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This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010] See more...
Aliases for LHX4 Gene
Aliases for LHX4 Gene
External Ids for LHX4 Gene
- HGNC: 21734
- Entrez Gene: 89884
- Ensembl: ENSG00000121454
- OMIM: 602146
- UniProtKB: Q969G2
Previous GeneCards Identifiers for LHX4 Gene
- GC01P177723
- GC01P175627
- GC01P176719
- GC01P177438
- GC01P176931
- GC01P178466
- GC01P180199
- GC01P151430
Summaries for LHX4 Gene
-
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010]
GeneCards Summary for LHX4 Gene
LHX4 (LIM Homeobox 4) is a Protein Coding gene. Diseases associated with LHX4 include Pituitary Hormone Deficiency, Combined, 4 and Pituitary Stalk Interruption Syndrome. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is LHX3.
UniProtKB/Swiss-Prot Summary for LHX4 Gene
-
May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536).
Additional gene information for LHX4 Gene
- HGNC(21734)
- Entrez Gene(89884)
- Ensembl(ENSG00000121454)
- OMIM(602146)
- UniProtKB(Q969G2)
- Open Targets Platform(ENSG00000121454)
- Monarch Initiative
- Search for LHX4 at DataMed
- Search for LHX4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LHX4 Gene
Genomics for LHX4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LHX4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LHX4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LHX4
- Top Transcription factor binding sites by QIAGEN in the LHX4 gene promoter:
-
- Bach1
- GR
- GR-alpha
- MyoD
- p300
- Sp1
- SRF
- SRF (504 AA)
Genomic Locations for LHX4 Gene
Genomic Locations for LHX4 Gene
- chr1:180,228,372-180,278,984
- (GRCh38/hg38)
- Size:
- 50,613 bases
- Orientation:
- Plus strand
- chr1:180,199,421-180,249,380
- (GRCh37/hg19)
- Size:
- 49,960 bases
- Orientation:
- Plus strand
Genomic View for LHX4 Gene
Genes around LHX4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.2 by HGNC
- 1q25.2 by Entrez Gene
- 1q25.2 by Ensembl
LHX4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LHX4 Gene
Proteins for LHX4 Gene
-
Protein details for LHX4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q969G2-LHX4_HUMAN
- Recommended name:
- LIM/homeobox protein Lhx4
- Protein Accession:
- Q969G2
- Q8NHE0
- Q8NHM1
- Q8TCJ1
- Q8WWX2
- Q969W2
Protein attributes for LHX4 Gene
- Size:
- 390 amino acids
- Molecular mass:
- 43124 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB62817.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Post-translational modifications for LHX4 Gene
Other Protein References for LHX4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences LHX4 Monoclonal Antibody
- Novus Biologicals Antibodies for LHX4
-
Abcam antibodies for LHX4
- Invitrogen Antibodies for LHX4 (AFLGC-LHX4)
-
Biorbyt antibodies for LHX4
-
Boster Bio Antibodies for LHX4
-
Santa Cruz Biotechnology (SCBT) Antibodies for LHX4
Protein Products
-
OriGene Purified Proteins for LHX4
- Search Origene for MassSpec and Protein Over-expression Lysates for LHX4
- Origene Custom Protein Services for LHX4
- antibodies-online: Show 4 available LHX4 Proteins ranked by validation data
- Compare Top LHX4 Proteins
-
Quality Products:
-
Abcam proteins for LHX4
Assay Products
No data available for DME Specific Peptides for LHX4 Gene
Domains & Families for LHX4 Gene
Gene Families for LHX4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for LHX4 Gene
- InterPro:
- Blocks:
-
- Zn-binding protein, LIM
- ProtoNet:
Suggested Antigen Peptide Sequences for LHX4 Gene
- GenScript: Design optimal peptide antigens:
-
- LIM/homeobox protein Lhx4 (LHX4_HUMAN)
- LIM homeobox protein 4 (Q5RLJ1_HUMAN)
- LIM homeobox protein 4 (Q5RLJ2_HUMAN)
- LIM homeobox protein 4 (Q5RLJ3_HUMAN)
- LIM homeobox 4 transcript variant (Q96JP7_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LHX4 Gene
Function for LHX4 Gene
Molecular function for LHX4 Gene
- UniProtKB/Swiss-Prot Function:
- May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536).
