729_9606 lncRNA 2657 2

HGNC: 40982,

RefSeq: NR_037642,

URS00009B66ED_9606 lncRNA 3082 2

LncBook: HSALNT0018236,

NONCODE: NONHSAT152606.1,

URS00008C1F41_9606 lncRNA 4803 1

LNCipedia: LHX4-AS1:7,

URS00003570A3_9606 lncRNA 2667 1

LNCipedia: LHX4-AS1:8,

URS0000D58A3C_9606 lncRNA 2657 1

LNCipedia: LHX4-AS1:9,

LHX4-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for LHX4-AS1 Gene

3 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for LHX4-AS1 Gene

No ASD Table

Relevant External Links for LHX4-AS1 Gene

GeneLoc Exon Structure for
LHX4-AS1

Expression for LHX4-AS1 Gene

Protein differential expression in normal tissues from HIPED for LHX4-AS1 Gene

This gene is overexpressed in Lymph node (11.2), Monocytes (9.8), and Testis (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LHX4-AS1 Gene



Protein tissue co-expression partners for LHX4-AS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LHX4-AS1

mRNA Expression by UniProt/SwissProt for LHX4-AS1 Gene:

Q9BR61-ACBD6_HUMAN
Tissue specificity: Detected in placenta and spleen (at protein level). Detected in placenta, umbilical cord blood, CD34-positive hematopoietic progenitor cells and bone marrow.

Evidence on tissue expression from TISSUES for LHX4-AS1 Gene

  • Lung(4.3)
  • Nervous system(2.4)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LHX4-AS1 Gene

Orthologs for LHX4-AS1 Gene

Evolution for LHX4-AS1 Gene

ENSEMBL:
Gene Tree for LHX4-AS1 (if available)
TreeFam:
Gene Tree for LHX4-AS1 (if available)

No data available for Orthologs for LHX4-AS1 Gene

Paralogs for LHX4-AS1 Gene

No data available for Paralogs for LHX4-AS1 Gene

Variants for LHX4-AS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LHX4-AS1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
720999 Benign: not provided 180,271,918(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
738533 Likely Benign: not provided 180,274,459(-) G/A SYNONYMOUS_VARIANT
744423 Likely Benign: not provided 180,274,376(-) G/A MISSENSE_VARIANT
746157 Likely Benign: not provided 180,274,375(-) C/T SYNONYMOUS_VARIANT
749051 Likely Benign: not provided 180,274,348(-) A/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for LHX4-AS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for LHX4-AS1 Gene

Variant ID Type Subtype PubMed ID
dgv474n100 CNV gain 25217958
nsv1013076 CNV gain 25217958
nsv466239 CNV gain 19166990
nsv548345 CNV gain 21841781
nsv832004 CNV gain 17160897

Additional Variant Information for LHX4-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LHX4-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for LHX4-AS1 Gene

Disorders for LHX4-AS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LHX4-AS1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
pituitary hormone deficiency, combined, 1
  • cphd1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LHX4-AS1

genes like me logo Genes that share disorders with LHX4-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LHX4-AS1 Gene

Publications for LHX4-AS1 Gene

  1. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4
  2. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4
  3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen JV … Mann M (Science signaling 2010) 4
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4
  5. Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells. (PMID: 18268358) Soupene E … Kuypers FA (Journal of lipid research 2008) 4

Products for LHX4-AS1 Gene

Sources for LHX4-AS1 Gene