Aliases for LGMN Gene
External Ids for LGMN Gene
Previous HGNC Symbols for LGMN Gene
Previous GeneCards Identifiers for LGMN Gene
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]
GeneCards Summary for LGMN Gene
LGMN (Legumain) is a Protein Coding gene. Diseases associated with LGMN include Schistosomiasis and Cerebral Amyloid Angiopathy, Cst3-Related. Among its related pathways are Lysosome and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type endopeptidase activity. An important paralog of this gene is PIGK.
UniProtKB/Swiss-Prot Summary for LGMN Gene
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.