This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as test... See more...

Aliases for LHCGR Gene

Aliases for LHCGR Gene

  • Luteinizing Hormone/Choriogonadotropin Receptor 2 3 5
  • LCGR 2 3 4
  • LGR2 2 3 4
  • LHR 2 3 4
  • Lutropin-Choriogonadotropic Hormone Receptor 3 4
  • Hypergonadotropic Hypogonadism 2 3
  • LH/CG-R 3 4
  • LHRHR 3 4
  • LSH-R 3 4
  • ULG5 2 3
  • Lutropin/Choriogonadotropin Receptor 3
  • Luteinizing Hormone Receptor 4
  • LH/CGR 3
  • LHCGR 5
  • HHG 3

External Ids for LHCGR Gene

Previous HGNC Symbols for LHCGR Gene

  • HHG

Previous GeneCards Identifiers for LHCGR Gene

  • GC02M048944
  • GC02M049082
  • GC02M048888
  • GC02M048825
  • GC02M048647
  • GC02M048862

Summaries for LHCGR Gene

Entrez Gene Summary for LHCGR Gene

  • This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]

GeneCards Summary for LHCGR Gene

LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor) is a Protein Coding gene. Diseases associated with LHCGR include Precocious Puberty, Male-Limited and Leydig Cell Hypoplasia, Type I. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and luteinizing hormone receptor activity. An important paralog of this gene is FSHR.

UniProtKB/Swiss-Prot Summary for LHCGR Gene

  • Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).

Gene Wiki entry for LHCGR Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LHCGR Gene

Genomics for LHCGR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LHCGR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LHCGR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LHCGR

Top Transcription factor binding sites by QIAGEN in the LHCGR gene promoter:
  • E4BP4
  • FOXJ2
  • FOXJ2 (long isoform)
  • GR
  • GR-alpha
  • GR-beta
  • Sp1

Genomic Locations for LHCGR Gene

Latest Assembly
chr2:48,686,774-48,755,730
(GRCh38/hg38)
Size:
68,957 bases
Orientation:
Minus strand

Previous Assembly
chr2:48,913,913-48,982,863
(GRCh37/hg19 by Entrez Gene)
Size:
68,951 bases
Orientation:
Minus strand

chr2:48,859,428-48,982,880
(GRCh37/hg19 by Ensembl)
Size:
123,453 bases
Orientation:
Minus strand

Genomic View for LHCGR Gene

Genes around LHCGR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LHCGR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHCGR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHCGR Gene

Proteins for LHCGR Gene

  • Protein details for LHCGR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22888-LSHR_HUMAN
    Recommended name:
    Lutropin-choriogonadotropic hormone receptor
    Protein Accession:
    P22888
    Secondary Accessions:
    • Q14751
    • Q15996
    • Q9UEW9

    Protein attributes for LHCGR Gene

    Size:
    699 amino acids
    Molecular mass:
    78643 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LHCGR Gene

    Alternative splice isoforms for LHCGR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LHCGR Gene

Post-translational modifications for LHCGR Gene

  • Sulfated.
  • Glycosylation at Asn99, Asn174, Asn195, Asn291, Asn299, and Asn313
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for LHCGR

No data available for DME Specific Peptides for LHCGR Gene

Domains & Families for LHCGR Gene

Gene Families for LHCGR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LHCGR Gene

InterPro:
Blocks:
  • Cysteine-rich flanking region, N-terminal
  • Glycoprotein hormone receptor signature
  • Lutropin-choriogonadotropic hormone receptor precursor signature

Suggested Antigen Peptide Sequences for LHCGR Gene

GenScript: Design optimal peptide antigens:
  • Luteinizing hormone receptor (LSHR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P22888

UniProtKB/Swiss-Prot:

LSHR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
genes like me logo Genes that share domains with LHCGR: view

Function for LHCGR Gene

Molecular function for LHCGR Gene

UniProtKB/Swiss-Prot Function:
Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).
GENATLAS Biochemistry:
luteinizing hormone/choriogonadotropin receptor,G protein coupled receptor superfamily,regulating in males,the devopment and function of Leyding cells with somatic activating mutations leading to Leyding cell and adenomes of the testis

Phenotypes From GWAS Catalog for LHCGR Gene

Gene Ontology (GO) - Molecular Function for LHCGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004964 luteinizing hormone receptor activity IEA,IMP 11847099
GO:0008528 G protein-coupled peptide receptor activity IBA 21873635
GO:0016500 protein-hormone receptor activity IEA --
GO:0035472 choriogonadotropin hormone receptor activity ISS --
genes like me logo Genes that share ontologies with LHCGR: view
genes like me logo Genes that share phenotypes with LHCGR: view

