LGR6 Gene (Protein Coding)

Leucine Rich Repeat Containing G Protein-Coupled Receptor 6

GC01P202193
GIFtS:
43
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing ... See more...

Aliases for LGR6 Gene

Aliases for LGR6 Gene

  • Leucine Rich Repeat Containing G Protein-Coupled Receptor 6 2 3 5
  • Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6 3 4
  • Gonadotropin Receptor 3
  • VTS20631 3
  • GPCR 3

External Ids for LGR6 Gene

Previous GeneCards Identifiers for LGR6 Gene

  • GC01P199847
  • GC01P197596
  • GC01P198629
  • GC01P199451
  • GC01P199461
  • GC01P198894
  • GC01P200429
  • GC01P202163
  • GC01P173328

Summaries for LGR6 Gene

Entrez Gene Summary for LGR6 Gene

  • This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGR6 Gene

LGR6 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 6) is a Protein Coding gene. Diseases associated with LGR6 include Myxedema and Eccrine Acrospiroma. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is LGR5.

UniProtKB/Swiss-Prot Summary for LGR6 Gene

  • Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.

Gene Wiki entry for LGR6 Gene

Additional gene information for LGR6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LGR6 Gene

Genomics for LGR6 Gene

GeneHancer (GH) Regulatory Elements for LGR6 Gene

Promoters and enhancers for LGR6 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J202203 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 761.2 +9.5 9500 1.2 ELF1 TEAD4 CBFA2T2 SMARCA4 TRIM24 IKZF1 DPF2 PRDM10 ZNF740 ATF1 LGR6 CHI3L1 HSALNG0009715 RF01210-032
GH01J202213 Promoter/Enhancer 1.1 EPDnew Ensembl dbSUPER 788.3 +20.5 20499 1.2 CTCF POLR2A ETS1 KLF1 LGR6 PTPRVP PTPN7 ARL8A HSALNG0009715 RF01210-033
GH01J202193 Promoter/Enhancer 1 EPDnew Ensembl dbSUPER 750.6 +0.1 99 0.8 CTCF EZH2 LGR6 PTPRVP RF01210-032
GH01J202195 Promoter/Enhancer 1 Ensembl dbSUPER 750.6 -0.6 -600 0.2 SIN3A CTCF RBPJ CC2D1A DACH1 KAT8 ZIC2 GATAD2A EZH2 ZBTB48 LGR6 lnc-LGR6-1
GH01J202192 Enhancer 0.9 ENCODE dbSUPER 750.6 -0.9 -893 0.2 SIN3A CTCF RBPJ CC2D1A RAD21 DACH1 AHR PPARG KAT8 ZIC2 LGR6 lnc-LGR6-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LGR6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LGR6 gene promoter:
  • Brachyury
  • HEN1
  • Ik-1
  • LCR-F1
  • SEF-1 (1)
  • ZIC2

Genomic Locations for LGR6 Gene

Genomic Locations for LGR6 Gene
chr1:202,193,901-202,319,785
(GRCh38/hg38)
Size:
125,885 bases
Orientation:
Plus strand
chr1:202,163,029-202,288,909
(GRCh37/hg19)
Size:
125,881 bases
Orientation:
Plus strand

Genomic View for LGR6 Gene

Genes around LGR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGR6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LGR6 Gene

Proteins for LGR6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for LGR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBX8-LGR6_HUMAN
    Recommended name:
    Leucine-rich repeat-containing G-protein coupled receptor 6
    Protein Accession:
    Q9HBX8
    Secondary Accessions:
    • Q5T509
    • Q5T512
    • Q6UY15
    • Q86VU0
    • Q96K69
    • Q9BYD7

    Protein attributes for LGR6 Gene

    Size:
    967 amino acids
    Molecular mass:
    104298 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55071.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LGR6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LGR6 Gene

Protein Expression for LGR6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LGR6 Gene

  • Glycosylation at Asn77 and Asn208
  • Modification sites at PhosphoSitePlus

Other Protein References for LGR6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LGR6 Gene

Domains & Families for LGR6 Gene

Gene Families for LGR6 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LGR6 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LGR6 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6_HUMAN)
  • Leucine-rich repeat-containing G protein-coupled receptor 6 (Q5T511_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HBX8

UniProtKB/Swiss-Prot:

LGR6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LGR6: view

Function for LGR6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for LGR6 Gene

UniProtKB/Swiss-Prot Function:
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.

Phenotypes From GWAS Catalog for LGR6 Gene

Gene Ontology (GO) - Molecular Function for LGR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity ISS --
GO:0004930 NOT G protein-coupled receptor activity IEA,ISS --
GO:0005515 protein binding IPI 21727895
GO:0008201 heparin binding IBA 21873635
GO:0016500 protein-hormone receptor activity IEA --
genes like me logo Genes that share ontologies with LGR6: view
genes like me logo Genes that share phenotypes with LGR6: view

Animal Models for LGR6 Gene

MGI Knock Outs for LGR6:
  • Lgr6 Lgr6<tm1Cle>
  • Lgr6 Lgr6<tm2.1(cre/ERT2)Cle>

Animal Model Products

  • Taconic Biosciences Mouse Models for LGR6

CRISPR Products

miRNA for LGR6 Gene

miRTarBase miRNAs that target LGR6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LGR6 Gene

Localization for LGR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGR6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGR6 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
extracellular 3
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LGR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LGR6: view

Pathways & Interactions for LGR6 Gene

genes like me logo Genes that share pathways with LGR6: view

Pathways by source for LGR6 Gene

1 BioSystems pathway for LGR6 Gene
1 KEGG pathway for LGR6 Gene

Gene Ontology (GO) - Biological Process for LGR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007411 axon guidance IBA 21873635
GO:0016055 Wnt signaling pathway IEA --
GO:0030177 positive regulation of Wnt signaling pathway IDA 22615920
genes like me logo Genes that share ontologies with LGR6: view

No data available for SIGNOR curated interactions for LGR6 Gene

Drugs & Compounds for LGR6 Gene

Products:

  1. Drug

(12) Drugs for LGR6 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
R-spondin-1 Pharma Full agonist, Agonist 0
R-spondin-2 Pharma Full agonist, Agonist 0
R-spondin-3 Pharma Agonist, Full agonist 0
R-spondin-4 Pharma Full agonist, Agonist 0

(4) Additional Compounds for LGR6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LGR6: view

Transcripts for LGR6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for LGR6 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(42) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGR6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5:
SP6:

ExUns: 23b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for LGR6 Gene

GeneLoc Exon Structure for
LGR6
ECgene alternative splicing isoforms for
LGR6

Expression for LGR6 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LGR6 Gene

mRNA expression in normal human tissues for LGR6 Gene
mRNA expression by BioGPS for LGR6 GenemRNA expression by GTEx for LGR6 Gene

mRNA differential expression in normal tissues according to GTEx for LGR6 Gene

This gene is overexpressed in Artery - Coronary (x13.4) and Artery - Aorta (x12.7).

Protein differential expression in normal tissues from HIPED for LGR6 Gene

This gene is overexpressed in Serum (59.8) and Platelet (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LGR6 Gene



Protein tissue co-expression partners for LGR6 Gene

NURSA nuclear receptor signaling pathways regulating expression of LGR6 Gene:

LGR6

SOURCE GeneReport for Unigene cluster for LGR6 Gene:

Hs.497402

Evidence on tissue expression from TISSUES for LGR6 Gene

  • Skin(2)
genes like me logo Genes that share expression patterns with LGR6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LGR6 Gene

Orthologs for LGR6 Gene

This gene was present in the common ancestor of animals.

Orthologs for LGR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LGR6 33 32
  • 94.7 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia LGR6 33 32
  • 86.74 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Lgr6 17 33 32
  • 86.42 (n)
rat
(Rattus norvegicus)
 Mammalia Lgr6 32
  • 86.39 (n)
oppossum
(Monodelphis domestica)
 Mammalia LGR6 33
  • 83 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia LGR6 33 32
  • 80.68 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia LGR6 33
  • 78 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LGR6 33 32
  • 73.01 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia LGR6 33
  • 67 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii lgr6 32
  • 65.57 (n)
fruit fly
(Drosophila melanogaster)
 Insecta rk 33
  • 22 (a)
 OneToMany
Species where no ortholog for LGR6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LGR6 Gene

ENSEMBL:
Gene Tree for LGR6 (if available)
TreeFam:
Gene Tree for LGR6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LGR6: view image

Paralogs for LGR6 Gene

Paralogs for LGR6 Gene

(10) SIMAP similar genes for LGR6 Gene using alignment to 3 proteins:

  • LGR6_HUMAN
  • D6R9F0_HUMAN
  • Q5T508_HUMAN
genes like me logo Genes that share paralogs with LGR6: view

Variants for LGR6 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for LGR6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035762 A colorectal cancer sample p.Gly725Cys
VAR_035763 A colorectal cancer sample p.Pro928His
rs1000003836 -- 202,289,578(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000032040 -- 202,250,270(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000074149 -- 202,198,572(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LGR6 Gene

Variant ID Type Subtype PubMed ID
dgv254n106 CNV deletion 24896259
esv1038842 CNV insertion 17803354
esv1167532 CNV insertion 17803354
esv1257220 CNV deletion 17803354
esv1458469 CNV insertion 17803354
esv2721550 CNV deletion 23290073
esv2721561 CNV deletion 23290073
esv3588577 CNV loss 21293372
esv3891059 CNV gain 25118596
nsv1010102 CNV gain 25217958
nsv1014912 CNV gain 25217958
nsv1110665 CNV insertion 24896259
nsv1142078 CNV tandem duplication 24896259
nsv473872 CNV novel sequence insertion 20440878
nsv473896 CNV novel sequence insertion 20440878
nsv478110 CNV novel sequence insertion 20440878
nsv522841 CNV gain 19592680
nsv946577 CNV duplication 23825009

Variation tolerance for LGR6 Gene

Residual Variation Intolerance Score: 60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LGR6 Gene

Human Gene Mutation Database (HGMD)
LGR6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LGR6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGR6 Gene

Disorders for LGR6 Gene

MalaCards: The human disease database

(10) MalaCards diseases for LGR6 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myxedema
eccrine acrospiroma
  • eccrine hidradenoma
eccrine sweat gland neoplasm
  • eccrine skin neoplasm
hair follicle neoplasm
  • hair matrix neoplasm
eccrine porocarcinoma
  • eccrine porocarcinoma of skin
- elite association - COSMIC cancer census association via MalaCards
Search LGR6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LGR6

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LGR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGR6 Gene

Publications for LGR6 Gene

  1. The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. (PMID: 10935549) Hsu SY … Hsueh AJ (Molecular endocrinology (Baltimore, Md.) 2000) 2 3 4 23 56
  2. LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. (PMID: 22615920) Gong X … Liu Q (PloS one 2012) 3 4 56
  3. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. (PMID: 21727895) de Lau W … Clevers H (Nature 2011) 3 4 56
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

ExternalLinks

View latest publications for LGR6 gene in Mastermind

Products for LGR6 Gene

Sources for LGR6 Gene