Phenotypes From GWAS Catalog for LHX4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 15998782 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for LHX4 Gene
- MGI mutant phenotypes for LHX4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LHX4:
Animal Models for LHX4 Gene
- MGI Knock Outs for LHX4:
-
- Lhx4 Lhx4<tm1Ssp>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LHX4 - Select products 50% OFF >
- * LHX4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LHX4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LHX4
-
Santa Cruz Biotechnology (SCBT) CRISPR for LHX4
miRNA for LHX4 Gene
- miRTarBase miRNAs that target LHX4
-
- hsa-miR-1-3p (MIRT023725)
- hsa-miR-4313 (MIRT623389)
- hsa-miR-3605-5p (MIRT623390)
- hsa-miR-6832-3p (MIRT623391)
- hsa-miR-6894-5p (MIRT656745)
- hsa-miR-548s (MIRT702265)
- hsa-miR-3688-5p (MIRT702266)
- hsa-miR-3926 (MIRT702267)
- hsa-miR-4470 (MIRT702268)
- hsa-miR-4786-5p (MIRT702269)
- hsa-miR-3190-5p (MIRT702270)
- hsa-miR-6849-3p (MIRT702271)
- hsa-miR-4433a-3p (MIRT702272)
- hsa-miR-4459 (MIRT702273)
- hsa-miR-4768-3p (MIRT702274)
- hsa-miR-6500-3p (MIRT702275)
- hsa-miR-3614-5p (MIRT702276)
- hsa-miR-548as-3p (MIRT702277)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LHX4
- Browse OriGene Inhibitory RNA Products For LHX4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LHX4
Clone Products
- Applied Biological Materials (abm): Clones for LHX4 - Select products 50% OFF >
- * LHX4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LHX4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LHX4
Cell Line Products
-
Horizon Cell Lines for LHX4
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LHX4 Gene
Localization for LHX4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LHX4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
- Nuclear speckles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA | 21873635 |
Pathways & Interactions for LHX4 Gene
Interacting Proteins for LHX4 Gene
Selected Interacting proteins:
Q969G2-LHX4_HUMAN
ENSP00000263726
for LHX4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for LHX4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001890 | placenta development | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0008045 | motor neuron axon guidance | IEA | -- |
| GO:0009887 | animal organ morphogenesis | IEA | -- |
| GO:0021526 | medial motor column neuron differentiation | IEA | -- |
No data available for Pathways by source for LHX4 Gene
Transcripts for LHX4 Gene
mRNA/cDNA for LHX4 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000263726 5844 nts (view in UCSC)
- ENST00000558139 721 nts (view in UCSC)
- ENST00000561113 603 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LHX4 - Select products 50% OFF >
- * LHX4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LHX4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LHX4
-
Santa Cruz Biotechnology (SCBT) CRISPR for LHX4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LHX4
- Browse OriGene Inhibitory RNA Products For LHX4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LHX4
Clone Products
- Applied Biological Materials (abm): Clones for LHX4 - Select products 50% OFF >
- * LHX4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LHX4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LHX4
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: |
Relevant External Links for LHX4 Gene
- GeneLoc Exon Structure for
- LHX4
Expression for LHX4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
-
Spinal Cord (Nervous System)
- Median Motor Neurons Median Motor Column
- Medial Neurons of the Median Motor Column Median Motor Column
-
Neurons
- Median Motor Neurons Median Motor Column
- Medial Neurons of the Median Motor Column Median Motor Column
- Gut Tube (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for LHX4 Gene
This gene is overexpressed in Testis (x5.1).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LHX4
SOURCE GeneReport for Unigene cluster for LHX4 Gene:
Hs.658487Evidence on tissue expression from TISSUES for LHX4 Gene
- Muscle(4.2)
- Nervous system(2.5)
Phenotype-based relationships between genes and organs from Gene ORGANizer for LHX4 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cheek
- cranial nerve
- ear
- eye
- face
- forehead
- head
- hypothalamus
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- pharynx
- pituitary gland
- skull
- thyroid
- tongue
Thorax:
- breast
- chest wall
- clavicle
- esophagus
- heart
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- abdominal wall
- adrenal gland
- intestine
- large intestine
- liver
- small intestine
- spleen
- stomach
Pelvis:
- ovary
- pelvis
- penis
- prostate
- rectum
- testicle
- urinary bladder
- uterus
- vagina
- vulva
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- coagulation system
- hair
- lymph node
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- spinal column
- spinal cord
- sweat gland
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for LHX4
-
OriGene qPCR primer pairs and template standards for LHX4
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for LHX4 Gene
Orthologs for LHX4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LHX4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LXH4 31 |
|
OneToOne | |
| LHX4 30 |
|
||||
| Dog (Canis familiaris) |
Mammalia | LHX4 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | LHX4 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Lhx4 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Lhx4 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | LHX4 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LHX4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | LHX4 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | lhx4 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Lim3 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | ceh-14 31 32 |
