Aliases for LGALSL Gene

Aliases for LGALSL Gene

  • Galectin Like 2 3 5
  • Galectin-Related Protein 2 3 4
  • Lectin Galactoside-Binding-Like Protein 3 4
  • Galectin-Like Protein 3 4
  • GRP 3 4
  • Lectin, Galactoside Binding Like 3
  • Lectin, Galactoside-Binding-Like 2
  • HSPC159 3

External Ids for LGALSL Gene

Previous GeneCards Identifiers for LGALSL Gene

  • GC02P064681

Summaries for LGALSL Gene

GeneCards Summary for LGALSL Gene

LGALSL (Galectin Like) is a Protein Coding gene. Diseases associated with LGALSL include Lipodystrophy, Congenital Generalized, Type 3 and Lipodystrophy, Congenital Generalized, Type 2. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS9.

UniProtKB/Swiss-Prot Summary for LGALSL Gene

Gene Wiki entry for LGALSL Gene

Additional gene information for LGALSL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LGALSL Gene

Genomics for LGALSL Gene

GeneHancer (GH) Regulatory Elements for LGALSL Gene

Promoters and enhancers for LGALSL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LGALSL on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LGALSL

Genomic Locations for LGALSL Gene

Genomic Locations for LGALSL Gene
chr2:64,453,969-64,461,383
(GRCh38/hg38)
Size:
7,415 bases
Orientation:
Plus strand
chr2:64,681,103-64,688,517
(GRCh37/hg19)
Size:
7,415 bases
Orientation:
Plus strand

Genomic View for LGALSL Gene

Genes around LGALSL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALSL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALSL Gene

Proteins for LGALSL Gene

  • Protein details for LGALSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCW2-LEGL_HUMAN
    Recommended name:
    Galectin-related protein
    Protein Accession:
    Q3ZCW2
    Secondary Accessions:
    • B2RBG8
    • D6W5E8
    • Q6P5T6
    • Q9P005

    Protein attributes for LGALSL Gene

    Size:
    172 amino acids
    Molecular mass:
    18986 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LGALSL Gene

neXtProt entry for LGALSL Gene

Post-translational modifications for LGALSL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALSL Gene

No data available for DME Specific Peptides for LGALSL Gene

Domains & Families for LGALSL Gene

Gene Families for LGALSL Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LGALSL Gene

Blocks:
  • Galectin, galactose-binding lectin
InterPro:
ProtoNet:
genes like me logo Genes that share domains with LGALSL: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LGALSL Gene

Function for LGALSL Gene

Molecular function for LGALSL Gene

UniProtKB/Swiss-Prot Function:
Does not bind lactose, and may not bind carbohydrates.

Phenotypes From GWAS Catalog for LGALSL Gene

Gene Ontology (GO) - Molecular Function for LGALSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LGALSL: view
genes like me logo Genes that share phenotypes with LGALSL: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LGALSL Gene

Localization for LGALSL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALSL gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LGALSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with LGALSL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LGALSL Gene

Pathways & Interactions for LGALSL Gene

PathCards logo

SuperPathways for LGALSL Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALSL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LGALSL Gene

Drugs & Compounds for LGALSL Gene

No Compound Related Data Available

Transcripts for LGALSL Gene

mRNA/cDNA for LGALSL Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALSL Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: -
SP3: -
SP4: - - - -

Relevant External Links for LGALSL Gene

GeneLoc Exon Structure for
LGALSL

Expression for LGALSL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LGALSL Gene

mRNA differential expression in normal tissues according to GTEx for LGALSL Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.7) and Skin - Not Sun Exposed (Suprapubic) (x7.6).

Protein differential expression in normal tissues from HIPED for LGALSL Gene

This gene is overexpressed in Platelet (24.4), Peripheral blood mononuclear cells (9.3), Monocytes (9.2), and Serum (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LGALSL Gene



Protein tissue co-expression partners for LGALSL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LGALSL

SOURCE GeneReport for Unigene cluster for LGALSL Gene:

Hs.372208

Evidence on tissue expression from TISSUES for LGALSL Gene

  • Nervous system(4.6)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with LGALSL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALSL Gene

Orthologs for LGALSL Gene

This gene was present in the common ancestor of chordates.

Orthologs for LGALSL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LGALSL 31 30
  • 98.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LGALSL 31 30
  • 94 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LGALSL 31 30
  • 93.99 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LGALSL 31
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 92 (a)
OneToMany
-- 31
  • 85 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lgalsl 17 31 30
  • 91.67 (n)
Gm5065 31
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Lgalsl 30
  • 89.92 (n)
chicken
(Gallus gallus)
Aves LGALSL 31 30
  • 78.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LGALSL 31
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lgalsl 30
  • 72.32 (n)
Str.459 30
zebrafish
(Danio rerio)
Actinopterygii lgalsla 30
  • 63.64 (n)
lgalslb 31
  • 57 (a)
OneToOne
Species where no ortholog for LGALSL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LGALSL Gene

ENSEMBL:
Gene Tree for LGALSL (if available)
TreeFam:
Gene Tree for LGALSL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LGALSL: view image

Paralogs for LGALSL Gene

(5) SIMAP similar genes for LGALSL Gene using alignment to 5 proteins:

  • LEGL_HUMAN
  • B9A055_HUMAN
  • F8WF17_HUMAN
  • U3KQ88_HUMAN
  • U3KQU5_HUMAN
genes like me logo Genes that share paralogs with LGALSL: view

Variants for LGALSL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LGALSL Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
782084 Benign: not provided 64,458,296(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for LGALSL Gene

Structural Variations from Database of Genomic Variants (DGV) for LGALSL Gene

Variant ID Type Subtype PubMed ID
nsv1006553 CNV gain 25217958
nsv582126 CNV gain 21841781
nsv582127 CNV gain 21841781
nsv7313 OTHER inversion 18451855
nsv834245 CNV gain 17160897

Variation tolerance for LGALSL Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LGALSL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LGALSL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALSL Gene

Disorders for LGALSL Gene

MalaCards: The human disease database

(5) MalaCards diseases for LGALSL Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LGALSL

genes like me logo Genes that share disorders with LGALSL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALSL Gene

Publications for LGALSL Gene

  1. Expression, purification, crystallization and preliminary X-ray characterization of the GRP carbohydrate-recognition domain from Homo sapiens. (PMID: 16682780) Zhou D … Liu P (Acta crystallographica. Section F, Structural biology and crystallization communications 2006) 2 3 4 54
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 54
  3. Crystal structure of the C-terminal conserved domain of human GRP, a galectin-related protein, reveals a function mode different from those of galectins. (PMID: 18320588) Zhou D … Niu L (Proteins 2008) 3 4 54
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 54
  5. HSPC159 promotes proliferation and metastasis by inducing epithelial-mesenchymal transition and activating the PI3K/Akt pathway in breast cancer. (PMID: 29737572) Zheng J … Lu S (Cancer science 2018) 3 54

Products for LGALSL Gene

Sources for LGALSL Gene