Human Phenotype Ontology for LHCGR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LHCGR Gene

MGI Knock Outs for LHCGR:

miRNA for LHCGR Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LHCGR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LHCGR Gene

Localization for LHCGR Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHCGR Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LHCGR gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LHCGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS 10617611
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LHCGR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LHCGR Gene

Pathways & Interactions for LHCGR Gene

genes like me logo Genes that share pathways with LHCGR: view

Pathways by source for LHCGR Gene

SIGNOR curated interactions for LHCGR Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LHCGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7719343
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with LHCGR: view

Drugs & Compounds for LHCGR Gene

(43) Drugs for LHCGR Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Goserelin Approved Pharma Target, agonist, activator 300
Choriogonadotropin alfa Approved Pharma Target, binder 0
Lutropin alfa Approved Pharma Target, agonist, binder 0
Menotropins Approved Pharma Target, binder 127
Cetrorelix Approved, Investigational Pharma Target 100

(13) Additional Compounds for LHCGR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LHCGR: view

Transcripts for LHCGR Gene

mRNA/cDNA for LHCGR Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LHCGR

Alternative Splicing Database (ASD) splice patterns (SP) for LHCGR Gene

No ASD Table

Relevant External Links for LHCGR Gene

GeneLoc Exon Structure for
LHCGR

Expression for LHCGR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LHCGR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LHCGR Gene

This gene is overexpressed in Esophagus - Muscularis (x13.1), Nerve - Tibial (x8.3), Esophagus - Gastroesophageal Junction (x6.7), and Ovary (x4.7).

Protein differential expression in normal tissues from HIPED for LHCGR Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LHCGR Gene



Protein tissue co-expression partners for LHCGR Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LHCGR

SOURCE GeneReport for Unigene cluster for LHCGR Gene:

Hs.468490

mRNA Expression by UniProt/SwissProt for LHCGR Gene:

P22888-LSHR_HUMAN
Tissue specificity: Gonadal and thyroid cells.

Evidence on tissue expression from TISSUES for LHCGR Gene

  • Thyroid gland(4.3)
  • Kidney(2.4)
  • Nervous system(2.4)
  • Blood(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LHCGR Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • skeleton
Regions:
Head and neck:
  • brain
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • pituitary gland
  • skull
Thorax:
  • breast
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • ovary
  • pelvis
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vas deferens
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • hair
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with LHCGR: view

Primer products for research

Orthologs for LHCGR Gene

This gene was present in the common ancestor of animals.

Orthologs for LHCGR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LHCGR 29 30
  • 99.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LHCGR 29 30
  • 90.2 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LHCGR 29 30
  • 89.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lhcgr 29
  • 84.89 (n)
Mouse
(Mus musculus)
Mammalia Lhcgr 29 16 30
  • 84.64 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LHCGR 30
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LHCGR 30
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LHCGR 29 30
  • 72.45 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lhcgr 29
  • 66.94 (n)
African clawed frog
(Xenopus laevis)
Amphibia lhcgr-A 29
Zebrafish
(Danio rerio)
Actinopterygii lhcgr 29 30
  • 58.6 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Lgr1 29 30
  • 50.91 (n)
OneToMany
Fsh 31
  • 37 (a)
rk 31
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRFSH 29
  • 49.4 (n)
Worm
(Caenorhabditis elegans)
Secernentea fshr-1 29 30
  • 46.42 (n)
OneToMany
C50H2.1 31
  • 29 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 36 (a)
OneToMany
Species where no ortholog for LHCGR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LHCGR Gene

ENSEMBL:
Gene Tree for LHCGR (if available)
TreeFam:
Gene Tree for LHCGR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LHCGR: view image
Alliance of Genome Resources:
Additional Orthologs for LHCGR

Paralogs for LHCGR Gene

Paralogs for LHCGR Gene

(3) SIMAP similar genes for LHCGR Gene using alignment to 9 proteins:

  • LSHR_HUMAN
  • E7ENI1_HUMAN
  • E7EQB5_HUMAN
  • E7ESK4_HUMAN
  • E9PDH1_HUMAN
  • H7C226_HUMAN
  • Q4ZFZ4_HUMAN
  • Q53S49_HUMAN
  • R4GN57_HUMAN
genes like me logo Genes that share paralogs with LHCGR: view