|
OneToMany | |
| lim-6 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2190 31 |
|
OneToMany |
- Species where no ortholog for LHX4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for LHX4 Gene
- ENSEMBL:
- Gene Tree for LHX4 (if available)
- TreeFam:
- Gene Tree for LHX4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LHX4: view image
Paralogs for LHX4 Gene
Paralogs for LHX4 Gene
(30) SIMAP similar genes for LHX4 Gene using alignment to 5 proteins:
- LHX4_HUMAN
- H0YKF4_HUMAN
- Q5RLJ1_HUMAN
- Q5RLJ2_HUMAN
- Q5RLJ3_HUMAN
Variants for LHX4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LHX4 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 708304 | Likely Benign: not provided | 180,248,403(+) | G/A | SYNONYMOUS_VARIANT | |
| 720999 | Benign: not provided | 180,271,918(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 727667 | Benign: not provided | 180,266,528(+) | G/A | MISSENSE_VARIANT | |
| 735772 | Likely Benign: not provided | 180,266,602(+) | G/C | INTRON_VARIANT | |
| 738533 | Likely Benign: not provided | 180,274,459(+) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv474n100 | CNV | gain | 25217958 |
| dgv476n100 | CNV | gain | 25217958 |
| esv23910 | CNV | loss | 19812545 |
| esv2660683 | CNV | deletion | 23128226 |
| esv2661645 | CNV | deletion | 23128226 |
| esv29505 | CNV | loss | 19812545 |
| esv3588063 | CNV | loss | 21293372 |
| esv3588064 | CNV | loss | 21293372 |
| nsv1013076 | CNV | gain | 25217958 |
| nsv466239 | CNV | gain | 19166990 |
| nsv548345 | CNV | gain | 21841781 |
| nsv832004 | CNV | gain | 17160897 |
| nsv946527 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.81;
93.41% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LHX4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHX4 Gene
Disorders for LHX4 Gene
(18) MalaCards diseases for LHX4 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pituitary hormone deficiency, combined, 4 |
|
|
| pituitary stalk interruption syndrome |
|
|
| hypothyroidism due to deficient transcription factors involved in pituitary development or function |
|
|
| combined pituitary hormone deficiencies, genetic forms |
|
|
| hypopituitarism |
|
Search LHX4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LHX4_HUMAN- Pituitary hormone deficiency, combined, 4 (CPHD4) [MIM:262700]: Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD4 is characterized by complete or partial deficiencies of growth hormone, thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone and adrenocorticotropic hormone. Clinical features include short stature, cerebellar defects, and small sella turcica. {ECO:0000269 PubMed:17527005, ECO:0000269 PubMed:18073311}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1. {ECO:0000269 PubMed:11567216}.
Additional Disease Information for LHX4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for LHX4 Gene
Publications for LHX4 Gene
- Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4. (PMID: 11567216) Machinis K … Amselem S (American journal of human genetics 2001) 2 3 4 23
- A novel missense mutation (P366T) of the LHX4 gene causes severe combined pituitary hormone deficiency with pituitary hypoplasia, ectopic posterior lobe and a poorly developed sella turcica. (PMID: 17527005) Tajima T … Fujieda K (Endocrine journal 2007) 3 4 23
- Impact of cytosine methylation on DNA binding specificities of human transcription factors. (PMID: 28473536) Yin Y … Taipale J (Science (New York, N.Y.) 2017) 3 4
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41
- Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion. (PMID: 20534763) Dateki S … Ogata T (The Journal of clinical endocrinology and metabolism 2010) 3 41
ExternalLinks
Products for LHX4 Gene
- Custom Antibody ServicesOriGene Antibodies for LHX4
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Search Origene for MassSpec and Protein Over-expression Lysates for LHX4
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- Browse OriGene Inhibitory RNA Products For LHX4
- OriGene qPCR primer pairs for LHX4
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- Browse OriGene miRNA Products For LHX4
- Sino Biological Human cDNA Clone for LHX4
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- High-throughput Antibody Production Service
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- Novus Biologicals Antibodies for LHX4
- Novus Biologicals proteins and lysates for LHX4
- Browse Antibodies
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- Browse ELISA Kits
- Abcam antibodies for LHX4
- Abcam proteins for LHX4
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- Browse Primary Antibodies
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- Invitrogen Antibodies for LHX4 (AFLGC-LHX4)
- VectorBuilder Custom and pre-made DNA vectors for LHX4 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Virus packaging for LHX4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for LHX4
- antibodies-online: Show 34 available LHX4 Antibodies ranked by validation data
- Compare Top LHX4 Antibodies
- antibodies-online: Show 10 available LHX4 Elisa Kits ranked by validation data
- Compare Top LHX4 Elisa Kits
- antibodies-online: Show 4 available LHX4 Proteins ranked by validation data
- Compare Top LHX4 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for LHX4
- Search Santa Cruz Biotechnology (SCBT) for LHX4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LHX4
- Horizon Cell Lines for LHX4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LHX4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LHX4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for LHX4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LHX4
- Boster Bio Antibodies for LHX4
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for LHX4
Sources for LHX4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB