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Aliases for LHCGR Gene

Aliases for LHCGR Gene

  • Luteinizing Hormone/Choriogonadotropin Receptor 2 3 5
  • Hypergonadotropic Hypogonadism 2 3
  • LH/CG-R 3 4
  • LHRHR 3 4
  • LSH-R 3 4
  • LCGR 3 4
  • LGR2 3 4
  • LHR 3 4
  • Lutropin-Choriogonadotropic Hormone Receptor 3
  • Lutropin/Choriogonadotropin Receptor 3
  • Luteinizing Hormone Receptor 4
  • LH/CGR 3
  • ULG5 3
  • HHG 3

External Ids for LHCGR Gene

Previous HGNC Symbols for LHCGR Gene

  • HHG

Previous GeneCards Identifiers for LHCGR Gene

  • GC02M048944
  • GC02M049082
  • GC02M048888
  • GC02M048825
  • GC02M048862

Summaries for LHCGR Gene

Entrez Gene Summary for LHCGR Gene

  • This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]

GeneCards Summary for LHCGR Gene

LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor) is a Protein Coding gene. Diseases associated with LHCGR include Precocious Puberty, Male-Limited and Leydig Cell Hypoplasia, Type I. Among its related pathways are Ovarian steroidogenesis and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and luteinizing hormone receptor activity. An important paralog of this gene is FSHR.

UniProtKB/Swiss-Prot for LHCGR Gene

  • Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).

Gene Wiki entry for LHCGR Gene

Additional gene information for LHCGR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHCGR Gene

Genomics for LHCGR Gene

GeneHancer (GH) Regulatory Elements for LHCGR Gene

Promoters and enhancers for LHCGR Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J048755 Promoter 0.5 EPDnew 650.7 +0.1 84 0.1 LHCGR ENSG00000279956 GC02P048647 STON1-GTF2A1L
GH02J048713 Enhancer 1 FANTOM5 Ensembl ENCODE 9.7 +40.7 40736 3 MEIS2 ZNF680 ZNF395 NFIC ZNF766 ZNF366 GLIS1 FOS PRDM10 WT1 LHCGR STON1-GTF2A1L STON1 ENSG00000279956 GC02P048647 GTF2A1L
GH02J048722 Enhancer 0.4 ENCODE 0.3 +32.7 32680 1.6 RFX1 GLIS1 FOS STON1-GTF2A1L LHCGR ENSG00000279956 GC02P048647 GTF2A1L
GH02J048693 Enhancer 0.4 ENCODE 0.2 +61.6 61634 1.9 USF1 NANOG GTF2A1L GC02P048647 LHCGR ENSG00000279956 STON1-GTF2A1L
GH02J048699 Enhancer 0.4 ENCODE 0.2 +56.1 56087 0.9 ATF4 POLR2A GC02P048647 ENSG00000279956 LHCGR GTF2A1L STON1-GTF2A1L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LHCGR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LHCGR gene promoter:
  • Sp1
  • E4BP4
  • FOXJ2 (long isoform)
  • FOXJ2
  • GR-beta
  • GR-alpha
  • GR

Genomic Locations for LHCGR Gene

Genomic Locations for LHCGR Gene
68,968 bases
Minus strand
123,453 bases
Minus strand

Genomic View for LHCGR Gene

Genes around LHCGR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LHCGR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHCGR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHCGR Gene

Proteins for LHCGR Gene

  • Protein details for LHCGR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lutropin-choriogonadotropic hormone receptor
    Protein Accession:
    Secondary Accessions:
    • Q14751
    • Q15996
    • Q9UEW9

    Protein attributes for LHCGR Gene

    699 amino acids
    Molecular mass:
    78643 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LHCGR Gene

    Alternative splice isoforms for LHCGR Gene


neXtProt entry for LHCGR Gene

Post-translational modifications for LHCGR Gene

  • Sulfated.
  • Glycosylation at posLast=313313, posLast=299299, posLast=291291, isoforms=2195, isoforms=2174, and isoforms=299
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LHCGR Gene

Domains & Families for LHCGR Gene

Gene Families for LHCGR Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LHCGR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
  • Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
genes like me logo Genes that share domains with LHCGR: view

Function for LHCGR Gene

Molecular function for LHCGR Gene

UniProtKB/Swiss-Prot Function:
Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).
GENATLAS Biochemistry:
luteinizing hormone/choriogonadotropin receptor,G protein coupled receptor superfamily,regulating in males,the devopment and function of Leyding cells with somatic activating mutations leading to Leyding cell and adenomes of the testis

Phenotypes From GWAS Catalog for LHCGR Gene

Gene Ontology (GO) - Molecular Function for LHCGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004963 follicle-stimulating hormone receptor activity IBA --
GO:0004964 luteinizing hormone receptor activity IEA,IMP 11847099
GO:0008528 G-protein coupled peptide receptor activity IBA --
genes like me logo Genes that share ontologies with LHCGR: view
genes like me logo Genes that share phenotypes with LHCGR: view

Human Phenotype Ontology for LHCGR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LHCGR Gene

MGI Knock Outs for LHCGR:

Animal Model Products

CRISPR Products

miRNA for LHCGR Gene

miRTarBase miRNAs that target LHCGR

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LHCGR

Clone Products

  • Addgene plasmids for LHCGR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LHCGR Gene

Localization for LHCGR Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHCGR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LHCGR gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LHCGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS 10617611
GO:0005886 plasma membrane TAS,IEA --
GO:0005887 integral component of plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LHCGR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LHCGR Gene

Pathways & Interactions for LHCGR Gene

genes like me logo Genes that share pathways with LHCGR: view

SIGNOR curated interactions for LHCGR Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LHCGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001545 primary ovarian follicle growth IBA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7719343
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA,ISS --
genes like me logo Genes that share ontologies with LHCGR: view

Drugs & Compounds for LHCGR Gene

(41) Drugs for LHCGR Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Goserelin Approved Pharma Full agonist, Agonist, activator, Target, agonist 240
Cetrorelix Approved, Investigational Pharma Antagonist, Target 68
Choriogonadotropin alfa Approved Pharma binder, Target 0
Lutropin alfa Approved Pharma binder, Target, agonist 0
Menotropins Approved Pharma binder, Target 66

(16) Additional Compounds for LHCGR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LHCGR: view

Transcripts for LHCGR Gene

mRNA/cDNA for LHCGR Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LHCGR Gene

Luteinizing hormone/choriogonadotropin receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LHCGR

Clone Products

  • Addgene plasmids for LHCGR

Alternative Splicing Database (ASD) splice patterns (SP) for LHCGR Gene

No ASD Table

Relevant External Links for LHCGR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LHCGR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LHCGR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LHCGR Gene

This gene is overexpressed in Esophagus - Muscularis (x13.1), Nerve - Tibial (x8.3), Esophagus - Gastroesophageal Junction (x6.7), and Ovary (x4.7).

Protein differential expression in normal tissues from HIPED for LHCGR Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LHCGR Gene

Protein tissue co-expression partners for LHCGR Gene

NURSA nuclear receptor signaling pathways regulating expression of LHCGR Gene:


SOURCE GeneReport for Unigene cluster for LHCGR Gene:


mRNA Expression by UniProt/SwissProt for LHCGR Gene:

Tissue specificity: Gonadal and thyroid cells.

Evidence on tissue expression from TISSUES for LHCGR Gene

  • Thyroid gland(4.2)
  • Kidney(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LHCGR Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • skeleton
Head and neck:
  • brain
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • pituitary gland
  • skull
  • breast
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
  • ovary
  • pelvis
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vas deferens
  • vulva
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • hair
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with LHCGR: view

Orthologs for LHCGR Gene

This gene was present in the common ancestor of animals.

Orthologs for LHCGR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LHCGR 34 33
  • 99.48 (n)
(Canis familiaris)
Mammalia LHCGR 34 33
  • 90.2 (n)
(Bos Taurus)
Mammalia LHCGR 34 33
  • 89.11 (n)
(Rattus norvegicus)
Mammalia Lhcgr 33
  • 84.89 (n)
(Mus musculus)
Mammalia Lhcgr 16 34 33
  • 84.64 (n)
(Monodelphis domestica)
Mammalia LHCGR 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia LHCGR 34
  • 55 (a)
(Gallus gallus)
Aves LHCGR 34 33
  • 72.45 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia lhcgr 33
  • 66.94 (n)
African clawed frog
(Xenopus laevis)
Amphibia lhcgr-A 33
(Danio rerio)
Actinopterygii lhcgr 34 33
  • 58.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta Lgr1 34 33
  • 50.91 (n)
Fsh 35
  • 37 (a)
rk 35
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRFSH 33
  • 49.4 (n)
(Caenorhabditis elegans)
Secernentea fshr-1 34 33
  • 46.42 (n)
C50H2.1 35
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
Species where no ortholog for LHCGR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LHCGR Gene

Gene Tree for LHCGR (if available)
Gene Tree for LHCGR (if available)
Evolutionary constrained regions (ECRs) for LHCGR: view image