Variants for LHCGR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LHCGR Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
74646 Conflicting Interpretations: Gonadotropin-independent familial sexual precocity; Leydig cell hypoplasia, type 1 48,708,956(-) C/T
NM_000233.4(LHCGR):c.672G>A (p.Pro224=)
SYNONYMOUS_VARIANT,INTRON
895518 Uncertain Significance: Gonadotropin-independent familial sexual precocity; Leydig cell hypoplasia, type 1 48,687,144(-) T/A
NM_000233.4(LHCGR):c.*553A>T
THREE_PRIME_UTR_VARIANT,INTRON
895594 Benign/Likely Benign: Gonadotropin-independent familial sexual precocity; Leydig cell hypoplasia, type 1 48,687,675(-) A/C
NM_000233.4(LHCGR):c.*22T>G
THREE_PRIME_UTR_VARIANT,INTRON
895595 Conflicting Interpretations: Gonadotropin-independent familial sexual precocity; Leydig cell hypoplasia, type 1 48,687,702(-) A/T
NM_000233.4(LHCGR):c.2095T>A (p.Cys699Ser)
MISSENSE_VARIANT,INTRON
895725 Conflicting Interpretations: Gonadotropin-independent familial sexual precocity; Leydig cell hypoplasia, type 1 48,725,688(-) C/T
NM_000233.4(LHCGR):c.371G>A (p.Arg124Gln)
MISSENSE_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LHCGR Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LHCGR Gene

Variant ID Type Subtype PubMed ID
nsv1002793 CNV gain 25217958
nsv817851 CNV gain 17921354
nsv833992 CNV gain 17160897

Variation tolerance for LHCGR Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LHCGR Gene

Human Gene Mutation Database (HGMD)
LHCGR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LHCGR
Leiden Open Variation Database (LOVD)
LHCGR

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHCGR Gene

Disorders for LHCGR Gene

MalaCards: The human disease database

(31) MalaCards diseases for LHCGR Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
precocious puberty, male-limited
  • sexual precocity, familial, gonadotropin-independent
leydig cell hypoplasia, type i
  • leydig cell hypoplasia with male pseudohermaphroditism
leydig cell hypoplasia type ii
  • 46,xy disorder of sex developement due to partial lh receptor inactivation
pseudohermaphroditism
  • indeterminate sex and pseudohermaphroditism
leydig cell hypoplasia
  • 46,xy disorder of sex development due to lh resistance or lhb deficiency
- elite association - COSMIC cancer census association via MalaCards
Search LHCGR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LSHR_HUMAN
  • Familial male precocious puberty (FMPP) [MIM:176410]: In FMPP the receptor is constitutively activated. {ECO:0000269 PubMed:11134146, ECO:0000269 PubMed:11391350, ECO:0000269 PubMed:7629248, ECO:0000269 PubMed:7692306, ECO:0000269 PubMed:7714085, ECO:0000269 PubMed:7757065, ECO:0000269 PubMed:8281137, ECO:0000269 PubMed:8829636, ECO:0000269 PubMed:8929952, ECO:0000269 PubMed:9467560, ECO:0000269 PubMed:9661624}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Luteinizing hormone resistance (LHR) [MIM:238320]: An autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. {ECO:0000269 PubMed:12050206, ECO:0000269 PubMed:15372531, ECO:0000269 PubMed:15472221, ECO:0000269 PubMed:19551906, ECO:0000269 PubMed:7719343, ECO:0000269 PubMed:8559204, ECO:0000269 PubMed:9215288, ECO:0000269 PubMed:9514160, ECO:0000269 PubMed:9626144, ECO:0000269 PubMed:9626653}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for LHCGR

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with LHCGR: view

No data available for Genatlas for LHCGR Gene

Publications for LHCGR Gene

  1. Luteinizing hormone signaling and breast cancer: polymorphisms and age of onset. (PMID: 12679452) Powell BL … Berns EM (The Journal of clinical endocrinology and metabolism 2003) 3 4 22 40
  2. A novel mutation of the human luteinizing hormone receptor in 46XY and 46XX sisters. (PMID: 9626144) Stavrou SS … Imperato-McGinley J (The Journal of clinical endocrinology and metabolism 1998) 3 4 22 72
  3. A homozygous mutation in the luteinizing hormone receptor causes partial Leydig cell hypoplasia: correlation between receptor activity and phenotype. (PMID: 9626653) Martens JW … Themmen AP (Molecular endocrinology (Baltimore, Md.) 1998) 3 4 22 72
  4. A splice site mutation combined with a novel missense mutation of LHCGR cause male pseudohermaphroditism. (PMID: 19551906) Qiao J … Song HD (Human mutation 2009) 3 4 22
  5. Polymorphisms of the luteinizing hormone/chorionic gonadotropin receptor gene: association with maldescended testes and male infertility. (PMID: 18300940) Simoni M … Gromoll J (Pharmacogenetics and genomics 2008) 3 22 40

Products for LHCGR Gene

  • Addgene plasmids for LHCGR

Sources for LHCGR Gene