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This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]
LHB (Luteinizing Hormone Subunit Beta) is a Protein Coding gene. Diseases associated with LHB include Hypogonadotropic Hypogonadism 23 Without Anosmia and Hypogonadism. Among its related pathways are Integrin Pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and hormone activity. An important paralog of this gene is CGB3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | TAS | 10484773 |
GO:0005179 | contributes_to hormone activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005796 | Golgi lumen | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
4 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
Nanog in Mammalian ESC Pluripotency
.62
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
5 | CREB Pathway |
CREB Pathway
.68
IP3 Pathway
.68
|
Activation of PKC through GPCR
.63
Intracellular Calcium Signaling
.50
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006701 | progesterone biosynthetic process | TAS | 14557487 |
GO:0007165 | signal transduction | TAS | 10484773 |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007267 | cell-cell signaling | TAS | 10484773 |
GO:0008584 | male gonad development | TAS | 6785294 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LHB 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LHB 30 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | LHB 30 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Lhb 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Lhb 30 17 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | LHB 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100490615 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | lhb 30 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
714891 | Benign: not provided | 49,016,305(-) | G/C | SYNONYMOUS_VARIANT | |
721564 | Likely Benign: not provided | 49,016,232(-) | G/A | MISSENSE_VARIANT | |
759653 | Likely Benign: not provided | 49,016,284(-) | C/T | SYNONYMOUS_VARIANT | |
769028 | Benign: not provided | 49,016,261(-) | G/T | MISSENSE_VARIANT | |
769029 | Benign: not provided | 49,017,058(-) | T/C | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
hypogonadotropic hypogonadism 23 without anosmia |
|
|
hypogonadism |
|
|
amenorrhea |
|
|
infertility |
|
|
hypogonadotropic hypogonadism |
|
|