Paralogs for LHCGR Gene

Paralogs for LHCGR Gene

(3) SIMAP similar genes for LHCGR Gene using alignment to 9 proteins:

  • H7C226_HUMAN
  • Q53S49_HUMAN
  • R4GN57_HUMAN
genes like me logo Genes that share paralogs with LHCGR: view

Variants for LHCGR Gene

Sequence variations from dbSNP and Humsavar for LHCGR Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs10176989 benign, Leydig cell agenesis, Hypergonadotropic hypogonadism, Gonadotropin-independent familial sexual precocity 48,755,729(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs10495956 benign, Gonadotropin-independent familial sexual precocity, Leydig cell agenesis, Hypergonadotropic hypogonadism 48,687,337(-) C/T 3_prime_UTR_variant
rs11125179 benign, not specified, Hypergonadotropic hypogonadism, Gonadotropin-independent familial sexual precocity, Leydig cell agenesis 48,688,732(-) A/G coding_sequence_variant, synonymous_variant
rs111834744 uncertain-significance, Gonadotropin-independent familial sexual precocity 48,713,934(-) A/ 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs114320052 likely-benign, Hypergonadotropic hypogonadism, Gonadotropin-independent familial sexual precocity, Leydig cell agenesis 48,688,437(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for LHCGR Gene

Variant ID Type Subtype PubMed ID
nsv1002793 CNV gain 25217958
nsv817851 CNV gain 17921354
nsv833992 CNV gain 17160897

Variation tolerance for LHCGR Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LHCGR Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHCGR Gene

Disorders for LHCGR Gene

MalaCards: The human disease database

(19) MalaCards diseases for LHCGR Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
precocious puberty, male-limited
  • sexual precocity, familial, gonadotropin-independent
leydig cell hypoplasia, type i
  • leydig cell hypoplasia with male pseudohermaphroditism
  • indeterminate sex and pseudohermaphroditism
precocious puberty
  • familial precocious puberty
leydig cell hypoplasia
  • leydig cell agenesis
- elite association - COSMIC cancer census association via MalaCards
Search LHCGR in MalaCards View complete list of genes associated with diseases


  • Familial male precocious puberty (FMPP) [MIM:176410]: In FMPP the receptor is constitutively activated. {ECO:0000269 PubMed:11134146, ECO:0000269 PubMed:11391350, ECO:0000269 PubMed:7629248, ECO:0000269 PubMed:7692306, ECO:0000269 PubMed:7714085, ECO:0000269 PubMed:7757065, ECO:0000269 PubMed:8281137, ECO:0000269 PubMed:8829636, ECO:0000269 PubMed:8929952, ECO:0000269 PubMed:9467560, ECO:0000269 PubMed:9661624}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Luteinizing hormone resistance (LHR) [MIM:238320]: An autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. {ECO:0000269 PubMed:12050206, ECO:0000269 PubMed:15372531, ECO:0000269 PubMed:15472221, ECO:0000269 PubMed:19551906, ECO:0000269 PubMed:7719343, ECO:0000269 PubMed:8559204, ECO:0000269 PubMed:9215288, ECO:0000269 PubMed:9514160, ECO:0000269 PubMed:9626144, ECO:0000269 PubMed:9626653}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for LHCGR

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LHCGR: view

No data available for Genatlas for LHCGR Gene

Publications for LHCGR Gene

  1. Luteinizing hormone signaling and breast cancer: polymorphisms and age of onset. (PMID: 12679452) Powell BL … Berns EM (The Journal of clinical endocrinology and metabolism 2003) 3 4 22 44 58
  2. A splice site mutation combined with a novel missense mutation of LHCGR cause male pseudohermaphroditism. (PMID: 19551906) Qiao J … Song HD (Human mutation 2009) 3 4 22 58
  3. Polymorphisms of the luteinizing hormone/chorionic gonadotropin receptor gene: association with maldescended testes and male infertility. (PMID: 18300940) Simoni M … Gromoll J (Pharmacogenetics and genomics 2008) 3 22 44 58
  4. Exclusion of coding-region mutations in luteinizing hormone and follicle-stimulating hormone receptor genes as the cause of ovarian hyperstimulation syndrome. (PMID: 17074323) Kerkelä E … Hovatta O (Fertility and sterility 2007) 3 22 44 58
  5. GnRH and LHR gene variants predict adverse outcome in premenopausal breast cancer patients. (PMID: 17692113) Piersma D … Berns EM (Breast cancer research : BCR 2007) 3 22 44 58

Products for LHCGR Gene

  • Addgene plasmids for LHCGR

Sources for LHCGR Gene

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